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Synthesis of novel analogues of zanamivir as neuraminidase inhibitors

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Chinese Chemical Letters 2010年第11期21卷 1338-1341页

作者： Rui Sheng Xiong Qing jie Zhao Hang Hang Zhu Zheng Liu Ya Bing wei Jing Shan Shen Shanghai Institute of Maieria Medica Chinese Academy of Sciences Shanghai 201203 China College of Materials Science and Engineering Nanjing University of Technology Nanjing 210009 China Topharman Shanghai Co. Ltd. Shanghai 201209 China

A versatile synthesis of novel zanamivir analogues modified at C-4 and C-8 positions was *** formation of amides from the acid with corresponding amines,followed by click chemistry generated the triazole substituted c... 详细信息

关键词： Zanamivir Triazole Click chemistry

Hepatopulmonary metastases from papillary thyroid microcarcinoma:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4661-4668页

作者： Chuan-Yu Yang Xuan-Wu Chen Dong Tang Wen-jun Yang Xiao-Xiao Mi jun-Ping Shi wei-Dong Du Department of Hepatobiliary Surgery The First Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 310003Zhejiang ProvinceChina Department of Medical Imaging The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina Department of Pathology The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina Institute of Translational Medicine The Affiliated Hospital of Hangzhou Normal UniversityHangzhou 310015Zhejiang ProvinceChina

BACKGROUND Papillary thyroid carcinoma(PTC)is the most common endocrine *** thyroid microcarcinoma(PTMC)accounts for the majority of PTC ***,concurrent pulmonary and hepatic metastases of PTMC are rarely ***,we present a patient with coexisting liver and lung metastases from *** SUMMARY We describe a 26-year-old woman with PTMC with multiple concurrent *** 3 d of unexplained fever,she was admitted to our *** thyroid functional tests were *** positron emission tomography(PET)/magnetic resonance imaging(MRI)examination showed increased fluorodeoxyglucose(FDG)metabolism and space-occupying lesions in the left lobe of the ***,PET/MRI images revealed multiple nodules in the lung and liver with increased FDG *** computer tomography(CT)showed multiple pulmonary *** ultrasound and liver MRI showed multiple space-occupying lesions in the *** patient underwent total thyroidectomy and central lymph node *** pathological analysis showed a papillary microcarcinoma multiplex in the left lobe of the thyroid.A diagnosis of hepatopulmonary metastases from papillary thyroid microcarcinoma was *** patient was given iodine-131 treatment one year after the *** recovered well after the operation,and the incision healed *** discharge,she was treated with oral levothyroxine sodium tablets,and symptomatic and supportive treatments were also given to promote radioactive excretion and prevent bone marrow suppression by iodine-131 *** Since patients with thyroid cancer concurrent with hepatopulmonary metastases have rarely been reported,our case will highlight the clinical and pathological profiles of these patients.

关键词： Papillary thyroid microcarcinoma Distant metastasis Liver Lung Case report

云南4个地震序列Q_c^(-1)值变化特征对比研究

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地震 2006年第1期26卷 19-25页

作者：王伟君刘杰中国地震局地震预测研究所北京100036 中国地震台网中心北京100036

对云南地区4个地震序列,分别为2000年姚安6.5级地震、2001年施甸5级震群、2001年永胜6.0级地震和2003年大姚6.2、6.1级震群,利用垂直向数字地震尾波分别计算地震序列周边台站3个频率段的Qc-1值,分析对比其时间演化趋势。发现对于主-余... 详细信息

对云南地区4个地震序列,分别为2000年姚安6.5级地震、2001年施甸5级震群、2001年永胜6.0级地震和2003年大姚6.2、6.1级震群,利用垂直向数字地震尾波分别计算地震序列周边台站3个频率段的Qc-1值,分析对比其时间演化趋势。发现对于主-余震型序列,主震后Qc-1值整体上变化幅度不大,趋于稳定。而对于震群(或双震)型序列,在第一个主震后,Qc-1值表现出上升-下降趋势,持续一段时间后强震发生。这些变化在序列周围的台站和三个频率段的变化整体趋势是一致的,但变化幅度不一致,可能与孕震区的位置和孕震应力的演变过程有关。上述研究为强余震的预报提供一个新的方法。

关键词：地震序列 Q^-1c值云南地区

Evaluating electron induced degradation of triple-junction solar cell by numerical simulation

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Optoelectronics Letters 2021年第5期17卷 276-282页

作者： LI jun-wei WANG Zu-jun SHI Cheng-ying XUE Yuan-yuan NING Hao XU Rui Xi’an Research Institute of High-Technology Xi’an710025China Northwest Institute of Nuclear Technology Xi’an710024China School of Materials Science and Engineering Xiangtan UniversityXiangtan411105China

In this paper,the degradation related parameters of GaInP/GaAs/Ge triple-junction solar cell induced by electron irradiation are carried out by numerical *** degradation results of short-circuit current,open-circuit voltage,maximum power have been investigated,and the degradation mechanism is *** the degradation results,the degradation of normalized parameters versus displacement damage dose is *** results show that the degradation increases with the increase of the electron fluence and electron irradiation *** degradation normalized related parameters versus displacement damage dose can be characterized by a special curve that is not affected by the type of irradiated *** calculating the annual displacement damage dose and the on-orbit operation time of special space orbit,the degradation of normalized parameters can be obtained with the fitting curve in the *** study will provide an approach to estimate the radiation damage of triple-junction solar cell induced by space particle irradiation.

关键词： Evaluating electron induced degradation of triple-junction solar cell by numerical simulation

Observer-based Dynamic Local Piecewise Control of a Linear Parabolic PDE System with Non-collocated Pointwise Measurements 36

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Observer-based Dynamic Local Piecewise Control of a Linear P...

Comparative analysis of four active compounds of Baikal skullcap and its classical TCM prescriptions according to different clinical curative effects

第36届中国控制会议

作者： Ya-Qiang Liu jun-wei Wang Chang-Yin Sun School of Automation and Electrical Engineering University of Science and Technology Beijing

ISBN: (纸本)9781538629185

This paper presents an observer-based dynamic feedback control design for a linear parabolic partial differential equation（PDE） system, where a finite number of actuators and sensors are active over part thereof and at specified points in the spatial domain, respectively. In the proposed design method, a Luenberger-type PDE observer is first constructed by using the non-collocated pointwise measurements to exponentially tract the state of the PDE system. Based on the estimated state,a collocated local piecewise state feedback controller is then proposed. By employing Lyapunov direct method, integration by parts, Wirtinger’s inequality and first mean value theorem for integrals, a sufficient condition on exponential stability of the resulting closed-loop system is presented in term of standard linear matrix inequalities（LMIs）. Numerical simulation results are presented to show the effectiveness of the proposed design method.

关键词： Distributed parameter systems Piecewise control Pointwise measurement Lyapunov direct method Observerbased feedback control

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World Journal of Traditional Chinese Medicine 2017年第1期3卷 22-30页

作者： Guang-wei Zhu Sheng-jun Ma Ao-Xue Liu Institute of Chinese Materia Medica China Academy of Chinese Medical Sciences School of Food Sciences and Pharmacy Xinjiang Agriculture University School of Chinese Materia Beijing University of Chinese Medicine

Objective: A sensitive HPLC-DAD detection method was established for the comparative analysis of the four active compounds(including baicalin, baicalein, wogonoside and wogonin) of Baikal Skullcap and its classical TCM prescriptions according to different clinical curative effects. And analyze the relationship between compatibility of medicines, content and clinical curative ***: Water extracts were analyzed by high-performance liquid chromatography-diode array detection(HPLC-DAD), using an Agilent extend-C_(18)(4.6 mm×250 mm,5μm) column by using solvent A(0.2% phosphoric acid water) and solvent B(methanol) in the ratio of 52:48(v/v) at a flow rate of 1 ml/min. The column temperature was maintained at 25°C and the detection wavelength was set at 280 ***: In quantitative analysis, the four selected markers showed good regression(R^2>0.999) within test ranges. The average recoveries were between 99.75~100.60% and their RSD values were between 0.97%~1.71%. The proportions of the four chemical compounds for different efficacy were 33.51~35.76: 6.78~6.87: 3.45~3.64: 1; 18.6~23.64: 3.63~4.27: 1.36~1.53: 1; 29.94~31.78: 5.14~5.23: 3.28~3.56: 1; 33.99~41.91:5.83~7.42: 2.83~3.39: ***: Clinical practice of thousands of years have proved that the curative effect of Traditional Chinese Medicine depends on the compatibility of different kinds of medicine material crude slices. According to this study we found that different compatibility of medicines leads to different proportions of the chemical compounds. We assume that there is a certain correlation between therapeutical effect of TCM and compatibility of medicines.

关键词： Baikal skullcap Couplet medicine Clinical curative effect Compatibility of medicines Proportions of the chemical compounds

Indian Ocean SST Biases in a Flexible Regional Ocean Atmosphere Land System(FROALS) Model

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Atmospheric and Oceanic Science Letters 2012年第4期5卷 273-279页

作者： HAN Zhen-Yu ZHOU Tian-jun ZOU Li-wei State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China

The authors examine the Indian Ocean sea surface temperature(SST) biases simulated by a Flexible Regional Ocean Atmosphere Land System(FROALS) *** regional coupled model exhibits pronounced cold SST biases in a large portion of the Indian Ocean warm *** biases in the net surface heat fluxes are evident in the model,leading to the cold biases of the *** analysis indicates that the negative biases in the net surface heat fluxes are mainly contributed by the biases of sensible heat and latent heat ***-surface meteorological variables that could contribute to the SST biases are also *** is found that the biases of sensible heat and latent heat flux are caused by the colder and dryer near-surface air in the model.

关键词： Indian Ocean SST biases FROALS evaluation

Effect of deep cryogenic treatment on martensitic lath refinement and nano-twins formation of low carbon bearing steel

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Journal of Iron and Steel Research International 2020年第1期27卷 105-113页

作者： Xin-yang Lü Zhi-wei Wu Xiao He jun Li Shao-hong Li Mao-sheng Yang Kun-yu Zhao Faculty of Material Science and Engineering Kunming University of Science and TechnologyKunming 650093YunanChina Institute for Special Steels Central Iron and Steel Research InstituteBeijing 100081China

The effect of heat treatment and deep cryogenic treatment on microstructural evolution of low carbon martensitic bearing steel was *** experimental results showed that the lath martensite was obtained by quenching and a few twins as substructures formed in some martensitic *** rudiment of sub-interfaces of martensitic lath was formed in the highdensity dislocation regions after deep cryogenic treatment;meanwhile,the number of twins increased,especially in the highdensity dislocation *** phenomenon is due to the increase in internal stress caused by cryogenic *** tempering,the rudiment of sub-interface further evolved into the martensitic lath boundary,and thus the original martensitic laths were *** twins formed by cryogenic treatment did not disappear after *** addition,small quantities of annealing twins formed in tempering *** laths morphology and substructures in different stages of the heat and deep cryogenic treatment were observed by tninsmission electron microscopy.

关键词： Low carbon bearing steel-Deep cryogenic treatment Internal stress Sub-interface Nano-twin

Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine

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Chinese Journal of Integrative Medicine 2024年第5期30卷 468-479页

作者： ZHONG Yi LI Xin-yue LIANG Tian-jun DING Bao-zhu MA Ke-xin REN Wen-xuan LIANG Wen-jie College of Integrated Traditional Chinese and Western Medicine Hebei University of Chinese MedicineHebei Key Laboratory of Integrated Traditional Chinese and Western Medicine in Liver and Kidney DiseasesInstitute of Integrated Traditional Chinese and Western MedicineShijiazhuang 050200China Department of Cardiovascular Internal Medicine the Second Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi Province 332000China Graduate School Hebei Medical UniversityShijiazhuang 050017China Rural Physician College Hebei Medical UniversityShijazhuang 050017China Medical Department the First Hospital of Hebei Medical UniversityShijiazhuang 050030China

Activation of the NOD-like receptor protein 3(NLRP3)inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases(CVDs),such as diabetic cardiomyopathy,ischemia/reperfusion injury,myocardial infarction,heart failure and *** RNAs(nc RNAs)are important regulatory *** Chinese medicine(CM)compounds,including their effective components,can regulate pyroptosis and exert myocardium-protecting *** mechanisms underlying this protection include inhibition of inflammasome protein expression,Toll-like receptor 4–NF-κB signal pathway activation,oxidative stress,endoplasmic reticulum stress(ERS),and mixed lineage kinase 3 expression and the regulation of silent information regulator *** NLRP3 protein is an important regulatory target for CVD prevention and treatment with *** the effects of the interventions mediated by CM and the related mechanisms provides new ideas and perspectives for CVD prevention and treatment.

关键词： pyroptosis cardiovascular diseases Chinese medicine NOD-like receptor protein 3 mechanisms