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Open Journal of Ecology 2016年第9期6卷 517-528页

作者： juan luis Aguirre Carlos Talabante Alejandro Aparicio Manuel Peinado Cátedra de Medio Ambiente Departamento de Ciencias de la Vida Universidad de Alcalá Madrid Spain

This paper describes and analyzes floristic, structural and conservation features of the shrubland occupied by Chersophilus duponti in the northwest corner of its world distribution range. This study relates the coverage, floristic composition with estimated lark density in the area. We identified four types of shrublands, three of them varied significantly in floristic composition for the habitats of this species in contrast with those of their world distribution: Cistus ladanifer scrubs;heaths dominated by Ericaceae, and scrubs dominated by the genera Lavandula, Thymus and Cytisus. The fourth type, dominated by aromatic chamaephytes and grass, fits descriptions of the bird’s typical habitat. The areas sampled are subject to different categories of threats, the most significant being the natural succession process due to the cessation of grazing, reforestation measures and the use of flat areas for farmlands or other uses. The density of larks in this area was directly related to coverage-composition of plant community.

关键词： Alaudidae Passerine Birds Vegetation-Birds Relationships Steppe Birds Conservation Status

Ion channels, phosphorylation and mammalian sperm apacitation

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Asian Journal of Andrology 2011年第3期13卷 395-405,511页

作者： Pablo E Visconti Dario Krapf Jose luis de la Vega-Beltran juan Jose Acevedo Alberto Darszon Department of Veterinary and Animal Science Paige Labs University of Massachusets Amherst MA 01003 USA Institute of Molecular and Cell Biology of Rosario （CONICETUNR） and Area Biologia Facultad de Ciencias Biologicas y Farmaceuticas UNR Rosario 2000 Argentina Departamento de Genetica del Desarrollo y Fisiologia Molecular Institute de Biotecnologia Universidad Nacional Autonoma de Mexico （UNAM） Cuemavaca Merelos C.P. 62510 Mexico Departamento de Fisiologia y Farmacologia Facultad de Medicina Universidad Autenoma del Estado de Morelas Cuernavaca C.P. 62510 Mexico

Sexually reproducing animals require an orchestrated communication between spermatozoa and the egg to generate a new individual. Capacitation, a maturational complex phenomenon that occurs in the female reproductive tract, renders spermatozoa capable of binding and fusing with the oocyte, and it is a requirement for mammalian fertilization. Capacitation encompasses plasma membrane reorganization, ion permeability regulation, cholesterol loss and changes in the phosphorylation state of many proteins. Novel tools to study sperm ion channels, image intracellular ionic changes and proteins with better spatial and temporal resolution, are unraveling how modifications in sperm ion transport and phosphorylation states lead to capacitation. Recent evidence indicates that two parallel pathways regulate phosphorylation events leading to capacitation, one of them requiring activation of protein kinase A and the second one involving inactivation of ser/thr phosphatases. This review examines the involvement of ion transporters and phosphorylation signaling processes needed for spermatozoa to achieve capacitation. Understanding the molecular mechanisms leading to fertilization is central for societies to deal with rising male infertility rates, to develop safe male gamete-based contraceptives and to preserve biodiversity through better assisted fertilization strategies.

关键词： capacitation ion channels lipids phosphorylation sperm

Preparation of a ε-caprolactonic diterpenoid derivate by unexpected oxidative cleavage/lactonization of 2-oxoaustroeupatol

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Natural Products and Bioprospecting 2022年第1期12卷 265-269页

作者： Pablo A.Chacón-Morales juan M.Amaro-luis luis Beltrán Rojas Fermín Rémi Jacquet Denis Deffieux Laurent Pouységu Stéphane Quideau Natural Products Laboratory Department of ChemistryFaculty of ScienceUniversity of Los AndesMérida 5101Venezuela Research Institute Faculty of Pharmacy and BioanalysisUniversity of Los AndesMérida 5101Venezuela ISM(CNRS-UMR 5255) Univ.Bordeaux351 cours de la Libération33405 Talence CedexFrance

From aerial parts of Austroeupatorium inulifolium was isolated the ent-nor-furano triol labdane austroeupatol *** compound 1 was treated with IBX showing an unexpected selectivity at the potentially oxidizable sites of the sub-strate yielding the 2-oxoaustroeupatol(2)and 2,19-dioxoaustroeupatol(3).The treatment of 2 with sodium periodate yields a heterocyclic derivative(ε-caprolactone derivate 4)formed by oxidative cleavage and unexpected intramo-lecular attack of the hydroxymethylene(C-19)oxygen to the ketonic carbon(C-2).A plausible mechanistic pathway for the obtention of compound 4 is proposed.

关键词： Oxidative cleavage Austroeupatol NaIO4 IBX Lactonization NMR

A new market segment for olive oil: Olive oil tourism in the south of Spain

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Agricultural Sciences 2014年第3期5卷 179-185页

作者： Genoveva Millán juan M. Arjona luis Amador Department of Economics Loyola Andalucía University Córdoba Spain Department of Quantitative Methods Loyola Andalucía University Córdoba Spain

Spain is the leading producer of olive oil. For Spain, olive oil and olive growing are not only an important source of economic wealth, but also symbols of its culture and gastronomy renowned both nationally and internationally. However, in rural areas where the olive is the primary source of income for resident families, proposals are being sought for activities that break away from the seasonality in income represented by dependence on agriculture. Among all these proposals there is one that is oleotourism, which is beginning to gain ground because of its facet of culinary tourism. This is due to its uniqueness, and it can also be considered an initiative for sustainable rural tourism. Given the interest aroused by this type of initiative, both on the part of the public administration and also the olive sector, this study involves the demand for oleotourism in Andalucía and is a strategic analysis of oleotourism as a new market sector in the south of Spain.

关键词： Olive Oil Oleotourism Sustainability Andalucía Rural Development

Primary malignant melanoma of the biliary tract: A case report and literature review

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World Journal of Clinical Cases 2019年第16期7卷 2302-2308页

作者： Soledad Cameselle-García José luis Fírvida Pérez María C Areses Jesús Daniel Fernández de Castro juan Mosquera-Reboredo Jesús García-Mata Department of Medical Oncology Complejo Hospitalario Universitario de OurenseSERGASOurense 32005Spain Department of Digestive Complejo Hospitalario Universitario de OurenseSERGASOurense 32005Spain Department of Pathology Hospital San RafaelA Coruna 15009Spain

BACKGROUND Primary malignant melanoma of the biliary tract (MBT) is a rare condition whose diagnosis requires excluding a primary origin in another *** paper reviews the most important characteristics of MBT cases published in the literature and reports a new *** patient reported here is the first case of primary malignant melanoma of the biliary tract with pulmonary metastasis treated with *** patient remains disease-free 36 mo after the treatment of metastatic lung *** SUMMARY A 51-year-old man was admitted to the gastrointestinal department to study obstructive jaundice of a 1 wk clinical *** resonance cholangiopancreatography revealed dilatation of the intrahepatic biliary tract and stenosis of the common hepatic *** the suspicion of biliary tract neoplasia,cholecystectomy and resection of the common hepatic duct were performed with hepatic jejunostomy free of ***-pathological diagnosis was *** intervention,the patient was referred to the Department of Medical Oncology,where a primary origin was excluded in the skin,mucosa,and *** confirmed diagnosis of primary biliary tract *** tomography was performed 12 mo after the procedure revealed several subcentimetric lung *** resection was *** confirming the diagnosis of pulmonary metastasis of primary melanoma of the biliary tract,the patient was started on immunotherapy with *** to treatment was *** patient remains disease-free 36 mo after the treatment of metastatic lung *** The patient reported here is the first case of primary malignant melanoma of the biliary tract with lung metastases successfully treated with immunotherapy.

关键词： Biliary tract Case report Immunotherapy Malignant melanoma

Occurrence data may provide unreliable thermal preferences and breadth of species

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Current Zoology 2015年第6期61卷 972-982页

作者： Sara VILLEN-PEREZ luis M. CARRASCAL Department of Biogeography and Global Change National Museum of Natural Sciences MNCN-CSIC. C/José Gutiérrez Abascal 2 28006 Madrid Spain.

Accurate information on the thermal preference and specialization of species is needed to understand and predict spe- cies geographical range size and vulnerability to climate change. Here we estimate the position and breadth of species within thermal gradients based on the shape of the response curve of species abundance to temperature. The objective of the study is to compare the measurements of this approach based on abundance data with those of the classical approach using species＇ occur- rence data. The relationship between species＇ relative abundance and minimum winter temperature of 106 bird species wintering in the Iberian Peninsula is modeled at 100 Km2 resolution with quadratic logistic regressions. From these models we calculated the preferred temperature of species as the temperature at which the abundance is maximized, and the thermal breadth of species as the relative area under the temperature-abundance curve. We also estimated the thermal preferences and breadth of species as the average temperature and temperature range of the UTM cells in which the species are present. The abundance-temperature response curves reveal that birds prefer higher temperatures to overwinter, and are more thermally selective, than is measured by the classical approach. Moreover, response curves detect a higher inter-specific variability in both thermal preferences and ther- mal breadth of species. As occurrence data gives the same weight to cells with one or many individuals, the average temperature of the cells in which the species is present roughly reflects the average temperature in the region of study and not the environ- mental preferences of species .

关键词： Abundance-temperature response curve Birds Species occurrence Thermal breadth Thermal preferences Winter

Identifcation of Immunity-related Genes in Arabidopsis and Cassava Using Genomic Data

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Genomics, Proteomics & Bioinformatics 2013年第6期11卷 345-353页

作者： luis Guillermo Leal A'lvaro Perez Andre's Quintero A'ngela Bayona juan Felipe Ortiz Anju Gangadharan David Mackey Camilo Lo'pez Liliana Lo'pez-Kleine Department of Statistics Universidad Nacional de Colombia Department of Biology Universidad Nacional de Colombia Department of Molecular Genetics The Ohio State University

Recent advances in genomic and post-genomic technologies have provided the opportu- nity to generate a previously unimaginable amount of information. However, biological knowledge is still needed to improve the understanding of complex mechanisms such as plant immune responses. Better knowledge of this process could improve crop production and management. Here, we used holistic analysis to combine our own microarray and RNA-seq data with public genomic data from Arabidopsis and cassava in order to acquire biological knowledge about the relationships between proteins encoded by immunity-related genes （IRGs） and other genes. This approach was based on a kernel method adapted for the construction of gene networks. The obtained results allowed us to propose a list of new IRGs. A putative function in the immunity pathway was predicted for the new IRGs. The analysis of networks revealed that our predicted IRGs are either well documented or recognized in previous co-expression studies. In addition to robust relationships between IRGs, there is evidence suggesting that other cellular processes may be also strongly related to immunity.

关键词： Arabidopsis Cassava Functional gene prediction Genomic data Kernel canonical correlation ajalysi Plant immunity

Dynamic Cerebral Microdialysis during Pallidotomy and Thalamotomy in Parkinson’s Disease: A Preliminary Neurochemical Study

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Open Journal of Modern Neurosurgery 2020年第2期10卷 284-296页

作者： Sergio A. Sacchettoni juan P. Abud Napoleon Torres Yngo García Daniel A. Onay juan luis Rodulfo juan Félix Del Corral Pedro Rada Rafael Galera luis Hernández Service of Neurosurgery Hospital and School of Medicine JJ Vargas Universidad Central de Venezuela Caracas Venezuela Unit of Surgical Research Hospital and School of Medicine JJ Vargas Universidad Central de Venezuela Caracas Venezuela Univ. Grenoble Alpes CEA LETI Clinatec France Laboratory of Behavioral Physiology Faculty of Medicine Universidad de Los Andes Mérida Venezuela

In Parkinson’s disease (PD), dopaminergic neurons reduce the regulation of glutamatergic (glutamate-Glu) input from the cortex to neostriatum (caudate and putamen nuclei) consequently leading to a hyperactivity of globus pallidus internae (GPi) neurons that release gamma-amino-butyric acid (GABA) into the thalamic ventrolateral (VL) nucleus. The objective of the present experiment was to measure changes in GABA and Glu in the caudate and the thalamus of 2 patients during the application of electrical stimuli following either a pallidotomy or a thalamotomy. Proper insertion of the electrode was tested by applying high frequency electrical pulses (HFEP). During these procedures, we obtained neurochemical information placing cerebral (CMD) microdialysis probes in caudate nucleus and VL nucleus of ipsi- and contra-lateral thalamus. In VL thalamus, extracellular GABA decreased during HFEP, tending to reach previous levels once HFEP was finalized. Following the pallido- or thalamotomy GABA decreased again. Similarly, in the contralateral VL thalamus, extracellular GABA levels showed a similar but less pronounced profile but did not show any decrement after the lesion. Caudate Glu decreases when HFEP is applied to the GPi and recovers to previous levels after HFEP, but did not decrease again after lesion (GPi-tomy), instead it continued to rise. These results suggest that HFEP exerts a similar but reversible biochemical effect as thermopallido- or thermothalamotomy on GABA extracellular concentration in the ipsilateral VL thalamus. We also observe a distant effect of HFEP, but not of thermolesion, on contralateral thalamic GABA and ipsilateral caudate Glu.

关键词： Cerebral Microdialysis Parkinson’s Disease Pallidotomy Thalamotomy Basal Ganglia Circuit Cerebral Electromodulation DBS

Convergence in leaf phenology traits of two understorey ferns in the northwestern Iberian Peninsula

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Journal of Plant Ecology 2018年第1期11卷 92-102页

作者： luis G.Quintanilla Beatriz Pías Department of Biology and Geology Physics and Inorganic ChemistrySchool of Environmental Sciences and TechnologyRey Juan Carlos Universityc/Tulipán s/n28933 MóstolesMóstolesSpain Department of Plant Sciences Faculty of BiologyComplutense of Madrid UniversityMadridSpain

Aims Plants control leaf phenology to maximize annual photosynthetic *** ferns play an important ecological role in many habitats,especially forests,their phenology traits have been poorly ***,we investigate the leaf phenology of two ferns of the forest understorey and analyse the relationship between the timing of leaf emergence and spore dispersal and the effect of between-year climatic *** We compared the leafing and sporing phenologies of two ferns with very large(>2 m),overwintering leaves:Culcita macrocarpa and Woodwardia *** regularly monitored individuals of six popu-lations in the northwestern Iberian Peninsula during a 3-year *** studied eight phenology variables:leafing start date,leafing end date,leaf expansion time,number of new leaves per individual,between-individual synchrony,within-individual synchrony,percentage of fertile leaves and spore release *** also determined leaf mass per area(LMA)and gathered data on air temperature and *** findings Both *** and *** produce few leaves(~2 leaves individual−1 year−1),which expand simultaneously for a very long period(from midwinter to early summer),are retained for more than 1 year(37 and 19 months,respectively)and have relatively high *** traits,together with large leaf size,have also been found in seed plants from the forest understorey and represent adap-tations to this light-limited *** of both study ferns are simultaneously released in late winter,with little between-year variation caused by differences in air *** remarkable similarity between species suggests that the convergence in tim-ing of leaf emergence favours the convergence in timing of spore dispersal.

关键词： Culcita macrocarpa leaf phenology spore dispersal temperate forest Woodwardia radicans

High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data

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World Journal of Gastroenterology 2020年第48期26卷 7693-7706页

作者： luis Antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise juan Pablo Arab Department of Gastroenterology Escuela de MedicinaPontificia Universidad Católica de ChileSantiago 8320000Chile Department of Internal Medicine Pontificia Universidad Católica de ChileSantiago 8320000Chile School of Medicine Pontificia Universidad Católica de ChileSantiago 8320000Chile Facultad de Ciencias Médicas Universidad Bernardo O'HigginsSantiago 8320000Chile Department of Laboratory Medicine and Pathology Mayo Clinic RochesterMinnesotaMN 55902United States Católica de Chile Santiago 8320000Chile Division of Gastroenterology and Hepatology Mayo Clinic RochesterMinnesotaMN 55905United States

BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the *** on hepatic histopathological findings in COVID-19 is *** To characterize hepatic pathological findings in patients with *** We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA *** trials were those including patients of any age and COVID-19 diagnosis based on a molecular *** reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were *** including less than ten patients were *** were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,*** We identified 18 studies from 7 countries;all were case reports and case series from *** the patients were over 15 years old,and 67.2%were *** performed a meta-analysis of 5 studies,including 116 *** prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and *** We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver *** frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or *** studies are needed to establish the mechanisms and implications of these findings.

关键词： Pathology SARS-CoV-2 COVID-19 Autopsies Liver Liver biopsies