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MH-STRALP:A scoring system for prognostication in patients with upper gastrointestinal bleeding

World Journal of Gastrointestinal Surgery 2024年第3期16卷 790-806页

作者： jun-nan hu Fei Xu Ya-Rong Hao Chun-Yan Sun Kai-Ming Wu Yong Lin Lan Zhong Xin Zeng Department of Gastroenterology Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Gastroenterology Shanghai Changzheng HospitalNavy Military Medical UniversityShanghai 200003China

BACKGROUND Upper gastrointestinal bleeding(UGIB)is a common medical emergency and early assessment of its outcomes is vital for treatment *** To develop a new scoring system to predict its *** In this retrospective study,692 patients with UGIB were enrolled from two cen-ters and divided into a training(n=591)and a validation cohort(n=101).The clinical data were collected to develop new prognostic prediction *** en-dpoint was compound outcome defined as(1)demand for emergency surgery or vascular intervention,(2)being transferred to the intensive care unit,or(3)death during *** models’predictive ability was compared with previously esta-blished scores by receiver operating characteristic(ROC)*** Totally 22.2%(131/591)patients in the training cohort and 22.8%(23/101)in the validation cohort presented poor *** on the stepwise-forward Lo-gistic regression analysis,eight predictors were integrated to determine a new post-endoscopic prognostic scoring system(MH-STRALP);a nomogram was de-termined to present the *** with the previous scores(GBS,Rock-all,ABC,AIMS65,and PNED score),MH-STRALP showed the best prognostic prediction ability with area under the ROC curves(AUROCs)of 0.899 and 0.826 in the training and validation cohorts,*** to the calibration cur-ve,decision curve analysis,and internal cross-validation,the nomogram showed good calibration ability and net clinical benefit in both *** removing the endoscopic indicators,the pre-endoscopic model(pre-MH-STRALP score)was ***,the pre-MHSTRALP score showed better predictive value(AUROCs of 0.868 and 0.767 in the training and validation cohorts,respectively)than the other pre-endoscopic *** The MH-STRALP score and pre-MH-STRALP score are simple,convenient,and accurate tools for prognosis prediction of UGIB,and may be applied for early decision on its management strategies.

关键词： Upper gastrointestinal bleeding Prognosis prediction Retrospective study Nomogram Post-endoscopic model Pre-endoscopic model

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体型参数对梯形旋流排沙渠道水力特性的影响

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水电能源科学 2024年第1期42卷 60-64页

作者：南军虎李伟代江龙马康宁汪超群兰州理工大学能源与动力工程学院甘肃兰州730050

为明确起旋室和排沙洞体型参数对梯形旋流排沙渠道水力特性的影响,采用试验研究与数值模拟相结合的方法,研究了各参数下旋流排沙渠道的分流比、空腔形态、压强、流速,对比分析了不同断面型式的水力特性。结果表明,增大起旋室进口宽度,... 详细信息

为明确起旋室和排沙洞体型参数对梯形旋流排沙渠道水力特性的影响,采用试验研究与数值模拟相结合的方法,研究了各参数下旋流排沙渠道的分流比、空腔形态、压强、流速,对比分析了不同断面型式的水力特性。结果表明,增大起旋室进口宽度,或减小起旋室出口宽度、起旋室高度、排沙洞直径,均能减小梯形旋流排沙渠道的分流比;起旋室出口宽度是影响分流比的主要因素,排沙洞直径偏小会限制排沙洞内空腔的发展;增加渠道水面与排沙洞出口间的落差后可在排沙洞内形成更有利于泥沙运动的旋转水流;梯形旋流排沙渠道的水资源利用效率更高,当渠道来流量为89.6 m^(3)/h时,梯形旋流排沙渠道的分流比较矩形渠道的降低了6.6个百分点,且同一位置处的旋转水流流速更大。研究成果可为旋流排沙渠道在引水工程中的设计与应用提供参考。

关键词：旋流排沙渠道体型参数分流比压强流速

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跌流竖井入流水舌处内嵌圆弧板的结构优化数值研究

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水电能源科学 2024年第4期42卷 80-84页

作者：魏佳芳张源芦三强黄盈盈南军虎兰州理工大学能源与动力工程学院甘肃兰州730050

跌流竖井是排水系统中结构简单且应用广泛的排水基础设施之一,但该结构入流水舌处的水气两相作用剧烈、流态复杂,且在该处常常出现竖井内的最大负压,也就容易从外界大量吸气造成下游管道臭气逸散、井喷或爆管等问题。为此,提出在竖井水... 详细信息

跌流竖井是排水系统中结构简单且应用广泛的排水基础设施之一,但该结构入流水舌处的水气两相作用剧烈、流态复杂,且在该处常常出现竖井内的最大负压,也就容易从外界大量吸气造成下游管道臭气逸散、井喷或爆管等问题。为此,提出在竖井水舌处设置内嵌圆弧板的结构优化方法,从而有效改善入流水舌流态,降低竖井内气压值和梯度变化,并减缓竖井从外界的吸气程度。在此基础上,采用Fluent三维数值模拟手段,对比分析了结构优化前后的流态、气压梯度、流速及水气分布等特性。结果表明,经过优化后的竖井模型改变了入流水舌处的液体流态,水流入射角度减小,水流撞击点的位置降低,竖井水舌处的负压值明显降低,垂直管内的整体压力梯度变化幅值减弱,从外界卷吸的气量也大幅度减小。可见所设计的新型竖井结构优化方法对跌流竖井入流水舌问题有较好的改善作用,同时也为排污管道竖井设计及优化提供一定的参考。

关键词：跌流竖井入流水舌内嵌圆弧板流态改善数值模拟

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Air-core characteristics in a swirling tunnel flow

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Journal of Hydrodynamics 2022年第4期34卷 634-646页

作者： jun-hu nan huan Gao Chao-qun Wang Kang-ning Ma James Yang Jia-fang Wei Guo-dong Li State Key Laboratory of Eco-hydraulics in Northwest Arid Region Xi'an University of TechnologyXi'an 710048China College of Energy and Power Engineering Lanzhou University of TechnologyLanzhou 730050China Department of Civil and Architectural Engineering Royal Institute of Technology(KTH)StockholmSweden

A cost-effective technique to dissipate the energy in hydropower systems is the formation of a swirling flow within a *** such flows,an air core with a significant cross section usually *** reveal the air-core features in the horizontal tunnel of a high-head shaft spillway,laboratory tests,numerical modeling,and prototype observations are performed,to examine issues such as the formation of the air core,the interjacent air motion,the air-carrying capacity,and the scale *** is shown that the shape of the air core varies greatly in the axial and radial directions along the tunnel and that the center of the core deviates from the axis of the *** motion of the air within the core is caused by the combined action of the water entrainment on the inner surface of the swirling flow and the axial pressure difference in the air *** aeration process can be divided into five processes with respect to the changes of the gate openings.A theoretical expression is established for the air-carrying capacity of the swirling *** vacuum degree is the similarity condition of the air-carrying capacity of the swirling flow between the model and prototype tests based on the Froude law of the similitude,and this similarity condition is verified by both the model and prototype *** work provides a reference for the application of the swirling flows in horizontal hydropower tunnels.

关键词： Horizontal tunnel swirlingflow air core air-carrying capacity scale effect

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有压管道内的泥沙冲淤特性

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水电能源科学 2024年第8期42卷 70-73页

作者：王永宁祁贵贤李正琪梁俞宋静白妍丽杜立鹏李伟南军虎庆阳市盐环定扬黄续建工程建设管理局甘肃庆阳745000 甘肃省水利水电勘测设计研究院有限责任公司甘肃兰州730000 兰州理工大学能源与动力工程学院甘肃兰州730050

为明确复杂地形条件下有压管道内泥沙的运动特征与临界不淤流速,采用模型试验研究了不同粒径泥沙在不同运动状态下的水流流速,分析了泥沙粒径、加沙量与泥沙级配对临界不淤流速的影响。结果表明,间歇式运动状态下,粒径介于(0.075~0.600... 详细信息

为明确复杂地形条件下有压管道内泥沙的运动特征与临界不淤流速,采用模型试验研究了不同粒径泥沙在不同运动状态下的水流流速,分析了泥沙粒径、加沙量与泥沙级配对临界不淤流速的影响。结果表明,间歇式运动状态下,粒径介于(0.075~0.600)mm的泥沙在管道上升段与水平段呈多个椭圆状运动,较陡的下降段呈带状分布,粒径介于(0.600~1.250)mm的泥沙在管道内呈山丘状运动;泥沙运动状态的临界水流速度随泥沙粒径的增大呈增加趋势,且连续式推移状态为最佳泥沙输送状态;临界不淤流速均随泥沙粒径、加沙量、泥沙级配的增大而增大,泥沙粒径是影响临界不淤流速的主要因素,加沙量与泥沙级配是影响临界不淤流速的次要因素。研究结果可为复杂地形条件下有压引水管道工程的设计和应用提供参考。

关键词：有压管道泥沙运动形态泥沙运动状态流速界定临界不淤流速

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Advances in the study of mitophagy in osteoarthritis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 197-211页

作者： Hong CAO Xuchang ZHOU Bowen XU Han hu Jianming GUO Miao WANG nan LI jun ZOU Department of Sport Rehabilitation Shanghai University of SportShanghai 200438China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China School of Sport Medicine and Rehabilitation Beijing Sport UniversityBeijing 100084China

Osteoarthritis(OA),characterized by cartilage degeneration,synovial inflammation,and subchondral bone remodeling,is among the most common musculoskeletal disorders globally in people over 60 years of *** initiation and progression of OA involves the abnormal metabolism of chondrocytes as an important pathogenic *** degeneration features mitochondrial dysfunction as one of the important causative factors of abnormal chondrocyte ***,maintaining mitochondrial homeostasis is an important strategy to mitigate *** is a vital process for autophagosomes to target,engulf,and remove damaged and dysfunctional mitochondria,thereby maintaining mitochondrial *** studies have revealed a strong association between mitophagy and OA,suggesting that the regulation of mitophagy may be a novel therapeutic direction for *** reviewing the literature on mitophagy and OA published in recent years,this paper elaborates the potential mechanism of mitophagy regulating OA,thus providing a theoretical basis for studies related to mitophagy to develop new treatment options for OA.

关键词： Mitophagy Osteoarthritis Chondrocyte Mitochondria Apoptosis

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Advances in the study of protein folding and endoplasmic reticulum-associated degradation in mammal cells

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第3期25卷 212-232页

作者： Hong CAO Xuchang ZHOU Bowen XU Han hu Jianming GUO Yuwei MA Miao WANG nan LI jun ZOU Department of Sport Rehabilitation Shanghai University of SportShanghai 200438China National Key Laboratory of Immunity and Inflammation Naval Medical UniversityShanghai 200433China

The endoplasmic reticulum is a key site for protein production and quality *** than one-third of proteins are synthesized and folded into the correct three-dimensional conformation in the endoplasmic ***,during protein folding,unfolded and/or misfolded proteins are prone to occur,which may lead to endoplasmic reticulum *** can monitor the quality of the proteins produced by endoplasmic reticulum quality control(ERQC)and endoplasmic reticulum-associated degradation(ERAD),which maintain endoplasmic reticulum protein homeostasis by degrading abnormally folded *** underlying mechanisms of protein folding and ERAD in mammals have not yet been fully ***,this paper reviews the process and function of protein folding and ERAD in mammalian cells,in order to help clinicians better understand the mechanism of ERAD and to provide a scientific reference for the treatment of diseases caused by abnormal ERAD.

关键词： Endoplasmic reticulum-associated degradation(ERAD) Protein folding Ubiquitination Retrotranslocation

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A Review of Contact Electrification at Diversified Interfaces and Related Applications on Triboelectric nanogenerator

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nano-Micro Letters 2024年第1期16卷 106-130页

作者： jun hu Mitsumasa Iwamoto Xiangyu Chen CAS Center for Excellence in nanoscience Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083People’s Republic of China School of nanoscience and Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Department of Physical Electronics Tokyo Institute of Technology2‑12‑1 S3‑33 O‑OkayamaMeguro‑KuTokyo 152‑8552Japan

The triboelectric nanogenerator(TENG)can effectively collect energy based on contact electrification(CE)at diverse interfaces,including solid–solid,liquid–solid,liquid–liquid,gas–solid,and gas–*** enables energy harvesting from sources such as water,wind,and *** this review,we provide an overview of the coexistence of electron and ion transfer in the CE *** elucidate the diverse dominant mechanisms observed at different interfaces and emphasize the interconnectedness and complementary nature of interface *** review also offers a comprehensive summary of the factors influencing charge transfer and the advancements in interfacial modification ***,we highlight the wide range of applications stemming from the distinctive characteristics of charge transfer at various ***,this review elucidates the future opportunities and challenges that interface CE may *** anticipate that this review can offer valuable insights for future research on interface CE and facilitate the continued development and industrialization of TENG.

关键词： Contact electrification Interfaces Triboelectric nanogenerators Diversified applications

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Outlier-resistant distributed fusion filtering for nonlinear discrete-time singular systems under a dynamic event-triggered scheme

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 237-249页

作者： Zhibin hu jun hu Cai CHEN Hongjian LIU Xiaojian YI Department of Applied Mathematics Harbin University of Science and TechnologyHarbin150080China Heilongjiang Provincial Key Laboratory of Optimization Control and Intelligent Analysis for Complex Systems Harbin University of Science and TechnologyHarbin150080China School of Automation Harbin University of Science and TechnologyHarbin150080China School of Mathematics and Physics Anhui Polytechnic UniversityWuhu241000China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing100081China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing314003China Tangshan Research Institute Beijing Institute of TechnologyTangshan063099China

This paper investigates the problem of outlier-resistant distributed fusion filtering(DFF)for a class of multi-sensor nonlinear singular systems(MSNSSs)under a dynamic event-triggered scheme(DETS).To relieve the effect of measurement outliers in data transmission,a self-adaptive saturation function is ***,to further reduce the energy consumption of each sensor node and improve the efficiency of resource utilization,a DETS is adopted to regulate the frequency of data *** the addressed MSNSSs,our purpose is to construct the local outlier-resistant filter under the effects of the measurement outliers and the DETS;the local upper bound(UB)on the filtering error covariance(FEC)is derived by solving the difference equations and minimized by designing proper filter ***,according to the local filters and their UBs,a DFF algorithm is presented in terms of the inverse covariance intersection fusion *** such,the proposed DFF algorithm has the advantages of reducing the frequency of data transmission and the impact of measurement outliers,thereby improving the estimation ***,the uniform boundedness of the filtering error is discussed and a corresponding sufficient condition is ***,the validity of the developed algorithm is checked using a simulation example.

关键词： Distributed fusion filtering Multi-sensor nonlinear singular systems Dynamic event-triggered scheme Outlier-resistant filter Uniform boundedness

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Advanced Sensors Towards Ubiquitous Power Internet of Things

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CSEE Journal of Power and Energy Systems 2024年第3期10卷 871-890页

作者： Jinliang He Zhifei Han jun hu Department of Electrical Engineering Tsinghua UniversityBeijing 100084China IEEE CSEE

The ubiquitous power Internet of Things(UPIoT)uses modern information technology and advanced communication technologies to realize interconnection and human-computer interaction in all aspects of the power *** has the characteristics of comprehensive state perception and efficient information processing,and has broad application prospects for transformation of the energy *** fundamental facility of the UPIoT is the sensor-based information *** using advanced sensors,Wireless Sensor Networks(WSNs),and advanced data processing technologies,Internet of Things can be realized in the power *** this paper,a framework of WSNs based on advanced sensors towards UPIoT is *** addition,the most advanced sensors for UPIoT purposes are reviewed,along with an explanation of how the sensor data obtained in UPIoT is utilized in various scenarios.

关键词： Advanced sensors ubiquitous power Internet of Things wireless sensor networks

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