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Development and Validation of a Carbohydrate Metabolism-Related Model for Predicting Prognosis and Immune Landscape in Hepatocellular Carcinoma Patients

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Current Medical Science 2024年第4期44卷 771-788页

作者： Hong-xiang HUANG pei-yuan zhong Ping LI Su-juan PENG Xin-jing DING Xiang-lian CAI Jin-hong CHEN Xie ZHUI Zhi-hui luI Xing-yu TAO Yang-yang LIU Li CHEN Department of Oncology The First Affiliated Hospital of Nanchang UniversityNanchang330006China Jiangxi Institute of Respiratory Disease The First Affiliated Hospital of Nanchang UniversityNanchang330006China Department of Oncology Jiangxi Provincial People’s HospitalThe First Affiliated Hospital of Nanchang Medical CollegeNanchang330006China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Nanchang UniversityNanchang330006China

Objective The activities and products of carbohydrate metabolism are involved in key processes of ***,its relationship with hepatocellular carcinoma(HCC)is *** The cancer genome atlas(TCGA)-HCC and ICGC-LIRI-JP datasets were acquired via public *** expressed genes(DEGs)between HCC and control samples in the TCGA-HCC dataset were identified and overlapped with 355 carbohydrate metabolism-related genes(CRGs)to obtain differentially expressed CRGs(DE-CRGs).Then,univariate Cox and least absolute shrinkage and selection operator(LASSO)analyses were applied to identify risk model genes,and HCC samples were divided into high/low-risk groups according to the median risk ***,gene set enrichment analysis(GSEA)was performed on the risk model *** sensitivity of the risk model to immunotherapy and chemotherapy was also *** A total of 8 risk model genes,namely,G6PD,PFKFB4,ACAT1,ALDH2,ACYP1,OGDHL,ACADS,and TKTL1,were ***,the risk score,cancer status,age,and pathologic T stage were strongly associated with the prognosis of HCC *** the stromal score and immune score had significant negative/positive correlations with the risk score,reflecting the important role of the risk model in immunotherapy ***,the stromal and immune scores had significant negative/positive correlations with risk scores,reflecting the important role of the risk model in immunotherapy ***,we found that high-/low-risk patients were more sensitive to 102 drugs,suggesting that the risk model exhibited sensitivity to chemotherapy *** results of the experiments in HCC tissue samples validated the expression of the risk model *** Through bioinformatic analysis,we constructed a carbohydrate metabolism-related risk model for HCC,contributing to the prognosis prediction and treatment of HCC patients.

关键词： hepatocellular carcinoma carbohydrate metabolism the cancer genome atlas bioinformatics

Polygonatum sibiricum polysaccharides attenuated colitis via regulating gut microbiota mediated colonic NLRP3/ASC/Caspase-1/GSDMD signaling pathway

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Food Science and Human Wellness 2024年

作者： zhong-yu yuan Xin-yu Wang Jun Wang yuan Xu Jing Chen Shu-Qi yu Zhi-Ming Chen pei-lu Chen Ji-Xiao Zhu Wei-Feng Huang Guang-Hui Xu Li-Tao Yi Department of Chemical and Pharmaceutical Engineering， College of Chemical Engineering， Huaqiao University Xiamen Medicine Research Institute Research Center of Traditional Chinese Medicine Resources and Ethnic Medicine， Jiangxi University of Chinese Medicine Department of Gastroenterology and Hepatology， The First Affiliated Hospital of Xiamen University， Xiamen University Institute of Pharmaceutical Engineering， Huaqiao University Fujian Provincial Key Laboratory of Biochemical Technology， Huaqiao University

Polygonatum sibiricum has long been a popular functional food in Asia， known for its anti-inflammatory properties. However， its efficacy in alleviating colitis has yet to be investigated. This study aimed to explore the therapeutic potential of Polygonatum sibiricum polysaccharides (PSP) in dextran sulfate sodium (DSS)-induced colitis， focusing on the related pyroptosis mechanisms. Scanning electron microscopy (SEM) analysis showed that PSP possesses a smooth surface with no pore structure and a dense， lamellar structure adorned with numerous spherical entities. PSP treatment significantly reduced colitis symptoms and decreased pro-inflammatory cytokines， likely through suppression of the TLR4/NF-κB signaling pathway. Additionally， PSP attenuated NLRP3/ASC/Caspase-1/GSDMD-mediated pyroptosis and mitochondria damage in the colon， while enhanced the expression of tight junction and adherens junction proteins. Microbiota sequencing showed that PSP increased the abundance of phylum Bacteroidota and genus such as Muribaculaceae， Lactobacillus， Clostridia， and Lachnospiraceae， while decreased the phylum Proteobacteria and the genus Enterobacter， Escherichia-Shigella， and Blautia. In conclusion， this study demonstrates that PSP exerts the potential therapeutic role against colitis， which was mediated by the regulation of gut microbiota and the inhibition of colonic NLRP3/ASC/Caspase-1/GSDMD signaling pathway.

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Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated,EGFR-mutated,advanced non-small cell lung cancer:data froma randomized phase III trial(AENEAS)

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Cancer Communications 2024年第9期44卷 1005-1017页

作者： Shun lu Xiaorong Dong Hong Jian Jianhua Chen Gongyan Chen yuping Sun Yinghua Ji ZipingWang Jianhua Shi Junguo lu Shaoshui Chen Dongqing Lv Guojun Zhang Chunling Liu juan Li Xinmin yu zhong Lin Zhuang yu ZhehaiWang Jiuwei Cui Xingxiang Xu Jian Fang Jifeng Feng Zhi Xu RuiMa Jie Hu Nong Yang Xiangdong Zhou XiaohongWu Chengping Hu Zhihong Zhang You lu Yanping Hu Liyan Jiang Qiming wang Renhua Guo Jianying Zhou Baolan Li Chunhong Hu Wancheng Tong Helong Zhang LinMa yuan Chen Zhijun Jie yu Yao Longzhen Zhang JieWeng Weidong Li Jianping Xiong Xianwei Ye Jianchun Duan Haihua Yang Meili Sun HongyingWei JiaweiWei Zheyu Zhang QiongWu Department of Medical Oncology Shanghai Chest Hospital Shanghai JiaoTong UniversityShanghaiP.R.China Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology-Chest Hunan Cancer Hospital&The Affiliated Cancer Hospital of Central South University Xiangya School of MedicineChangshaHunanP.R.China Thoracic OncologyMedicine HarbinMedical University Cancer HospitalHarbinHeilongjiangP.R.China Department of Oncology Jinan Central HospitalJinanShandongP.R.China Department of Oncology First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanP.R.China Department of Chest Medicine Beijing Cancer HospitalBeijingP.R.China Department of Internal Medicine Linyi Cancer HospitalLinyiShandongP.R.China Department of Respiratory Medicine Nantong Tumor HospitalNantongJiangsuP.R.China Department of Oncology Binzhou Medical University HospitalBinzhouShandongP.R.China Breath Internal Medicine Taizhou Hospital of Zhejiang ProvinceLinhaiZhejiangP.R.China Department of Respiration The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of lung Internal Medicine Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiangP.R.China Department of Thoracic Oncology Sichuan Cancer HospitalChengduSichuanP.R.China Thoracic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)HangzhouZhejiangP.R.China Department of Thoracic Oncology The Fifth Subsidiary Sun Yat-sen University HospitalZhuhaiGuangdongP.R.China Department of Oncology The Affiliated Hospital of QingdaoUniversityQingdaoShandongP.R.China Department of Oncology Shandong Cancer HospitalJinanShandongP.R.China Department of Oncology The First BethuneHospital of Jilin UniversityChangchunJilinP.R.China Department of Respiration Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhouJiangsuP.R.China Department of Internal

Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor(EGFR)-mutated advanced non-small cell lung cancer(NSCLC).Metastatic disease in the central nervous system(CNS)remains a challenge in the management of *** study aimed to compare the efficacy of aumolertinib versus gefitinib among patients with baseline CNS metastases in the ANEAS ***:Eligible patients were enrolled and randomly assigned in a 1:1 ratio to orally receive either aumolertinib or gefitinib in a double-blinded *** with asymptomatic,stable CNS metastases were ***-up imaging of the same modality as the initial CNS imaging was performed every 6 weeks for 15 months,then every *** responsewas assessed by a neuroradiological blinded,independent central review(neuroradiological-BICR).The primary endpoint for this subgroup analysis was CNS progression-free survival(PFS).Results:Of the 429 patients enrolled and randomized in the ANEAS study,106 patients were found to have CNS metastases(CNS Full Analysis Set,cFAS)at baseline by neuroradiological-BICR,and 60 of them had CNS target lesions(CNS Evaluable for Response,cEFR).Treatment with aumolertinib significantly prolonged median CNS PFS compared with gefitinib in both cFAS(29.0 vs.8.3 months;hazard ratio[HR]=0.31;95%confidence interval[CI],0.17-0.56;P<0.001)and cEFR(29.0 vs.8.3 months;HR=0.26;95%CI,0.11-0.57;P<0.001).The confirmed CNS overall response rate in cEFRwas 85.7%and 75.0%in patients treated with aumolertinib and gefitinib,*** risk analysis showed that the estimated probability of CNS progression without prior non-CNS progression or death was consistently lower with aumolertinib than with gefitinib in patients with and without CNSmetastases at *** new safety findings were ***:The

关键词： aumolertinib brain metastasis non-small cell lung cancer third-generation EGFR-TKI

基于葡萄糖氧化酶作用的黑小麦粉面团理化性质及加工性能研究

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粮油食品科技 2024年第5期32卷 51-59页

作者：姜钰璐邓利玲陈圆圆刘丁与张诗沛周斌钟耕西南大学食品科学学院重庆400715 重庆高等医药专科学校重庆401331 重庆市粮油质量监督检验站重庆400040 川渝共建特色食品重庆市重点实验室重庆400716

为改善黑小麦粉面团理化特性及加工性能,探究葡萄糖氧化酶(GOD)添加量对黑小麦粉糊化、热机械学面团拉伸、流变学等特性及微观结构的影响,并从蛋白质组分变化角度加以解释。结果表明:适量添加GOD能显著降低黑小麦粉面团中游离巯基的含量... 详细信息

为改善黑小麦粉面团理化特性及加工性能,探究葡萄糖氧化酶(GOD)添加量对黑小麦粉糊化、热机械学面团拉伸、流变学等特性及微观结构的影响,并从蛋白质组分变化角度加以解释。结果表明:适量添加GOD能显著降低黑小麦粉面团中游离巯基的含量,同时增加二硫键的含量,从而加深蛋白质交联程度,对黑小麦粉面团理化特性有显著改善作用。当GOD添加量为0.8%时,面团结构和性质改善效果最佳,且此时麦醇溶蛋白与麦谷蛋白比值(0.81)接近最适比(1.0)。此研究为开发黑小麦食品、提高其食用品质提供了一定参考。

关键词：黑小麦粉面团葡萄糖氧化酶理化特性加工性能

单宁酸改性石墨/聚酰亚胺复合材料的制备及摩擦学性能

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化工新型材料 2024年第3期52卷 71-75,80页

作者：陆洋郑佳佳俞娟王晓东黄培南京工业大学化工学院材料化学工程国家重点实验室南京211800

通过非共价键改性的方法,将单宁酸(TA)包覆在石墨表面,从而改善石墨(Gr)与聚酰亚胺(PI)基体的界面相容性,并考察单宁酸修饰前后的石墨对PI基复合材料摩擦学性能的影响。结果表明:采用TA对Gr进行非共价修饰可以提高Gr与PI基体中的相容性... 详细信息

通过非共价键改性的方法,将单宁酸(TA)包覆在石墨表面,从而改善石墨(Gr)与聚酰亚胺(PI)基体的界面相容性,并考察单宁酸修饰前后的石墨对PI基复合材料摩擦学性能的影响。结果表明:采用TA对Gr进行非共价修饰可以提高Gr与PI基体中的相容性和界面结合强度,进而提高复合材料的耐热性能和摩擦学性能,当复合体系中TA@Gr质量分数为15%时,材料的摩擦系数达到0.206,磨损率为3.71×10^(-14)m^(3)/(N·m),分别比纯PI降低了21.4%和62.8%,分别比PI/Gr复合材料降低了6.36%和14.7%。

关键词：单宁酸石墨相容性聚酰亚胺摩擦

汉黄芩素-苦豆碱共晶在大鼠体内的药代动力学研究

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药学学报 2024年第9期59卷 2606-2611页

作者：解钟水贾春雪梁雨璐赵孝俊李彬冉韩京中王红娟黄建梅北京中医药大学中药学院北京100102

药物共晶是改善药物理化性质和生物学特性的前沿技术,但目前关于药物共晶体内代谢的研究较少。本文在前期制备汉黄芩素-苦豆碱共晶的基础上,进一步研究汉黄芩素药物共晶在正常大鼠体内的药代动力学。首先,建立超高效液相色谱-串联质谱方... 详细信息

药物共晶是改善药物理化性质和生物学特性的前沿技术,但目前关于药物共晶体内代谢的研究较少。本文在前期制备汉黄芩素-苦豆碱共晶的基础上,进一步研究汉黄芩素药物共晶在正常大鼠体内的药代动力学。首先,建立超高效液相色谱-串联质谱方法(ultra-performanceliquidchromatography-tandemmass spectrometry,UPLC-MS/MS)同时测定大鼠血浆中汉黄芩素及其代谢产物汉黄芩苷含量,并进行方法学考察;将该方法应用于汉黄芩素-苦豆碱共晶在大鼠体内的药代动力学研究。结果显示,汉黄芩素及其代谢产物汉黄芩苷在1~800ng·mL^(-1)内线性关系良好,在此范围内的精密度、准确度、基质效应及稳定性考察均符合生物分析要求;相较于汉黄芩素直接给药,以共晶形式给药后,大鼠体内汉黄芩素及其代谢产物汉黄芩苷的C_(max)分别提高至7.44倍和9.15倍,AUC_(0-t)提高至1.67倍和3.72倍,汉黄芩素口服生物利用度提高为187.66%。汉黄芩素-苦豆碱共晶可显著提高汉黄芩素及其代谢产物汉黄芩苷的C_(max)、AUC及口服生物利用度,为汉黄芩素的临床应用提供了新思路。本研究经北京中医药大学实验动物伦理审查委员会批准(批准编号为:BUCM-2023032307-1148)。

关键词：汉黄芩素苦豆碱药物共晶药代动力学生物利用度

钝化剂对湘中稻田土壤Cd有效性及水稻Cd积累的影响

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湖南师范大学自然科学学报 2024年第1期47卷 32-41页

作者：杨佳曹雪莹谭长银蔡润众程学宇刘路路黄硕霈湖南师范大学地理科学学院中国长沙410081 长沙学院乡村振兴研究院中国长沙410022

为了揭示不同钝化剂对湘中地区不同程度Cd污染土壤Cd有效性及水稻Cd积累的影响,筛选出适合湘中地区中轻度Cd污染农田安全利用的钝化材料,采用盆栽和大田两种试验方式,分别研究了巯基化海泡石(SGP)、海泡石复合材料(ISS)、铁改性木本泥炭... 详细信息

为了揭示不同钝化剂对湘中地区不同程度Cd污染土壤Cd有效性及水稻Cd积累的影响,筛选出适合湘中地区中轻度Cd污染农田安全利用的钝化材料,采用盆栽和大田两种试验方式,分别研究了巯基化海泡石(SGP)、海泡石复合材料(ISS)、铁改性木本泥炭(IMP)和生物有机肥(OF)4种钝化材料对中度和轻度Cd污染土壤pH值、土壤有机质、土壤Cd形态、土壤有效态Cd含量以及不同时期水稻各部位Cd含量的影响。研究结果表明:1)在盆栽试验中:与CK相比,施用钝化剂的处理,在水稻分蘖期、灌浆期与成熟期,土壤有效态Cd含量分别降低1.59%~25.40%,3.57%~26.79%和15.67%~37.32%;与CK相比,水稻成熟期弱酸提取态Cd含量降低了4.29%~7.27%,可氧化态Cd含量提高了6.86%~11.00%;水稻根系、茎和稻壳中Cd含量分别降低26.45%~44.34%,35.79%~59.01%和21.24%~45.36%;2)在大田试验中:与CK相比,在水稻分蘖期与灌浆期,ISS和OF处理土壤pH值提高了约0.3个pH单位;水稻灌浆期与成熟期土壤有效态Cd含量分别降低15.11%~35.95%和27.19%~49.24%;水稻根系、茎叶和糙米中Cd含量分别降低61.29%~84.86%,41.00%~84.42%和26.47%~85.29%;水稻根—茎、茎—壳转运系数分别为0.18~0.31和0.32~1.11。研究结果表明,施用SGP、IMP和ISS处理均可显著降低中轻度Cd污染土壤的有效态Cd含量,影响水稻各部位对Cd的转运吸收,从而降低植株对土壤Cd的吸收和积累,使Cd在叶片中富集而减少在稻米中的积累。ISS处理可显著提高土壤pH值。

关键词：复合材料 Cd 水稻有效性吸收转运赋存形态

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基础有机化学电子效应教学实践

遵义师范学院学报 2024年第5期26卷 118-121,127页

作者：陈新陈丽娟汪玉娟钟煜皖西学院材料与化工学院安徽六安237012 安徽省仿生与传感重点实验室安徽六安237012

电子效应是“基础有机化学”课程教学的主线之一,采用集中学习与分散学习相结合的教学方法,有利于学生深入全面地理解有机物的性质。绪论部分集中学习电子效应的分类和概念、电子效应对酸碱性、稳定性、亲核性、反应活性、反应方向和反... 详细信息

电子效应是“基础有机化学”课程教学的主线之一,采用集中学习与分散学习相结合的教学方法,有利于学生深入全面地理解有机物的性质。绪论部分集中学习电子效应的分类和概念、电子效应对酸碱性、稳定性、亲核性、反应活性、反应方向和反应机理的影响,培养学生自觉运用电子效应分析相关问题的思维习惯。在各类官能团化合物的教学中分散学习电子效应,帮助学生深刻理解和熟练运用电子效应。实践证明,将电子效应贯穿于“基础有机化学”教学的始终能显著提高学生的学习效率,提升教师的教学效果。

关键词：电子效应诱导效应共轭效应超共轭效应

Recent Advances in Research on Hepadnaviral Infection in the Woodchuck Model

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Virologica Sinica 2008年第2期23卷 107-115页

作者： Ina Schulte E-juan ZHANG zhong-ji MENG Rong-juan pei Mengji lu Michael Roggendorf Institute of Virology University Hospital Essen University of Duisburg-Essen 45122 Essen Germany Department of Microbiology Tongji Medical College Huazhong University of Science and Technology Wuhan430030 China State Key Lab of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan430071 China

The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B.

关键词： Chronic hepatitis B Woodchuck hepatitis virus (WHV) Hepatitis B virus (HBV)