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Record-high near-band-edge optical nonlinearities and two-level model correction of poled polymers by spectroscopic electromodulation and ellipsometry

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Science China Chemistry 2022年第3期65卷 584-593页

作者： Taili Liu Di Zhang md Rashedul Huqe Wen Wang juan Antonio Zapien Sai-Wing Tsang Jingdong Luo Shenzhen Research Institute City University of Hong KongShenzhen 518057China Department of Chemistry City University of Hong KongHong Kong SARChina Department of Materials Science and Engineering City University of Hong KongHong Kong SARChina Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong SARChina

The determination of nonlinearities near the band edge of organic and polymeric electro-optic(EO)materials is important from the viewpoint of molecular nonlinear optics(NLO)and photonic device *** on transmission-mode Stark effect electromodulation(EM)spectroscopy,we study the electric-field-induced changes in optical absorption and refraction of newly developed EO polymers from the visible to near-infrared(NIR)wavelengths and report record-high near-band-edge complex EO effects from poled thin *** ofΔn andΔk up to 10^(-3) and 10^(-2) are found at an applied electric field of 2.0×10^(5)-3.0×10^(5)V/*** study of linear optical properties of poled films by spectroscopic ellipsometry shows large polinginduced birefringence and a nearly two-fold increase in the extinction coefficients at the extraordinary *** the Kramers-Kronig analysis,we obtained the real and imaginary second-order nonlinear coefficients up to~3,500 and~5,600 pm/V,respectively,which are believed to be the highest NLO coefficients of poled polymers through the resonance *** approach goes beyond the previous works,applicable only to several discrete wavelengths,to a full-spectral analysis with independent verification of slab waveguide *** considering both the electroabsorption and electrorefraction effects,our study overcomes the limitation of the classic qualitative two-level model and provides a quantitative understanding of near-resonance optical nonlinearities of organic EO *** can inspire the exploration of high-speed,absorptive,or phase-shifting light-modulators using EO polymers for on-chip applications.

关键词： poled polymers electroabsorption electro-optic effect second-order nonlinear susceptibilities

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A multidimensional review of the cash management problem

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Financial Innovation 2023年第1期9卷 1840-1874页

作者： francisco Salas‑Molina juan A.Rodríguez‑Aguilar Montserrat Guillen Universitat Politècnica de València Ferrándiz y Carbonell03801 AlcoySpain IIIA‑CSIC Campus UAB08913 CerdanyolaSpain Universitat de Barcelona Av.Diagonal69008034 BarcelonaSpain

In this paper,we summarize and analyze the relevant research on the cash manage-ment problem appearing in the ***,we identify the main dimensions of the cash management ***,we review the most relevant contributions in this field and present a multidimensional analysis of these contributions,according to the dimensions of the *** this analysis,several open research questions are highlighted.

关键词： Cash management Models Dimensions Review

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Microbial Degradation of Organophosphate Pesticides： A Review

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Pedosphere 2018年第2期28卷 190-208页

作者： Shardendu KUMAR Garima KAUSHIK Mohd Ashraf DAR Surendra NIMESH Ulrico Javier LOPEZ-CHUKEN juan francisco VILLARREAL-CHIU Department of Environmental Science School of Earth Sciences Central University of Rajasthan Ajmer 305817 (India) Department of Biotechnology School of Life Sciences Central University of Rajasthan Ajmer 305817 (India) Laboratorio de InvestigaciSn en Ciencias Ambientales Facultad de Cieneias Quimicas Universidad AutSnoma de Nuevo León Nuevo LeSn 66455 (Mexico) Laboratorio de Biotecnologla Facultad de Ciencias Qulmicas Universidad AutSnoma de Nuevo LeSn Nuevo Ledn 66455 (Mexico)

Pesticides have become an inevitable part of the modern environment as they are widely used in agriculture,household,and public health sectors and,hence,are extensively distributed throughout most ***,organophosphate pesticides are the most commercially favored group of pesticides,with large application areas all over the *** on their fate,these organophosphorus compounds may become bioavailable for microbial *** microbes,such as Aspergillus,Pseudomonas,Chlorella,and Arthrobacter,are capable of coupling a variety of physical and biochemical mechanisms for the degradation of organophosphate pesticides,including adsorption,hydrolysis of P–O alkyl and aryl bonds,photodegradation,and enzymatic ***,such as esterase,diisopropyl fluorophosphatase,phosphotriesterase,somanase,parathion hydrolase,and paraoxonase,have been isolated from microbes to study and understand the catabolic pathways involved in the biotransformation of these xenobiotic *** review highlights various aspects of biodegradation of organophosphate pesticides along with biological and molecular characterization of some organophosphate pesticide-degrading bacteria.

关键词： biodegradation enzymes insecticide metabolic pathways pesticide-degrading bacteria organophosphorus compound xenobiotics

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Hospital without dyspnea： rationale and design of a multidisciplinary intervention

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Journal of Geriatric Cardiology 2016年第7期13卷 625-631页

作者： Lourdes Vicent juan Manuel Nunez Olarte Luis Puente-Maestu Esther Artajona francisco Fernandez-Aviles Manuel Martinez-Selles Department of Cardiology Gregorio Maranon General Hospital Madrid Spain Department of Palliative Care Gregorio Maranon General Hospital Madrid Spain Department of Respirology Gregorio Maranon General Hospital Madrid Spain European University of Madrid Madrid Spain Complutense University of Madrid Madrid Spain

Dyspnea is a common and disabling symptom of respiratory and heart diseases, which is growing in incidence. During hospital admis- sion, breathlessness is under-diagnosed and under-treated, although there are treatments available for controlling the symptom. We have developed a tailored implementation strategy directed to medical staff to promote the application of these pharmacological and non-pharmacological tools in dealing with dyspnea. The primary aim is to decrease the rate of patients that do not receive an adequate relief of dyspnea. This is a four-stage quasi-experimental study. The intervention consists in two teaching talks that will be taught in Cardiology and Respiratory Medicine Departments. The contents will be prepared by Palliative Care specialists, based on available tools for management of dyspnea and patients＇ needs. A cross-sectional study of dyspnea in hospitalized patients will be performed before and after the intervention to ascertain an improvement in dyspnea intensity due to changes in medical practices. The last phase consists in the creation of consensus protocols for dyspnea management based in our experience. The results of this study are expected to be of great value and may change clinical practice in the near future and promote a changing for the better of dyspnea care.

关键词： Chronic pulmonary disease Dyspnea Heart failure Palliative care

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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan juan Alec C.Bancroft Ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard Juhoon Lee Sowmya Ramesh Aaron W.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi Center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPC *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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NADPH Thioredoxin Reductase C Is Involved in Redox Regulation of the Mg-Chelatase I Subunit in Arabidopsis thaliana Chloroplasts

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Molecular Plant 2014年第7期7卷 1252-1255页

作者： juan Manuel Pérez-Ruiz Manuel Guinea Leonor Puerto-Galán francisco Javier Cejudo Instituto de Bioquímica Vegetal y Fotosíntesis Universidad de Sevilla-Consejo Superior de Investigaciones Científicas 41092-Sevilla Spain Umea Plant Science Centre Department of Plant Physiology Umea University S-901 87 Umea Sweden

Dear Editor, The synthesis of tetrapyrroles, including chlorophylls, is central for chloroplast function. The metabolic pathway of tetrapyrrole biosynthesis in Arabidopsis is initiated with the formation of amino levulinic acid （ALA）, which is con- verted by a series of common reactions to protoporphy- tin IX （Proto IX）（Tanaka et al., 2011）. Then the pathway diverges into two branches： the synthesis of heme/bilin and chlorophylls. The insertion of Mg2＋ into Proto IX, cata- lyzed by Mg-chelatase, is the first committed reaction of the chlorophyll branch and is considered a key step for the regulation of the whole pathway. Mg-chelatase is a het- erotrimeric enzyme composed of subunits CHLI, CHLD, and CHLH, the reaction mechanism of which has been estab- lished. It is a two-step process consisting in the Mg-ATP- dependent activation of the enzyme, which implies the formation of a ternary complex of subunits CHLI and CHLD with ATP-Mg2＋, and Mg2＋ chelation, which is catalyzed by CHLH driven by ATP hydrolysis, CHLI providing ATPase activity to the complex （Tanaka et al., 2011）. In Arabidopsis, CHLH and CHLD are encoded by single genes, whereas two genes, CHLI-I and CHLI-2, encode the two isoforms of CHLI.

关键词： synthesis of tetrapyrroles chlorophylls Arabidopsis

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Textbook of Hepatology: From Basic Science to Clinical Practice, Third Edition 3

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2007年

作者： juan Rodés md Jean‐Pierre Benhamou md Andres T. Blei md Jürg Reichen md Mario Rizzetto md

ISBN: (数字)9780470691861

ISBN: (纸本)9781405127417

THE encyclopedic guide to hepatology – for consultation by clinicians and basic scientists Previously the Oxford Textbook of Clinical Hepatology , this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people). Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter – giving you the best science and clinical practice discussed by the best authors. It includes unique sections on: Symptoms and signs in liver disease Industrial diseases affecting the liver The effects of diseases of other systems on the liver The effects of liver diseases on other systems It's bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more. Plus, it comes with a fully searchable CD ROM of the entire content. Click here to view a sample chapter on the liver and coagulation

关键词： LiverDiseases.

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Hyperammonemia,brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication

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World Journal of Gastroenterology 2004年第9期10卷 1321-1324页

作者： Camila Scorticati juan P.Prestifilippo francisco X.Eizayaga Salvador Romay MaríaA Fernández AbrahamLemberg juan C.Perazzo José L.Castro Cátedra de Fisiopatología Facultad de Farmaciay BioquímicaUniversidad de Buenos AiresBuenos AiresArgentina Cátedra de Farmacología Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresBuenos AiresArgentina

AIM:To study the blood-brain barrier integrity,brain edema, animal behavior and ammonia plasma levels in prehepatic portal hypertensive rats with and without acute liver intoxication. METHODS:Adults male Wistar rats were divided into four *** Ⅰ:sham operation;Ⅱ:Prehepatic portal hypertension,produced by partial portal vein ligation;Ⅲ: Acetaminophen intoxication and Ⅳ:Prehepatic portal hypertension plus *** was administered to produce acute hepatic *** pressure,liver serum enzymes and ammonia plasma levels were *** cortex water content was registered and trypan blue was utilized to study blood brain barrier *** and behavioral tests were recorded. RESULTS:Portal hypertension was significantly elevated in groups Ⅱ and Ⅳ.Uver enzymes and ammonia plasma levels were increased in groups Ⅱ,Ⅲ and Ⅳ.Prehepatic portal hypertension (group Ⅱ),acetaminophen intoxication (group Ⅲ) and both (group Ⅳ) had changes in the blood brain-barrier integrity (trypan blue) and *** edema was present in rats with acute hepatic injury in groups Ⅲ and Ⅳ.Behavioral test (rota rod) was altered in group Ⅳ. CONCLUSION:These results suggest the possibility of another pathway for cortical edema production because blood brain barrier was altered (vasogenic) and hyperammonemia was registered (oltotoxic).Group Ⅳ,with behavioral altered test,can be considered as a model for study at an early stage of portal-systemic encephalopathy.

关键词： Acetaminophen Analgesics, Non-Narcotic Animals Behavior, Animal Blood-Brain Barrier Brain Edema Humans Hyperammonemia Hypertension, Portal Liver Male Rats Rats, Wistar

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Hydrogen sulfide:A novel component in Arabidopsis peroxisomes which triggers catalase inhibition

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Journal of Integrative Plant Biology 2019年第7期61卷 871-883页

作者： francisco J.Corpas juan B.Barroso Salvador Gonzalez-Gordo Maria A.Munoz-Vargas Jose M.Palma Group of Antioxidants Free Radicals and Nitric Oxide in BiotechnologyFood and AgricultureDepartment of BiochemistryCell and Molecular Biology of PlantsEstacion Experimental del ZaidfnCSICC/Profesor Albareda 1E-18008 GranadaSpain Group of Biochemistry and Cell Signaling in Nitric oxide Department of Biochemistry and Molecular BiologyCampus"Las Lagunillas"E-23071University of JaenJaenSpain

Plant peroxisomes have the capacity to gen erate different reactive oxygen and nitrogen species(ROS and RNS),such as H2O2,superoxide radical(O2^·-),nitric oxide and peroxynitrite(ONOO^-).These organelles have an active nitrooxidative metabolism which can be exacerbated by adverse stress *** sulfide(H2S)is a new signaling gasotransmitter which can mediate the posttranslational modification(PTM)*** used Arabidopsis thaliana transgenic seedlings expressing cyan fluorescent protein(CFP)fused to a canonical peroxisome targeting signal 1(PTS1)to visualize peroxisomes in living cells,as well as a specific fluorescent probe which showed that peroxisomes contain H2S.H2S was also detected in chloroplasts under glyphosate-induced oxidative stress *** enzyme activities,including catalase,photorespiratory H2O2-generating glycolate oxidase(GOX)and hydroxypyruvate reductase(HPR),were assayed in vitro with a H2S *** line with the persulfidation of this enzyme,catalase activity declined significantly in the presence of the H2S *** corroborate the inhibitory effect of H2S on catalase activity,we also assayed pure catalase from bovine liver and pepper fruit-enriched samples,in which catalase activity was *** together,these data provide evidenee of the presence of H2S in plant peroxisomes which appears to regulate catalase activity and,consequently,the peroxisomal H2O2 metabolism.

关键词： Hydrogen sulfide triggers catalase inhibition

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Intravitreal fluorogold tracing as a method to label retinal neurons and the retinal pigment epithelium

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Neural Regeneration Research 2021年第10期16卷 2000-2001页

作者： francisco Javier Valiente-Soriano Fernando Lucas-Ruiz juan A.Miralles de Imperial-Ollero Manuel Vidal-Sanz Marta Agudo-Barriuso Departamento de Oftalmología Facultad de MedicinaUniversidad de Murcia and Instituto Murciano de Investigación Biosanitaria-Virgen de la Arrixaca(IMIB-Arrixaca)MurciaSpain

Techniques to label the neuroretina and the retinal pigment epithelium(RPE)have been the topic of many studies for *** reliability and reproducibility of these techniques are essential to investigate retinal alterations of ocular pathologies and possible *** particular,the study of the integrity of the RPE is of great importance in pathologies such as retinitis pigmentosa or age-related macular degeneration(Gu et al.,2012;Fisher and Ferrington,2018;Zhang et al.,2019).The most common approaches use antibodies to identify different cell ***,we have described a novel technique to study the integrity of the neuroretina and the RPE,as well as the functionality of the RPE in rats(Valiente-Soriano et al.,2020).

关键词： epithelium al. alterations

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