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Clinical Analysis and Mental Health Survey of Hemophilia Carriers:a Cross-sectional Study

Current Medical Science 2024年第2期44卷 435-440页

作者： Wen WANG Li-juan jiang Dong-yan CUI Ai ZHANG Xiong WANG Ai-guo LIU Qun HU Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Laboratory Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

Objective:Hemophilia carriers(HCs),who are heterozygous for mutations in the clotting factor VIII/clotting factor IX gene(F8 or F9),may have a wide range of clotting factor levels,from very low,similar to afflicted males,to the upper limit of normal,and may experience mental health *** purpose of this study was to provide genetic information on mothers of hemophilia patients and to understand the clotting factor activity and phenotype of ***,we aimed to investigate the mental health status of HCs in ***:A total of 127 hemophilia mothers,including 93 hemophilia A(HA)mothers and 34 hemophilia B(HB)mothers,were enrolled in this *** distance PCR,multiplex PCR,and Sanger sequencing were used to analyze mutations in F8 or *** factor activity was detected by a one-stage clotting *** Symptom Checklist 90(SCL-90,China/Mandarin version)was given to HCs at the same time to assess their mental ***:A total of 90.6%of hemophilia mothers were diagnosed genetically as carriers,with inversion in intron 22 and missense mutations being the most common mutation types in HA and HB carriers,*** median clotting factor level in carriers was 0.74 IU/mL(ranging from 0.09 to 1.74 IU/mL)compared with 1.49 IU/mL(ranging from 0.93 to 1.89 IU/mL)in noncarriers,of which 14.3%of HCs had clotting factor levels of 0.40 IU/mL or below.A total of 53.8%(7/13)of HA carriers with low clotting factor levels(less than 0.50 IU/mL)had a history of bleeding,while none of the HB carriers displayed a bleeding *** total mean score and the global severity index of the SCL-90 for surveyed HCs were 171.00(±60.37)and 1.78(±0.59),respectively.A total of 67.7%of the respondents had psychological symptoms,with obsessive-compulsive disorder being the most prevalent and *** pooled estimates of all nine factors were significantly higher than those in the general population(P<0.05).Conclusions:The detection rate of gene mutations

关键词： hemophilia A hemophilia B mutation carrier mental health

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High-quality Development of the Pearl River Night Tour in the Context of Deep Integration of Culture and Tourism

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Meteorological and Environmental Research 2024年第1期15卷 38-45页

作者： juan jiang Lianrong PANG Guangdong Polytechnic of Industry and Commerce Guangzhou 510510China Lingnan Normal University Zhanjiang 524043China

Urban night tourism is a new form of urban tourism development and an important driving force for the prosperity of urban night *** the most prestigious business card among many night tour projects in Guangzhou,the Pearl River water night tour has contributed to the development of Guangzhou s night economy,which cannot be ***,in the process of rapid development,there are also problems such as diversified operators,insufficient integration of intangible cultural elements,excessive commercial attributes,issues of tourism facilities and service *** the new stage of integrated development of culture and tourism,how to use mutual promotion of culture and tourism in the Pearl River night tour to seek innovative paths for high-quality development in the future is the main problem expected to be solved in this ***,based on the perspective of culture and tourism integration,this paper analyzes the general situation and development status of the Pearl River night tour,and proposes five development strategies:the overall planning of culture and tourism integration,the deep integration of intangible cultural elements,the balance of commercial attributes and tourism attributes,the high integration of culture,business,tourism and education,and the creation of tourism atmosphere,in order to provide inspiration for the healthy,orderly and high-quality development of the Pearl River night tour.

关键词： Integration of culture and tourism The Pearl River night tour High-quality development Intangible cultural elements

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Mechanism of Tourists’Happiness in Traditional Village Tourism: A Perspective Grounded in Nostalgia and Cultural Attachment

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Journal of Landscape Research 2024年第4期16卷 73-79页

作者： jiang juan LIU Yu Guangdong Polytechnic of Industry and Commerce GuangzhouGuangdong 510510China

In recent years,traditional villages have emerged as popular tourist destinations due to their distinctive resource *** situated in remote and less developed areas,traditional villages boast primitive natural surroundings and rich historical and cultural *** characteristics offer urban dwellers a temporary escape from the complexities of modern life,allowing them to experience physical and mental rejuvenation,mental relaxation,and overall happiness during their *** conducting a review of the existing literature concerning tourists’happiness in traditional villages,this study establishes a framework to understand tourists’happiness in traditional village *** the Qiangang ancient village in Conghua District,Guangzhou as a case study,the research examines the current state of rural characteristics,the establishment of cultural brands,and the promotion of the active utilization of ancient villages within the context of integrating culture,sports,tourism,and *** on this analysis,the author proposes strategies to enhance tourists’happiness,including the preservation and development of rural characteristics,the promotion and preservation of local cultural attributes,and the collaborative advancement of culture,sports,tourism,and agriculture to engage key stakeholders actively.

关键词： Traditional village Qiangang ancient village Nostalgia Cultural attachment Happiness

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Surface-sensitive electronic structure of kagome superconductor CsV_(3)Sb_(5)

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Chinese Physics B 2024年第10期33卷 35-40页

作者： Zhisheng Zhao jianghao Yao Rui Xu Yuzhe Wang Sen Liao Zhengtai Liu Dawei Shen Shengtao Cui Zhe Sun Yilin Wang Donglai Feng juan jiang School of Emerging Technology and Department of Physics University of Science and Technology of ChinaHefei 230026China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China National Synchrotron Radiation Laboratory School of Nuclear Science and Technology and New Cornerstone Science LaboratoryUniversity of Science and Technology of ChinaHefei 230026China

We systematically study the electronic structure of a kagome superconductor CsV_(3)Sb_(5)at different temperatures coveringboth its charge density wave state and normal state with angle-resolved photoemission *** observe thatthe V-shaped band aroundГshows three different behaviors,referred to as a/a',βandγ,mainly at different *** investigations confirm that these bands are all from the same bulk Sb-p_(z)origin,but they are quite sensitiveto the sample surface conditions mainly modulated by ***,the intriguing temperature dependent electronicbehavior of the band nearГis affected by the sample surface condition,rather than intrinsic electronic behavior originatingfrom the phase *** result systematically reveals the confusing electronic structure behavior of the energy bandsaroundГ,facilitating further exploration of the novel properties in this material.

关键词： kagome ARPES charge density wave surface sensitive

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Efficacy of Huangma Ding or autologous platelet-rich gel for the diabetic lower extremity arterial disease patients with foot ulcers

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World Journal of Diabetes 2024年第5期15卷 923-934页

作者： Xue-Qin Wang Dan-Lan Pu Wei-Ling Leng Xiao-Tian Lei jiang juan Zou La Ding Yao Jia-Zhuang Xi Li Jian Teng Miao Qi-Nan Wu Endocrinology Department The People’s Hospital of Yubei District of Chongqing CityChongqing 401120China Department of Endocrinology Chongqing Yubei District People’s HospitalChongqing 400030China Endocrinology Department The First Affiliated Hospital of the Army Medical UniversityChongqing 400038China Endocrinology and Nephrology Department Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer HospitalChongqing 400016China Department of Endocrinology Dazu Hospital of Chongqing Medical UniversityThe People’s Hospital of DazuChongqing 402360China

BACKGROUND Diabetes foot is one of the most serious complications of diabetes and an important cause of death and disability,traditional treatment has poor efficacy and there is an urgent need to develop a practical treatment *** To investigate whether Huangma Ding or autologous platelet-rich gel(APG)treatment would benefit diabetic lower extremity arterial disease(LEAD)patients with foot *** A total of 155 diabetic LEAD patients with foot ulcers were enrolled and divided into three groups:Group A(62 patients;basal treatment),Group B(38 patients;basal treatment and APG),and Group C(55 patients;basal treatment and Huangma Ding).All patients underwent routine follow-up visits for six *** follow-up,we calculated the changes in all variables from baseline and determined the differences between groups and the relationships between *** The infection status of the three groups before treatment was the ***(PCT)improved after APG and Huangma Ding treatment more than after traditional treatment and was significantly greater in Group C than in Group *** regression analysis revealed that PCT was positively correlated with total amputation,primary amputation,and minor amputation *** ankle-brachial pressure and the transcutaneous oxygen pressure in Groups B and C were greater than those in Group *** major amputation rate,minor amputation rate,and total amputation times in Groups B and C were lower than those in Group *** Our research indicated that diabetic foot ulcers(DFUs)lead to major amputation,minor amputation,and total amputation through local infection and poor microcirculation and *** Ding and APG were effective attreating *** clinical efficacy of Huangma Ding was better than that of autologous platelet gel,which may be related to the better control of local infection by Huangma *** finding suggested that in patients with DFUs combined with coinfection,controll

关键词： Diabetic foot ulcer Huangma Ding Autologous platelet-rich gel Ankle-brachial index Transcutaneous oxygen partial pressure

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Investigation and analysis of the status of cancer health popularization in China,2023

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World Journal of Clinical Oncology 2024年第10期15卷 1269-1279页

作者： Hai-Tao Hu Yu-juan jiang Xin-Xin Shao Yi-Ming Lu Yan-Tao Tian Quan Xu Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Cancer presents a significant public health challenge in China,necessitating broad collaboration across *** Chinese government has articulated a goal to increase the overall five-year survival rate for cancer by 15%by *** this objective requires not only advances in medical technology,but also an im-provement in the dissemination of knowledge pertaining to cancer prevention and *** To provide a comprehensive understanding of the status of cancer prevention and level of popularization in China in *** From January 2023 to May 2023,online questionnaires were distributed to 3000 participants,including medical personnel,patients with cancer,their families,and the general *** were 2711 valid responses,covering the entire *** A total of 1020 medical personnel and 1691 patients with cancer,their family members,and the general public participated in the *** medical personnel,93.2%had popularized cancer *** addressed topics included cancer prevention(85.9%)and cancer screening(77.8%).Primary challenges included time constraints(73.9%),insufficient personnel and material support(66.7%),and uncertainty as to where to begin(49.3%).Among patients with cancer,their family members,and the general public,93.4%reported reading or watching cancer science popularization materials and 56.9%expressed a desire for deeper *** most sought-after topics in cancer science popularization included cancer screening(80.2%)and cancer prevention(75.8%).The greatest challenge encountered in accessing cancer health popularization was an abundance of misinformation(67.5%).CONCLUSION Most clinical doctors,patients,family,and the general public wish to participate in cancer ***,improvement in the quality of content in cancer prevention and treatment education is required.

关键词： Cancer health popularization Patient education Science popularization Cancer prevention

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党史教育融入高校思想政治教育工作研究

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淮南职业技术学院学报 2024年第1期24卷 64-66页

作者：姜娟汉江师范学院湖北十堰442000

把党史教育纳入高校思想政治教育体系,对于高校落实“立德树人”根本任务,培养具有全面素养的时代新人,实现“三全育人”目标,具有促进作用.结合高校党史教育的实践,阐释了党史教育与高校思想政治教育相结合的时代价值和原则,探索了将... 详细信息

把党史教育纳入高校思想政治教育体系,对于高校落实“立德树人”根本任务,培养具有全面素养的时代新人,实现“三全育人”目标,具有促进作用.结合高校党史教育的实践,阐释了党史教育与高校思想政治教育相结合的时代价值和原则,探索了将党史教育融入高校思想政治教学的有效途径,不断增强大学生的政治认同、思想认同、理论认同和情感认同.

关键词：党史教育思想政治教育融入三全育人

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基于HACCP方法的科技查新质量监控体系研究

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江苏科技信息 2024年第14期41卷 89-91页

作者：姜娟江南大学图书馆无锡江苏214122

科技查新作为国家科技创新体系中的重要环节,能为各类科技评审活动提供客观评价依据。如何保障、提高科技查新的质量,把好科技评审的第一关,成为查新机构急需解决的重要课题。文章将危害分析及关键点控制方法(HACCP)引入科技查新全过程... 详细信息

科技查新作为国家科技创新体系中的重要环节,能为各类科技评审活动提供客观评价依据。如何保障、提高科技查新的质量,把好科技评审的第一关,成为查新机构急需解决的重要课题。文章将危害分析及关键点控制方法(HACCP)引入科技查新全过程的质量控制中,使整个查新过程始终处于受控状态,降低了查新质量风险,为科技查新质量的提升提供了一条新的思路。

关键词：科技查新危害分析及关键点控制方法质量

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学生主体性发展视角下的刑事诉讼法学教学改革研究

河北法律职业教育

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河北法律职业教育 2024年第2期2卷 43-47页

作者：蒋隽雅湖北文理学院理工学院

刑事诉讼法学教学改革应以围绕学生主体性发展为核心。当前,刑事诉讼法学教学面临一些挑战,从社会需求的变化、学科知识更新和学生个体差异三个方面都足以看出刑事诉讼法学教学改革的必要性,为此,应建立以学生主体性发展为核心的刑事诉... 详细信息

刑事诉讼法学教学改革应以围绕学生主体性发展为核心。当前,刑事诉讼法学教学面临一些挑战,从社会需求的变化、学科知识更新和学生个体差异三个方面都足以看出刑事诉讼法学教学改革的必要性,为此,应建立以学生主体性发展为核心的刑事诉讼法学教学改革方案,从教学内容的优化、教学方法的选择、教学环境的改善、教学改革效果的评估等多个方面完善刑事诉讼法学教学体系。

关键词：学生主体性刑事诉讼教学改革教学方法

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基于UPLC-Q-TOF-MS/MS技术的黄芩清热除痹胶囊化学成分分析

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分析测试学报 2024年第6期43卷 814-825页

作者：姜娟娟刘晓闯张艳艳张明媚刘健安徽中医药大学第一附属医院药学部安徽合肥230031 安徽中医药大学药学院安徽合肥230012 安徽中医药大学第一附属医院风湿科安徽合肥230031

应用超高效液相色谱-四极杆-飞行时间质谱(UPLC-Q-TOF-MS/MS)法,对黄芩清热除痹胶囊(HQC)的化学成分进行快速鉴定,采用Water ACQUITY UPLC BEH C_(18)(2.1 mm×100 mm,1.7μm)色谱柱,以0.1%甲酸水-乙腈为流动相进行梯度洗脱,采用电喷雾... 详细信息

应用超高效液相色谱-四极杆-飞行时间质谱(UPLC-Q-TOF-MS/MS)法,对黄芩清热除痹胶囊(HQC)的化学成分进行快速鉴定,采用Water ACQUITY UPLC BEH C_(18)(2.1 mm×100 mm,1.7μm)色谱柱,以0.1%甲酸水-乙腈为流动相进行梯度洗脱,采用电喷雾电离源(ESI)在正、负离子模式下分别采集HQC的基峰色谱图。建立HQC的化学成分数据库,基于天然产物后处理筛查平台(UNIFI)进行靶向分析,结合化合物的精确分子量、二级碎片离子信息、对照品和文献数据等进行化学结构确认。从HQC中共鉴定出82个化合物,包括37个黄酮类、11个有机酸类、14个萜类、7个苷类、5个氨基酸类、8个其他类化合物;HQC主要以黄酮类成分为主。UPLC-Q-TOF-MS/MS结合UNIFI平台的分析方法可快速鉴定HQC的化学成分。

关键词：黄芩清热除痹胶囊超高效液相色谱-四极杆-飞行时间质谱 UNIFI分析平台化学成分类风湿关节炎

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