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A Self-Healing Optoacoustic Patch with High Damage Threshold and Conversion Efficiency for Biomedical Applications

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Nano-Micro Letters 2024年第7期16卷 31-45页

作者： Tao Zhang Cheng-Hui Li Wenbo Li Zhen Wang Zhongya Gu Jiapu Li junru Yuan jun ou-yang Xiaofei yang Benpeng Zhu School of Integrated Circuit Wuhan National Laboratory for OptoelectronicsHuazhong University of Science and TechnologyWuhan 430074People’s Republic of China State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced MicrostructuresSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093People’s Republic of China National Institute of Dental and Craniofacial Research(NIDCR) National Institutes of Health(NIH)35A Convent DriveBethesdaMD 20892USA Department of Neurology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030People’s Republic of China

Compared with traditional piezoelectric ultrasonic devices,optoacoustic devices have unique advantages such as a simple preparation process,anti-electromagnetic interference,and wireless long-distance power ***,current optoacoustic devices remain limited due to a low damage threshold and energy conversion efficiency,which seriously hinder their widespread *** this study,using a self-healing polydimethylsiloxane(PDMS,Fe-Hpdca-PDMS)and carbon nanotube composite,a flexible optoacoustic patch is developed,which possesses the self-healing capability at room temperature,and can even recover from damage induced by cutting or laser ***,this patch can generate high-intensity ultrasound(>25 MPa)without the focusing *** laser damage threshold is greater than 183.44 mJ cm^(-2),and the optoacoustic energy conversion efficiency reaches a major achievement at 10.66×10^(-3),compared with other carbon-based nanomaterials and PDMS *** patch is also been successfully examined in the application of acoustic flow,thrombolysis,and wireless energy *** findings in this study provides new insight into designing and fabricating of novel ultrasound devices for biomedical applications.

关键词： Optoacoustic Self-healing PDMS Acoustic flow Thrombolytic Wireless energy harvesting

Ultrasound:A new strategy for artificial synapses modulation

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InfoMat 2024年第6期6卷 110-120页

作者： junru Yuan Yi Li Meng Wang Xiaodi Huang Tao Zhang Kan-Hao Xue junhui Yuan jun ou-yang Xiaofei yang Xiangshui Miao Benpeng Zhu School of Integrated Circuits Huazhong University of Science and TechnologyWuhanthe People's Republic of China

Due to its non-invasive nature,ultrasound has been widely used for neuromodulation in biological systems,where its application influences the synaptic weights and the process of neurotransmitter ***,such modulation has not been emulated in physical *** are ideal electrical components for artificial synapses,but up till now they are hardly reported to respond to ultrasound *** we design and fabricate a HfOx-based memristor on 64Y-X LiNbO_(3) single crystal substrate,and successfully realize artificial synapses modulation by shear-horizontal surface acoustic wave(SH-SAW).It is a prominent short-term resistance modulation,where ultrasound has been shown to cause resistance drop for various resistance states,which could fully recover after the ultrasound is shut *** physical mechanism illustrates that ultrasound induced polarization potential in the HfOx dielectric layer acts on the Schottky barrier,leading to the resistance *** emulation of neuron firing frequency modulation through ultrasound signals is ***,the joint application of ultrasound and electric voltage yields fruitful functionalities,such as the enhancement of resistance window and synaptic plasticity through ultrasound *** these promising results provide a new strategy for artificial synapses modulation,and also further advance neuromorphic devices toward system applications.

关键词： artificial synapse memristor neuromodulation ultrasound

Effect of Nucleating Agent on the Crystallization of Tailings Glass Ceramics Prepared by One-time Sintering

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Journal of Wuhan University of Technology(Materials Science) 2009年第4期24卷 658-662页

作者：刘军 School of Material Science and Engineering Shenyang Jian Zhu University

Glass ceramics was made by the one-time sintering method using the main raw material of iron tailings. On the basis of quaternary system of CaO-MgO-Al2O3-SiO2, using DTA, XRD and SEM, the effects of different nucleating agents and mixing amounts as well as heat treatment on the crystallization of railings glass ceramics were studied. The experimental results show that, nucleating agent and heat treatment are two necessary conditions for one-time sintering preparation of tailings glass ceramics namely, only adding nucleating agent or experiencing heat treatment, the quaternary system can not crystallize. The composite nucleating agent consisting of Cr2O3 and TiO2 can further lead to the crystallization of the CaO-MgO-A1203-SiO2 quaternary system at the lower temperature, with the major phase of diopside. In the range of mass content, 0%-4%, crystal intensity and crystal content grow. But when mass content is more than 4%, the crystal size will become coarser and the crystal distribution will be less regular. Different heat treatment regimes do not change the composition of the crystalline major phase in the glass ceramics crystallization of CaO-MgO-Al2O3-SiO2 system. In the range of 30-60 minutes, with the extension of nucleation and crystallization, crystallization degree enhanced, but if the holding time surpasses 60 minutes, the crystallization is worse.

关键词： nucleating agent one-time sintering tailings glass ceramics crystallization

超声造影判定术前直肠癌T分期的临床应用价值

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世界华人消化杂志 2020年第6期28卷 236-240页

作者：刘志红欧阳骏张荣浙江省德清县人民医院乾元内一科浙江省湖州市313200 浙江省德清县人民医院B超室浙江省湖州市313200 浙江医院B超室浙江省杭州市310013

背景准确判定直肠癌T分期状态,对于指导临床治疗有着重要价值.超声具有操作简便,无创等优点,在直肠癌诊治中发挥着重要作用.超声造影(contrast-enhanced ultrasonography,CEUS)可动态反映直肠癌的微循环灌注状态,显示病灶浸润范围,提高... 详细信息

背景准确判定直肠癌T分期状态,对于指导临床治疗有着重要价值.超声具有操作简便,无创等优点,在直肠癌诊治中发挥着重要作用.超声造影(contrast-enhanced ultrasonography,CEUS)可动态反映直肠癌的微循环灌注状态,显示病灶浸润范围,提高病灶边界精确度,有助于准确判定直肠癌的T分期状态.目的探讨运用CEUS判定术前直肠癌T分期的临床应用价值.方法选取在浙江医院行手术切除治疗的66例直肠癌患者作为研究对象.所有患者术前均行经直肠常规超声检查以及CEUS检查,观察并记录病灶的CEUS增强特征及T分期结果,与术后病理结果进行比较分析.结果CEUS判定术前直肠癌T分期的总诊断符合率92.42%(61/66)明显高于常规超声的总诊断符合率72.73%(48/66),差异有统计学意义(P0.05).结论CEUS能实时动态反映直肠癌的微循环灌注状态,能清晰显示病灶浸润范围,从而准确判定术前直肠癌T分期,具有较高临床应用价值.

关键词：超声造影造影剂直肠癌病理 T分期

超声造影定量评估新辅助治疗后直肠癌的微循环血流及与微血管密度相关性

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世界华人消化杂志 2020年第3期28卷 108-112页

作者：梅晓丽张红杨琴琴欧阳骏浙江德清县人民医院超声科浙江省湖州市313200 浙江萧山医院超声科浙江省杭州市311200 绍兴市柯桥区中医医院药剂科浙江省绍兴市312030

背景新辅助治疗有助于进一步提高直肠癌患者的术后疗效,降低肿瘤复发率,改善患者生活质量.准确评估其疗效意义重大.超声造影(contrast-enhanced ultrasound,CEUS)作为一种能实时显示目标组织微循环状态的超声新技术,能为临床评估疗效提... 详细信息

背景新辅助治疗有助于进一步提高直肠癌患者的术后疗效,降低肿瘤复发率,改善患者生活质量.准确评估其疗效意义重大.超声造影(contrast-enhanced ultrasound,CEUS)作为一种能实时显示目标组织微循环状态的超声新技术,能为临床评估疗效提供可靠的血流动力学参考.目的探讨CEUS定量评估新辅助治疗后直肠癌的微循环血流灌注状态变化,及其与微血管密度(microvessel density,MVD)相关性.方法选取在我院行新辅助治疗的进展期直肠癌患者106例,所有患者于治疗前后行CEUS检查,测定病灶微循环血流灌注参数,并与手术后标本MVD进行比较分析.结果新辅助治疗后病灶最大直径较治疗前明显减少,差异有统计学意义(P<0.05);新辅助治疗后病灶曲线下面积(area under the curve,AUC)、峰值强度(peak intensity,PI)较治疗前明显下降,差异有统计学意义(P<0.05);新辅助治疗后病灶PI、AUC分别与MVD呈正相关(r=0.82,P<0.05;r=0.79,P<0.05).结论CEUS能客观反映直肠癌微循环血流灌注状态,其血流灌注参数与MVD有较好相关性,可为临床评估直肠癌新辅助治疗效果提供血流动力学参考.

关键词：超声造影直肠癌新辅助治疗病理微血管密度

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左肾上腺区占位误诊荟萃分析

中国现代医学杂志 2021年第1期31卷 92-95页

作者：张志昱欧阳骏浦金贤侯建全张江磊苏州大学附属第一医院泌尿外科江苏苏州215000

目的总结左肾上腺区占位误诊的经验教训,提高诊疗水平。方法在中国期刊全文数据库及万方数据库中搜集关于左肾上腺区肿物误诊的文献报道,分析其临床特征及误诊原因。结果共收集到符合要求的文献31篇,总病例数47例,包括副脾15例、血管瘤... 详细信息

目的总结左肾上腺区占位误诊的经验教训,提高诊疗水平。方法在中国期刊全文数据库及万方数据库中搜集关于左肾上腺区肿物误诊的文献报道,分析其临床特征及误诊原因。结果共收集到符合要求的文献31篇,总病例数47例,包括副脾15例、血管瘤5例、支气管源性囊肿15例、胃肠道间质瘤6例、淋巴管瘤1例、胃憩室2例、畸胎瘤2例及隔离肺1例。误诊原因包括局部解剖结构不熟悉、阅片能力不足及影像学检查不完善等。结论对不能确诊的左肾上腺区占位的患者,应加强对相关疾病的认识,完善三维立体CT及MRI等检查,请有经验的影像科医生会诊,提高诊疗水平。

关键词：左肾上腺区占位误诊鉴别诊断

A novel vitamin K4 derivative-1,2,4-trinaphthol-acetic ester

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中国医药导报 2006年第14期 240-242页

作者： Hong-liu Xu, Rong- jun ou, Ke- er yang, Shan- ling Tong, Yan Yan*(Department of Chemistry, Shantou University, Shantou 515063, People’s Republic of China)Feng- shou Xiao*(State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130023,People’s Republic of China)

A novel derivative of vitamin K4, 1, 2, 4- trinaphthol- acetic ester, is synthesized by directly reacting of2- hydroxy- 1, 4- naphthoquinone with acetic anhydride, where zinc powder is used as reductant. By examiningthe influences of reacting time, temperature and reactant ratio, the esterification conditions are optimized. The ex-perimental result shows that, the esterification yield can reach 40% with a single cycle of the simple synthetic route.

关键词： 2-hydroxy-1 4-naphthoquinone acetic anhydride derivative of Vitamin K4 1 2 4-trinaphthol-acetic ester.

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PowerBuilder中动态报表的设计

武汉工业学院学报 2002年第4期21卷 61-64页

作者：汪军欧阳峥峥武汉工业学院计算机与信息工程系湖北武汉430023

报表的设计一向是数据库应用系统的重要过程 ,所以灵活适用的报表无疑是非常重要的。通过实例介绍了在PowerBuilder中动态生成报表的两种设计方法 ,在这个设计实现过程中 ,首先对数据的来源 (DataStore)以及ListView对象进行了说明。

关键词： PowerBuilder 设计 ListViewitem 数据窗口 DataStore 动态报表数据库应用系统

2型糖尿病患者血清Betatrophin与周围神经病变的关系

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中国现代医学杂志 2020年第4期30卷 106-109页

作者：莫娟欧阳俊王颖杨腾舜刘罗坤长沙市第一医院医务科湖南长沙410005 长沙市第一医院内分泌科湖南长沙410005

目的探讨2型糖尿病(T2DM)患者血清Betatrophin水平与周围神经病变的关系。方法选取2016年1月—2016年11月在长沙市第一医院就诊的88例T2DM患者的临床资料,根据临床症状、体征及电生理检查,将患者分为58例糖尿病周围神经病变(DPN)组和30... 详细信息

目的探讨2型糖尿病(T2DM)患者血清Betatrophin水平与周围神经病变的关系。方法选取2016年1月—2016年11月在长沙市第一医院就诊的88例T2DM患者的临床资料,根据临床症状、体征及电生理检查,将患者分为58例糖尿病周围神经病变(DPN)组和30例未合并DPN(NDPN)组。采用ELISA法检测血清Betatrophin水平;分别对两组血压、血糖、糖化血红蛋白、血脂及Betatrophin等指标进行比较分析,并对DPN危险因素行Logistic回归分析。结果两组糖尿病病程、血清Betatrophin水平有差异(P<0.05)。Logistic回归分析显示,糖尿病病程、血清Betatrophin水平是T2DM患者合并DPN的独立危险因素(P<0.05)。结论T2DM患者血清Betatrophin水平与DPN发生关系密切。

关键词：糖尿病2型糖尿病神经病变回归分析危险因素