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e.iology of sinonasal inve.te. papilloma: A narrative.re.ie.

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World Journal of Otorhinolaryngology-He.d and Ne.k Surge.y 2017年第1期3卷 -页

作者： Ming-Jie.Wang julia e.Noe. De.artme.t of Otolaryngology-He.d and Ne.k Surge.y Beijing TongRen HospitalCapital Medical UniversityBeijing 100730China De.artme.t of Otolaryngology-He.d and Ne.k Surge.y Division of Rhinology and Endoscopic Skull Base SurgeryStanford University Medical CenterStanfordCA 94305USA

Obje.tive.Sinonasal inve.te. papilloma (IP) is a be.ign and uncommon tumor of the.nasal cavity and paranasal sinuse. with a te.de.cy for re.urre.ce.and e.e. malignant *** the.morphology and clinical be.avior of this le.ion has be.n we.l de.cribe.,its e.iology re.ains ***:Compute.ize. se.rche. we.e.pe.forme. in PubMe.,Scopus,and Google.scholar through May *** this re.ie.,e.iologic factors including human papilloma virus (HPV),e.ste.n-Barr virus (e.V),ce.l cycle.re.ate. prote.ns and angioge.ic factors,occupational and e.vironme.tal e.posure.,and chronic inflammation,will be.***:Many studie. indicate.that HPV has be.n de.e.te. in a significant pe.ce.tage.of IP,while.e.V has not be.n shown to be.significantly *** ce.l cycle.re.ulatory factors and angioge.ic prote.ns contribute.to the.dysre.ulation of prolife.ation and apoptosis,and facilitate.migration and tumor *** e.posure.,such as we.ding and organic solve.ts,have.be.n implicate.,and smoking se.ms more.critical to re.urre.ce.and dysplasia rathe. than initial IP *** inflammation may also have.a causative.re.ationship with inve.te. papilloma,but the.me.hanism is ***:Though e.iology of sinonasal IP re.ains controve.sial,the.studie. re.ie.e. he.e.indicate.a role.for viral infe.tion,ce.l cycle.and angioge.ic factors,e.vironme.tal and occupational e.posure.and chronic *** study on e.iologic factors is ne.e.sary for clinical guidance.and the.ape.tic targe.s.

关键词： Sinonasal inve.te. papilloma Human papilloma virus Occupational e.posure Smoking Chronic inflammation

e.fe.ts of e.troge. re.e.tor modulators on cytoske.e.al prote.ns in the.ce.tral ne.vous syste.

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Ne.ral Re.e.e.ation Re.e.rch 2017年第8期12卷 1231-1240页

作者： julia J.Se.ura-Uribe.Rodolfo Pinto-Almazán Angélica Coyoy-Salgado Claudia e.Fue.te.-Ve.ado Christian Gue.ra-Araiza Unidad de.Inve.tigacion Modica e. e.fe.me.ade. Ne.rologicas Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico Se.cion de.e.tudios de.Posgrado e.Inve.tigacion Escuela Superior de Medicina Instituto Politecnico Nacional Mexico City Mexico Unidad de.Inve.tigacion Hospital Re.ional de.Alta e.pe.ialidad Ixtapaluca Ixtapaluca Mexico Institute.for the.De.e.oping Mind Children's Hospital Los Angeles Los Angeles CA USA De.artme.t of Pe.iatrics Keck School of Medicine University of Southern California Los Angeles CA USA Conse.o Nacional de.Cie.cia y Te.nologia Mexico City Mexico Clinica de.Trastornos de. Sue.o Universidad Autonoma Metropolitana-Iztapalapa Mexico City Mexico Se.vicio de.Me.icina Fisica y Re.abilitacion Hospital General de Zona No. 197 Texcoco Mexico Unidad de.Inve.tigacion Modica e. Farmacologla Hospital de Especialidades Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico

e.troge. re.e.tor modulators are.compounds of inte.e.t be.ause.of the.r e.troge.ic agonistic/antagonistic e.fe.ts and tissue.spe.ificity. The.e.compounds have.many clinical applications, particularly for bre.st cance. tre.tme.t and oste.porosis in postme.opausal wome., as we.l as for the.tre.tme.t of climacte.ic symptoms. Similar to e.troge.s, ne.roprote.tive.e.fe.ts of e.troge. re.e.tor modulators have.be.n de.cribe. in diffe.e.t mode.s. Howe.e., the.me.hanisms of action of the.e.compounds in the.ce.tral ne.vous syste. have.not be.n fully de.cribe.. We.conducte. a syste.atic se.rch to inve.tigate.the.e.fe.ts of e.troge. re.e.tor modulators in the.ce.tral ne.vous syste., focusing on the.modulation of cytoske.e.al prote.ns. We.found that raloxife.e. tamoxife., and tibolone.modulate.some.cytoske.e.al prote.ns such as tau, microtuble.associate. prote.n 1（MAP1）, MAP2, ne.rofilame.t 38（NF38） by diffe.e.t me.hanisms of action and at diffe.e.t le.e.s： ne.ronal microfilame.ts, inte.me.iate.filame.ts, and microtubule.associate. prote.ns. Finally, we.e.phasize.the.importance.of the.study of the.e.compounds in the.tre.tme.t of ne.rode.e.e.ative.dise.se. since.the. pre.e.t the.be.e.its of e.troge.s without the.r side.e.fe.ts.

关键词： e.troge. re.e.tor modulators se.e.tive.e.troge. re.e.tor modulators microtubule. ne.rofilame.ts tibolone tamoxife. raloxife.e

Cobaltae.e.tro-Catalyze. C—H Acyloxylation

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Chine.e.Journal of Che.istry 2019年第6期37卷 552-556页

作者： Cong Tian Uttam Dhawa julia Struwe.Lutz Acke.mann Institut fur Organische.und Biomole.ulare.Che.ie Georg-August-Universitat GottingenTammannstraβe 237077 GottingenGermany

Cobaltae.e.trocatalysis se. the.stage.for sustainable.C—H acyloxylations in biomass-de.ive. γ-vale.olactone.as a re.e.able.solve.t. The.sustainable.e.e.trocatalysis re.ime.fe.ture. ample.scope. along with high le.e.... 详细信息

关键词： C-H activation cobalt e.e.trosynthe.is biomass solve.t

Disaste. Tale. as Communication Tool for Incre.sing Risk Re.ilie.ce

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Inte.national Journal of Disaste. Risk Scie.ce 2021年第3期12卷 341-354页

作者： Paola Mazzoglio Ste.ano Macchia e.rico Gallo julia Winte. Pie.luigi Claps De.artme.t of e.vironme.t Land and Infrastructure Engineering(DIATI-Dipartimento di Ingegneria dell’Ambientedel Territorio e delle Infrastrutture)Politecnico di Torino10129 TorinoItaly Comune.di Torino 10152 TorinoItaly PwC(Price.ate.house.oope.s)Italy 10122 TorinoItaly

Age.cie. in charge.of flood manage.e.t use.disaste. re.orts(DRs)as the.pre.e.re. source.of information on past flooding e.e.ts.A syste.atic surve. of DRs pre.are. by Italian age.cie. sugge.ts that DRs could be.wide.y e.hance. in vie. of targe.ing more.e.fe.tive.communication to citize.s,re.nforcing the.communication pillar in civil prote.tion planning and manage.e.t,and improving the.re.ilie.ce.of the.population to e.tre.e.*** loss of the.rigor and de.ails re.uire. for all the.usual te.hnical use. of DRs,we.sugge.t re.ompiling the. in the.form of"disaste. tale."(DTs),as tools that offe. wide. knowle.ge.of the.e.e.ts to improve.pe.ple.s pre.are.ne.s and se.f-prote.tion *** major flooding e.e.ts have.de.onstrate. the.communication pote.tial that vide.s and picture. take. by citize.s have.for risk pe.ce.tion and disaste. *** watching and liste.ing to what has happe.e. the.communication re.ipie.t can be.te. unde.stand the.fe.lings of the.pe.ple.e.pe.ie.cing an *** structure.of the.improve. re.orts,we.sugge.t,will finally inte.rate.data,graphs,and maps with inte.active.tools and be.able.to pre.e.t handie. multime.ia vie.s of the.*** to thre. case.studie. of flooding in Italy illustrate. how to concre.e.y imple.e.t the.sugge.te. disaste. re.orts to cre.te.more.re.dily acce.sible.disaste. tale..

关键词： Disaste. communication Disaste. narrative. Flood risk pe.ce.tion Italy Storyte.ling

The.re.ical study of de.e.t impact on two-dime.sional MoS_2

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Journal of Se.iconductors 2015年第12期36卷 18-23页

作者： Anna V.Krivoshe.va Victor L.Shaposhnikov Victor e.Borise.ko Je.n-Louis Lazzari Chow Waile.ng julia Gusakova Be.g Kang Tay Be.arusian State.Unive.sity of Informatics and Radioe.e.tronics CNRS Aix-Marseille Université NOVITAS Nanoelectronics Centre of Excellence School of Electrical and Electronic Engineering Nanyang Technological University CINTRA CNRS NTUTHALES Nanyang Technological University

Our the.re.ical findings de.onstrate.for the.first time.a possibility of band-gap e.gine.ring of monolaye. MoS2 crystals by oxyge. and the.pre.e.ce.of vacancie.. Oxyge. atoms are.re.e.le. to substitute.sulfur one., forming stable.MoS2-xOx te.nary compounds, or adsorb on top of the.sulfur atoms. The.substituting oxyge. provide. a de.re.se.of the.band gap from 1.86 to 1.64 e. and transforms the.mate.ial from a dire.t-gap to an indire.t-gap se.iconductor. The.surface.adsorbe. oxyge. atoms de.re.se.the.band gap up to 0.98 e. de.e.ding on the.r location te.ding to the.me.allic characte. of the.e.e.tron e.e.gy bands at a high conce.tration of the.adsorbe. atoms. Oxyge. plasma proce.sing is propose. as an e.fe.tive.te.hnology for such band-gap modifications.

关键词： two-dime.sional crystal molybde.um disulfide band gap vacancy oxyge.

Simulation of four re.piratory viruse. and infe.e.ce.of e.ide.iological parame.e.s

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Infe.tious Dise.se.Mode.ling 2018年第1期3卷 23-34页

作者： julia Re.s Je.fre. Shaman a Biological Syste.s e.gine.ring Virginia TechBlacksburgVAUSA De.artme.t of e.vironme.tal He.lth Scie.ce. Mailman School of Public HealthColumbia UniversityNew YorkNYUSA

While.influe.za has be.n simulate. e.te.sive.y to be.te. unde.stand its be.avior and pre.ict future.outbre.ks,most othe. re.piratory viruse. have.se.dom be.n *** this study,we.provide.an ove.vie. of four common re.piratory viral infe.tions:re.piratory syncytial virus(RSV),re.piratory ade.ovirus,rhinovirus and parainflue.za,pre.e.t spe.ime. data colle.te. 2004e.014,and simulate.outbre.ks in 19 ove.lapping re.ions in the.Unite. *** a compartme.tal mode. and data assimilation me.hods,we.infe. ke. e.ide.iological parame.e.s gove.ning transmission:the.basic re.roductive.numbe. R0 and le.gth of infe.tion *** had be.n pre.iously simulate.,and our me.n e.timate.of D and R0 of 5.2 days and 2.8,re.pe.tive.y,are.within publishe. clinical and mode.ing *** the.four virus groupings,me.n e.timate. of R0 range.from 2.3 to 3.0,with a lowe. and uppe. quartile.range.of 2.0e..8 and 2.6e..2,*** rapid PCR te.ting be.ome. more.common,e.timate. of the.obse.ve. virule.ce.and duration of infe.tion for the.e.viruse. could inform de.ision making by clinicians and officials for managing patie.t tre.tme.t and re.ponse.

关键词： re.piratory parame.e.s e.timate.

Microbiota alte.ations in acute.and chronic gastrointe.tinal inflammation of cats and dogs

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World Journal of Gastroe.te.ology 2014年第44期20卷 16489-16497页

作者： julia B Honne.fe. Yasushi Minamoto Jan S Suchodolski Gastrointe.tinal Laboratory Department of Small Animal Clini-cal Sciences College of Veterinary Medicine and Biomedical Science Texas A & M University College Station TX 77843 United States

The.inte.tinal microbiota is the.colle.tion of the.living microorganisms(bacte.ia, fungi, protozoa, and viruse.) inhabiting the.gastrointe.tinal tract. Nove. bacte.ial ide.tification approache. have.re.e.le. that the.gastrointe.tinal microbiota of dogs and cats is, similarly to humans, a highly comple. e.osyste.. Studie. in dogs and cats have.de.onstrate. that acute.and chronic gastrointe.tinal dise.se., including inflammatory bowe. dise.se.IBD), are.associate. with alte.ations in the.small inte.tinal and fe.al microbial communitie.. Of inte.e.t is that the.e.alte.ations are.ge.e.ally similar to the.dysbiosis obse.ve. in humans with IBD or animal mode.s of inte.tinal inflammation, sugge.ting that microbial re.ponse. to inflammatory conditions of the.gut are.conse.ve. across mammalian host type.. Studie. have.also re.e.le. possible.unde.lying susce.tibilitie. in the.innate.immune.syste. of dogs and cats with IBD, which furthe. de.onstrate.the.intricate.re.ationship be.we.n gut microbiota and host he.lth. Commonly ide.tifie. microbiome.change. in IBD are.de.re.se. in bacte.ial groups within the.phyla Firmicute. and Bacte.oide.e., and incre.se. within Prote.bacte.a. Furthe.more. a re.uction in the.dive.sity of Clostridium cluste.s XIVa and IV(i.e., Lachnospirace.e.and Clostridium coccoide. subgroups) are.associate. with IBD, sugge.ting that the.e.bacte.ial groups may play an important role.in mainte.ance.of gastrointe.tinal he.lth. Future.studie. are.warrante. to e.aluate.the.functional change. associate. with inte.tinal dysbiosis in dogs and cats.

关键词： Microbiome 16S rRNA Inflammatory bowe. dise.se Probiotic Dog Cat

Annual Time.se.ie. Analyse. of Total Gase.us Me.cury Me.sure.e.t and its Impact Factors on the.Gongga Mountains in the.Southe.ste.n Fringe.of the.Qinghai-Tibe.an Plate.u

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Journal of Mountain Scie.ce 2008年第1期5卷 17-31页

作者： ZHU Wanze.FU Xue.u Fe.G Xinbin julia Y. Lu Institute.of Mountain Hazard and e.vironme.t Chinese Academy of Sciences Chengdu 610041 China State.Ke. Laboratory of e.vironme.tal Ge.che.istry Institute of Geochemistry Chinese Academy of Sciences Guiyang 550002 China De.artme.t of Che.istry and Biology Ryerson University Toronto Ontario M5B 2K3 Canada

Long-te.m monitoring programs for me.sure.e.t of atmosphe.ic me.cury conce.trations are.pre.e.tly re.ognize. as powe.ful tools for local,re.ional and global studie. of atmosphe.ic long-range.transport proce.se.,and the. could also provide.valuable.information about the.impact of e.ission controls on the.global budge. of atmosphe.ic me.cury,the.r obse.vance.and an insight into the.global me.cury cycle. China is be.ie.e. to be.an incre.sing atmosphe.ic me.cury e.ission source. Howe.e.,only a fe. me.sure.e.ts of me.cury,to our knowle.ge.have.be.n done.in ambie.t air ove. China. The.highly-time.re.olve. atmosphe.ic me.cury conce.-trations have.be.n me.sure. at Moxi Base.Station (102°72′e.29°92′N,1640 m asl) of the.Gongga Alpine.e.osyste. Obse.vation and e.pe.ime.t Station of Chine.e.Acade.y of Scie.ce. (CAS) from May 2005 to June.2006 by using a se. of Automatic Atmosphe.ic Me.cury Spe.iation Analyze.s (Te.ran 2537A). Me.sure.e.ts we.e.carrie. out with a time.re.olution of e.e.y 15 minute.. The.ove.all ave.age.total gase.us me.cury (TGM) cove.ing the.me.sure.e.t pe.iods was 4±1.38 ng·m-3 (N=57310),which is highe. than the.global background le.e. of approximate.y 1.5～2.0 ng·m-3. The.me.sure.e.ts in all se.sons showe. a similar diurnal change.patte.n with a high conce.tration during daytime.re.ative.to nighttime.and maximum conce.tration ne.r solar noon and minimum conce.tration imme.iate.y be.ore.sunrise. The.pre.e.ce.of diurnal TGM pe.ks during spring and summe. was found e.rlie. than that during autumn and winte.. Whe. divide. se.sonally,it was found that the.conce.trations of TGM we.e.highe.t in winte. with 6.13 ± 1.78 ng·m-3 and lowe.t in summe. with 3.17 ± 0.67 ng·m-3. The.e.we.e.no significant diffe.e.ce. in TGM among wind se.tors during e.ch se.son. Whe.e.s Hg ge.e.ally e.hibite. significant corre.ations with the.parame.e.s,such as te.pe.ature.saturate. vapor pre.sure.pre.ipitation,ultraviole. radiation (UV) and atmosphe.ic pre.sure.at the.whole.me.sure.e.t stage.

关键词： Total gase.us me.cury (TGM) diurnal variability se.sonal variability me.e.rological factor Gongga Mountains

Machine.le.rne. me.rics for pre.icting the.like.ihood of succe.s in mate.ials discove.y

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npj Computational Mate.ials 2020年第1期6卷 539-547页

作者： Yoolhe. Kim e.ward Kim e.in Antono Bryce.Me.e.ig julia Ling Citrine.Informatics Redwood CityCA 94063USA

Mate.ials discove.y is ofte. compare. to the.challe.ge.of finding a ne.dle.in a *** much work has focuse. on accurate.y pre.icting the.prope.tie. of candidate.mate.ials with machine.le.rning(ML),which amounts to e.aluating whe.he. a give. candidate.is a pie.e.of straw or a ne.dle.le.s atte.tion has be.n paid to a critical que.tion:are.we.se.rching in the.right haystack?We.re.e. to the.haystack as the.de.ign space.for a particular mate.ials discove.y proble.(i.e.,the.se. of possible.candidate.mate.ials to synthe.ize.,and thus frame.this que.tion as one.of de.ign space.*** this pape.,we.introduce.two me.rics,the.pre.icte. fraction of improve. candidate.(PFIC),and the.cumulative.maximum like.ihood of improve.e.t(CMLI),which we.de.onstrate.can ide.tify discove.y-rich and discove.y-poor de.ign space.,re.pe.tive.y.A combine. classification syste.,compose. of the.CMLI and PFIC me.rics,is the. use. to ide.tify optimal de.ign space. with high pre.ision,and thus show the.pote.tial to significantly acce.e.ate.ML-drive. mate.ials discove.y.

关键词： like.ihood pre.icting se.rching