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Efficacy and safety of transvaginal mesh repair in a cohort with a minimum of 10-year follow-up

Science china(Life Sciences) 2024年第5期67卷 1061-1068页

作者： Zhibo Zhang Jianbin guo Weijie Tian Ye Zhang Yuelun Zhang Tianshu Sun Jiali Duan Xinmiao Bao Yuan Wang Yang Ye Qianqian gao Honghui Shi Abraham Nick Morse juan chen Lan Zhu Departmentof Obstetrics and gynecology Peking Union MedicalCollege HospitalChinese Academyof Medical Sciences&Peking Union MedicalCollegeNational Clinical Research Center for Obstetricand Gynecologic DiseasesBeijing 100730China Department of gynecology Guizhou Provincial People’s HospitalMedical College of Guizhou UniversityGuiyang 550002China Department of Obstetrics and gynecology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450000China Medical Research center Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Medical Doctor Program Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pathology Peking Union Medical College HospitalBeijing 100730China Tufts University School of Medicine Boston MA 02111USA

Although transvaginal mesh(TVM)repair is no longer used in some countries,long-term outcomes after TVM surgery are of great importance ***,reports with follow-up>10 years are ***,this study aimed to report outcomes in a prospective cohort with at least 10 years of *** with stageⅢ–Ⅳsymptomatic prolapse were approached consecutively from 2008 to 2013 at one tertiary *** main outcome measure was symptomatic *** outcomes included anatomic failure,recurrence,patient satisfaction,complications,and *** Kaplan-Meier curve was used to estimate the cumulative failure *** the 121 patients enrolled in the study,103(85.1%)completed a median follow-up of 11 *** estimated probability rates of symptomatic and anatomic failure were 17.6%and 8.8%in 11 years,*** estimated incidence of symptomatic failure increased by 8.2%between 5 and 11 years;however,the corresponding rate for anatomic failure was 3.7%.The most common complication was vaginal mesh exposure,and its estimated probability increased from 19.3%to 28.4%from 5 to 11 years,*** trimming resolved 80.0%of vaginal *** patients did not report decreased overall *** with vaginal mesh exposure requiring>3 office procedures or mesh removal in the operating room(5.8%by 11 years)had lower satisfaction rates(Pg severe mesh *** rates of postoperative pain,reoperation,and Patient global Impression of Improvement≥2 were 2.5%,3.3%,and 94.2%,*** results of this study implied that TVM treatment gradually increased the symptomatic failure rate but provided durable anatomical support of the vaginal *** mesh exposure was common in women who were largely not sexually active;however,80%of the cases could be managed in the outpatient clinic,which did not affect patient satisfaction.

关键词： complication efficacy long-term follow-up pelvic organ prolapse safety transvaginal mesh

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Preliminary exploration of animal models of congenital choledochal cysts

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World Journal of gastroenterology 2024年第10期30卷 1420-1430页

作者： Shu-Hao Zhang Yue-Bin Zhang Duo-Te cai Tao Pan Ken chen Yi Jin Wen-juan Luo Zong-Wei Huang Qing-Jiang chen Zhi-gang gao Department of general Surgery Children’s HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BAcKgROUND Various animal models have been used to explore the pathogenesis of choledochal cysts(ccs),but with little convincing *** surgical techniques can achieve satisfactory outcomes for treatment of ***,recent studies have focused more on clinical issues rather than basic ***,we need appropriate animal models to further basic *** To establish an appropriate animal model that may contribute to the investigation of the pathogenesis of *** Eighty-four specific pathogen-free female Sprague-Dawley rats were randomly allocated to a surgical group,sham surgical group,or control group.A rat model of cc was established by partial ligation of the bile *** reliability of the model was confirmed by measurements of serum biochemical indices,morpho-logy of common bile ducts of the rats as well as molecular biology experiments in rat and human *** Dilation classified as mild(diameter,≥1 mm togical group,respectively,while no dilation was observed in the control and sham surgical *** levels of alanine aminotransferase,aspartate aminotrans-ferase,total bilirubin,direct bilirubin,and total bile acids were significantly elevated in the surgical group as compared to the control group 7 d after surgery,while direct bilirubin,total bilirubin,and gamma-glutamyltransferase were further increased 14 d after *** of the biochemical indices gradually decreased to normal ranges 28 d after *** protein expression trend of signal transducer and activator of transcription 3 in rat model was consistent with the human cc *** The model of partial ligation of the bile duct of juvenile rats could morphologically simulate the cystic or fusiform cc,which may contribute to investigating the pathogenesis of cc.

关键词： choledochal cyst Animal model Partial ligation cystic and fusiform dilation Juvenile rats

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LiOH-mediated crystallization regulating strategy enhancing electrochemical performance and structural stability of SiO anodes for lithium-ion batteries

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Nano Research 2024年第9期17卷 8174-8183页

作者： Zhengqiu He Zewen Xu Yu Long Jiexin Zhu Hao Yang Kuo chen Qiang Zhou Ning cao Xiaobo Wang juan Wang Xiaojie Tan Litao Wang Luhai Wang Shengbao He Mengdi Zhang Han Hu Mingbo Wu State Key Laboratory of Heavy Oil Processing College of Chemistry and Chemical EngineeringChina University of Petroleum(East China)Qingdao 266580China Department of chemistry National University of Singapore3 Science Drive 3Singapore 117543Singapore School of chemical Sciences University of AucklandAuckland 1010New Zealand Petrochemical Research Institute Petro China Company Ltd.Beijing 102206China

Silicon monoxide(SiO)is widely recognized as a promising anode material for next-generation lithium-ion *** to its metastable amorphous structure,SiO exhibits a highly complex degree of crystallization at the microscopic level,which significantly influences its electrochemical *** a consequence,accurately regulating the crystallization of SiO,and further establishing the relationship between crystallinity and electrochemical performance are very critical for SiO *** this article,carbon-coated SiO materials with different crystallinity degrees were synthesized using lithium hydroxide monohydrate(LiOH·H_(2)O)as a structural modifier to reveal this ***,moderate amount of LiOH·H_(2)O addition results in the forming of an oxygen-rich shell,which effectively inhibits the inward migration of oxygen atoms on the SiO surface and suppresses volume ***,the crystallinity of SiO will gradually enhance and the crystalline phase appears with increasing the amount of LiOH·H_(2)O,which will generate a deteriorative Li+diffusion *** balancing the above two contradictions,a mass fraction of 1%LiOH·H_(2)O for the additive yielded SiO@c-1,characterized by optimal ***@c-1 demonstrates exceptional long-cycle stability with 74.8%capacity retention after 500 cycles at 1 A·g^(-1).Furthermore,it achieves a capacity retention of 52.2%even at a high density of 5 A·g^(-1).This study first reveals the relationship between SiO crystallinity and electrochemical performance,which efficiently guides the design of high-performance SiO anodes.

关键词： lithium-ion batteries SiO anodes crystallinity regulation high rate long life

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An allelic variation in the promoter of the LRR-RLK gene,qSS6.1,is associated with melon seed size

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Journal of Integrative Agriculture 2024年第10期23卷 3522-3536页

作者： Xiaoxue Liang Jiyu Wang Lei cao Xuanyu Du Junhao Qiang Wenlong Li Panqiao Wang juan Hou Xiang Li Wenwen Mao Huayu Zhu Luming Yang Qiong Li Jianbin Hu college of Horticulture Henan Agricultural UniversityZhengzhou 450002China Henan Engineering Research center for cucurbit germplasm Enhancement and Utilization Zhengzhou 450002China International Joint Laboratory of Henan Horticultural crop Biology Zhengzhou 450002China

Seed size is an important agronomic trait in melons that directly affects seed germination and subsequent seedling ***,the genetic mechanism underlying seed size in melon remains *** the present study,we employed Bulked-Segregant Analysis sequencing(BSA-seq)to identify a candidate region(~1.35 Mb)on chromosome 6 that corresponds to seed *** interval was confirmed by QTL mapping of three seed size-related traits from an F2 population across three *** mapping region represented nine QTLs that shared an overlapping region on chromosome 6,collectively referred to as *** InDel markers were developed in the qSS6.1 region,narrowing it down to a 68.35 kb interval that contains eight annotated *** variation analysis of the eight genes identified a SNP with a c to T transition mutation in the promoter region of MELO3c014002,a leucine-rich repeat receptor-like kinase(LRR-RLK)*** mutation affected the promoter activity of the MELO3c014002 gene and was successfully used to differentiate the large-seeded accessions(c-allele)from the small-seeded accessions(T-allele).qRT-PcR revealed differential expression of MELO3c014002 between the two parental *** predicted protein has typical LRR-RLK family domains,and phylogenetic analyses reveled its similarity with the homologs in several plant ***,these findings suggest MELO3c014002 as the most likely candidate gene involved in melon seed size *** results will be helpful for better understanding the genetic mechanism regulating seed size in melons and for genetically improving this important trait through molecular breeding pathways.

关键词： melon QTL mapping seed size candidate gene allelic variation

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Intravitreal injection of conbercept for diabetic macular edema complicated with diabetic nephropathy

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 304-310页

作者： Yuan-Zhang Zhu Zhi-Zhi Dou Wen-Ying Wang Qing-Yue Ma Wen-Dan Yi Ning-Ning Yao Yi-chong Liu Xiao-Di gao Qian Zhang Wen-juan Luo Department of Ophthalmology the Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

AIM:To observe the therapeutic effect of conbercept on diabetic macular edema(DME)complicated with diabetic nephropathy(DN).METHODS:In this retrospective study,54 patients(54 eyes)that diagnosed as DME from January 2017 to October 2021 were *** patients were divided into two groups:DME patients with DN(25 eyes),and DME patients without DN(29 eyes).general conditions were collected before treatment,laboratory tests include fasting blood glucose,HbA1c,microalbumin/creatinine,serum *** coherence tomography(OcT)was used to check the ellipsoidal zone(EZ)and external limiting membrane(ELM)*** macular thickness(cMT),best corrected visual acuity(BcVA),and retinal hyperreflective foci(HF)as well as numbers of injections were ***:There were significant differences between fasting blood glucose,HbA1c,serum creatinine,urinary microalbumin/creatinine,and estimated glomerular filtration rate(egFR)between the two groups(all Pcontinuity in the DME+DN group was worse than that in the DME group(PcVA(logMAR)in the DME group was significantly better than that in the DME+DN group at the same time points during treatment(all PcMT and HF values were significantly higher in the DME+DN group than that in the DME group at the all time points(all Pgnificantly decreased in both groups with time during *** 6mo after treatment,the mean number of injections in the DME+DN and DME group was 4.84±0.94 and 3.79±0.86,***:conbercept has a significant effect in short-term treatment of DME patients with or without DN,and can significantly ameliorate BcVA,cMT and the number of HF,treatment efficacy of DME patients without DN is better than that of DME patients with DN.

关键词： conbercept diabetic nephropathy diabetic macular edema optical coherence tomography

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Inhibition of xanthine oxidase alleviated pancreatic necrosis via HIF-1α-regulated LDHA and NLRP3 signaling pathway in acute pancreatitis

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3591-3604页

作者： juan Rong chenxia Han Yan Huang Yiqin Wang Qi Qiu Manjiangcuo Wang Shisheng Wang Rui Wang Juqin Yang Xia Li chenggong Hu Zhiyao chen Lihui Deng Wei Huang Qing Xi Dan Du West china center of Excellence for Pancreatitis Institute of Integrated Traditional Chinese and Western MedicineWest China Hospital/West China Medical SchoolSichuan UniversityChengdu 610041China State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Advanced Mass Spectrometry center Research Core FacilityFrontiers Science Center for Disease-related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610213China Proteomics-Metabolomics Platform Research Core FacilityInstitutes for Systems GeneticsWest China HospitalSichuan UniversityChengdu 610093China Biobank West China HospitalSichuan UniversityChengdu 610093China West china School of Nursing Sichuan UniversityChengdu 610041China Department of critical care Medicine West China HospitalSichuan UniversityChengdu 610041China

Acute pancreatitis(AP)is a potentially fatal condition with no targeted treatment *** inhibiting xanthine oxidase(XO)in the treatment of AP has been studied in several experimental models and clinical trials,whether XO is a target of AP and what its the main mechanism of action is remains ***,we aimed to re-evaluate whether XO is a target aggravating AP other than merely generating reactive oxygen species that trigger *** first revealed that XO expression and enzyme activity were significantly elevated in the serum and pancreas of necrotizing AP *** also found that allopurinol and febuxostat,as purine-like and non-purine XO inhibitors,respectively,exhibited protective effects against pancreatic acinar cell death in vitro and pancreatic damage in vivo at different doses and treatment time ***,we observed that conditional Xdh overexpression aggravated pancreatic necrosis and *** mechanism analysis showed that XO inhibition restored the hypoxia-inducible factor 1-alpha(HIF-1α)-regulated lactate dehydrogenase A(LDHA)and NOD-like receptor family pyrin domain containing 3(NLRP3)signaling pathways and reduced the enrichment of^(13)c_(6)-glucose to^(13)c_(3)-***,we observed that clinical circulatory XO activity was significantly elevated in severe cases and correlated with c-reactive protein levels,while pancreatic XO and urate were also increased in severe AP *** results together indicated that proper inhibition of XO might be a promising therapeutic strategy for alleviating pancreatic necrosis and preventing progression of severe AP by downregulating HIF-1α-mediated LDHA and NLRP3 signaling pathways.

关键词： Xanthine oxidase inhibitor Multi-omics HIF-1a Necrotizing acute pancreatitis Lactate Therapeutic target NLRP3 Metabolic flux

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Analysis of the correlation Between Visceral Fat Area and Insulin Resistance in Patients with Type 2 Diabetes and Abdominal Obesity

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Journal of clinical and Nursing Research 2024年第4期8卷 243-247页

作者： guohui Zhang juan Xu Qiong Peng Yalei Xu Shaochang Ma guandu People’s Hospital of Kunming Kunming 650200China

Objective: To analyze the correlation between visceral fat area and insulin resistance index (HOMA-IR) in patients with type 2 diabetes mellitus (T2DM) and abdominal obesity and to provide a reference for screening and related research of such patients. Methods: Two hundred patients with T2DM admitted to guandu People’s Hospital of Kunming were included. The study was carried out from October 2022 to December 2023. The patients were divided into three groups according to different abdominal visceral fat areas (VFA): group A (n = 65) was less than 75cm2, group B (n = 75) was 75-100 cm2, and group c (n = 60) was greater than 100 cm2. The subjects in the three groups were all tested for glycated hemoglobin (HbA1c), fasting insulin (FINS), and fasting blood glucose (FPg). Height and weight were measured to calculate body mass index (BMI). The HOMA-IR and TYg (fasting triglyceride and glycemic index) were also calculated. changes in the BMI, VFA, HOMA-IR, and TYg levels were observed in the three groups. Results: The VFA, BMI, HbA1c, FPg, FINS, HOMA-IR, and TYg of the patients all increased, with a more significant increase in the BMI, FINS, HOMA-IR, and TYg levels (P gression analyses used visceral fat area (VFA) as the dependent variable. The results showed that VFA was closely related to BMI, FINS, HOMA-IR, and TYg. conclusion: Early reduction of VFA to reduce insulin resistance may be a better treatment and effective method for T2DM, providing powerful measures and new strategies for effective blood sugar control and early prevention in the treatment of metabolic diseases.

关键词： Type 2 diabetes Abdominal obesity Visceral fat area Insulin resistance

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Stay in touch with the endoplasmic reticulum

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Science china(Life Sciences) 2024年第2期67卷 230-257页

作者： Sha Sun gan Zhao Mingkang Jia Qing Jiang Shulin Li Haibin Wang Wenjing Li Yunyun Wang Xin Bian Yan g.Zhao Xun Huang ge Yang Huaqing cai Jose c.Pastor-Pareja Liang ge chuanmao Zhang Junjie Hu National Laboratory of Biomacromolecules Institute of BiophysicsUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100101China The Ministry of Education Key Laboratory of cell Proliferation and Differentiation College of Life SciencesPeking UniversityBeijing 100871China State Key Laboratory of Membrane Biology Tsinghua-Peking Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China Laboratory of computational Biology&Machine Intelligence School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Medicinal chemical Biology College of Life SciencesNankai UniversityTianjin 300071China Brain Research center Department of BiologySchool of Life SciencesSouthern University of Science and TechnologyShenzhen 518055China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovation Academy for Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Neurosciences Consejo Superior de Investigaciones Científicas-Universidad Miguel HernándezSan Juan de Alicante 03550Spain

The endoplasmic reticulum(ER),which is composed of a continuous network of tubules and sheets,forms the most widely distributed membrane system in eukaryotic *** a result,it engages a variety of organelles by establishing membrane contact sites(McSs).These contacts regulate organelle positioning and remodeling,including fusion and fission,facilitate precise lipid exchange,and couple vital signaling ***,we systematically review recent advances and converging themes on ER-involved organellar *** molecular basis,cellular influence,and potential physiological functions for ER/nuclear envelope contacts with mitochondria,golgi,endosomes,lysosomes,lipid droplets,autophagosomes,and plasma membrane are summarized.

关键词： endoplasmic reticulum nuclear envelope mitochondria golgi apparatus endosome lysosome lipid droplets autophagosome plasma membrane membrane contact site

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characteristics and in-hospital mortality of elderly patients with heart failure in Spanish hospitals

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Journal of geriatric cardiology 2023年第4期20卷 247-255页

作者： Alberto Esteban-Fernández Manuel Anguita-Sánchez juan Luis Bonilla-Palomas María Anguita-gámez María garcía JoséLuis Bernal Náyade Del Prado cristina Fernández-Pérez Julián Pérez-Villacastin juan Joségómez-Doblas Francisco Javier Elola cardiology Department Hospital Universitario Severo OchoaMadridSpain cardiology Department Hospital Universitario Reina SofíaCórdobaSpain cardiology Department Hospital San Juan de la CruzÚbedaSpain cardiology Department Hospital Clínico San CarlosMadridSpain Fundación Instituto para la Mejora de la Asistencia Sanitaria MadridSpain Management control Department Hospital Universitario 12 de OctubreMadridSpain Department of Preventive Medicine Área Sanitaria de Santiago de Compostela y BarbanzaInstituto de Investigación de SantiagoSantiago de CompostelaSpain cardiology Department Hospital Universitario Virgen de la VictoriaMálagaSpain

BAcKgROUND The prevalence of heart failure(HF)increases with age,and it is one of the leading causes of hospitalization and death in older ***,there are little data on in-hospital mortality in patients with HF≥75 years in *** A retrospective analysis of the Spanish Minimum Basic Data Set was performed,including all HF episodes discharged from public hospitals in Spain between 2016 and *** was performed using the International classification of Diseases,10th ***≥75 years with HF as the principal diagnosis were *** calculated:(1)the crude in-hospital mortality rate and its distribution according to age and sex;(2)the risk-standardized in-hospital mortality ratio;and(3)the association between in-hospital mortality and the availability of an intensive cardiac care unit(IccU)in the *** We included 354,792 HF episodes of patients over 75 *** mean age was 85.2±5.5 years,and 59.2%of patients were *** most frequent comorbidities were renal failure(46.1%),diabetes mellitus(35.5%),valvular disease(33.9%),cardiorespiratory failure(29.8%),and hypertension(26.9%).In-hospital mortality was 12.7%,and increased with age[odds ratio(OR)=1.07,95%cI:1.07–1.07,PcI:0.92–0.97,Pctors of mortality were the presence of cardiogenic shock(OR=19.5,95%cI:16.8–22.7,PcI:3.0–4.0,Pced cancer(OR=2.6,95%cI:2.5–2.8,PccU,the in-hospital risk-adjusted mortality tended to be lower(OR=0.85,95%cI:0.72–1.00,P=0.053).cONcLUSIONS In-hospital mortality in patients with HF≥75 years between 2016 and 2019 was 12.7%,higher in males and elderly *** main predictors of mortality were cardiogenic shock,stroke,and advanced *** was a trend toward lower mortality in centers with an IccU.

关键词： patients mortality diagnosis

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Efficacy of Huangma Ding or autologous platelet-rich gel for the diabetic lower extremity arterial disease patients with foot ulcers

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World Journal of Diabetes 2024年第5期15卷 923-934页

作者： Xue-Qin Wang Dan-Lan Pu Wei-Ling Leng Xiao-Tian Lei Jiang juan Zou La Ding Yao Jia-Zhuang Xi Li Jian Teng Miao Qi-Nan Wu Endocrinology Department The People’s Hospital of Yubei District of Chongqing CityChongqing 401120China Department of Endocrinology Chongqing Yubei District People’s HospitalChongqing 400030China Endocrinology Department The First Affiliated Hospital of the Army Medical UniversityChongqing 400038China Endocrinology and Nephrology Department Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer HospitalChongqing 400016China Department of Endocrinology Dazu Hospital of Chongqing Medical UniversityThe People’s Hospital of DazuChongqing 402360China

BAcKgROUND Diabetes foot is one of the most serious complications of diabetes and an important cause of death and disability,traditional treatment has poor efficacy and there is an urgent need to develop a practical treatment *** To investigate whether Huangma Ding or autologous platelet-rich gel(APg)treatment would benefit diabetic lower extremity arterial disease(LEAD)patients with foot *** A total of 155 diabetic LEAD patients with foot ulcers were enrolled and divided into three groups:group A(62 patients;basal treatment),group B(38 patients;basal treatment and APg),and group c(55 patients;basal treatment and Huangma Ding).All patients underwent routine follow-up visits for six *** follow-up,we calculated the changes in all variables from baseline and determined the differences between groups and the relationships between *** The infection status of the three groups before treatment was the ***(PcT)improved after APg and Huangma Ding treatment more than after traditional treatment and was significantly greater in group c than in group *** regression analysis revealed that PcT was positively correlated with total amputation,primary amputation,and minor amputation *** ankle-brachial pressure and the transcutaneous oxygen pressure in groups B and c were greater than those in group *** major amputation rate,minor amputation rate,and total amputation times in groups B and c were lower than those in group *** Our research indicated that diabetic foot ulcers(DFUs)lead to major amputation,minor amputation,and total amputation through local infection and poor microcirculation and *** Ding and APg were effective attreating *** clinical efficacy of Huangma Ding was better than that of autologous platelet gel,which may be related to the better control of local infection by Huangma *** finding suggested that in patients with DFUs combined with coinfection,controll

关键词： Diabetic foot ulcer Huangma Ding Autologous platelet-rich gel Ankle-brachial index Transcutaneous oxygen partial pressure

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