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Coexistence of papillary thyroid microcarcinoma and mucosa-associated lymphoid tissue lymphoma in a context of Hashimoto's thyroiditis

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Asian Pacific Journal of Tropical Medicine 2016年第8期9卷 789-791页

作者： Saul Levy-Blitchtein Stefany Plasencia-Rebata Domingo Morales Luna juana del valle mendoza School of Medicine Faculty of Health Sciences Universidad Peruana de Ciencias Aplicadas (UPC) Research Center and Innovation of the Health Sciences Faculty Universidad Peruana de Ciencias Aplicadas (UPC) Pathologist Service Hospital Nacional Edgardo Rebagliati Martins (HNERM)

Papillary thyroid cancer(PTC)represents 80%-85%of thyroid cancer and its prevalence has been rising in the last *** thyroid lymphoma(PTL)accounts for 3%of extranodal lymphomas and about 5%of thyroid malignancies,having a prevalence of one or two cases per million ***-Associated Lymphoid Tissue lymphoma represents approximately30%of *** entities have an indolent course and a very good *** is made by ultrasound and fine needle aspiration(FNA)or surgery specimen *** have also been associated with Hashimoto’s thyroiditis(HT),but pathogenesis and its links remains to be *** remains controversial and surgery is generally accepted in cases of disease limited to thyroid,as the *** with thyroid nodules should be observed and *** there is an enlargement by ultrasound or clinical symptoms,FNA should be performed *** with HT deserve additional surveillance,since this condition is associated with both PTC and *** this case,the management with surgery and radioactive iodine ablation therapy was effective for both *** with thyroid nodules should be properly evaluated with ultrasound and thyroid function *** there is an enlargement of the neck,reported by symptoms or ultrasound,it requires further *** is associated to both PTC and PTL so if the enlargement of the nodules is on this context additional tests such as FNA should be *** this case,the patient was managed with surgery and radioactive iodine ablation therapy and it was effective for both entities.

关键词： Thyroid cancer-clinical Hashimoto’s thyroiditis Pathology-thyroid Thyroid diseases

Is glucose-6-phosphate dehydrogenase deficiency more prevalent in Carrion's disease endemic areas in Latin America?

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Asian Pacific Journal of Tropical Medicine 2015年第12期8卷 1045-1046页

作者： Fernando Mazulis Claudia Weilg Carlos Alva-Urcia Maria J.Pons juana del valle mendoza School of Medicine Research Center of the Health Sciences FacultyUniversidad Peruana de Ciencias Aplicadas(UPC)

Glucose-6-phosphate dehydrogenase(G6PD) is a cytoplasmic enzyme with an important function in cell oxidative damage *** have a predisposition towards oxidized environments due to their lack of mitochondria,giving G6 PD a major role in its stability.G6 PD deficiency(G6PDd) is the most common enzyme deficiency in humans:it affects approximately 400 million individuals *** overall G6 PDd allele frequency across malaria endemic countries is estimated to be 8%.corresponding to approximately 220 million males and 133 million ***,there are no reports on the prevalence of G6 PDd in Andean communities where bartonellosis is prevalent.

关键词： Glucose-6-phosphate dehydrogenase G6PD Bartonella

Antibacterial activity of Bixa orellana L.(achiote) against Streptococcus mutans and Streptococcus sanguinis

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 400-403页

作者： Dyanne Medina-Flores Gabriela Ulloa-Urizar Rosella Camere-Colarossi Stefany Caballero-García Frank Mayta-Tovalino juana del valle-mendoza School of Dentistry Faculty of Health SciencesPeruvian University of Applied Sciences-UPC Research and Innovation Center of the Faculty of Health Sciences Peruvian University of Applied Sciences-UPC Molecular Biology Laboratory Nutrition Research Institute

Objective: To evaluate the cytotoxic and antibacterial effect of Bixa orellana L.(B. orellana)(achiote) methanol extract against Streptococcus mutans(ATCC 25175)(S. mutans) and Streptococcus sanguinis(ATCC 10556)(S. sanguinis).Methods: Two methanol extracts of B. orellana were prepared in vitro, from the seeds and leaves. The antibacterial activity of extracts against S. mutans and S. sanguinis was evaluated using the cup-plate agar diffusion method. The minimum inhibitory concentration(MIC) was determined using the microdilution method and the cytotoxic activity was determinated by using the cell line ***: A stronger antibacterial effect was observed with the leaves methanolic extract with an inhibition zone of(19.97 ± 1.31) mm against S. mutans and(19.97 ± 1.26) mm against S. sanguinis. The methanolic extract of the seeds had an activity of(15.11 ± 1.03)mm and(16.15 ± 2.15) mm against S. mutans and S. sanguinis, respectively. The MIC of the leaf and the seed extracts against S. sanguinis was 62.5 and 125 mg/m L, respectively,and the MIC of the leaf extract against S. mutans was 62.5 mg/m L, and for the seed extract it was 31.25 mg/m L. The 50% cytotoxic concentration was 366.45 and 325.05 mg/m L for the leaves and seeds extracts, ***: The experimental findings demonstrated the antibacterial effect of the methanolic extract of B. orellana(achiote) on S. mutans and S. sanguinis. The extract of this plant is cytotoxic at high concentrations.

关键词： Antibacterial effect Medicinal plants Bixa orellana L. Cytotoxicity

Antibacterial activity of Myrciaria dubia(Camu camu) against Streptococcus mutans and Streptococcus sanguinis

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Asian Pacific Journal of Tropical Biomedicine 2016年第9期6卷 740-744页

作者： Rosella Camere-Colarossi Gabriela Ulloa-Urizar Dyanne Medina-Flores Stefany Caballero-García Frank Mayta-Tovalino juana del valle-mendoza School of Dentistry Faculty of Health SciencesPeruvian University of Applied Sciences-UPC Research and Innovation Center of the Faculty of Health Sciences Peruvian University of Applied Sciences-UPC Molecular Biology Laboratory Nutrition Research Institute

Objective:To evaluate the antibacterial and cytotoxic effect of Myrciaria dubia(Camu camu)(***) methanol extract,against Streptococcus mutans(ATCC 25175)(***) and Streptococcus sanguinis(ATCC 10556)(***).Methods:Two methanol extracts of *** were prepared in vitro,from the seeds and *** independent tests were prepared for each type of extract,using 0.12% chlorhexidine solution as positive *** diffusion test was used by preparing wells with the experimental solutions cultivated in anaerobic conditions for 48 h at ***,the minimum inhibitory concentration and the cytotoxic effect over MDCK cell line was ***:A higher antibacterial effect was observed with the methanol seed extract with an inhibitory halo of(21.36 ± 6.35) mm and(19.21 ± 5.18) mm against *** and ***,*** methanol extract of the pulp had an effect of(16.20 ± 2.08)mm and(19.34 ± 2.90) mm,*** minimum inhibitory concentration of the pulp extract was 62.5 mg/mL for both strains,whereas for the seed antibacterial activity was observed even at low *** CC50 of the seeds extract was at a higher concentration than 800 mg/mL and 524.37 mg/mL for the pulp ***:The experimental findings demonstrated the antibacterial effect of the methanol extract of *** against *** and *** extracts were not cytotoxic at high concentrations.

关键词： Antibacterial effect Medicinal plants Myrciaria dubia Cytotoxicity

Seronegative disseminated Bartonella spp. infection in an immunocompromised patient

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Asian Pacific Journal of Tropical Medicine 2016年第12期9卷 1197-1200页

作者： Claudia Weilg Olguita del Aguila Fernando Mazulis Wilmer Silva-Caso Carlos Alva-Urcia Rosario Cerpa-Polar Erick Mattos-Villena juana del valle mendoza Medicine School Research Center and Innovation of the Health Sciences FacultyUniversidad Peruana de Ciencias Aplicadas Pediatric Service Hospital Nacional Edgardo Rebagliati Martins Molecular biology laboratory Instituto de Investigación Nutricional Pediatric Hematology Service Hospital Edgardo Rebagliati Martins

An 11 year old, hispanic girl with a history of B-cell acute lymphoblastic leukemia was admitted to the hospital for symptoms compatible with Bartonella henselae infection. The first molecularly diagnosed case of disseminated Bartonella henselae infection was reported in an immunocompromised patient in Lima, Peru. The analysis was confirmed by Polymerase Chain Reaction and automated sequencing of a liver biopsy sample, even though the serologic tests were negative. In conclusion, Bartonella spp. infection should have a particular diagnostic consideration in immunocompromised patients with fever of unknown origin and further investigation regarding the patient's past exposures with cats should also be elicited.

关键词： Bartonella spp. Bartonella henselae B-cell acute lymphoblastic leukemia Peru

Encephalitis with convulsive status in an immunocompetent pediatric patient caused by Bartonella henselae

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 591-594页

作者： Rosario Cerpa Polar Gabriela Orellana Wilmer Silva Caso José Sánchez Carbonel Javier Santisteban juana del valle mendoza Javier Santisteban Infectogía Pediátrica Servicio de Pediatría Especializada Hospital Edgardo Rebagliati Martins Neurologia Pediátrica Hospital Edgardo Rebagliati Martins School of Medicne Faculty of Health Sciences Universidad Peruana de Ciencias Aplicadas Faculty of Health Sciences Research Center of the Faculty of Health Sciences Universidad Peruana de Ciencias Aplicadas Clínica Pediatrica Hospital Edgardo Rebagliati Martins

Cat scratch's disease caused by Bartonella henselae, is known to be a self-limited benign process in immunocompetent children. The association with neurologic manifestations is very uncommon especially in patient with no immunologic defects and in cases without specific treatment. A 7 years old male patient, without any immunocromised defect, presented an atypic presentation of the cat scratch disease. The patient came to the hospital in two opportunities in a status epilepticus, in both cases the diagnosis was encephalitis by Bartonella henselae and the evolution with treatment was monitored with PCR(polymerase chain reaction) in cerebrospinal fluid and blood, as well as IFI(IgM, IgG) serology(indirect immunofluorescence). The patient had a favorable clinical and laboratory evolution for 6 months showing no recurrence of the disease.

关键词： Bartonella henselae Encephalitis Immunocompetent Pediatric patient Convulsive status Cat scratch’s disease

An atypical case of disseminated cutaneous leishmaniasis due to Leishmania peruviana in the valleys of Ancash-Peru

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1101-1103页

作者： Diego Espinoza-Morales Aldo Lucchetti Rodríguez Wilmer Silva-Caso Luis Suarez-Ognio María J.Pons juana del valle mendoza School of Medicine Health Sciences FacultyUniversidad Peruana de Ciencias AplicadasAv.San Marcos cdra Cedros de Villa LimaPeru 2Infectology ServicieHospital Arzobispo LoayzaAv.Alfonso Ugarte 848Cercado de LimaLimaPeru Research Center and Innovation of the Health Sciences Faculty Universidad Peruana de Ciencias AplicadasAv.San Marcos cdra 2 ChorrillosLimaPeru

We present an atypical case of disseminated cutaneous leishmaniasis in the Sihuas district, located in the Andean valleys of Ancash-Peru. A 62-year-old man with no particular medical history presented multiple lesions located on the inferior abdomen, lumbar region and the right anterior thigh. Histological analysis found leishmanial amastigotes in the lesion sample, the Montenegro reaction was positive for Leishmania spp, and the polymerase chain reaction was positive for Leishmania peruviana. In conclusion, the atypical presentation of this disease may be related to the presence of an uncommon parasite strain or host immune deficiencies. The molecular identification of the etiology for disseminated leishmaniasis, will allow a better understanding of the presentation and proper treatment,as well as associated risk factors.

关键词： Leishmaniasis Leishmania peruviana PCR Peru

Characterization of two Achromobacter xylosoxidans isolates from patients with pertussis-like symptoms

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Asian Pacific Journal of Tropical Medicine 2015年第6期8卷 465-468页

作者： Fiorella Orellana-Peralta Michelle Jacinto Maria J.Pons Cláudia Gomes Carlos Bada Isabel Reyes juana del valle mendoza Joaquim Ruiz Facultad de Ciencias de la Salud.Universidad Peruana de Ciencias Aplicadas-LiPC LimaPeru ISGlobal Barcelona Ctr.Int.Health Res.(CRESIB)Hospital Clinic-Universitat de Barcelona Hospital de Emergencias Pediatricas.Lima Peru Instituto de Investigacion Nutrirional LimaPeru

Objective:To characterize two Achromobaeter xylosoxidans recovered from 2 patients diagnosed with pertussis during a Bordetella pertussis surveillance ***:Nasopharyngeal swabs from 2 children under 1 year of age with clinical suspicion of pertussis were analyzed by culture and ***:Two Achromobaeter xylosoxidans A8,closely related to Bordetella *** recovered from 2 patients diagnosed of pertussis,both carrying the ptxA gene and IS418 the pertussis toxin encoding ***,antibiotic susceptibility was evaluated by disk-diffusion method and by ***:Although more detailed studies are needed,the present data highlight the possibility that Achromobaeter *** related Bordetella pertussis microorganisms and not covered under the vaccine umbrella,might also result in cases of whooping *** further surveillance is necessary to determine the extension and relevance of their pathogenic role in order to discriminate their real public health implication.

关键词： Achromobacter xylosoxidans Bordetella pertussis

Antibacterial activity of five Peruvian medicinal plants against Pseudomonas aeruginosa

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Asian Pacific Journal of Tropical Biomedicine 2015年第11期5卷 928-931页

作者： Gabriela Ulloa-Urizar Miguel Angel Aguilar-Luis María del Carmen De Lama-Odría José Camarena-Lizarzaburu juana del valle mendoza Centro de Investigacin de la Facultad de Ciencias de la Salud Universidad Peruana de Ciencias Aplicadas-UPC Facultad de Ciencias Biolgicas Universidad Nacional Mayor de San Marcos (UNMSM) Instituto de Investigacin Nutricional

Objective: To evaluate the susceptibility of Pseudomonas aeruginosa(P. aeruginosa)in vitro to the ethanolic extracts obtained from five different Peruvian medicinal ***: The plants were chopped and soaked in absolute ethanol(1:2, w/v). The antibacterial activity of compounds against P. aeruginosa was evaluated using the cupplate agar diffusion ***: The extracts from Maytenus macrocarpa("Chuchuhuasi"), Dracontium loretense Krause("Jergon Sacha"), Tabebuia impetiginosa("Tahuari"), Eucalyptus camaldulensis Dehn(eucalyptus), Uncaria tomentosa("U?a de gato") exhibited favorable antibacterial activity against P. aeruginosa. The inhibitory effect of the extracts on the strains of P. aeruginosa tested demonstrated that Tabebuia impetiginosa and Maytenus macrocarpa possess higher antibacterial ***: The results of the present study scientifically validate the inhibitory capacity of the five medicinal plants attributed by their common use in folk medicine and contribute towards the development of new treatment options based on natural products.

关键词： Pseudomonas Medicinal plants Maytenus macrocarpa D