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clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of geriatric cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios c.rlos Perez Muñoz juan cosín-Sales Alejandro IPérez cabeza Vanesa Roldán Schilling carles Rafols Priu Esteban Orenes-Piñero María Asunción Es-teve-Pastor Department of cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital galdakao-Usansolo BizkaiaSpain Department of cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical center La capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of cardiology Hospital Arnau de VilanovaValenciaSpain Department of car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial fibrillation(AF),taking rivaroxaban in clinical *** Observational and non-interventional study that included AF adults recruited from 79 Spanish centers,anticoagulated with rivaroxaban ≥ 6 months before being *** were analyzed according to age(≥ 80 vs.ctogenarians at *** to younger patients,octogenarians had more comorbidities,higher cHA2DS2-VASc(4.5 ± 1.3 vs.3.0 ± 1.4;P cores(2.0 ± 1.0 vs.1.4 ± 1.0;P cribed in 83.4% of patients,but more frequently in the younger population(71.1% vs.89.1%;P = 0.039).After a mean follow-up of 2.2 ± 0.6 years,annual rates of stroke + systemic embolism + transient ischemic attack,MAcE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03% and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar compared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with MAcE,and higher HAS-BLED score with major *** In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately prescribed in the majority of octogenarians.

关键词： patients atrial bleeding

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Etching Mechanism of Ti_(3)c_(2)cl_(2) MXene Phases by cucl_(2)-Lewis Molten Salt Method

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 863-868页

作者：严明 ZHU Yu HUANg Jiangtao cHEN Haoyu DENg Yuxiao cHEN Yanlin 王娟 Jan-Michael Albina Hubei Provincial Key Laboratory of green Materials for Light Industry Hubei University of TechnologyWuhan 430068China New Materials and green Manufacturing Talent Introduction and Innovation Demonstration Base Hubei University of TechnologyWuhan 430068China Hubei Longzhong Laboratory Xiangyang 441000China

We described a method for obtaining fluorine-free Ti_(3)c_(2)cl_(2)MXene phases by melting copper in cucl_(2)instead of aluminum in Ti_(3)Alc_(2).XRD results show that when molten salt cucl_(2)etches Ti_(3)Alc_(2),it forms an intermediate product Ti_(3)cuc_(2),and then reacts with Ti_(3)cuc_(2)to obtain Ti_(3)c_(2)cl_(2).The reaction of Ti_(3)Alc_(2)and cucl_(2)at a temperature of 800℃for 2 h to obtain Ti_(3)c_(2)cl_(2)with an optimal lamellar structure is shown in SEM *** pseudopotential plane-wave(PP-PW)method is used to calculate on the electronic *** etching mechanism is investigated by the total energies of each *** chemical reaction of Ti_(3)Alc_(2)and cucl_(2)will first become Ti_(3)cuc_(2)and cu,and then become Ti_(3)c_(2)cl_(2)during the Lewis acid etching process,which are consistent with the experimental results.

关键词： molten salt method cucl_(2) MXene first-principles calculations etching mechanism

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A piezoelectric-driven microneedle platform for skin disease therapy

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The Innovation 2024年第3期5卷 110-121页

作者： Ziyan chen Xin Liu Zixi Jiang Huayi Wu Tao Yang Lanyuan Peng Lisha Wu Zhongling Luo Mi Zhang juan Su Yan Tang Jinmao Li Yang Xie Han Shan Qibo Lin Xiuli Wang Xiang chen Hanmin Peng Shuang Zhao Zeyu chen Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410008China Furong Laboratory(Precision Medicine) Changsha 410008China National Engineering Research center of Personalized Diagnostic and Therapeutic Technology Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Engineering Research center of Skin Health and Disease Xiangya HospitalCentral South UniversityChangsha 410008China Hunan Key Laboratory of Skin cancer and Psoriasis Xiangya HospitalCentral South UniversityChangsha 410008China National clinical Research center of geriatric Disorders Xiangya HospitalCentral South UniversityChangsha 410008China School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083China Department of Dermatology Xijing HospitalThe Fourth Military Medical UniversityXi’anShaanxi 710000China State Key Laboratory of Mechanics and control for Aerospace Structures Nanjing University of Aeronautics&AstronauticsNanjing 210016China Institute of Photomedicine Shanghai Skin Disease HospitalSchool of MedicineTongji UniversityShanghai 200443China

With over a million cases detected each year,skin disease is a global public health problem that diminishes the quality of life due to its difficulty to eradicate,propensity for recurrence,and potential for post-treatment *** therapy(PDT)is a treatment with minimal invasiveness or scarring and few side effects,making it well tolerated by ***,this treatment requires further research and development to improve its effective clinical ***,a piezoelectric-driven microneedle(PDMN)platform that achieves high efficiency,safety,and non-invasiveness for enhanced PDT is *** platform induces deep tissue cavitation,increasing the level of protoporphyrin IX and significantly enhancing drug penetration.A clinical trial involving 25 patients with skin disease was conducted to investigate the timeliness and efficacy of PDMN-assisted PDT(PDMN-PDT).Our findings suggested that PDMN-PDT boosted treatment effectiveness and reduced the required incubation time and drug concentration by 25%and 50%,respectively,without any anesthesia compared to traditional *** findings suggest that PDMN-PDT is a safe and minimally invasive approach for skin disease treatment,which may improve the therapeutic efficacy of topical medications and enable translation for future clinical applications.

关键词： needle anesthesia clinical

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Hepatocyte culture in a radial-flow bioreactor with plasma polypyrrole coated scaffolds

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BIOcELL 2015年第2期39卷 9-14页

作者： Odin RAMÍREZ-FERNÁNDEZ Rafael gODÍNEZ Esmeralda ZUÑIgA-AgUILAR Luis E.gÓmez-QUIROZ María c.gUTIÉRREZ-RUIZ juan MORALES Roberto OLAYO Departamento de Ingeniería Eléctrica Universidad Autónoma MetropolitanaUnidad IztapalapaApdo.Postal 55-534IztapalapaMéxico. Departamento de ciencias de la Salud Universidad Autónoma MetropolitanaUnidad IztapalapaApdo.Postal 55-534IztapalapaMéxico Departamento de Física Universidad Autónoma MetropolitanaUnidad IztapalapaApdo.Postal 55-534IztapalapaMéxico

We have designed and evaluated a radial-flow bioreactor for three-dimensional liver carcinoma cell culture on a new porous coated *** designed a culture chamber where a radial flow of culture medi-um was continuously delivered through *** this system was established,flow was simulated using flow dy-namics software based on numeric methods to solve Navier-Stockes flow *** within cell culture scaffolds was simulated using a flow velocity of 7 mL/min and found that cell culture medium was distributed unhindered in the bioreactor ***,the bioreactor was built according to the simulated design and was tested with liver carcinoma cells(Hepg2)cultured over an L-polylactic acid scaffold whose surface was modified with iodine-doped *** bioreactor was tested under non-flow and in radial flow *** density under radial flow conditions was almost double than that under static conditions and both total protein and albumin output was also increased under radial flow conditions.

关键词： cell cultures Flow Simulation Flow Features Hepg2 cells Plasma Polymerization

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Design and optimization of cSP power plants for Pakistan:a comparative study

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clean Energy 2023年第3期7卷 690-704页

作者： Kashif Liaqat juan c.Ordonez Department of Mechanical Engineering FAMU-FSU College of EngineeringEnergy and Sustainability Centerand Center for Advanced Power SystemsFlorida State UniversityTallahasseeFL 32310USA

Despite having very high solar irradiance,Pakistan still does not have any installed concentrated solar power(cSP)*** studies have shown that multiple locations within the country are suitable for cSP plants,but there is limited availability of comprehensive comparative ***,this article presents a comparative analysis of different cSP technologies in Pakistan,focusing on their potential to address the country’s energy *** study evaluates the pros and cons of different cSP technologies at various locations through site assessment,modelling,optimization and economic analysis using the System Advisor *** and Nawabshah were selected as the locations for modelling multiple scenarios of 100-MW plants,using central receiver systems,parabolic trough collectors and linear Fresnel *** plants were integrated with thermal energy storage and the storage capacity was optimized using parametric *** results showed that a central receiver system for the location of Quetta was the most favourable option,with an annual energy yield of 622 gWh at 7.44 cents/kWh,followed by a central receiver system for Nawabshah(608 gWh,9.03 cents/kWh).This study is the first to show that switching between line-concentrated and point-concentrated cSP technologies can open new opportunities for sites in Pakistan with relatively high solar resources,resulting in a 21.3%reduction in the levelized cost.

关键词： concentrated solar power parabolic trough collector linear Fresnel reflector central receiver System Advisor Model Pakistan

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推拿结合热奄包治疗椎动脉型颈椎病(风寒湿型)的临床研究

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中国医学创新 2024年第3期21卷 81-86页

作者：肖娟赣州市中医院超声科江西赣州341000

目的:探究推拿结合热奄包治疗椎动脉型颈椎病(风寒湿型)的临床效果。方法:选取2022年1-10月在赣州市中医院治疗的105例椎动脉型颈椎病(风寒湿型)患者作为研究对象,按照患者的治疗意愿,将以上患者分为A组、B组、c组,A组采取推拿治疗,B组... 详细信息

目的:探究推拿结合热奄包治疗椎动脉型颈椎病(风寒湿型)的临床效果。方法:选取2022年1-10月在赣州市中医院治疗的105例椎动脉型颈椎病(风寒湿型)患者作为研究对象,按照患者的治疗意愿,将以上患者分为A组、B组、c组,A组采取推拿治疗,B组采取热奄包治疗,c组采取推拿结合热奄包治疗,三组均治疗3个月。比较三组治疗效果、中医症状评分、眩晕残障程度、双侧椎动脉的血流情况。结果:相比A组(65.71%)及B组(80.00%),c组总有效率(91.43%)显著升高(χ^(2)=7.021,P=0.030)。治疗后,三组中医症状评分较治疗前均显著改善,且c组患者的眩晕、心悸、耳鸣、头痛、畏寒肢冷及肢体麻木评分均显著低于A组、B组(Pc组躯体亚表、情绪亚表、功能亚表评分与总分均显著低于A组、B组(Pc组收缩期血流速度峰值(Vp)、平均血流速度(Vm)、舒张末期血流速度(Vd)均显著低于A组、B组(P<0.05)。结论:推拿结合热奄包治疗椎动脉型颈椎病(风寒湿型)患者,其椎动脉血流显著改善,临床症状降低,治疗效果较好。

关键词：推拿热奄包椎动脉型颈椎病椎动脉

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“局外人”:高校思想政治教育逃遁现象透视及其纾解

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现代教育科学 2024年第4期 65-72页

作者：任娟复旦大学上海200433

高校思想政治教育逃遁现象主要缘于“局外人”思想观念的隐匿性、心理观念的漠然性、价值观念的逃遁性,相应形成形式在场、边缘在场、外围出场3种不同现实表征。这一现象与“局外人”受困于自身思想现实、社会思潮的隐性浸染,以及高校... 详细信息

高校思想政治教育逃遁现象主要缘于“局外人”思想观念的隐匿性、心理观念的漠然性、价值观念的逃遁性,相应形成形式在场、边缘在场、外围出场3种不同现实表征。这一现象与“局外人”受困于自身思想现实、社会思潮的隐性浸染,以及高校思政工作的迟滞呈现等密切相关,对个体身份认同、高校思政建设、国家高质量人才培养战略有效达成均造成一定阻隔。促成高校思想政治教育“局外人”主动向“局内人”转变的重要举措为:提振受教者学习能力,重塑身份认同;完善教师队伍建设,提升教师素质;优化思政工作机制,增强育人实效。

关键词：局外人思想政治教育逃遁现象人才培养主流价值

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进展期胃癌生存预测:基于增强cT深度学习模型的构建

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放射学实践 2024年第4期39卷 488-495页

作者：张文娟张利文邓娟任铁柱徐敏周俊林兰州大学第二医院放射科/甘肃省医学影像重点实验室/医学影像人工智能甘肃省国际科技合作基地甘肃兰州730030 中国科学院自动化所分子影像重点实验室北京100190

目的:探讨基于术前增强cT构建的深度学习(DL)模型对进展期胃癌(Agc)1、2、3年生存概率的预测价值。方法:回顾性分析2013年1月-2015年12月在本院经病理证实为Agc的337例患者的临床和cT资料。按照7:3的比例将患者随机分为训练集(n=237)和... 详细信息

目的:探讨基于术前增强cT构建的深度学习(DL)模型对进展期胃癌(Agc)1、2、3年生存概率的预测价值。方法:回顾性分析2013年1月-2015年12月在本院经病理证实为Agc的337例患者的临床和cT资料。按照7:3的比例将患者随机分为训练集(n=237)和验证集(n=100)。采用数据增强技术增加训练集的数据量,随后基于术前cT增强静脉期图像构建残差卷积神经网络结构的DL模型,预测Agc患者1、2、3年的生存概率。经cox单因素及多因素分析构建临床模型,然后联合DL模型和临床模型构建综合模型并绘制其诺莫图。计算各模型的Harrel一致性指数(c-index)和风险比(HR),并应用Kaplan-Meier曲线、校准曲线及临床决策曲线比较3种模型对OS的预测效能。结果:在训练集和验证集中,临床模型、DL模型和综合模型的c-index值分别为0.70(95%cI:0.65~0.75)、0.72(95%cI:0.67~0.76)、0.74(95%cI:0.69~0.78)和0.64(95%cI:0.56~0.71)、0.66(95%cI:0.58~0.73)、0.67(95%cI:0.59~0.74),表明综合模型具有最优的生存期预测能力;三个模型的HR分别为2.72(95%cI:2.06~4.02)、2.88(95%cI:1.89~4.39)、2.72(95%cI:2.13~3.49)和2.11(95%cI:1.43~3.11)、4.32(95%cI:1.66~11.24)、1.89(95%cI:1.36~2.60),均以DL模型的HR最高,表明DL模型预测的高危人群具有更高的死亡风险。校准曲线分析显示基于综合模型的诺莫图预测Agc患者1、2、3年生存概率与实际的预后随访结果具有较高的一致性。临床决策曲线显示综合模型的净收益优于其它2种模型。结论:基于cT增强静脉期图像利用残差卷积神经网络构建的DL模型是一种良好的Agc患者生存风险评估模型,对Agc患者生存期的早期预判具有较高的临床应用价值。

关键词：进展期胃癌体层摄影术,X线计算机残差卷积神经网深度学习预后

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基于HPLc指纹图谱及多成分定量对刺五加的质量评价

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中草药 2024年第4期55卷 1326-1333页

作者：宋娟张晶玉吕重宁路金才沈阳药科大学中药学院辽宁沈阳110016

目的建立刺五加Acanthopanax senticosus HPLc指纹图谱及原儿茶酸、松柏苷、紫丁香苷、绿原酸、刺五加苷B1、刺五加苷E、丁香树脂酚7种成分含测定方法。方法采用Diamonsil 5μm c18(2)色谱柱(4.6 mm×250 mm,5μm),乙腈-0.1%磷酸水溶液... 详细信息

目的建立刺五加Acanthopanax senticosus HPLc指纹图谱及原儿茶酸、松柏苷、紫丁香苷、绿原酸、刺五加苷B1、刺五加苷E、丁香树脂酚7种成分含测定方法。方法采用Diamonsil 5μm c18(2)色谱柱(4.6 mm×250 mm,5μm),乙腈-0.1%磷酸水溶液为流动相,梯度洗脱;检测波长210 nm,柱温30℃,体积流量0.8 mL/min,进样量10μL。通过“中国色谱指纹图谱相似度评价系统”(2012版),建立了刺五加HPLc指纹图谱,同时测定了7种成分的含量。结合主成分分析、正交偏最小二乘法判别分析和皮尔逊相关性分析对刺五加进行了质量评价。结果建立了刺五加HPLc指纹图谱,共确定了18个共有色谱峰;原儿茶酸、松柏苷、紫丁香苷、绿原酸、刺五加苷B1、刺五加苷E以及丁香树脂酚线性关系良好,r2均大于等于0.9991,平均回收率分别为92.51%、97.63%、95.11%、101.08%、105.29%、98.92%、85.44%、94.89%。主成分分析提取了2个主成分,其方差累积为66.920%,表明这2个主成分可包含原有数据的大部分信息;正交偏最小二乘法判别分析筛选出刺五加样品中2个差异性成分(紫丁香苷、刺五加苷B1);皮尔逊相关性分析显示紫丁香苷、绿原酸和刺五加苷B1与其他化学成分的相关性最强。结论建立的刺五加HPLc指纹图谱及多成分含量测定方法简单、准确、重复性好,可用于刺五加的质量评价,为其质量控制提供依据。

关键词：刺五加指纹图谱原儿茶酸松柏苷紫丁香苷绿原酸刺五加苷B1 刺五加苷E 丁香树脂酚主成分分析

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排水对我国两种典型湿地土壤有机碳微生物转化过程的影响

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应用生态学报 2024年第1期35卷 133-140页

作者：贾娟李星奇冯晓娟中国科学院植物研究所植被与环境变化国家重点实验室北京100093 国家植物园北京100093 中国科学院大学北京100049

湿地储存了全球三分之一的土壤有机碳(SOc),并受到人为排水的强烈影响。然而,排水引起的水位下降对不同湿地碳循环(特别是微生物转化)过程的影响尚不明确。为此,本研究以我国两种典型湿地(贫营养型的大九湖湿地和富营养型的红原湿地)土... 详细信息

湿地储存了全球三分之一的土壤有机碳(SOc),并受到人为排水的强烈影响。然而,排水引起的水位下降对不同湿地碳循环(特别是微生物转化)过程的影响尚不明确。为此,本研究以我国两种典型湿地(贫营养型的大九湖湿地和富营养型的红原湿地)土壤为研究对象,通过添加13c标记葡萄糖的室内培养试验,分析了短期和长期排水对SOc降解、胞外酶活性、微生物碳利用效率(cUE)和微生物碳积累效率(cAE)的影响。结果表明:长期和短期排水显著提高了两种湿地SOc降解速率(从淹水处理的1.47μg c·g^(-1)·h^(-1)升高到排水处理的2.47μg c·g^(-1)·h^(-1))、葡萄糖来源的微生物生物量碳(从0.21 mg c·g^(-1)升高到1.00 mg c·g^(-1))和cAE(从0.29升高到0.73),但未改变cUE(变化范围为0.34~0.86)。长期排水提高了大九湖湿地α-葡萄糖苷酶活性,但降低了红原湿地β-葡萄糖苷酶和酚氧化酶活性。综上,排水主要通过增强微生物胞内代谢过程(包括呼吸)提高湿地土壤“微生物碳泵”作用和效率,同时加速了SOc降解。

关键词：微生物碳利用效率微生物碳积累效率土壤有机碳循环湿地排水

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