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Stem cells as an option for the treatment of COVID-19

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World Journal of Clinical Cases 2022年第18期10卷 6338-6340页

作者： Maria Veronica Cuevas-González juan carlos Cuevas-González Institute of Biomedical Sciences Universidad Autonoma de Ciudad JuarezJuarez 32310ChihuahuaMexico Institute of Biomedical Sciences Autonomous University of Ciudad JuárezCiudad Juarez 32310ChihuahuaMexico

The application of stem cells is among the many strategies currently available for the treatment of multiple *** cells are characterized as undifferentiated cells that have the ability to differentiate towards multiple lineages and selfrenewal,among other *** the first umbilical cord stem cell transplant for the treatment of Fanconi anemia,the use of stem cells for the treatment of multiple diseases,including coronavirus disease 2019,has increased,showing promising results that require evaluation through research studies that include a longer follow-up ***,the main objective of this Letter is to provide an update on the use of stem cells in the treatment of severe acute respiratory syndrome coronavirus 2,as well as identify the main challenges and limitations presented by this type of therapy.

关键词： COVID-19 Stem cells Multiple diseases Undifferentiated cells Appropriate treatment Cytokines granulocyte-macrophage colony-stimulating factor

Time-frequency multiresolution of fault-generated transient signals in transmission lines using a morphological filter

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Protection and Control of Modern Power Systems 2023年第2期8卷 85-98页

作者： juan carlos Quispe John Morales Eduardo Orduna Carlo Liebermann Michael Bruhns Peter Schegner Universidad Nacional de San juan-CONICET San JuanArgentina Universidad Tecnológica del Perú LimaPerú Technical University of Dresden DresdenGermany

The ongoing transformation of electrical power systems highlights the weaknesses of the protection schemes of traditional devices because they are designed and configured according to traditional characteristics of the ***,this work proposes a new methodology to study the fault-generated high frequency transient signals in transmission lines through multiresolution *** high frequency components are determined by a new digital filtering technique based on mathematical morphology theory and a spectral energy ***,wide spectra of signals in the time–frequency domain are *** performance of this method is verified on an electrical power system modeled in ATP-Draw,where simulation and test signals are developed for different locations,fault resistances,inception angles,high frequency noises,sampling frequencies,types of faults,and shapes of the structuring *** results show the characteristics of the fault such as the traveling wave frequency,location,and starting time.

关键词： Digital filter High frequency Mathematical morphology Time–frequency Traveling waves

Recent Near-surface Temperature Trends in the Antarctic Peninsula from Observed,Reanalysis and Regional Climate Model Data

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Advances in Atmospheric Sciences 2020年第5期37卷 477-493页

作者： Deniz BOZKURT David HBROMWICH Jorge CARRASCO Keith MHINES juan carlos MAUREIRA and Roberto RONDANELLI Department of Meteorology University of ValparaísoValparaíso 2340000Chile Center for Climate and Resilience Research(CR)2 Santiago 8320000Chile Polar Meteorology Group Byrd Polar and Climate Research CenterThe Ohio State UniversityColumbusOH 43210USA Centro de Investigacion GAIA Antártica Universidad de MagallanesPunta Arenas 6200000Chile Center for Mathematical Modeling(CMM) University of ChileSantiago 8320000Chile Department of Geophysics University of ChileSantiago 8320000Chile

This study investigates the recent near-surface temperature trends over the Antarctic *** make use of available surface observations,ECMWF’s ERA5 and its predecessor ERA-Interim,as well as numerical simulations,allowing us to contrast different data *** use hindcast simulations performed with Polar-WRF over the Antarctic Peninsula on a nested domain configuration at 45 km(PWRF-45)and 15 km(PWRF-15)spatial resolutions for the period 1991?*** addition,we include hindcast simulations of KNMI-RACMO21P obtained from the CORDEX-Antarctica domain(~50 km)for further *** show that there is a marked windward warming trend except during *** windward warming trend is particularly notable in the autumn season and likely to be associated with the recent deepening of the Amundsen/Bellingshausen Sea low and warm advection towards the Antarctic *** the other hand,an overall summer cooling is characterized by the strengthening of the Weddell Sea low as well as an anticyclonic trend over the Amundsen Sea accompanied by northward *** persistent cooling trend observed at the Larsen Ice Shelf station is not captured by ERA-Interim,whereas hindcast simulations indicate that there is a clear pattern of windward warming and leeward ***,larger temporal correlations and lower differences exhibited by PWRF-15 illustrate the existence of the added value in the higher spatial resolution simulation.

关键词： dynamical downscaling cloud computing added value reanalysis Amundsen/Bellingshausen Sea Weddell Sea temperature trend

Conical tank level control using fractional order PID controllers： a simulated and experimental study

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Control Theory and Technology 2016年第4期14卷 369-384页

作者： Cristian JAUREGUI Manuel A. DUARTE-MERMOUD Rodrigo OROSTICA juan carlos TRAVIESO-TORRES Orlando BEYTIA Electrical Engineering Department and Advanced Mining Technology Center Universidad de Chile Av. Tupper 2007 Casilla 412-3 Santiago Chile Industrial Technologies Department Technological Faculty Universidad de Santiago de Chile Av. El Belloto 3735 Santiago Chile

In this paper, simulated and experimental results on the conical tank level control are presented. PI/PID controllers of integer order （IO） as well as of fractional order （FO） are studied and compared. The tuning parameters are obtained first by using root locus （RL） and Ziegler and Nichols methods, for comparison purposes. Next, particle swarm optimization （PSO） is employed to determine the optimal controllers＇ parameters using as fitness function the integral of the absolute value of tracking error （IAE）. From the experimental results it is concluded that PI/FOPI are the controllers presenting the lowest IAE indexes, whereas PID/FOPID controllers present the lowest energy consumption by the control signal.

关键词： Level control conical tank PID control fractional PID control experimental control

First progeria monkey model generated using base editor

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Protein & Cell 2020年第12期11卷 862-865页

作者： Pradeep Reddy Yanjiao Shao Reyna Hernandez-Benitez Estrella Nunez Delicado juan carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de Murcia(UCAM) Campus de los JerdnimosN°13512Guadalupe 30107Spain

In this issue,Wang et *** on the generation of a nonhuman primate model of Hutchinson-Gilford progeria syndrome(HGPS)using a base *** editing is an emerging novel genome editing technique for modifying a single base pair at specific sites in the *** editors(BEs)have two prin cipal comp orients,a catalytically in active or single strand cleaving Cas-variant,which binds to the guide RNA and a nucleobase deaminase domain to convert specific base pairs at the target loci(Komor et al.,2016;Nishida et al.,2016;Gaudelli et al.,2017).Cytosine base editor(CBE)and adenine base editor(ABE)are two baseeditors,which con vert Cytosi ne-Gua nine(C-G)to Thymine-Adenine(T-A)and A-T to G-C,respectively.

关键词： base convert editor

Comparison of biological fitness in crosses between subspecies of Meccus phyllosomus （Hemiptera： Reduviidae： Triatominae） in southern Mexico

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Insect Science 2017年第1期24卷 114-121页

作者： Jose Alejandro Martinez-Ibarra Benjamin Nogueda-Torres Luis Fernando Salazar-Montano juan carlos Garcia-Lino Demver Arroyo-Reyes juan Angel Hernandez-Navarro Area de Entomologia Medica Universidad de Guadalajara Ciudad Guzman Jalisco Mexico Becario de COFAA Escuela Nacional de Ciencias Biologicas Instituto Politecnico Nacional D.F. Mexico Carrera de Medicina Departamento de Salud y Bienestar Centro Universitario del Sur Universidad de Guadalajara Ciudad Guzman Jalisco Mexico

Understanding the biological parameters of some triatomine subspecies of Meccus phyllosomus （Burmeister） is a crucial first step in estimating the epidemiologie importance of this group. Biological parameters related to hatching, lifetime, number of blood meals to molt, percentage of females at the end of the cycle, number of laid eggs, and mortality for each instar of 3 M. phyllosomus subspecies [M. p. mazzottii （Usinger）, M. p. pallidipennis （Stal）, and M. p. phyllosomus] and their laboratory hybrids were evaluated and compared. No significant differences （P 〉 0.05） were found among the experimental hybrids （MaPa, MaPhy, PaPhy） and reciprocal cohorts. In 5 （hatching, number of blood meals to molt, accumulative mortality, percentage of females, and mean number of laid eggs） of the 6 studied parameters （with the exception of development time）, the hybrid cohorts had better fitness results than the parental cohorts involved in each set of crosses. The increase in hybrid fitness found in our study could lead to an increase in the epidemiologic risks caused by transmission of Trypanosoma cruzi to humans.

关键词： biological parameters Chagas disease Meccus subspecies Mexico tri- atomines Trypanosoma cruzi transmission

Symptomatic accommodative and binocular dysfunctions from the use of flat-panel displays

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International Journal of Ophthalmology(English edition) 2018年第3期11卷 501-505页

作者： Esteban Porcar juan carlos Montalt Alvaro M. Pons Enrique Espana-Gregor Department of Optics Optometry and Vision Sciences Physics College University of Valencia Burjassot (Valencia) 46100 Spain Department of Surgery Ophthalmology Unit Faculty of Medicine and Odontology la Fe University and Polytechnic Hospital Valencia 46026 Spain

AIM： To determine the presence of symptomatic accommodative and non-strabismic binocular dysfunctions （***） in a non-presbyopic population of video display unit （VDU） users with flat-panel displays. METHODS： One hundred and one VDU users, aged between 20 to 34y, initially participated in the study. This study excluded contact-lens wearers and subjects who had undergone refractive surgery or had any systemic or ocular disease. First, subjects were asked about the type and nature of eye symptoms they experienced during VDU use. Then, a thorough eye examination excluded those subjects with a significant uncorrected refractive error or other problem, such as ocular motility disorders, vertical deviation, strabismus and eye diseases. Finally, the remaining participants underwent an exhaustive assessment of their accommodative and binocular vision status. RESULTS： Eighty-nine VDU users （46 females and 43 males） were included in this study. They used flat-panel displays for an average of 5±1.9h a day. Twenty subjects presented *** （22.5%）. Convergence excess was the most frequent non-strabismic binocular dysfunction （9 subjects）, followed by fusional vergence dysfunction （3 subjects） and convergence insufficiency （2 subjects）. Within the accommodative dysfunctions, accommodative excess was the most common （4 subjects）, followed by accommodative insufficiency （2 subjects）. Moderate to severe eye symptoms were found in 13 subjects with ANSBD. CONCLUSION： Significant eye symptoms in VDU users with accommodative and/or non-strabismic binocular dysfunctions often occur and should not be underestimated; therefore, an appropriate evaluation of accommodative and binocular vision status is more important for this population,

关键词： general binocular dysfunctions accommodativedysfunctions non-strabismic binocular dysfunctions eyesymptoms video display unit

Need for infliximab dose intensification in Crohn's disease and ulcerative colitis

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World Journal of Gastroenterology 2014年第27期20卷 9170-9177页

作者： carlos Taxonera David Olivares juan L Mendoza Manuel Díaz-Rubio Enrique Rey Inflammatory Bowel Disease Unit Department of Gastroenterology Hospital Clínico San Carlos Instituto de Investigación del Hospital Clínico San carlos (IdISSC) Department of Gastroenterology Hospital Clínico San Carlos

AIM: To compare the need for infliximab dose intensification in two cohorts of patients with Crohn’s disease (CD) or ulcerative colitis (UC).

关键词： Crohn's disease Ulcerative colitis Infliximab Dose intensification Costs

Design of microaerobically inducible miniR1 plasmids

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mLife 2023年第1期2卷 101-104页

作者： Fabiola Islas Andrea Sabido juan-carlos Sigala Alvaro R.Lara Departamento de Procesos y Tecnología Universidad Autónoma MetropolitanaCiudad de MexicoMéxico

Plasmid DNA(pDNA)is the active pharmaceutical ingredient in the so-called DNA vaccines1 and in gene therapy *** first pDNA vaccine for use in humans,which has shown high protection against SARS-CoV-2,was recently appr... 详细信息

关键词： inducible products. template