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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos Josémiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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社会热力学——访谈Iaki balos

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城市建筑 2015年第31期12卷 103-113页

作者： Iaki balos Marta Barrera Altemir Javier Caro Domínguez miguel Gentil Fernández 米格.马德拉.多诺索李媛 balos+Sentkiewicz事务所哈佛大学设计研究生院

能量、人流、感受、知识、人类进化、金钱、空间转换、光线……任何事物之间都可以相互转化,所以可以从渗透性、公差、焓或熵的概念来理解它们。最近几年Iaki balos从热力学视角,发展出了一种最实用且通用的现代建筑设计方法。与其... 详细信息

能量、人流、感受、知识、人类进化、金钱、空间转换、光线……任何事物之间都可以相互转化,所以可以从渗透性、公差、焓或熵的概念来理解它们。最近几年Iaki balos从热力学视角,发展出了一种最实用且通用的现代建筑设计方法。与其说这是一种建造方法,不如说是一种知识组织的方式、一个学科的新工具。这种设计方法不仅使Iaki balos在 balos+Sentkiewicz事务所中的新创作更惹人注目,同时也使人们从一个全新的视角重新审视他之前的所有作品,包括和juan Herreros一起合作的作品。从业以来, balos的作品中既有投资充裕的也有捉襟见肘的,既有高技术也有低技术的解决办法(甚至会同时出现)。

关键词：空间转换现代建筑设计 aki balos 洛格罗尼奥人类进化知识组织 landscape 建造方法 instance

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The Administration of Ocoxin Increases the Quality of Life of Patients with Advanced Epithelial or Metastatic Ovarian Cancer Undergoing Neoadjuvant Chemotherapy

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Journal of Cancer Therapy 2022年第9期

作者： karen lópez miguel daniel ricardo martínez ávila llisetálvarezpérez gisselle martínez rabasa alejandro linchenat lambert roberto esperón noa lisandra heredia manzano margarita de quesada amigó rafael i. reyes velázquez danay corrales otero ramon ropero toirac idelmis curbelo heredia mircea betancourt cabeza tania a. agrelo ramos rosa maría muñoz reyes juan jesús lence anta rosalía fuentes sosa karelia silvera candó kirenia silva rodríguez zaida lastre sosa mayte robaina garcía eduardo sanz david marquez

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菲律宾Zambales蛇绿岩套的再研究:对其特提斯来源的启示(英文)

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地球学报 2012年第S1期33卷 58-58页

作者： Karlo L.QUEANO Carla B.DIMALANTA Graciano P.YUMUL JR Decibel V.FAUSTINO-ESLAVA Edanjarlo J.MARQUEZ Noelynna T.RAMOS Keisuke ISHIDA Shigeyuki SUZUKI Ricky C.SALAPARE Michael Peter M.SANCHEZ juan miguel R.GUOTANA Rose Ann B.CONCEPCION School of Civil Environmental and Geological EngineeringMapua Institute of TechnologyMuralla St.IntramurosManilaPhilippines Rushurgent Working Group National Institute of Geological SciencesUniversity of the Philippines-DilimanQuezon CityPhilippines Monte Oro Resources and Energy Inc. Makati CityPhilippines School of Environmental Science and Management University of the Philippines-Los Ba osLagunaPhilippines Department of Physical Sciences and Mathematics University of the Philippines-ManilaPadre FauraManilaPhilippines Institute of Socio-Arts and Sciences University of TokushimaJapan Department of Earth Sciences Okayama UniversityJapan Department of Civil Engineering Adamson UniversityManilaPhilippines

A number of geological studies have already been conducted on the Zambales Ophiolite Complex(ZOC), a north-south trending complete ophiolite sequence exposed in the western portion of Central Luzon, *** works recogniz... 详细信息

关键词： Zambales Ophiolite Complex Tethyan radiolarians Philippines

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Pathogenesis of glomerular haematuria

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World Journal of Nephrology 2015年第2期4卷 185-195页

作者： Claudia Yuste Eduardo Gutierrez Angel Manuel Sevillano Alfonso Rubio-Navarro juan Manuel Amaro-Villalobos Alberto Ortiz Jesus Egido Manuel Praga juan Antonio Moreno Department of Nephrology Gregorio Mara?on Hospital Department of Nephrology Renal Vascular and Diabetes Research LabⅡS-Fundación Jiménez Díaz Autonoma University (UAM) Renal Vascular and Diabetes Research LabⅡS-Fundación Jiménez DíazAutonoma University (UAM)

Haematuria was known as a benign hallmark of some glomerular diseases, but over the last decade, new evidences pointed its negative implications on kidney disease progression. Cytotoxic effects of oxidative stress induced by hemoglobin, heme, or iron released from red blood cells may account for the tubular injury observed in human biopsy specimens. However, the precise mechanisms responsible for haematuria remain unclear. The presence of red blood cells(RBCs) with irregular contours and shape in the urine indicates RBCs egression from the glomerular capillary into the urinary space. Therefore glomerular haematuria may be a marker of glomerular filtration barrier dysfunction or damage. In this review we describe some key issues regarding epidemiology and pathogenesis of haematuric diseases as well as their renal morphological findings.

关键词：肾小球血红素治疗方法临床分析

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Hepatoprotective effect of Geranium schiedeanum against ethanol toxicity during liver regeneration

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World Journal of Gastroenterology 2015年第25期21卷 7718-7729页

作者： Eduardo Madrigal-Santillán Mirandeli Bautista juan A Gayosso-De-Lucio Yadira Reyes-Rosales Araceli Posadas-Mondragón ángel Morales-González Marvin A Soriano-Ursúa Jazmín García-Machorro Eduardo Madrigal-Bujaidar Iselaálvarez-González JoséA Morales-González Laboratorio de Medicina de Conservación Escuela Superior de MedicinaInstituto Politécnico NacionalPlan de San Luis y Díaz MirónMéxico DF 11340México área Académica de Farmacia ICSaUniversidad Autónoma del Estado de HidalgoPachuca de Sotoestado de HidalgoCP 42000México Escuela Superior de Cómputo Instituto Politécnico NacionalAv.Juan de Dios Bátiz s/n esquina Miguel Othón de MendizabalUnidad Profesional Adolfo López Mateos Departamento de Fisiología Escuela Superior de MedicinaInstituto Politécnico NacionalPlan de San Luis y Díaz MirónColonia Casco de Santo TomasDel.Miguel HidalgoMéxico DF 11340México Laboratorio de Genética Escuela Nacional de Ciencias BiológicasInstituto Politécnico NacionalAv.Wilfrido MassieuUnidad A.López MateosZacatencoMéxico DF 07700México

AIM: To evaluate the effect of an extract of Geranium schiedeanum(Gs) as a hepatoprotective agent against ethanol(Et OH)-induced toxicity in rats. METHODS: Male Wistar rats weighing 200-230 g were subjected to a 70% partial hepatectomy(PH); they were then divided into three groups(groups 1-3). During the experiment, animals in group 1 drank only water. The other two groups(2-3) drank an aqueous solution of Et OH(40%, v/v). Additionally, rats in group 3 received a Gs extract daily at a dose of 300 mg/kg body weight intragastically. Subsequently, to identify markers of liver damage in serum, alanine aminotransferase, aspartate aminotransferase, albumin and bilirubin were measured by colorimetric methods. Glucose, triglyceride and cholesterol concentrations were also determined. In addition, oxidative damage was estimated by measuring lipid peroxidation [using thiobarbituric-acid reactive substances(TBARS)] in both plasma and the liver and by measuring the total concentration of antioxidants in serum and the total antioxidant capacity in the liver. In addition, a liver mass gain assessment, total DNA analysis and a morpho-histological analysis of the liver from animals in all three groups were performed and compared. Finally, the number of deaths observed in the three groups was ***: Administration of the Geranium shiedeanum extract significantly reduced the unfavorable effect of ethanol on liver regeneration(restitution liver mass: PHEt OH group 60.68% vs PH-Gs-Et OH group 69.22%). This finding was congruent with the reduced levels of hepatic enzymes and the sustained or increased levels of albumin and decreased bilirubin in serum. The extract also modified the metabolic processes that regulate glucose and lipid levels, as observed from the serum measurements. Lower antioxidant levels and the liver damage induced by Et OH administration appeared to be mitigated by the extract, as observed from the TBARs(PH-Et OH group 200.14 mmol/mg vs PH-Gs-Et OH group 5

关键词： Geranium schiedeanum Liver regeneration Ethanol Free radicals Nuclear factor erythroid-2-relatedfactor 2

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Structural and Vibrational Study of 2-（Quinolin-8-yloxy）-Acetic Acid based on FT-IR-Raman Spectroscopy and DFT Calculations

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Journal of Chemistry and Chemical Engineering 2011年第8期5卷 747-758页

作者： Gerardo R. Arganaraz Elida Romano juan Zinczuk Silvia A. Brandan Catedra de Quimica General. Instituto de Quimica Inorganiea. Faeultad de Bioquimica Quimica y Farmacia. Universidad Nacional de Tucuman. Ayacucho 471. 4000. San Miguel de Tucuman. Tucumcin. R. Argentina Instituto de Qulmica Rosario （CONICET-UNR） Facultad de Ciencias Bioquimicas y Farmacduticas Suipacha 531 2000 Rosario Santa Fe. R. Argentina

We have prepared the 2-(quinolin-8-yloxy)-acetic acid and characterized it by infrared and Raman spectroscopies in the solid phase. The Density Functional Theory (DFT) method, together with the 6-31G* and 6-311++G** basis sets, show that three stable molecules, for the anhydrous and monohydrated compounds were theoretically determined in the gas phase, and that probably the two more stable conformations are present in the solid phase of the monohydrated compound. The harmonic vibrational wavenumbers for the optimized geometries were calculated at B3LYP/6-31G*and B3LYP/6-311++G** levels. For a complete assignment of all the observed bands in the vibrational spectra the DFT calculations were combined with Pulay’s scaled quantum mechanical force field (SQMFF) methodology in order to fit the theoretical wavenumber values to the experimental ones. The characteristics of the electronic delocalization of all structures of both forms were performed by using natural bond orbital (NBO), while the corresponding topological properties of electronic charge density are analysed by employing Bader’s atoms in molecules theory (AIM).

关键词： DFT计算拉曼光谱振动波数乙酸基喹啉氧基结构红外

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Comparative study of breast cancer in Mexican and Mexican-American women

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Health 2010年第9期2卷 1040-1048页

作者： Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-Pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera juan Manuel Castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora Antonio Oceguera-Villanueva miguel Angel Ortiz Martinez Laura Perez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health University of ArizonaTucsonUSA Departamento de Investigaciones Cientificas y Tecnologicas Universidad de SonoraHermosilloMexico University of Texas M.D.Anderson Cancer Center HoustonUSA Departamento de Fisiologia Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Instituto Tecnologico de Sonora Ciudad ObregónMexico Instituto Mexicano del Seguro Social HermosilloMexico Instituto Mexicano del Seguro Social CMNOGuadalajaraJalisco Centro de Investigacion en Alimentacion y Desarrollo HermosilloMexico Instituto Mexicano del Seguro Social Ciudad ObregonMexico OPD Hospital Civil de Guadalajara GuadalajaraMexico Departamento de Salud Publica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMexico Maricopa Medical Center Department of SurgeryPhoenixUSA University of North Carolina Lineberger Cancer CenterChapel HillUSA Arizona Cancer Center and Department of Family and Community Medicine University of ArizonaTucsonUSA Instituto Jalisciense de Cancerologia GuadalajaraMexico

Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关键词： Binational Study Breast Cancer Hispanics Mexico United States

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Endophytic bacteria in grass crop growth promotion and biostimulation

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Grass Research 2021年第1期1卷 33-41页

作者： James F.White Xiaoqian Chang Kathryn L.Kingsley Qiuwei Zhang Peerapol Chiaranunt April Micci Fernando Velazquez Matthew Elmore Sharron Crane Shanjia Li Jiaxin Lu María Carmen Molina Natalia González-Benítez miguel J.Beltrán-García Kurt P.Kowalski Department of Plant Biology Rutgers UniversityNew BrunswickNew Jersey 08901USA Department of Biochemistry and Microbiology Rutgers UniversityNew BrunswickNew Jersey 08901USA Department of Bioengineering Lanzhou University of TechnologyLanzhou 730050P.R.China College of Agro-grassland Science Nanjing Agricultural UniversityNanjing 210095P.R.China Department of Biology GeologyApplied Physics and Inorganic ChemistryKing Juan Carlos UniversityMadrid 28032Spain Department of Biotechnology and Environmental Sciences Autonomous University of GuadalajaraGuadalajara 45140Mexico U.S.Geological Survey Great Lakes Science CenterAnn ArborMichigan 48105USA.

Plants naturally carry microbes on seeds and within seeds that may facilitate development and early survival of *** crops have lost seed-vectored microbes in the process of domestication or during seed storage and seed *** microbes from wild plants were used by pre-modern cultures to re-acquire beneficial seed *** some companies have developed or are developing the use of microbes obtained from soils or plant sources to stimulate plant development and *** of these biostimulant microbes are endophytic in *** products also include humic substances,which appear to function as signal molecules in plants,triggering increased internalization of soil microbes into root cells and *** addition,protein coatings on seeds fuel the growth of seed surface-vectored microbes,increasing microbial activity around and within *** this article,we provide evidence of the endophytic nature of many biostimulant microbes,and suggest that many of the beneficial effects of microbial biostimulants stem from their action as endophytes or as participants or stimulants of rhizophagy cycle activity.

关键词： crops soil promotion

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多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识

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中国呼吸与危重监护杂志 2021年第2期20卷 77-84页

作者：王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi 中国人民解放军空军军医大学航空航天医学系陕西西安710032 Department of Cardiac Sciences King Abdulaziz Medical City and King Abdullah International Medical Research Center 不详

新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征... 详细信息

新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。

关键词：体征和症状肺炎公共卫生体系呼吸系统首次报道专家共识疫情

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