First progeria monkey model generated using base editor

作     者：Pradeep Reddy Yanjiao Shao Reyna Hernandez-Benitez Estrella Nunez Delicado Juan Carlos Izpisua Belmonte Pradeep Reddy;Yanjiao Shao;Reyna Hernandez-Benitez;Estrella Nuñez Delicado;Juan Carlos Izpisua Belmonte

作者机构：Gene Expression LaboratorySalk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de Murcia(UCAM)Campus de los JerdnimosN°13512Guadalupe 30107Spain 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2020年第11卷第12期

页      面：862-865页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071002[理学-动物学] 

基　　金：We thank M.Schwarz for administrative support.This work was supported by the Moxie Foundation,Department of Defense(grant number W81XWH-17-1-0552) The Progeria Research Foundation and UCAM 

主　　题：base convert editor 

摘      要：In this issue,Wang et *** on the generation of a nonhuman primate model of Hutchinson-Gilford progeria syndrome(HGPS)using a base *** editing is an emerging novel genome editing technique for modifying a single base pair at specific sites in the *** editors(BEs)have two prin cipal comp orients,a catalytically in active or single strand cleaving Cas-variant,which binds to the guide RNA and a nucleobase deaminase domain to convert specific base pairs at the target loci(Komor et al.,2016;Nishida et al.,2016;Gaudelli et al.,2017).Cytosine base editor(CBE)and adenine base editor(ABE)are two baseeditors,which con vert Cytosi ne-Gua nine(C-G)to Thymine-Adenine(T-A)and A-T to G-C,respectively.