Efficacy of Huangma Ding or autologous platelet-rich gel for the diabetic lower extremity arterial disease patients with foot ulcers

作     者：Xue-Qin Wang Dan-Lan Pu Wei-Ling Leng Xiao-Tian Lei Jiang Juan Zou La Ding Yao Jia-Zhuang Xi Li Jian Teng Miao Qi-Nan Wu 

作者机构：Endocrinology DepartmentThe People’s Hospital of Yubei District of Chongqing CityChongqing 401120China Department of EndocrinologyChongqing Yubei District People’s HospitalChongqing 400030China Endocrinology DepartmentThe First Affiliated Hospital of the Army Medical UniversityChongqing 400038China Endocrinology and Nephrology DepartmentChongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer HospitalChongqing 400016China Department of EndocrinologyDazu Hospital of Chongqing Medical UniversityThe People’s Hospital of DazuChongqing 402360China 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2024年第15卷第5期

页      面：923-934页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Chongqing Science and Technology Bureau and Health Commission of Chinese Medicine Technology Innovation and Application Development Project,No.2020ZY013540 General Project of Chongqing Natural Science Foundation,No.CSTB2023NSCQMSX0246 and No.CSTB2022NSCQ-MSX1271 Science and Health Joint Project of Dazu District Science and Technology Bureau,No.DZKJ2022JSYJ1001 

主　　题：Diabetic foot ulcer Huangma Ding Autologous platelet-rich gel Ankle-brachial index Transcutaneous oxygen partial pressure 

摘      要：BACKGROUND Diabetes foot is one of the most serious complications of diabetes and an important cause of death and disability,traditional treatment has poor efficacy and there is an urgent need to develop a practical treatment *** To investigate whether Huangma Ding or autologous platelet-rich gel(APG)treatment would benefit diabetic lower extremity arterial disease(LEAD)patients with foot *** A total of 155 diabetic LEAD patients with foot ulcers were enrolled and divided into three groups:Group A(62 patients;basal treatment),Group B(38 patients;basal treatment and APG),and Group C(55 patients;basal treatment and Huangma Ding).All patients underwent routine follow-up visits for six *** follow-up,we calculated the changes in all variables from baseline and determined the differences between groups and the relationships between *** The infection status of the three groups before treatment was the ***(PCT)improved after APG and Huangma Ding treatment more than after traditional treatment and was significantly greater in Group C than in Group *** regression analysis revealed that PCT was positively correlated with total amputation,primary amputation,and minor amputation *** ankle-brachial pressure and the transcutaneous oxygen pressure in Groups B and C were greater than those in Group *** major amputation rate,minor amputation rate,and total amputation times in Groups B and C were lower than those in Group *** Our research indicated that diabetic foot ulcers(DFUs)lead to major amputation,minor amputation,and total amputation through local infection and poor microcirculation and *** Ding and APG were effective attreating *** clinical efficacy of Huangma Ding was better than that of autologous platelet gel,which may be related to the better control of local infection by Huangma *** finding suggested that in patients with DFUs combined with coinfection,controll