Identifcation of Immunity-related Genes in Arabidopsis and Cassava Using Genomic Data

作     者：Luis Guillermo Leal A'lvaro Perez Andre's Quintero A'ngela Bayona Juan Felipe Ortiz Anju Gangadharan David Mackey Camilo Lo'pez Liliana Lo'pez-Kleine 

作者机构：Department of StatisticsUniversidad Nacional de Colombia Department of BiologyUniversidad Nacional de Colombia Department of Molecular GeneticsThe Ohio State University 

出 版 物：《Genomics, Proteomics & Bioinformatics》 (基因组蛋白质组与生物信息学报（英文版）)

年 卷 期：2013年第11卷第6期

页      面：345-353页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 09[农学] 071007[理学-遗传学] 0714[理学-统计学（可授理学、经济学学位）] 0703[理学-化学] 0901[农学-作物学] 0701[理学-数学] 090102[农学-作物遗传育种] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：financially supported by the Direccio'n de Investi-gacio'n Sede Bogota'of the Universidad Nacional de Colombia(Grant No.201010016738) 

主　　题：Arabidopsis Cassava Functional gene prediction Genomic data Kernel canonical correlation ajalysi Plant immunity 

摘      要：Recent advances in genomic and post-genomic technologies have provided the opportu- nity to generate a previously unimaginable amount of information. However, biological knowledge is still needed to improve the understanding of complex mechanisms such as plant immune responses. Better knowledge of this process could improve crop production and management. Here, we used holistic analysis to combine our own microarray and RNA-seq data with public genomic data from Arabidopsis and cassava in order to acquire biological knowledge about the relationships between proteins encoded by immunity-related genes （IRGs） and other genes. This approach was based on a kernel method adapted for the construction of gene networks. The obtained results allowed us to propose a list of new IRGs. A putative function in the immunity pathway was predicted for the new IRGs. The analysis of networks revealed that our predicted IRGs are either well documented or recognized in previous co-expression studies. In addition to robust relationships between IRGs, there is evidence suggesting that other cellular processes may be also strongly related to immunity.