Pathogenesis of glomerular haematuria

作     者：Claudia Yuste Eduardo Gutierrez Angel Manuel Sevillano Alfonso Rubio-Navarro Juan Manuel Amaro-Villalobos Alberto Ortiz Jesus Egido Manuel Praga Juan Antonio Moreno 

作者机构：Department of NephrologyGregorio Mara?on Hospital Department of Nephrology RenalVascular and Diabetes Research LabⅡS-Fundación Jiménez Díaz Autonoma University (UAM) RenalVascular and Diabetes Research LabⅡS-Fundación Jiménez DíazAutonoma University (UAM) 

出 版 物：《World Journal of Nephrology》 (世界肾病学杂志（英文版）)

年 卷 期：2015年第4卷第2期

页      面：185-195页

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 

基　　金：Supported by Grants from FIS (Programa Miguel Servet:CP10/00479,PI13/00802 and PI14/00883) Spanish Society of Nephrology to Moreno JA Institute of Research Queen Sophia,FRIAT and ISCIII fund PI10/00072 to Egido J. 

主　　题：肾小球 血红素 治疗方法 临床分析 

摘      要：Haematuria was known as a benign hallmark of some glomerular diseases, but over the last decade, new evidences pointed its negative implications on kidney disease progression. Cytotoxic effects of oxidative stress induced by hemoglobin, heme, or iron released from red blood cells may account for the tubular injury observed in human biopsy specimens. However, the precise mechanisms responsible for haematuria remain unclear. The presence of red blood cells(RBCs) with irregular contours and shape in the urine indicates RBCs egression from the glomerular capillary into the urinary space. Therefore glomerular haematuria may be a marker of glomerular filtration barrier dysfunction or damage. In this review we describe some key issues regarding epidemiology and pathogenesis of haematuric diseases as well as their renal morphological findings.