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China Ocean Engineering 2024年第4期38卷 586-601页

作者： LIAN Ji-jian ZHU Hang guo Yao-hua WANG Hai-jun YU Tong-shun State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300072China School of Civil Engineering Tianjin UniversityTianjin 300072China Tianjin University of Technology Tianjin 300384China College of Engineering Ocean University of ChinaQingdao 266100China

As offshore wind farms expand into deeper and farther ocean regions and the unit capacity of offshore wind turbines(OWTs)increases,there is a pressing need for a new foundation structure that can accommodate deep-sea conditions and support large capacities while maintaining economical and *** meet this goal of integrated transportation and one-step installation,a novel five-bucket jacket foundation(FBJF),with its suction installation and leveling methods in sand,has been proposed,analyzed and experimentally ***,seepage failure experiments of the FBJF at various depths were conducted,and a formula for calculating the critical suction of seepage failure suitable for the FBJF in sand was chosen and recommended for use with a range of values for the permeability coefficient ***,through leveling experiments of the FBJF at different depths,the maximum adjustable leveling angle during the sinking process was defined using seepage failure and the adjustable leveling angle of the foundation as control *** leveling control strategies were proposed and ***,an automatic sinking and leveling control system for the FBJF was developed and experimentally verified for feasibility.

关键词： offshore wind turbine(OWT) bucket foundation seepage failure suction installation

Controlling solid form and crystal habit of triphenylmethanol by antisolvent crystallization in a microfluidic device

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Chinese Chemical Letters 2024年第4期35卷 393-398页

作者： jun Lu Jinrui Yan Yaohao guo junjie Qiu Shuangliang Zhao Bo Bao East China University of Science and Technology Shanghai 200237China Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification Technology and School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China

Crystal habit and crystal form are critical elements in determining product properties and functions. In this work, we developed a microfluidic antisolvent crystallization technique to rapidly screen and accurately control the solid form and crystal habit of triphenylmethanol(Ph_(3)COH). This advanced technique separates the primary mixing of solutions from crystal formation(nucleation and growth) by introducing the microfluidic device, avoiding clogging in microchannels to obtain high-quality crystals. The results show that we can achieve controllable preparation of pure 2Ph_(3)COH·DMSO(DMSO solvate), pure Ph_(3)COH(form β), and mixed crystals with different mass ratios. Moreover, the microscale can prompt the DMSO solvate to grow into hexagonal sheet-like and bulk crystals. We can regulate the aspect ratio of hexagonal sheet-like crystals in binary solvents and control the crystal habit of the form β to transition between long needle-like shapes and short hexagonal prisms in DMF-H_(2)O. Meanwhile, we revealed that the solvent ratio, the antisolvent flow rate, and the initial concentration of Ph_(3)COH are the main factors affecting the solid form selectivity and morphology transition. Such a novel method would be considered as a promising technique to be extended to screen and control key crystallization parameters of other substances.

关键词： Microfluidics Triphenylmethanol Antisolvent crystallization Crystal habit Solid form

Heterobimetallic lanthanide tetrahedral cages:Synthesis,design and application for potential multimodal imaging contrast agent

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Journal of Rare Earths 2024年第2期42卷 278-285,I0002页

作者： Yongxiu Li Feng guo Siwei Wei Duofu Li jun Zhang Kai Xu Dongping Li Department of Chemistry Nanchang UniversityNanchang330031China Key Laboratory of Functional Molecule Design and Interface Process Anhui Jianzhu UniversityHefei230601China Department of Otolaryngology Head and Neck SurgeryThe Second Affiliated Hospital of Nanchang UniversityNanchang330006China

The construction and functionalization of lanthanide-organic cages have been a research hotspot in coordination *** from the unique luminescent and magnetic properties of lanthanide ions,the potential applications of lanthanide-organic cages in biological imaging applications are promising,but only a few corresponding explorations have been *** rein,we introduced a series of lanthanide tetrahedral cages,(Eu_(n)Gd_(4-n)L_(4))(sol)_8(n=0,1,2,3 and 4,where L=(4,4',4"-tris(4,4,4-trifluoro-1,3-dioxobutyl)-triphenylamine,and sol=dimethyl sulfoxide and methanol),with potential applications in biological *** the good luminescent and magnetic properties of Eu^(3+) and Gd^(3+) ions,Eu_(4)L_(4) and Gd_(4)L_(4) complexes show a high luminescence quantum yield of 29% in DMSO and large longitudinal relaxivity(r_(1)) of 11.4(mmol/L)^(-1)/s at 0.5 T in water containing 1 vol% DMSO,*** heterobimetallic Eu-Gd complexes achieve a dual imaging mode by combining luminescent and magnetic centers in one *** the Gd:Eu ratio increases from 1:3 to 3:1,the r_(1) values increases from 5.33 to 8.64(mmoI/L)^(-1)/s,higher than that of commercial contrast agent Gd-DOTA(3.23(mmol/L)^(-1)/s).Owing to their low toxicity and good cell imaging ability toward ECA 109 cells,the selfassembled Eu-Gd heterobimetallic tetrahedral cages could be potential candidates for the multimodal imaging contrast agent.

关键词： Lanthanide organic cage Luminescence Cell imaging Contrast agents Rare earths

MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1-extracellular signal-regulated kinase-1/2 axis

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2123-2140页

作者： Hong-xia Bai Xue-Mei Qiu Chun-Hong Xu Jian-Qiang guo Department of Gastroenterology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina Department of Gastroenterology Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Reproductive Center Zaozhuang Maternal and Child Health Care HospitalZaozhuang 277000Shandong ProvinceChina

BACKGROUND MicroRNAs(miRNAs)regulate gene expression and play a critical role in cancer ***,there is still a limited understanding of the function and regulatory mechanism of miRNAs in gastric cancer(GC).AIM To investigate the role and molecular mechanism of miRNA-145-5p(miR145-5p)in the progression of *** Real-time polymerase chain reaction(RT-PCR)was used to detect miRNA expression in human GC tissues and *** ability of cancer cells to migrate and invade was assessed using wound-healing and transwell assays,*** proliferation was measured using cell counting kit-8 and colony formation assays,and apoptosis was evaluated using flow *** of the epithelial-mesenchymal transition(EMT)-associated protein was determined by Western *** of miR-145-5p were predicated using bioinformatics analysis and verified using a dual-luciferase reporter *** family E member 1(SERPINE1)expression in GC tissues and cells was evaluated using RT-PCR and immunohistochemical *** correlation between SERPINE1 expression and overall patient survival was determined using Kaplan-Meier plot *** association between SERPINE1 and GC progression was also tested.A rescue experiment of SERPINE1 overexpression was conducted to verify the relationship between this protein and *** mechanism by which miR-145-5p influences GC progression was further explored by assessing tumor formation in nude *** GC tissues and cells had reduced miR-145-5p expression and SERPINE1 was identified as a direct target of this *** of miR-145-5p was associated with decreased GC cell proliferation,invasion,migration,and EMT,and these effects were reversed by forcing SERPINE1 ***-Meier plot analysis revealed that patients with higher SERPINE1 expression had a shorter survival rate than those with lower SERPINE1 *** mouse tumorigenesis experiments confirmed that miR-145-5p target

关键词： Gastric cancer MicroRNA-145-5p Serpin family E member 1 Epithelial-mesenchymal transition Proliferation Extracellular signal-regulated kinase-1/2

Glycine betaine modulates extracellular polymeric substances to enhance microbial salinity tolerance

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Environmental Science and Ecotechnology 2024年第4期20卷 259-268页

作者： Yan xia Xinbai Jiang Shuaishuai guo Yuxuan Wang Yang Mu Jinyou Shen Key Laboratory of Environmental Remediation and Ecological Health Ministry of Industry and Information TechnologySchool of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing210094China CAS Key Laboratory of Urban Pollutant Conversion Department of Environmental Science and EngineeringUniversity of Science&Technology of ChinaHefei230026China

High salinity inhibits microbial activity in the bioremediation of saline *** alleviate osmotic stress,glycine betaine(GB),an osmoprotectant,is added to enhance the secretion of extracellular polymeric substances(EPS).These EPS are pivotal in withstanding environmental stressors,yet the intricate interplay between GB supplementation and microbial responses through EPS modificationsdencompassing composition,molecular architecture,and electrochemical featuresdremains elusive in hypersaline *** we show microbial strategies for salinity endurance by investigating the impact of GB on the dynamic alterations of EPS *** findings reveal that GB supplementation at 3.5%salinity elevates the total EPS(T-EPS)content from 12.50±0.05 to 24.58±0.96 mg per g dry cell *** observed shift in zeta potential from-28.95 to-6.25 mV at 0%and 3.5%salinity,respectively,with GB treatment,indicates a reduction in electrostatic repulsion and ***,the EPS protein secondary structure transition from b-sheet to a-helix,with GB addition,signifies a more compact protein configuration,less susceptible to salinity *** analyses,including cyclic voltammetry(CV)and differential pulse voltammetry(DPV),reveal GB's role in promoting the release of exogenous electron shuttles,such as flavins and c-type cytochromes(c-Cyts).The enhancement in DPV peak areas(Q_(DPV))with GB addition implies an increase in available extracellular electron transfer *** investigation advances our comprehension of microbial adaptation mechanisms to salinity through EPS modifications facilitated by GB in saline habitats.

关键词： High salinity Extracellular polymeric substances Glycine betaine Protein secondary structure Extracellular electron transfer

Theoretical study on the effect of H_(2)O on the formation mechanism of NO_(x) precursors during indole pyrolysis

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 99-112页

作者： Ziqi Wang jun Shen Xuesong Liu Sha Wang Shengxiang Deng Hai Zhang Yun guo School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai 201620China School of Mechanical Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The incineration technology of kitchen waste is one of the effective technologies to achieve the resource utilization of municipal solid *** is an important stage of *** is a rich initial product in the pyrolysis process of kitchen waste,and the presence of H_(2)O has a significant impact on the decomposition of indole to form NO_(x) ***,this study uses density functional theory method to study the effect of H_(2)O on the thermal decomposition of indole to produce NH_(3),HNCO,and *** H_(2)O participates in the reaction,it can provide oxidative groups to generate a new product HNCO,which is different from the previous findings by indole pyrolysis without the presence of H_(2)***,this study theoretically proves that NH_(3) is easier to form than *** is consistent with the phenomenon that NH_(3) release is higher than HCN release in pyrolysis *** addition,compared with the individual pyrolysis of indole,the participation of H_(2)O reduces the energy barriers for the formation of NH_(3) and HCN during indole pyrolysis,thereby promoting the formation of NH_(3) and HCN.

关键词： indole pyrolysis H_(2)O NO_(x)precursors DFT

BET inhibitors enhance the anti-cancer effect of etoposide by suppressing the MRN-ATM axis in the DNA damage response

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Genes & Diseases 2024年第1期11卷 19-22页

作者： Zhenhai Li Wenchao Xu Feng Chen jun Zhang Wei-guo Zhu Guangdong Key Laboratory of Genome Instability and Human Disease Prevention Department of Biochemistry and Molecular BiologyShenzhen University School of MedicineShenzhenGuangdong 518055China School of Pharmaceutical Sciences Shenzhen University Health Science CenterShenzhenGuangdong 518055China Base for International Science and Technology Cooperation:Carson Cancer Stem Cell Vaccines R&D Center International Cancer CenterShenzhen University Health Science CenterShenzhenGuangdong 518055China Shenzhen Bay Laboratory Shenzhen University School of MedicineShenzhenGuangdong 518055China Marshall Laboratory of Biomedical Engineering Shenzhen University School of MedicineShenzhenGuangdong 518055China

Etoposide is widely used for cancer chemotherapy in the ***,long-term etoposide treatment can lead to adverse effects or drug *** improve the situation,we evaluated the therapeutic efficiency of etoposide combined with inhibitors of bromodomain and extraterminal(BET)family proteins,which have recently emerged as novel anti-cancer targets due to their critical roles in cancer ***,we showed BRD4,one of the main targets of BET inhibitors,was involved in DNA damage response(DDR)via the homologous recombination(HR)repair pathway.

关键词： etoposide damage cancer

Bioinspired coacervate-based bioinks for construction of multiscale tissue engineering scaffolds

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Nano Research 2024年第9期17卷 8209-8219页

作者： Zhongwei guo Shiqiang Zhang Yilin guo Jingjing xia xiao Wu Hao Hu Rongcheng Hu Fangli Huang Qiulei Gao Chun Liu Jingjiang Qiu Wei Sun School of Mechanics and Safety Engineering Zhengzhou UniversityZhengzhou 450001China Department of Mechanical Engineering and Mechanics Tsinghua UniversityBeijing 100084China Precision Medicine Institute Guangdong Provincial Key Laboratory of Orthopedics and TraumatologyThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Mechanical Engineering Drexel UniversityPhiladelphiaPA 19104USA

Engineering hydrogels that resemble biological tissues of various lengths via conventional fabrication techniques remains ***-dimensional(3D)bioprinting has emerged as an advanced approach for constructing complex biomimetic 3D architectures,which are currently restricted by the limited number of available bioinks with high printability,biomimicry,biocompatibility,and proper mechanical *** by ubiquitous coacervation phenomena in biology,we present a unique mineral-biopolymer coacervation strategy that enables the hierarchical assembly of nanoclay and recombinant human collagen(RHC).This system was observed to undergo a coacervation transition(liquid‒liquid phase separation)*** formed dense phase separated from its supernatant is the coacervate of clay-RHC-rich complexes,where polymer chains are sandwiched between silicate *** dynamics simulation was first used to verify and explore the coacervation ***,the coacervates were demonstrated to be potential bioinks that exhibited excellent self-supporting and shear-thinning viscoelastic *** extrusion-based printing,the versatility of the bioink was demonstrated by reconstructing the key features of several biological tissues,including multilayered lattice,vascular,nose,and ear-like structures,without the need for precrosslinking operations or support ***,the printed scaffolds were cytocompatible,elicited minimal inflammatory responses,and promoted bone regeneration in calvarial defects.

关键词： bioinks coacervation mineral-biopolymer nanoclay tissue engineering scaffold

Thermoelectric transport properties of p-type Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3) high entropy compounds

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Rare Metals 2024年第7期43卷 3415-3421页

作者： Feng Jiang Cheng-Liang xia Yong-Bin Zhu jun Li Yue Chen Wei-Shu Liu Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China Guangdong Provincial Key Laboratory of Functional Oxide Materials and Devices Southern University of Science and TechnologyShenzhen 518055China

The introduction of entropy concept into thermoelectric materials recently has attracted broad ***,we showed the phase diagram of the ternary systems of Bi_(2)Se_(3)-Sb_(2)Se_(3)-In_(2)Se_(3).Among the high entropy compounds (HECs),we have identified an intrinsic p-type region near our previously reported Bi_(0.8)Sb_(0.8)In_(0.4)Se_(3) in the phase diagram.

关键词： entropy (3) compounds

Construction of MnS/MoS_(2) heterostructure on two-dimensional MoS_(2) surface to regulate the reaction pathways for high-performance Li-O_(2) batteries

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Journal of Energy Chemistry 2024年第6期93卷 443-452,I0012页

作者： guoliang Zhang Han Yu xia Li Xiuqi Zhang Chuanxin Hou Shuhui Sun Yong Du Zhanhu guo Feng Dang Key Laboratory for Liquid-Solid Structure Evolution and.Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061ShandongChina School of Environmental and Material Engineering Yantai UniversityYantai 264005ShandongChina Institute National de la Recherche Scientifique CentreÉnergie Matériaux et TélécommunicationsVarennesQuébec J31S2Canada State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083HunanChina Integrated Composites Lab Department of Mechanical and Construction EngineeringNorthumbria UniversityNewcastle Upon TyneNE18STUK

The inherent catalytic anisotropy of two-dimensional(2D) materials has limited the enhancement of LiO_(2) batteries(LOBs) performance due to the significantly different adsorption energies on 2D and edge *** the adsorption strength in 2D materials to the reaction intermediates is essential for achieving high-performance ***,a MnS/MoS_(2) heterostructure is designed as a cathode catalyst by adjusting the adsorption behavior at the *** from the toroidal-like discharge products on the MoS_(2) cathode,the MnS/MoS_(2) surface displays an improved adsorption energy to reaction species,thereby promoting the growth of the film-like discharge *** can disturb the layer growth of MoS_(2),in which the stack edge plane features a strong interaction with the intermediates and limits the growth of the discharge *** and theoretical results confirm that the MnS/MoS_(2) heterostructure possesses improved electron transfer kinetics at the interface and plays an important role in the adsorption process for reaction species,which finally affects the morphology of Li_2O_(2),In consequence,the MnS/MoS_(2) heterostructure exhibits a high specific capacity of 11696.0 mA h g^(-1) and good cycle stability over 1800 h with a fixed specific capacity of 600 mA h g^(-1) at current density of100 mA g^(-1) This work provides a novel interfacial engineering strategy to enhance the performance of LOBs by tuning the adsorption properties of 2D materials.

关键词： Li-O_(2)batteries Two-dimensional materials MnS/MoS_(2)heterostructure Edge plane Adsorption behavior