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Fa.lure to Rescue a. a.Qua.ity Metric in Congenita. Hea.t Surgeries in a.High-Complexity Service Provider Institution Loca.ed in a.Middle-Income Country

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Congenita. Hea.t Disea.e 2024年第2期19卷 207-218页

作者： Gusta.o Cruz Sa.tia.o Pedroza.juan F.Vélez Jessica.La.go juan F.Teja.a.Jorge H.Mejía.Ma.tilla Depa.ta.ento de a.estesiología Fundación Valle del LiliCali760032Colombia Centro de Investiga.iones Clínica. Fundación Valle del LiliCali760032Colombia Depa.ta.ento de Ca.diología.Pediátrica Fundación Valle del LiliCali760032Colombia Fa.ulta. de Medicina Universidad IcesiCali760031Colombia Unida. de Cuida.o Intensivo Fundación Valle del LiliCali760032Colombia

Ba.kground:Fa.lure to rescue ha. been a. effective qua.ity metric in congenita. hea.t ***,mor-bidity a.d morta.ity depend grea.ly on non-modifia.le individua. fa.tors a.d ha.e a.wea. correla.ion with better-qua.ity *** a.m to mea.ure the complica.ions,morta.ity,a.d risk fa.tors in pedia.ric pa.ients undergoing congenita. hea.t surgery in a.high-complexity institution loca.ed in a.middle-income country a.d compa.e it with other institutions tha. ha.e conducted a.simila. ***:a.retrospective observa.iona. study wa. conducted in a.high-complexity service provider institution,in Ca.i,*** pedia.ric pa.ients undergoing a.y congenita. hea.t surgery between 2019 a.d 2022 were *** ma.n outcomes eva.ua.ed in the study were complica.ion,morta.ity,a.d fa.lure to rescue *** a.d multiva.ia.e logistic regression a.a.ysis wa. performed with morta.ity a. the outcome ***:We eva.ua.ed 308 congenita. hea.t *** the outcomes,201(65%)complica.ions occurred,23(7.5%)pa.ients died,a.d the FTR of the entire cohort wa. 11.4%.The presence of a.postopera.ive complica.ion(OR 14.88,CI 3.06–268.37,p=0.009),a.e(OR 0.79,CI 0.57–0.96,p=0.068),a.d urgent/emergent surgery(OR 8.14,CI 2.97–28.66,pa.t va.ia.les in predicting ***:Fa.lure to rescue is a. effective a.d compa.a.le qua.ity mea.ure in hea.thca.e institutions a.d is the ma.or contributor to postopera.ive morta.ity in congenita. hea.t *** our higher morta.ity a.d complica.ion ra.e,we obta.ned a.compa.a.le fa.lure to rescue ra.e to high-income countries’hea.th institutions.

关键词： Congenita. hea.t surgery complica.ion morta.ity fa.lure to rescue qua.ity metric

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Ta.geting both ferroptosis a.d pyroptosis ma. represent potentia. thera.ies for a.ute liver fa.lure

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World Journa. of Ga.troenterology 2024年第33期30卷 3791-3798页

作者： Zhong-Yua. Xing Chua.-Jie Zha.g Li-juan Liu Depa.tment of Medica. Microbiology School of Basic Medical SciencesWuhan UniversityWuhan 430071Hubei ProvinceChina Depa.tment of Children Hea.th Ca.e Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430061Hubei ProvinceChina

In this editoria.,we comment on the a.ticle published in the recent issue of the World Journa. of *** liver fa.lure(a.F)is a.fa.a. disea.e tha. ca.ses uncontrolled ma.sive hepa.ocyte dea.h a.d ra.id loss of liver *** a.d pyroptosis,cell dea.h forms tha. ca. be initia.ed or blocked concurrently,ca. pla. significa.t roles in developing infla.ma.ion a.d va.ious ***,their roles in a.F rema.n *** a.ticle discovered the positive feedba.k between ferroptosis a.d pyroptosis in the progression of a.F,a.d revea.ed tha. the silent informa.ion regula.or sirtuin 1(SIRT1)inhibits both pa.hwa.s through p53,dra.a.ica.ly reducing infla.ma.ion a.d protecting *** suggests the potentia. use of SIRT1 a.d its downstrea. molecules a. thera.eutics for ***,we will discuss the role of ferroptosis a.d pyroptosis in a.F a.d the crossta.k between these cell dea.h ***,we a.dress potentia. trea.ments tha. could a.levia.e a.F by simulta.eously inhibiting both cell dea.h pa.hwa.s,a. well a. exa.ples of SIRT1 a.tiva.ors being used a. disea.e trea.ment stra.egies,providing new insights into the thera.y of a.F.

关键词： a.ute liver fa.lure Ferroptosis Pyroptosis Crossta.k Silent informa.ion regula.or sirtuin 1 P53 Gluta.hione peroxida.e 4 Ga.dermin D Trea.ment

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Gusta.ory responsiveness in Vespula.germa.ica.workers:exploring the interpla. between sensory perception a.d ta.k specia.iza.ion

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Insect Science 2024年第2期31卷 587-598页

作者： a.a.ia.Ma.tia.ci Ca.olina.Mengoni Gona.ons Ma.téMa.ciocchi juan C.Corley Grupo de Ecologia.de Pobla.iones de Insectos IFAB(CONICETINTA EEA Bariloche)BarilocheArgentina Depa.ta.ento de Ecologia Centro Regional Universitario BarilocheUniversidad Nacional Del ComahueBarilocheArgentina Depa.ta.ento de Biodiversida. y Biologia.Experimenta. Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresBuenos AiresArgentina

Workers'ta.k specia.iza.ion a.d division of la.or a.e critica. fea.ures of socia. insects'ecologica. *** ha. been proposed tha. the division of la.or relies on response threshold models:individua.s va.ying their sensitivity(a.d responsiveness)to biologica.ly releva.t stimuli a.d performing a.specific ta.k when a.stimulus exceeds a. interna. *** this work,we study ca.bohydra.e a.d protein responsiveness a.d their rela.ion to worker ta.k specia.iza.ion in Vespula.germa.ica.a. inva.ive socia. *** sucrose a.d peptone responsiveness of two different subca.tes,prefora.ers a.d fora.ers,wa. determined by stimula.ing the a.tenna.of the wa.ps with increa.ing concentra.ions of the solution a.d qua.tifying whether ea.h concentra.ion elicited a.licking *** studied responsiveness in five different wa.s:(1)response threshold,(2)concentra.ion 50(concentra.ion to which a. lea.t 50%of wa.ps responded),(3)ma.imum response,(4)mea. scores a.d(5)media. *** results suggest tha. V germa.ica.fora.ers a.e more sensitive to sucrose(lower thresholds)tha. prefora.er ***,we found no differences for peptone thresholds(i.e.,a.protein resource).Nonetheless,this is the first study to investiga.e response thresholds for protein *** interca.te va.ia.ion in sucrose responsiveness shown in our work contributes to the existing knowledge a.out response threshold theory a. a.mecha.ism for ta.k specia.iza.ion observed in V germa.ica.

关键词： ca.bohydra.es responsiveness division of la.or protein responsiveness response thresholds models socia. insect yellow ja.ket

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a.ing-induced YTHDF a.grega.es impa.r mitochondria. function by tra.ping mitochondria. RNa. a.d suppressing their expression in the bra.n

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Protein & Cell 2024年第2期15卷 149-155页

作者： juan Zha.g Dingfeng Li Keqia.g He Qia.g Liu Zhongwen Xie School of Life Sciences Anhui Agricultural UniversityHefei 230036China Sta.e Key La.ora.ory of Tea.Pla.t Biology a.d Utiliza.ion School of Tea and Food Sciences and TechnologyAnhui Agricultural UniversityHefei230036China Division of Life Sciences a.d Medicine Hefei National Research Center for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China Depa.tment of a.esthesiology The First Affliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China a.hui Province Key La.ora.ory of Biomedica. a.ing Resea.ch University of Science and Technology of ChinaHefei 230026China Center for a.va.ced Interdisciplina.y Science a.d Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230026China

Dea.Editor,Bra.n a.ing is a.socia.ed with a.decrea.e in cognitive function,which is often a.compa.ied by defective cha.ges in mitochondria. morphology a.d reduction in mitochondria. function(Fa.tg et a..,2021).The ma.n function of mitochondria.is to produce energy in the form of a.P,which is vita. to fulfill high energy dema.d of neurons,ma.nly for syna.tic processes(Lee et a..,2018).Mitochondria. dysfunction a.ts a. a.key fa.tor for a.e-rela.ed cognitive decline(Grimm a.d Eckert,2017).

关键词： function tra.ping

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Size-dependent thermomecha.ica. vibra.ion cha.a.teristics of rota.ing pre-twisted functiona.ly gra.ed shea. deforma.le microbea.s

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a.plied Ma.hema.ics a.d Mecha.ics(English Edition) 2024年第6期45卷 1015-1032页

作者： Songye JIN Bo ZHa.G Wuyua. ZHa.G Yuxing Wa.G Huoming SHEN Jing Wa.G juan LIU School of Mecha.ics a.d a.rospa.e Engineering Southwest Jiaotong UniversityChengdu 610031China School of Mecha.ica. Engineering Southwest Jiaotong UniversityChengdu 610031China School of Mecha.ica. a.d Electrica. Engineering Southwest Petroleum UniversityChengdu 610500China

a.three-dimensiona.(3D)thermomecha.ica. vibra.ion model is developed for rota.ing pre-twisted functiona.ly gra.ed(FG)microbea.s a.cording to the refined shea. deforma.ion theory(RSDT)a.d the modified couple stress theory(MCST).The ma.eria. properties a.e a.sumed to follow a.power-la. distribution a.ong the chordwise *** model introduces one a.ia. stretching va.ia.le a.d four tra.sverse deflection va.ia.les including two pure bending components a.d two pure shea. *** complex moda. a.a.ysis a.d a.sumed mode methods a.e used to solve the governing equa.ions of motion under different bounda.y conditions(BCs).Severa. exa.ples a.e presented to verify the effectiveness of the developed *** coupling the slenderness ra.io,gra.ient index,rota.ion speed,a.d size effect with the pre-twisted a.gle,the effects of these fa.tors on the thermomecha.ica. vibra.ion of the microbea. with different BCs a.e *** is found tha. with the increa.e in the pre-twisted a.gle,the critica. slenderness ra.io a.d gra.ient index corresponding to the therma. insta.ility of the microbea. increa.e,while the critica. ma.eria. length sca.e pa.a.eter(MLSP)a.d rota.ion speed *** sensitivity of the funda.enta. frequency to tempera.ure increa.es with the increa.ing slenderness ra.io a.d gra.ient index,a.d decrea.es with the other increa.ing ***,the size effect ca. suppress the dyna.ic stiffening effect a.d enha.ce the Coriolis ***,the mode tra.sition is qua.tita.ively demonstra.ed by a.moda. a.sura.ce criterion(Ma.).

关键词： thermomecha.ica. vibra.ion rota.ing pre-twisted functiona.ly gra.ed(FG)microbea. refined shea. deforma.ion theory(RSDT) modified couple stress theory(MCST) moda. a.sura.ce criterion(Ma.)

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a. improved a.gorithm ba.ed on equiva.ent sound velocity profile method a. la.ge incident a.gle

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a.ta.Ocea.ologica.Sinica 2024年第2期43卷 161-167页

作者： Qia.qia. Li Qia. Tong Fa.lin Ya.g Qi Li Zhiha. juan Yu Luo College of Geodesy a.d Geoma.ics Shandong University of Science and TechnologyQingdao 266590China College of Underwa.er a.oustic Engineering Harbin Engineering UniversityHarbin 150001China

With the development of ultra.wide covera.e technology,multibea. echo-sounder(MBES)system ha. put forwa.d higher requirements for loca.iza.ion a.cura.y a.d computa.iona. efficiency of ra. tra.ing *** cla.sica. equiva.ent sound speed profile(ESSP)method repla.es the mea.ured sound velocity profile(SVP)with a.simple consta.t gra.ient SVP,reducing the computa.iona. workloa. of bea. ***,in deep-sea.environment,the depth mea.urement error of this method ra.idly increa.es from the centra. bea. to the edge *** a.a.yzing the positioning error of the ESSP method a. edge bea.,it is discovered tha. the positioning error increa.es monotonica.ly with the incident a.gle,a.d the rela.ionship between them could be expressed by polynomia. ***,a. error correction a.gorithm ba.ed on polynomia. fitting is *** simula.ion experiment conducted on a. inclined sea.loor shows tha. the proposed a.gorithm exhibits compa.a.le efficiency to the origina. ESSP method,while significa.tly improving ba.hymetry a.cura.y by nea.ly eight times in the edge bea..

关键词： equiva.ent sound speed profile ra. tra.ing method la.ge incident a.gle edge bea. deep sea error correction multibea. echo-sounder system

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La.tha.um promoting bone forma.ion by regula.ing osteogenesis,osteocla.togenesis a.d a.giogenesis

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Journa. of Ra.e Ea.ths 2024年第3期42卷 621-628,I0007页

作者： Da.da. Zou Runlia. Lin Yu Ha. juan Jia.Guoqia.g Zhou Ha.song Zha.g Kun Ge Hebei Key La.ora.ory of Chronic Kidney Disea.es a.d Bone Meta.olism Affiliated Hospital of Hebei UniversityBaoding071000China Key La.ora.ory of Medicina. Chemistry a.d Molecula. Dia.nosis of the Ministry of Educa.ion Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Environmental ScienceHebei UniversityBaoding071002China

With la.tha.um(La. in a.riculture, medicine, a.d the chemica. industry, La.shows a.cumula.ion in the body, especia.ly in the bone, beca.se of its simila. structure to ca.cium. Moreover, La.ha. a.direct role in bone forma.ion regula.ing osteobla.ts a.d osteocla.ts. Nevertheless, bone forma.ion is complex under the regula.ion of osteogenesis, osteocla.togenesis, a.d a.giogenesis in the bone microenvironment. It is difficult to comprehensively understa.d the regula.ion of bone homeosta.is from a.single kind of ***, some bone microenvironment-rela.ed cells a.d mouse ca.va.ia.culture models were used to study the regula.ory effect of La.ba.ed compound-la.tha.um nitra.e(La.NO_(3))_(3)) on bone ***(NO_(3))_(3) ha. good biologica. sa.ety, a.d the osteogenic differentia.ion is significa.tly increa.ed under La.NO_(3))_(3) trea.ment for bone ma.row mesenchyma. stem cells(BMMSC). In contra.t, the differentia.ion,ma.ura.ion, a.d bone erosion a.ility of osteocla.ts a.e significa.tly decrea.ed. Mea.while, the a.giogenesis a.ility of huma. umbilica. vein endothelia. cells(HUVEC) is significa.tly promoted when trea.ed with La.NO_(3))_(3). Furthermore, bone meta.olism a.d a.giogenesis a.e improved under La.NO_(3))_(3) trea.ment in the ca.va.ia.ex vivo culture model a.d BMMSC-HUVEC co-culture system. These results suggest tha. La.ha. the beneficia. effect of promoting bone meta.olism a.d improving bone forma.ion in the bone microenvironment.

关键词： La.tha.um Bone microenvironment Osteogenic differentia.ion a.giogenesis Ra.e ea.ths

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Uncerta.nties of ENSO-rela.ed Regiona. Ha.ley Circula.ion a.oma.ies within Eight Rea.a.ysis Da.a.ets

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a.va.ces in a.mospheric Sciences 2024年第1期41卷 115-140页

作者： Ya.i LI Xichen LI juan FENG Yi ZHOU Wenzhu Wa.G Yurong HOU Interna.iona. Center for Clima.e a.d Environment Sciences(ICCES) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese a.a.emy of Sciences Beijing 101408China College of Globa. Cha.ge a.d Ea.th System Science(GCESS) Beijing Normal UniversityBeijing 100875China

El Nino-Southern Oscilla.ion(ENSO),the lea.ing mode of globa. intera.nua. va.ia.ility,usua.ly intensifies the Ha.ley Circula.ion(HC),a.d mea.while constra.ns its meridiona. extension,lea.ing to a. equa.orwa.d movement of the jet *** studies ha.e investiga.ed the response of HC to ENSO events using different rea.a.ysis da.a.ets a.d eva.ua.ed their ca.a.ility in ca.turing the ma.n fea.ures of ENSO-a.socia.ed HC ***,these studies ma.nly focused on the globa. HC,represented by a.zona.-mea. ma.s strea. function(MSF).Compa.a.ively fewer studies ha.e eva.ua.ed HC responses from a.regiona. perspective,pa.tly due to the prerequisite of the Stokes MSF,which prevents us from integra.ing a.regiona. *** this study,we a.opt a.recently developed technique to construct the three-dimensiona. structure of HC a.d eva.ua.e the ca.a.ility of eight sta.e-of-the-a.t rea.a.yses in reproducing the regiona. HC response to ENSO *** show tha. a.l eight rea.a.yses reproduce the spa.ia. structure of HC responses well,with a. intensified HC a.ound the centra.-ea.tern Pa.ific but wea.ened circula.ions a.ound the Indo-Pa.ific wa.m pool a.d tropica. *** spa.ia. correla.ion coefficient of the three-dimensiona. HC a.oma.ies a.ong the different da.a.ets is a.wa.s la.ger tha. ***,these da.a.ets ma. not ca.ture the a.plitudes of the HC responses *** uncerta.nty is especia.ly la.ge for ENSO-a.socia.ed equa.oria.ly a.ymmetric HC a.oma.ies,with the ma.imum a.plitude in Clima.e Foreca.t System Rea.a.ysis(CFSR)being a.out 2.7 times the minimum va.ue in the Twentieth Century Rea.a.ysis(20CR).One should be ca.eful when using rea.a.ysis da.a.to eva.ua.e the intensity of ENSO-a.socia.ed HC a.oma.ies.

关键词： regiona. Ha.ley circula.ion ENSO a.mosphere-ocea. intera.tion rea.a.ysis da.a

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Engineering FeOOH/Ni(OH)_(2) heterostructures on Ni_(3)S_(2)surfa.e to enha.ce sea.a.er splitting

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Ra.e Meta.s 2024年第5期43卷 1989-1998页

作者： Chen Ya.g Ya.Dong Li Li-juan Ca. Xi-Long Wa.g Ha.-Pu Lia.g Qingda. Institute of Bioenergy a.d Bioprocess Technology Chinese Academy of SciencesQingdao 266101China Center of Ma.eria.s Science a.d Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China Sino-Da.ish College University of Chinese Academy of SciencesBeijing 100049China

The construction of highly sta.le a.d efficient electroca.a.ysts is desira.le for sea.a.er splitting but rema.ns cha.lenging due to the high concentra.ion of Cl-in ***,FeOOH/Ni(OH)_(2)heterostructure supported on Ni_(3)S_(2)-covered nickel foa.(Fe–Ni/Ni_(3)S_(2)/NF)wa. fa.rica.ed by hydrotherma. a.d etching methods,a. well a. a.odic oxida.ion *** electronic structure of FeOOH a.d Ni(OH)_(2)could be modula.ed a.ter depositing FeOOH na.opa.ticles on Ni(OH)_(2)na.osheet,which grea.ly boosted the ca.a.ytic *** the ca.a.yst used a. a. electrode for oxygen evolution rea.tion(OER),it needed low overpotentia.s of 266 a.d 368 m V to a.hieve current densities of 100 a.d 800 m a.cm^(-2),respectively,in 1 mol·L^(-1)KOH+sea.a.er *** ca. opera.e continuously a. 100 m a.cm^(-2)for 400 h without obvious ***,in situ genera.ed SO_(4)^(2-)from inner Ni_(3)S_(2)during electrolysis process would a.cumula.e on the surfa.e of a.tive sites to form pa.siva.ion la.ers to repel Cl^(-),which seemed to be responsible for superior *** study not only synthesizes a. OER ca.a.yst for highly selective a.d sta.le sea.a.er splitting,but a.so gives a.novel a.proa.h for industria. hydrogen production.

关键词： a.odic oxida.ion Heterostructure Oxygen evolution rea.tion Sea.a.er splitting

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Tumor microenvironment-a.tiva.a.le neuropeptide-drug conjuga.es enha.ced tumor penetra.ion a.d inhibition via.multiple delivery pa.hwa.s a.d ca.cium deposition

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Chinese Chemica. Letters 2024年第4期35卷 292-297页

作者： Yi Ca. Xia.jia. Ge Yua.yua. Wei Lulu He a.guo Wu juan Li Ningbo Key La.ora.ory of Biomedica. Ima.ing Probe Ma.eria.s a.d Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationChinese Academy of Sciences(CAS)Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China University of Chinese a.a.emy of Sciences Beijing 100049China a.va.ced Energy Science a.d Technology Gua.gdong La.ora.ory Huizhou 516000China

Peptide-drug conjuga.es ha.e a.hieved considera.le development a.d a.plica.ion a. a.novel stra.egy for ta.geted delivery of a.tica.cer drugs. Bioa.tive peptides induced ca.cium deposition ca. irreversibly a.sist inhibition of tumors. However, a.tive regula.ion of ca.cium level through signa. tra.sduction of bioa.tive substa.ces ha. not been reported yet. In this study, novel neuropeptide-doxorubicin conjuga.es(NP-DOX) with lysosome-specific a.id response were described for neuropeptide Y_1 receptor(Y_1R)-overexpressed triple-nega.ive brea.t ca.cer. The delivery mecha.ism of NP-DOX wa. cla.ified tha. diverse pa.hwa.s were involved, including intra.ellula. a.d intercellula. tra.sport. Importa.tly, up-regula.ion of Y_1 R-media.ed intra.ellula. ca.cium level via.second messenger inositol triphospha.e wa. presented in NP-DOX trea.ed MDa.MB-231 cells. In vivo a.titumor effica.y demonstra.ed tha. NP-DOX showed less orga. toxicity a.d enha.ced tumor inhibition benefited from its controlled relea.e a.d Y_1R-media.ed ca.cium deposition, compa.ed with free DOX. This bioconjuga.e is a.proof-of-concept confirming tha. neuropeptide-media.ed control of signa.ing responses in neuropeptide-drug conjuga.es ena.les grea. potentia. for further a.plica.ions in tumor chemothera.y.

关键词： Neuropeptide-drug conjuga.e Tumor penetra.ion Ca.cium deposition Tumor inhibition Triple-nega.ive brea.t ca.cer

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