Hyperammonemia,brain edema and blood-brain barrier alterations in prehepatic portal hypertensive rats and paracetamol intoxication

作     者：Camila Scorticati Juan P.Prestifilippo Francisco X.Eizayaga Salvador Romay MaríaA Fernández AbrahamLemberg Juan C.Perazzo José L.Castro 

作者机构：Cátedra de FisiopatologíaFacultad de Farmaciay BioquímicaUniversidad de Buenos AiresBuenos AiresArgentina Cátedra de FarmacologíaFacultad de Farmacia y BioquímicaUniversidad de Buenos AiresBuenos AiresArgentina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2004年第10卷第9期

页      面：1321-1324页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Grant #TB 56 from the University of Buenos Aires Argentina 

主　　题：Acetaminophen Analgesics, Non-Narcotic Animals Behavior, Animal Blood-Brain Barrier Brain Edema Humans Hyperammonemia Hypertension, Portal Liver Male Rats Rats, Wistar 

摘      要：AIM:To study the blood-brain barrier integrity,brain edema, animal behavior and ammonia plasma levels in prehepatic portal hypertensive rats with and without acute liver intoxication. METHODS:Adults male Wistar rats were divided into four *** Ⅰ:sham operation;Ⅱ:Prehepatic portal hypertension,produced by partial portal vein ligation;Ⅲ: Acetaminophen intoxication and Ⅳ:Prehepatic portal hypertension plus *** was administered to produce acute hepatic *** pressure,liver serum enzymes and ammonia plasma levels were *** cortex water content was registered and trypan blue was utilized to study blood brain barrier *** and behavioral tests were recorded. RESULTS:Portal hypertension was significantly elevated in groups Ⅱ and Ⅳ.Uver enzymes and ammonia plasma levels were increased in groups Ⅱ,Ⅲ and Ⅳ.Prehepatic portal hypertension (group Ⅱ),acetaminophen intoxication (group Ⅲ) and both (group Ⅳ) had changes in the blood brain-barrier integrity (trypan blue) and *** edema was present in rats with acute hepatic injury in groups Ⅲ and Ⅳ.Behavioral test (rota rod) was altered in group Ⅳ. CONCLUSION:These results suggest the possibility of another pathway for cortical edema production because blood brain barrier was altered (vasogenic) and hyperammonemia was registered (oltotoxic).Group Ⅳ,with behavioral altered test,can be considered as a model for study at an early stage of portal-systemic encephalopathy.