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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng yi Jiali Song Luojia Wu Wei Wan Xiuqin Rao Yue Lin Gen Wei jun ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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竞争环境下双目标零售平台销售模式选择

管理工程学报 2025年第1期39卷 227-242页

作者：张冲朱祎宋君南京邮电大学管理学院

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求... 详细信息

电子商务行业发展迅速,具有“超越利润”战略导向以实现更广泛目标的组织正变得越来越普遍,兼顾消费者利益成为企业凸显竞争优势的方式。为此,本文构建由一个制造商和两个零售平台组成的两级供应链。其中,制造商和其中一个零售平台追求自身利润最大化,另外一个零售平台追求自身利润和消费者剩余的线性组合最大化,即考虑双目标最优。本文具体考虑两个零售平台分别选择转售模式或代理模式共四种情形,进而研究双目标零售平台销售模式选择问题,及其对供应链成员最优决策和供应链整体绩效的影响。结果表明:(1)在一定条件下,双目标零售平台能获得比竞争对手更高的利润;(2)当双目标零售平台选择转售模式时,无论其竞争对手选择哪种销售模式,其双目标策略都能使供应链总体利润得到优化;(3)当双目标零售平台的竞争对手选择代理模式时,其自身根据不同情况选择转售模式或者代理模式可以使两个零售平台的销售模式选择形成均衡。

关键词：双目标企业社会责任零售平台销售模式双渠道

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Direct Z-scheme CdFe_(2)O_(4)/g-C3N4 hybrid photocatalysts for highly efficient ceftiofur sodium photodegradation

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Journal of Materials Science & Technology 2020年第21期56卷 133-142页

作者： miao-miao Fang jun-Xia Shao Xiang-Gang Huang Jin-yi Wang Wei Chen School of Pharmaceutical and Materials Engineering Taizhou UniversityTaizhou 318000China

A direct Z-scheme CdFe_(2)O_(4)/g-C3N4 hybrid systems with different weight ratios of CdFe2O4 nanoparticles were successfully designed and constructed for ceftiofur sodium *** as-obtained CdFe_(2)O_(4)/g-C_(3)N_(4) hybrid samples composed of CdFe_(2)O_(4) nanoparticles and g-C3N4 nanosheets were systematically characterized by different techniques including X-ray diffraction,scanning electron microscope,transmission electron microscope,Fourier transform infrared spectroscopy,X-ray photoelectron spectroscopy,UV–vis DRS,chemical oxygen demand,inductively coupled plasma mass spectrometer,photochemical test and electron spin resonance spectrometer *** optimal photocatalytic activity for ceftiofur sodium photodegradation was achieved by modulating the weight ration between CdFe_(2)O_(4) nanoparticles and g-C_(3)N_(4) *** result from photocatalytic tests indicate that Cd Fe_(2)O_(4)/g-C_(3)N_(4)-2 hybrid sample exhibit highly efficient photocatalytic activity towards ceftiofur sodium removal in comparison with pristine CdFe_(2)O_(4) nanoparticles and pure g-C_(3)N_(4) *** the excellent photocatalytic stability of CdFe_(2)O_(4)/g-C_(3)N_(4)-2 hybrid sample was also verified during recycling runs towards photocatalytic ceftiofur sodium *** significant enhancement of photocatalytic activity was attributed to the Z-scheme charge separation and transfer based on the construction of tight heterogeneous interface and well-matched band *** expect this research to provide a new insight into the design and preparation of direct Z-scheme hybrid photocatalysts for environmental remediation.

关键词： CdFe2O4 g-C3N4 Z-scheme Photodegradation

A method to Estimate Dynamic Responses of VLFS Based on Multi-Floating-Module Model Connected by Elastic Hinges

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China Ocean Engineering 2021年第5期35卷 687-699页

作者： HUANG Heng CHEN Xu-jun LIU jun-yi miao Yu-ji JI Song College of Field Engineering Army Engineering University of PLANanjing 210007China China Ship Scientific Research Center Wuxi 214082China

Based on the elastic foundation beam theory and the multi-floating-module hydrodynamic theory,a novel method is proposed to estimate the dynamic responses of VLFS(Very Large Floating Structure).In still water,a VLFS can be simplified as an elastic foundation beam model or a multi-floating-module model connected by elastic *** to equivalent displacement of the two models in static analysis,the problem of rotation stiffness of elastic hinges can be ***,based on the potential flow theory,the dynamic responding analysis of multi-floatingmodule model under wave loads can be computed in ANSYS-AQWA *** assembling the time domain analysis results of each module,the dynamic responses of the VLFS can be *** of the method is conducted through a series of comparison calculations,which mainly includes a continuous structure and a three-part structure connected by hinges in regular *** results of this paper method show a satisfactory agreement with the experiment and calculation data given in relative references.

关键词： Very Large Floating Structure(VLFS) dynamic responses elastic foundation beam multi-floatingmodule model elastic hinge

A Comprehensive Review of Redirected Walking Techniques:Taxonomy,Methods,and Future Directions

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Journal of Computer Science & Technology 2022年第3期37卷 561-583页

作者： yi-jun Li Frank Steinicke miao Wang State Key Laboratory of Virtual Reality Technology and Systems School of Computer Science and EngineeringBeihang UniversityBeijing 100191China Department of Informatics Universität HamburgHamburg 20146Germany Peng Cheng Laboratory Shenzhen 518055China

Virtual reality(VR)allows users to explore and experience a computer-simulated virtual environment so that VR users can be immersed in a totally artificial virtual world and interact with arbitrary virtual ***,the limited physical tracking space usually restricts the exploration of large virtual spaces,and VR users have to use special locomotion techniques to move from one location to *** these techniques,redirected walking(RDW)is one of the most natural locomotion techniques to solve the problem based on near-natural walking *** core idea of the RDW technique is to imperceptibly guide users on virtual paths,which might vary from the paths they physically walk in the real *** a similar way,some RDW algorithms imperceptibly change the structure and layout of the virtual environment such that the virtual environment fits into the tracking *** this survey,we first present a taxonomy of existing RDW *** on this taxonomy,we compare and analyze both contributions and shortcomings of the existing methods in detail,and find view manipulation methods offer satisfactory visual effect but the experience can be interrupted when users reach the physical boundaries,while virtual environment manipulation methods can provide users with consistent movement but have limited application ***,we discuss possible future research directions,indicating combining artificial intelligence with this area will be effective and intriguing.

关键词： virtual reality locomotion redirected walking

VR content creation and exploration with deep learning: A survey

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Computational Visual Media 2020年第1期6卷 3-28页

作者： miao Wang Xu-Quan Lyu yi-jun Li Fang-Lue Zhang State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing 100191China. Peng Cheng Laboratory Shenzhen 518000China School of Engineering and Computer Science Victoria University of WellingtonNew Zealand

Virtual reality(VR)offers an artificial,computer generated simulation of a real life *** originated in the 1960 s and has evolved to provide increasing immersion,interactivity,imagination,and *** deep learning systems are able to represent and compose information at various levels in a deep hierarchical fashion,they can build very powerful models which leverage large quantities of visual media *** of VR methods and applications has been significantly boosted by the recent developments in deep learning *** content creation and exploration relates to image and video analysis,synthesis and editing,so deep learning methods such as fully convolutional networks and general adversarial networks are widely employed,designed specifically to handle panoramic images and video and virtual 3 D *** article surveys recent research that uses such deep learning methods for VR content creation and *** considers the problems involved,and discusses possible future directions in this active and emerging research area.

关键词： virtual reality deep learning neural networks 360°image and video virtual content

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang jun-Zhao Xiao yi-Fan Wang Tian-Yu Wei Jia-Wei Jiang Ye Wang Qian Peng Liang yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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Asymmetrical Bell state analysis for photon-atoms hybrid system

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Science China(Physics,Mechanics & Astronomy) 2019年第12期62卷 10-18页

作者： yi-Lin Liu miao-Wei Wang Chun-Yu Bai Tie-jun Wang School of Science Beijing University of Posts and TelecommunicationsBeijing 100876China State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China

Bell-state analysis(BSA) has great application in the quantum communication. To our best knowledge, the current works are devoted to the physical realization of symmetrical 2×2-dimensional or 2^N× 2^N-dimensional 2-qudit BSA, and there is no work focused on the physical realization of the asymmetrical high-dimensional(for example 3×4-dimensional 2-qudit) Bell-states complete analysis. In this paper, by using the nonlinear interaction between the atoms and photons, we propose a scheme to completely distinguish the asymmetrical 3×4-dimensional 2-qudit Bell states of a hybrid system. We use the quantum information splitting, which is exploited to resolve the degree-mismatch issue in the quantum state sharing schemes, as an example to show the application of the asymmetrical BSA. Finally, we discuss its possible realization with current experimental techniques. Our asymmetrical high-dimensional BSA protocol may pave a new way for high-capacity long-distance quantum communication.

关键词： quantum optics quantum information processing quantum cryptography

Convergence analysis of an incremental approach to online inverse reinforcement learning

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Journal of Zhejiang University-Science C(Computers and Electronics) 2011年第1期12卷 17-24页

作者： Zhuo-jun JIN Hui QIAN Shen-yi CHEN miao-liang ZHU School of Computer Science and Technology Zhejiang University Hangzhou 310027 China

Interest in inverse reinforcement learning (IRL) has recently increased,that is,interest in the problem of recovering the reward function underlying a Markov decision process (MDP) given the dynamics of the system and the behavior of an *** paper deals with an incremental approach to online ***,the convergence property of the incremental method for the IRL problem was investigated,and the bounds of both the mistake number during the learning process and regret were provided by using a detailed *** an online algorithm based on incremental error correcting was derived to deal with the IRL *** key idea is to add an increment to the current reward estimate each time an action mismatch *** leads to an estimate that approaches a target optimal *** proposed method was tested in a driving simulation experiment and found to be able to efficiently recover an adequate reward function.

关键词： Incremental approach Reward recovering Online learning Inverse reinforcement learning Markov decision process