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Tribological behaviour of fused deposition modelling printed short carbon fibre reinforced nylon composites with surface textures under dry and water lubricated conditions

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Friction 2022年第12期10卷 2045-2058页

作者： Ming LUO Siyu huang Ziyan MAN julie M.CAIRNEy Li CHANG School of Aerospace Mechanical and Mechatronic EngineeringThe University of SydneySydney NSW 2006Australia Australian Centre for Microscopy and Microanalysis The University of SydneySydney NSW 2006Australia

Fused deposition modelling(FDM)printed short carbon fibre reinforced nylon(SCFRN)composites were fabricated.The friction and wear behaviour of printed materials were systematically investigated under both dry sliding and water lubricated conditions.The results showed that with short fibre enhancements,the printed SCFRN achieved a lower friction coefficient and higher wear resistance than nylon under all tested conditions.Further,under water lubricated conditions,the printed SCFRN exhibited a low,stable friction coefficient due to the cooling and lubricating effects of water.However,the specific wear rate of the printed specimens could be higher than that obtained under dry sliding conditions,especially when the load was relatively low.The square textured surface was designed and created in the printing process to improve materials’tribological performance.It was found that with the textured surface,the wear resistance of the printed SCFRN was improved under dry sliding conditions,which could be explained by the debris collection or cleaning effect of surface texture.However,such a cleaning effect was less noticeable under lubricated conditions,as the liquid could clean the surface effectively.On the other hand,surface textures could increase the surface area exposed to water,causing surface softening due to the higher water absorption rate.As a result,the samples having surface textures showed higher wear rates under lubricated conditions.The work has provided new insights into designing wear resistant polymer materials using three-dimensional(3D)printing technologies,subjected to different sliding conditions.

关键词： fused deposition modelling(FDM) short carbon fibre reinforced nylon(SCFRN)composites transfer film friction and wear

TGF-β-induced CD4+FoxP3+regulatory T cell-derived extracellular vesicles modulate Notch1 signaling through miR-449a and prevent collagen-induced arthritis in a murine model

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Cellular & Molecular Immunology 2021年第11期18卷 2516-2529页

作者： Jingrong Chen Feng huang yuluan Hou Xiaorong Lin Rongzhen Liang Xiaojiang Hu Jun Zhao julie Wang Nancy Olsen Song Guo Zheng Department of Clinical Immunology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Department of Internal Medicine Division of RheumatologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdongChina Division of Rheumatology Department of MedicinePenn State University Hershey Medical CenterHersheyPAUSA

CD4^(+)FOXP3^(+)Treg cells are central to the maintenance of self-tolerance and can be defective in autoimmunity.In autoimmune rheumatic diseases,dysfunctional self-tolerance,is to a large extent,caused by insufficient Treg-cell activity.Although nTregs have therapeutic effects in vivo,their relative scarcity and slow rate of in vitro expansion hinder the application of nTreg therapy.It was previously reported that EVs contribute significantly to the suppressive function of FOXP3^(+)Treg cells.Considering that the stability and plasticity of nTregs remain major challenges in vivo,we established EVs derived from in vitro TGF-β-induced Treg cells(iTreg-EVs)and assessed their functions in a murine model of autoimmune arthritis.The results demonstrated that iTreg-EVs preferentially homed to the pathological joint and efficiently prevented the imbalance in Th17/Treg cells in arthritic mice.Furthermore,we found that miR-449a-5p mediated Notch1 expression modulation and that miR-449a-5p knockdown abolished the effects of iTreg-EVs on effector T cells and regulatory T cells in vitro and in vivo.Taken together,our results show that iTreg-EVs control the inflammatory responses of recipient T cells through miR-449a-5p-dependent modulation of Notch1 and ameliorate the development and severity of arthritis,which may provide a potential cell-free strategy based on manipulating iTreg-EVs to prevent autoimmune arthritis.

关键词： EVs iTreg Arthritis Th17 MicroRNA Notch1

Medicinal plants of Chinese Pharmacopoeia and Daodi:Insights fromphylogeny and biogeography

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Chinese Herbal Medicines 2018年第3期10卷 269-278页

作者： Di Lei Jie wu Christine Leon Lin-fang huang julie A.Hawkins School of Biological Sciences University of ReadingReading RC6 6BXUnited Kingdom Institute of Chinese Materia Mediea China Academy of Chinese Medical SciencesBeijing 100700China Royol Botanic Gardens KewRichmondSurrey TW9 3ABUnited Kingdom Institute of Medicinal Plant Development Peking Union Medical College&Chinese Academy of Medical SciencesBeijing 100193China

Objective: The Chinese Pharmacopoeia(2015) includes 584 plant medicines, of which 284 also contain high quality subsets, so called "Daodi" components, where Daodi denotes superior clinical properties compared to non-Daodi counterparts despite being sourced from the same species. Commercial and clinical drivers of selection for Daodi have been described elsewhere. Our objective is to investigate the overall composition of Daodi to determine in what ways medicines with Daodi as a whole differ from the other plants of the Chinese Pharmacopoeia. A further objective is to characterise the Chinese Pharmacopoeia and Daodi in terms of the plant species including their traits and distribution.Methods: We used trait analysis to identify whether Daodi species were significantly different from the remaining Chinese Pharmacopoeia plant species in any traits. We used biogeographic methods and an existing classification of Daodi into 10 regions to identify spatial patterns amongst the species. Regression and binomial analyses were used to test for over-and under-use of plant families and endemic species.Preferences for lineages were visualized using phylogenetic mapping.Results: We found that Daodi species(species with any Daodi subset) were more likely to be roots that are "hot" or "warm", and less likely to be "oxic", according to traditional Chinese medicine(TCM) concepts. Roots were over-represented in the Bei region, and whole plants over-represented in Guang. Both the Chinese Pharmacopoeia and Daodi indicated preferences for families not common in previously studied ethnopharmacopoeias, and fewer endemic species were represented than expected by chance.Conclusion: Using the phylogenetic and biogeographical methods, we highlighted patterns of plant use,and the biological characters of Daodi medicinal plants. Our study points towards cultural preferences in need of scientific explanation.

关键词： biogeography Chinese Pharmacopoeia Daodi phylogeny

鸡血藤精准煮散饮片与原饮片质量的对比性研究

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世界科学技术-中医药现代化 2017年第1期19卷 83-88页

作者：徐文雷迪张靖徐江黄志海丘小惠 julie A.Hawkins 陈士林广州中医药大学第二附属医院/广东省中医药科学院/中国中医科学院广东分院广州510006 雷丁大学生物科学学院英国RG66AH 中国中医科学院中药研究所北京100700

目的:本研究采用化学指纹图谱法及DNA条形码分子鉴定技术对鸡血藤饮片煮散质量体系进行探索研究。方法:应用ITS2序列作为DNA条形码对鸡血藤进行鉴定,对比鸡血藤原饮片及精准煮散饮片的出膏率;收集3个批次鸡血藤饮片,采用HPLC法进行3批... 详细信息

目的:本研究采用化学指纹图谱法及DNA条形码分子鉴定技术对鸡血藤饮片煮散质量体系进行探索研究。方法:应用ITS2序列作为DNA条形码对鸡血藤进行鉴定,对比鸡血藤原饮片及精准煮散饮片的出膏率;收集3个批次鸡血藤饮片,采用HPLC法进行3批次饮片混合粉碎前后质量均一性、指纹图谱与相似度评价。结果:ITS2序列对鸡血藤药材可实现准确鉴定。鸡血藤煮散饮片出膏率及指标成分表儿茶素含量均略高于原饮片;原饮片批间表儿茶素溶出量有明显差异性RSD为11.0%,混合后制成煮散饮片后差异性明显降低RSD为1.0%。指纹图谱中14个共有峰相对峰面积均有所提高,RSD值明显减少。结论:鸡血藤精准煮散饮片提高原饮片的浸出率,成分溶出率及质量均一性,表明鸡血藤煮散饮片有较好的的临床应用优势。

关键词：精准煮散饮片鸡血藤均一性 DNA条形码质量体系

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三七精准煮散饮片的研制--质量均一性分析

中国实验方剂学杂志 2017年第11期23卷 13-17页

作者：张靖雷迪丘小惠黄志海徐文李西文 julie A.Hawkins 陈士林广州中医药大学第二附属医院广东省中医药科学院中国中医科学院广东分院广州510006 雷丁大学生物科学学院雷丁999020 中国中医科学院中药研究所北京100700

目的:饮片质量均一性是中药临床疗效稳定的基础,利用化学指纹图谱结合DNA分子鉴定技术考察三七精准煮散饮片与市售原饮片质量的均一性。方法:应用第二内转录间隔区(ITS2)序列DNA条形码对三七饮片进行分子鉴定;对比三七市售原饮片及精准... 详细信息

目的:饮片质量均一性是中药临床疗效稳定的基础,利用化学指纹图谱结合DNA分子鉴定技术考察三七精准煮散饮片与市售原饮片质量的均一性。方法:应用第二内转录间隔区(ITS2)序列DNA条形码对三七饮片进行分子鉴定;对比三七市售原饮片及精准煮散饮片的干膏收率;采用HPLC-DAD检测3批三七饮片混合粉碎前后的质量均一性和指纹图谱相似度。结果:三七煮散饮片出膏率显著高于原饮片出膏率;不同批次原饮片间指标成分三七皂苷R_1,人参皂苷Rg_1及Rb_1溶出量有明显的差异性,RSD分别为13.1%,32.7%及24.5%,混合制成煮散饮片后溶出量差异减小,RSD分别为3.6%,2.6%及3.5%;精准煮散饮片提取液中化学成分溶出量较原饮片高。混合粉碎后指纹图谱相似度提高,标定了共有峰14个,峰面积均有提高。结论:三七精准煮散饮片与市售原饮片基本属性相一致,但煮散饮片的浸出、有效成分溶出及质量均一性均有明显提高,提示煮散饮片可提高临床用药的精准性。

关键词：三七精准煮散饮片 DNA条形码指纹图谱三七皂苷类人参皂苷类

ITK inhibitor BMS509744 ameliorates Collagen-Induced Arthritis via shifting the balance between Th17 and regulatory Th17 cells

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ITK inhibitor BMS509744 ameliorates Collagen-Induced Arthrit...

不一样的课程专业,不一样的工学结合——高职管理类专业工学结合教育教学方法探索与实践

第十三届全国免疫学学术大会

作者： ye Chen julie Wang Weishan huang David Brand Avery August Song Guo Zheng Sun yat-sen University Penn State Univ Cornell Univ Univ of Tennessee

Rheumatoid arthritis(RA) is a chronic inflammation disease that cannot be cured and current approaches have the severe side effects. Although the pathogenesis is not completely understood, many studies have suggested that the imbalance between Th17 cells/inflammatory cytokines and suppressive Foxp3 T regulatory cells(Tregs) is associated with the pathogenesis and development in RA progression. ITK is involved in signaling cascades mediating T-lymphocyte proliferation, differentiation, and migration and pro-inflammatory cytokine production. The small molecule BMS509744 covalently binds ITK and inhibits the kinase activity of ITK. Here we report that BMS509744 effectively Skewed Th cells to Treg under Th17 differentiation conditions and promote Treg induction under Treg differentiation condition, and give rise to increased Foxp3 expression across TCR doses under Th17 and Treg condition, these effects can be reversed by SGK1 inhibitor. Moreover, we found that Itk inhibitor decreased mTor activity and altered metabolic marker HIF1 a and SLC3 a which regulate the balance between Th17 and Treg cells. Additionally, BMS509744 effectively ameliorate collagen-induced arthritis in mice by shifting the Th17/Treg cell balance from Th17 predominance to Treg cell predominance. Our result indicates that BMS509744 is an effective RA therapeutic.

关键词： Itk Th17 Treg SGK1 CIA

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清远职业技术学院学报 2009年第5期2卷 24-26页

作者：陆红光黄静李举烈清远职业技术学院旅游与家政管理系广东清远511510

工学结合的内涵就是基于生产的学习和基于学习的生产,我国在提倡工学结合方面取得了一些成绩,但远远不能与德国的"双元制"等模式相提并论,主要是存在意识形态因素、物质因素和到目前为止的实施效果几方面的制约。通过一些管理类的专业实... 详细信息

工学结合的内涵就是基于生产的学习和基于学习的生产,我国在提倡工学结合方面取得了一些成绩,但远远不能与德国的"双元制"等模式相提并论,主要是存在意识形态因素、物质因素和到目前为止的实施效果几方面的制约。通过一些管理类的专业实践,我们认为,对于工学结合的理解不同,可能会导致拘泥于其形式,妨碍工学结合教学的实践,理解透彻工学结合教学模式的内涵,就会发现,对于不同的专业,不同的课程,会有不同的工学结合模式,只要融入工学结合的理念,从适当的方位取得突破,工学结合教学模式就前途宽广。

关键词：工学结合岗位专业课程

Directed migration of human neural progenitor cells to interleukin-1βis promoted by chemokines stromal cell-derived factor-1 and monocyte chemotactic factor-1 in mouse brains

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Translational Neurodegeneration 2012年第1期1卷 112-122页

作者： yumei Wu Qiang Chen Hui Peng Huanyu Dou you Zhou yunlong huang Jialin C Zheng Department of Pharmacology and Experimental Neuroscience Neuroimmunology and Regenerative Therapy LaboratoryUniversity of Nebraska Medical CenterOmahaNebraska 68198USA Department of Pathology and Microbiology University of Nebraska Medical CenterOmahaNebraska 68198USA Department of Pharmacology School of PharmacyThe Fourth Military Medical UniversityXi’anShaanxi 710032People’s Republic of China Center for Biotechnology University of Nebraska LincolnLincolnNebraska 68588USA

Background:Neurogenesis,including the proliferation,migration and differentiation of neural progenitor cells(NPCs),is impaired in HIV-1 associated dementia(HAD).We previously demonstrated HIV-1-infected macrophages(HIV-MDM)regulate stromal cell-derived factor 1(SDF-1)production in astrocytes through Interleukin-1β(IL-1β).Chemokines are known to induce NPC migration;however,it remains unclear how chemokines produced in inflammation regulate NPC migration.Methods:The secretion of SDF-1 and Monocyte chemotactic preotein-1(MCP-1)in astrocytes upon IL-1βstimulation was measured by ELISA assay.Human NPCs were injected parallel along with IL-1β,SDF-1 or MCP-1 intracranially into basal ganglion 1 mm apart in SCID mice,and immunofluorescent staining was used to study the survival and migration of injected human NPCs.Results:SDF-1 and MCP-1 are secreted by astrocytes upon IL-1βstimulation in a time-dependent manner.Injected human NPCs survived in SCID mice and migrated towards sites of IL-1β,SDF-1 and MCP-1 injection.Conclusions:In conclusion,chemokines SDF-1 or MCP-1 secreted by astrocytes in the presence of IL-1βinjection are attractive to NPCs injected into SCID mouse brains,suggesting that SDF-1 and MCP-1 play important roles in NPC migration during neuroinflammation.

关键词： progenitor stimulation injection

聚焦青少年科学教育未来——“涵养青少年科学志趣培养基础科学后备人才”专题论坛综述

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科普研究 2023年第5期18卷 85-88页

作者：杨沨范体宇黄锦华中国科协青少年科技中心北京100038 《中国科技教育》杂志社北京100037

2023年9月20日,2023世界公众科学素质促进大会“涵养青少年科学志趣培养基础科学后备人才”专题论坛在北京首钢园举行,论坛邀请美国科学教育协会(National Science Teaching Association,NSTA)1主席朱莉·安妮·卢夫特(julie Anne Luft... 详细信息

2023年9月20日,2023世界公众科学素质促进大会“涵养青少年科学志趣培养基础科学后备人才”专题论坛在北京首钢园举行,论坛邀请美国科学教育协会(National Science Teaching Association,NSTA)1主席朱莉·安妮·卢夫特(julie Anne Luft)、经济合作组织科学基金会(Economic Cooperation Organization Science Foundation,ECOSF)前主席曼泽·胡塞恩·索木尔(Manzoor Hussain Soomro)、非洲科学院联盟(Network of African Science Academies,NASAC)执行理事杰奎琳·爱丽丝·阿金伊·卡多(Jacqueline Alice Akinyi Kado)。

关键词：经济合作组织公众科学素质杰奎琳北京首钢基础科学执行理事爱丽丝