A novel vitamin K4 derivative-1,2,4-trinaphthol-acetic ester

作     者：Hong-liu Xu, Rong- jun Ou, Ke- er Yang, Shan- ling Tong, Yan Yan*(Department of Chemistry, Shantou University, Shantou 515063, People’s Republic of China)Feng- shou Xiao*(State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130023,People’s Republic of China) 

出 版 物：《中国医药导报》 (China Medical Herald)

年 卷 期：2006年第14期

页      面：240-242页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

主　　题：2-hydroxy-1 4-naphthoquinone acetic anhydride derivative of Vitamin K4 1 2 4-trinaphthol-acetic ester. 

摘      要：A novel derivative of vitamin K4, 1, 2, 4- trinaphthol- acetic ester, is synthesized by directly reacting of2- hydroxy- 1, 4- naphthoquinone with acetic anhydride, where zinc powder is used as reductant. By examiningthe influences of reacting time, temperature and reactant ratio, the esterification conditions are optimized. The ex-perimental result shows that, the esterification yield can reach 40% with a single cycle of the simple synthetic route.