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The molecular interaction of ADAMTS-1 and fibulin-1 and its potential contribution to breast cancer biology

Journal of Cancer Metastasis and Treatment 2019年第5期4卷 1-15页

作者： Yamina Mohamedi Tania Fontanil Teresa cobo Jose A.Vega juan l.cobo Olivia García-Suárez juan cobo Santiago Cal Alvaro J.Obaya Departamento de Bioquímica y Biología Molecular Universidad de OviedoOviedo 33006AsturiasSpain Instituto Universitario de Oncología IUOPAUniversidad de OviedoOviedo 33006AsturiasSpain Departamento de Investigación Clínica OrdonezOviedo 33012AsturiasSpain Instituto Asturiano de Odontología Universidad de OviedoOviedo 33006AsturiasSpain Departamento de Cirugía y Especialidades Médico-Quirúrgicas Universidad de OviedoOviedo 33006AsturiasSpain Departamento de Morfología y Biología Celular Facultad de MedicinaUniversidad de OviedoOviedo 33006AsturiasSpain Facultad de Ciencias de la Salud Universidad Autónoma de ChileProvidenciaSantiago 7500912Chile Servicio de Cirugía Maxilofacial Hospital Universitario Central de Asturias(HUCA)Oviedo 33011AsturiasSpain Departamento de Biología Funcional Area de FisiologíaUniversidad de OviedoOviedo 33006AsturiasSpain

Aim: Fibulins and ADAMTSs are two families of extracellular matrix proteins implicated in key functional and pathological processes. The fact that the fibulin-1 and ADAMTS-1 proteins interact raises new questions about the roles of these extracellular matrix proteins in modulating tumor progression. Herein, we described the functional implications of the interaction between fibulin-1 and ADAMTS-1 on the behavior of breast cancer cell lines. Methods: Fibulin-1 and ADAMTS-1 were exogenously expressed in MCF-7 and MDA-MB-231 cell lines to assay the effect of their interaction in cellular properties. Results: ADAMTS-1 expression exacerbates tumor effects in terms of proliferation, invasion and mammosphere formation. In contrast, the simultaneous expression of ADAMTS-1 and fibulin-1 impairs these effects. The analysis of the expression of both proteins in human breast cancer tissue arrays provides new insights into the complex roles of fibulin-1 and ADAMTS-1 in this type of tumor. ;Conclusion: Our results suggests that the interaction between ADAMTS-1 and fibulin-1 induces a pronounced anti-tumoral effect.

关键词： ADAMTS-1 fibulin-1 cell migration cell proliferation breast cancer MCF-7 MDA-MB-231

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： Danko Jeremic lydia Jiménez-Díaz juan D.Navarro-lópez NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(AD)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in AD,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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An ultra-wideband circularly polarized microstrip patch antenna loaded with split-ring resonator

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Optoelectronics letters 2025年

作者： WANG Shike XIA Dan lü lianrong QIN juan WANG Meng REN Haiping School of Integrated Circuit Science and Engineering， Tianjin University of Technology

In this paper， the effect of a single-opening split-ring resonator （SRR） structure on the performance of ultra-wideband （UWB） microstrip patch antenna （MPA） is studied. Here a UWB MPA based on partial grounding is proposed， and the SRR structure is utilized to optimize other characteristics of the low-profile microstrip antenna while ensuring the bandwidth and gain remain unchanged. The proposed metamaterial structure， consisting of a 2 × 2 array of SRR， is loaded on the reverse side of the substrate. The volume of the proposed antenna is 61.6×67.6×1.5mm3. According to simulation and experimental results， the proposed microstrip antenna loaded with 2×2 SRRs performs better than that without SRR structure. It produces an operating band of 1.62 GHz-8 GHz while achieving circular polarization characteristics with an axial ratio （AR） bandwidth of 3.92 GHz-4.57 GHz. In addition， the performance of the proposed antenna is superior to relevant works of literature The antenna can be widely utilized in wireless communication systems.

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Tractable XMl data exchange via relations

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Frontiers of Computer Science 2012年第3期6卷 243-263页

作者： Rada CHIRKOVA leonid lIBKIN juan l. REUTTER Department of Computer Science North Carolina State University Raleigh NC 27606 USA School of Informatics University of Edinburgh Edinburgh EH8 9AB UK

We consider data exchange for XMl documents： given source and target schemas, a mapping between them, and a document conforming to the source schema, construct a target document and answer target queries in a way that is consistent with the source information. The problem has pri- marily been studied in the relational context, in which data- exchange systems have also been built. Since many XMl documents are stored in relations, it is natural to consider using a relational system for XMl data exchange. However, there is a complexity mismatch between query answering in relational and in XMl data exchange. This indicates that to make the use of relational systems pos- sible, restrictions have to be imposed on XMl schemas and mappings, as well as on XMl shredding schemes. We isolate a set of five requirements that must be ful- filled in order to have a faithful representation of the XMl data-exchange problem by a relational translation. We then demonstrate that these requirements naturally suggest the in- lining technique for data-exchange tasks. Our key contribu- tion is to provide shredding algorithms for schemas, docu- ments, mappings and queries, and demonstrate that they en- able us to correctly perform XMl data-exchange tasks using a relational system.

关键词： data exchange XMl XMl shredding inlining

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Existence and Uniqueness of Fixed Point in Partially Ordered Sets and Applications to Ordinary Differential Equations

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Acta Mathematica Sinica,English Series 2007年第12期23卷 2205-2212页

作者： juan J.NIETO RosanaRODRGUEZ-lPEZ Departamento de Análisis Matemático Facultad de MatemáticasUniversidad de Santiago de Compostela

We prove some fixed point theorems in partially ordered sets, providing an extension of the Banach contractive mapping theorem. Having studied previously the nondecreasing case, we consider in this paper nonincreasing mappings as well as non monotone mappings. We also present some applications to first-order ordinary differential equations with periodic boundary conditions, proving the existence of a unique solution admitting the existence of a lower solution.

关键词： fixed point partially ordered set first-order differential equation lower and upper solutions

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Cloud Classification and Distribution of Cloud Types in Beijing Using Ka-Band Radar Data

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Advances in Atmospheric Sciences 2019年第8期36卷 793-803页

作者： juan HUO Yongheng BI Daren lü Shu DUAN Key laboratory for Atmosphere and Global Environment Observation Chinese Academy of Sciences

A cloud clustering and classification algorithm is developed for a ground-based Ka-band radar system in the vertically pointing mode. Cloud profiles are grouped based on the combination of a time–height clustering method and the k-means clustering method. The cloud classification algorithm, developed using a fuzzy logic method, uses nine physical parameters to classify clouds into nine types: cirrostratus, cirrocumulus, altocumulus, altostratus, stratus, stratocumulus, nimbostratus,cumulus or cumulonimbus. The performance of the clustering and classification algorithm is presented by comparison with all-sky images taken from January to June 2014. Overall, 92% of the cloud profiles are clustered successfully and the agreement in classification between the radar system and the all-sky imager is 87%. The distribution of cloud types in Beijing from January 2014 to December 2017 is studied based on the clustering and classification algorithm. The statistics show that cirrostratus clouds have the highest occurrence frequency(24%) among the nine cloud types. High-level clouds have the maximum occurrence frequency and low-level clouds the minimum occurrence frequency.

关键词： clouds clustering algorithm classification algorithm radar cloud type

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Optimal design of culling compensation policy under the African swine fever——Based on simulations of typical pig farms in China

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Journal of Integrative Agriculture 2023年第2期22卷 611-622页

作者： GUO Shi-juan lü Xin-ye HU Xiang-dong Institute of Agricultural Economics and Development Chinese Academy of Agricultural SciencesBeijing 100081P.R.China Institute of Agricultural Information and Economy Shandong Academy of Agricultural SciencesJinan 250000P.R.China

This paper aims to optimize the culling compensation policy from a micro perspective through scenario *** on an investigation of 273 pig farms in eight regions,four typical pig farms were constructed according to farm size and breeding mode,representing the swine producers in ***,a decision objective function of pig farms facing suspected African swine fever(ASF)outbreaks was *** study used a mathematical programming model to design and simulate scenarios based on compensation standards and local implementation levels,aiming to incentivize pig farms to report *** results show that the optimal decisions on epidemic reports differed among typical farms and by herd daily *** results suggest the following adjustments for optimizing culling compensation policies:(1)to set culling compensation standards based on the market value and(2)to maintain a high level of epidemic surveillance capability in the animal husbandry and veterinary sector.

关键词： culling compensation African swine fever epidemic report mathematical programming model

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Effect of relative humidity on the desulfurization performance of calcium-based desulfurizer

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Journal of Environmental Sciences 2024年第4期138卷 179-188页

作者： juan lǖ Yu Fu Haiyan Yu HuanWang Zhe Wang Haiyan Chen School of Environment and Resource Southwest University of Science and TechnologyMianyang 621010China Guangyuan Emergency Management bureau Guangyuan 628000China

low desulfurization efficiency impedes the wide application of dry desulfurization technology,which is a low-cost and simple process,and one significant solution is the development and manufacture of high-performance *** this study,firstly,a steam jet mill was used to digest quicklime;then,we utilized numerical simulation to study the flow field distribution and analyze the driving factors of quicklime digestion;and lastly,the desulfurization performance of the desulfurizer was evaluated under different relative *** results show that the desulfurizer prepared via the steam jet mill had better apparent activity than traditional ***,the entire jet flow field of the steam jet mill is in a supersonic and highly turbulent flow state,with high crushing intensity and good particle acceleration *** contact with the nascent surface maximizes the formation of slaked *** experiments demonstrated that the operating time with 100%desulfurization efficiency and the“break-through”time for the desulfurizer prepared via the steam jet mill is longer than that of traditional desulfurizers,and has significant advantages,especially at low flue gas relative *** with traditional desulfurizers,the desulfurizer prepared via steam jet mill expands the range of acceptable flue gas temperature,and the failure temperature is 1.625 times that of traditional *** work breaks through the technical bottleneck of low dry desulfurization efficiency,which is an important step in pushing forward the application of dry desulfurization.

关键词： Dry desulfurization Relative humidity Desulfurization efficiency High-efficiency desulfurizer Quicklime digestion

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The Extension Degree Conditions for Fractional Factor

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Acta Mathematica Sinica,English Series 2020年第3期36卷 305-317页

作者： Wei GAO Wei Fan WANG juan l.G.GUIRAO School of Information Science and Technology Yunnan Normal UniversityKunming 650500P.R.China Department of Mathematics Zhejiang Normal UniversityJinhua 321004P.R.C hina Departamento de Matematica Aplicada y Estadistica.Universidad Politecnica de Cartagena Hospital de Marina30203-CartagenaRegion de MurciaSpain

In Gao’s previous work, the authors determined several degree conditions of a graph which admits fractional factor in particular settings. It was revealed that these degree conditions are tight if b = f(x) = g(x) = a for all vertices x in G. In this paper, we continue to discuss these degree conditions for admitting fractional factor in the setting that several vertices and edges are removed and there is a difference Δ between g(x) and f(x) for every vertex x in G. These obtained new degree conditions reformulate Gao’s previous conclusions, and show how Δ acts in the results. Furthermore,counterexamples are structured to reveal the sharpness of degree conditions in the setting f(x) =g(x) + Δ.

关键词： Fractional factor degree condition independent set

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Oligodendroctyes:the forgotten players of diabetes pathophysiology

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Neural Regeneration Research 2024年第11期19卷 2349-2350页

作者： juan Antonio lópez-Villodres Beatriz García-Díaz Departamento Fisiología Humana Histología HumanaAnatomía Patológica y Educación Física y DeportivaFacultad de MedicinaUniversidad de MálagaMálagaSpain UGC Neurociencia.Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina(IBIMA Plataforma Bionand) MálagaSpain

Oligodendrocytes(Ols),glial cells that provide myelin sheaths to axons in the central nervous system(CNS),have a dual ***,this myelin fatty cover around the axons protects the nerves and is crucial for the saltatory propagation of action *** and not less important,Ols provide trophic support to neurons and ***,Ol metabolism is important for Ol well-being and the proper accomplishment of their functions,and Ol metabolism energetics directly affect the energy metabolism of neighboring neurons.

关键词： metabolism nerves myelin

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