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Comprehensive Bile Acid Profiling of ABCB4-mutated Patients and the Prognostic Role of Taurine-conjugated􀀖􀄮􀀏􀀙􀄮􀀏􀀚􀄮􀀏􀀔􀀕􀄮􀀐􀀷􀁈􀁗􀁕􀁄􀁋􀁜􀁇􀁕􀁒􀁛􀁜􀁏􀁄􀁗􀁈􀁇􀀃􀀥􀁌􀁏􀁈􀀃􀀤􀁆􀁌􀁇􀀃􀁌􀁑􀀃􀀦􀁋􀁒􀁏􀁈􀁖􀁗􀁄􀁖􀁌􀁖

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Journal of Clinical and Translational Hepatology 2024年第2期12卷 151-161页

作者： Teng liu Ren-Xue Wang Jun Han Zhong-Die li Jonathan ASheps li-juan Zheng Xiao-Xiao Xu Victor ling Jian-She Wang Department of Pediatrics Shanghai Medical CollegeFudan UniversityThe Center for Pediatric Liver DiseasesChildren’s Hospital of Fudan UniversityShanghaiChina BC Cancer Agency VancouverBritish Columbia V5Z 1L3Canada University of Victoria-Genome BC Proteomics Center University of VictoriaVictoriaBritish Columbia V8Z 7X8Canada Shanghai Key laboratory of Birth Defect ShanghaiChina

Background and Aims:We asked if comprehensive bile acid profiling could provide insights into the physiopathology of ABCB4-mutated patients and evaluated the prognostic value of taurine-conjugated tetrahydroxylated bile acid(tauro-THBA)in ***:Serum bile acid profiles were evaluated in 13 ABCB4-mutated patients with 65 healthy controls by ultra-high-performance liquid chromatography/multiple-reaction monitoring-mass spectrometry(UPlC/MRM-MS).The concentration of tauro-THBA was compared between ABCB4-mutated patients with different *** areas under the curve(AUCs)of tauro-THBA were compared between ABCB11-mutated patients with native liver survival and those who died or underwent liver transplantation before 3 years of age by receiver operating characteristic curve(ROC),with another patient cohort for further ***:The overall hydrophobicity indices of bile acids in ABCB4-mutated patients(12.99±3.25 m)were significantly lower than those of healthy controls(14.02±1.74 m,pmarkedly increased bile acid modifications including conjugation,sulfation,and *** in the tauro-THBA concentration in ABCB4-mutated patients with different prognoses were not *** analysis indicated that levels of tauro-THBA oflded an AUC of 0.900 with a sensitivity of 80%and specificity of 87.5%for ABCB11-mutated patients with different prognoses(p=0.0192).Of the 15 patients with good prognosis,14 were classified correctly and four of the five patients with a poor prognosis were classified correctly(14:15 vs.1:5,p=0.005)with tauro-THBA as a ***:Tauro-THBA concentration may be a biomarker for predicting the clinical outcome in low gammaglutamyl transferase intrahepatic cholestasis patients.

关键词： Bile acids MDR3 BSEP PFIC liquid chromatography-mass spectrometry

Accelerating Deprotonation Kinetics of RuO_(2)for Efficient Acidic Water Oxidation

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Renewables 2024年第3期2卷 204-212页

作者： Hongnan Jia Zhichang liao juan Zhu Wei luo College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072

The development of a highly efficient noniridium-based oxygen evolution reaction catalyst is the key to realizing large-scale commercial application of the proton-exchange membrane water ***_(2)is the most promising alternative to IrO_(2),but if usually suffers from lattice-oxygenmediated corrosion and sluggish proton transfer kinetics under acidic ***,we propose an effective strategy of embedding RuO_(2)nanoparticles into a N-doped carbon support,termed as RuO_(2)-NC,to simultaneously prevent Ru dissolution and accelerate the bridging-oxygen-assisted deprotonation *** obtained RuO_(2)-NC electrocatalyst presents high activity with an overpotential of 159 mV to reach 10 ma cm^(−2) and remarkable stability for over 240 *** investigation and theoretical calculations reveal that the electron-rich NC substrate,as an electron donor,provides a buffered charge compensation to protect RuO_(2)from excessive oxidation and lattice oxygen loss by switching into a conventional adsorbate evolution mechanism(AEM).More importantly,the activated bridging oxygen(Obri)sites can facilitate the deprotonation of*OOH intermediates,leading to an optimized bridging-oxygen-assisted deprotonation AEM pathway.

关键词： acidic oxygen evolution reaction electronic donation NC support RuO_(2) adsorbate evolution mechanism bridging-oxygen-assisted deprotonation

Fine-mapping of a candidate gene for web blotch resistance in Arachis hypogaea l.

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Journal of Integrative Agriculture 2024年第5期23卷 1494-1506页

作者： Xiaohui Wu Mengyuan Zhang Zheng Zheng Ziqi Sun Feiyan Qi Hua liu juan Wang Mengmeng Wang Ruifang Zhao Yue Wu Xiao Wang Hongfei liu Wenzhao Dong Xinyou Zhang College of Agronomy Henan Agricultural UniversityZhengzhou 450046China Henan Academy of Agricultural Sciences/Henan Academy of Crop Molecular Breeding/Key laboratory of Oil Crops in Huang-Huai-Hai Plain Ministry of Agriculture and Rural Affairs/Henan Provincial Key Laboratory for Oil Crop ImprovementZhengzhou 450002China The Shennong laboratory Zhengzhou 450002China Shangqiu Academy of Agricultural and Forestry Sciences Shangqiu 476000China

Peanut(Arachis hypogaea l.)is a globally important oil *** blotch is one of the most important foliar diseases affecting peanut,which results in serious yield losses *** web blotch-resistant peanut varieties is the most effective and economically viable method for minimizing yield losses due to web *** the current study,a bulked segregant analysis with next-generation sequencing was used to analyze an F2:3 segregating population and identify candidate loci related to web blotch *** on the fine-mapping of the candidate genomic interval using kompetitive allele-specific PCR(KASP)markers,we identified a novel web blotch resistance-related locus spanning approximately 169 kb on chromosome *** region included four annotated genes,of which only Arahy.35VVQ3 had a non-synonymous single nucleotide polymorphism in the coding region between the two *** markers(Chr.16.12872635 and Chr.16.12966357)linked to this gene were shown to be co-segregated with the resistance of peanut web blotch by 72 randomly selected recombinant inbred lines(RIl),which could be used in marker-assisted breeding of resistant peanut varieties.

关键词： peanut web blotch bulked segregant analysis KAsP markers resistant gene

姜黄素通过降低miR-135b-5p和FEN1表达增强卵巢癌OVCAR-3细胞顺铂敏感性

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江苏大学学报（医学版） 2024年第4期34卷 324-330页

作者：马蓉李娟王芳新疆维吾尔自治区中医医院妇科新疆乌鲁木齐830099

目的:探究姜黄素对卵巢癌OVCAR-3细胞顺铂敏感性的影响及其潜在机制。方法:(1)体外常规培养卵巢癌亲本细胞OVCAR-3并构建顺铂耐药OVCAR-3/DDP细胞,将OVCAR-3细胞分为Control(常规培养)、DDP-1(1μmol/l顺铂)、DDP-5(5μmol/l顺铂)、DDP-... 详细信息

目的:探究姜黄素对卵巢癌OVCAR-3细胞顺铂敏感性的影响及其潜在机制。方法:(1)体外常规培养卵巢癌亲本细胞OVCAR-3并构建顺铂耐药OVCAR-3/DDP细胞,将OVCAR-3细胞分为Control(常规培养)、DDP-1(1μmol/l顺铂)、DDP-5(5μmol/l顺铂)、DDP-10(10μmol/l顺铂)、DDP-15(15μmol/l顺铂)、DDP-20(20μmol/l顺铂)、DDP-30(30μmol/l顺铂)、姜黄素+DDP-1(20μmol/l姜黄素+1μmol/l顺铂)、姜黄素+DDP-5(20μmol/l姜黄素+5μmol/l顺铂)、姜黄素+DDP-10(20μmol/l姜黄素+10μmol/l顺铂)、姜黄素+DDP-15(20μmol/l姜黄素+15μmol/l顺铂)、姜黄素+DDP-20(20μmol/l姜黄素+20μmol/l顺铂)、姜黄素+DDP-30组(20μmol/l姜黄素+30μmol/l顺铂);将OVCAR-3/DDP细胞分为Control(常规处理)、DDP-10(10μmol/l顺铂)、DDP-20(20μmol/l顺铂)、DDP-30(30μmol/l顺铂)、DDP-40(40μmol/l顺铂)、DDP-50(50μmol/l顺铂)、DDP-60(60μmol/l顺铂)、姜黄素+DDP-10(20μmol/l姜黄素+10μmol/l顺铂)、姜黄素+DDP-20(20μmol/l姜黄素+20μmol/l顺铂)、姜黄素+DDP-30(20μmol/l姜黄素+30μmol/l顺铂)、姜黄素+DDP-40(20μmol/l姜黄素+40μmol/l顺铂)、姜黄素+DDP-50(20μmol/l姜黄素+50μmol/l顺铂)、姜黄素+DDP-60组(20μmol/l姜黄素+60μmol/l顺铂),CCK-8法检测细胞活性,计算顺铂半数抑制浓度(IC 50),筛选顺铂和姜黄素的合适作用浓度。(2)将OVCAR-3细胞分为对照组(常规处理)、DDP组(20.5μg/ml顺铂)、姜黄素组(20μmol/l姜黄素)、姜黄素+DDP组(20μmol/l姜黄素+20.5μg/ml顺铂);将OVCAR-3/DDP细胞分为对照组(常规处理)、DDP组(42.1μg/ml顺铂)、姜黄素组(20μmol/l姜黄素)、姜黄素+DDP组(20μmol/l姜黄素+42.1μg/ml顺铂),采用流式细胞术检测细胞凋亡率,实时荧光定量(qRT)-PCR检测miR-135b-5p表达,qRT-PCR和免疫印迹法分别检测瓣状核酸内切酶-1(flap endonuclease 1,FEN1)mRNA和蛋白表达。结果:相同顺铂浓度时,与DDP组比较,姜黄素+DDP联合组OVCAR-3和OVCAR-3/DDP细胞活性明显降低(P均l和42.1μg/ml。与OVCAR组或OVCAR/DDP组相较,姜黄素或顺铂致OVCAR-3和OVCAR-3/DDP细胞凋亡率明显增加(P均<0.001),两者联合作用时效果更显著。此外,姜黄素或顺铂处理可明显降低OVCAR-3和OVCAR-3/DDP细胞中miR-135b-5p表达及FEN1表达(P<0.01或<0.001),两者联合时效果更显著。结论:姜黄素可增强卵巢癌OVCAR-3细胞顺铂敏感性,其可能与降低miR-135b-5p和FEN1表达相关。

关键词：姜黄素 miR-135b-5p 瓣状核酸内切酶-1(FEN1) 卵巢癌顺铂敏感性

Deficiency of circadian gene Per2 blocks luteolin-induced adipocyte browning in mice through weakening liver PPARα/RXRα/FGF21 pathway

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Food Science and Human Wellness 2024年

作者： Shanshan Shui juan Chen Yan lin Jingjing Yuan Xin Wang Xian Zhang Jian liu lei Zheng Engineering Research Center of Bio-process， Ministry of Education， Hefei University of Technology Key laboratory of Health Risk Factors for Seafood of Zhejiang Province， College of Food Science and Pharmacy， Zhejiang Ocean University School of Food and Biological Engineering， Hefei University of Technology

During the development of diet-induced obesity， the change of energy matebolism is closely related to the function of the circadian clock in mammals. luteolin (lU)， one of the most common natural flavonoids riched in many edible plants， can ameliorate obesity by activating adipose tissue browning， but its effect on circadian clock in this process remains poorly understood. Here we found that dietary lU improved circadian misalignment of energy expenditure in high-fat diet (HFD)-fed wild-type (WT) mice. Moreover， dietary lU efficiently elevated UCP1 levels in adipose tissue during the dark period， which was similar to the lU-increased hepatic PER2 expressions. Hepatic PPARα/RXRα/FGF21 pathway was rhythmically elevated by dietary lU in HFD-fed WT mice， whereas the promotion was inhibited in Per2-/-mice. Meanwhile， Per2 deletion abolished the effects of dietary lU on adipose tissue browning in HFD-fed mice. Further， lU treatment directly activated PPARα/RXRα/FGF21 signaling in primary cultured hepatocytes from WT mice rather than Per2-/-mice. Taken together， the deletion of the core clock component Per2 impedes lU-induced adipose tissue browning through weakening PPARα/RXRα/FGF21 pathway in mice， providing a new insight into the interplay of energy metabolism and circadian clock for the anti-obesity activity of lU.

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A widely used nonionic surfactant with desired functional groups as aqueous electrolyte additives for stabilizing Zn anode

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Rare Metals 2024年第8期43卷 3692-3701页

作者： Yue-Xian Song Xiao-Feng Wang Cai-Bin liu Kai-Xuan Guo Xu-Huan Guo Xiao-Bin Zhong Yao-Hui Zhang Kai Wang Hui-juan Guo li-Xin Zhang Jun-Fei liang School of Energy and Power Engineering North University of ChinaTaiyuan 030051China Key laboratory of Green Chemical Process of Ministry of Education Hubei Key Laboratory of Novel Chemical Reactor and Green Chemical TechnologySchool of Chemical Engineering and PharmacyWuhan Institute of TechnologyWuhan 430073China Shanxi Provincial Key laboratory for High Performance Battery materials and Devices Taiyuan 030051China

Aqueous Zn-ion batteries(AZIBs) have emerged as potential candidates for li-ion batteries due to their intrinsic safety and high ***,metallic Zn anodes encounter dendrite growth and water-induced corrosion,rendering poor stability and severe irreversibility at the electrode/electrolyte interface during *** stabilize the Zn anode,we report a low-cost and effective nonionic surfactant,Tween-20 polymer,as an electrolyte additive for *** Tween-20,sequential oxyethylene groups tended to be preferentially adsorbed on the Zn electrode to form a shielding layer for regulating uniform Zn ***,the hydrophobic hendecyl chains prevented H_(2)O-induced corrosion on the Zn anode *** from the desired functional groups,when only trace amounts of Tween-20(0.050 g·l^(-1)) were used,the Zn anode displayed good cycling stability over 2170 h at10 ma·cm^(-2) and a high average Coulombic efficiency of98.94% over 1000 *** Tween-20 polymer can also be effectively employed in MnO_(2)/Zn full *** their toxicity,price and amount of usage,these surfactant additives provide a promising strategy for realizing the stability and reversibility of high-performance Zn anodes.

关键词： Zn anode Dendrite growth Tween-20 polymer Surfactant additive Aqueous electrolyte

Review Integration of smartphone technology and artificial intelligence for advanced ophthalmic care:A systematic review

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Advances in Ophthalmology Practice and Research 2024年第3期4卷 120-127页

作者： Kai Jin Yingyu li Hongkang Wu Yih Chung Tham Victor Koh Yitian Zhao Ryo Kawasaki Andrzej Grzybowski juan Ye Eye Center The Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang Provincial Key Laboratory of OphthalmologyZhejiang Provincial Clinical Research Center for Eye DiseasesZhejiang Provincial Engineering Institute on Eye DiseasesHangzhouChina Centre for Innovation and Precision Eye Health National University of SingaporeSingapore Department of Ophthalmology National University of SingaporeSingapore Singapore Eye Research Institute Singapore National Eye CentreSingapore Ophthalmology and Visual Science Academic Clinical Program Duke-NUS Medical SchoolSingapore Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Ningbo Eye Hospital NingboChina Zhejiang International Scientific and Technological Cooperative Base of Biomedical.materials and Technology Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Zhejiang Engineering Research Center for Biomedical.materials Ningbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina Division of Public Health Department of Social MedicineGraduate School of MedicineOsaka UniversityOsakaJapan Artificial Intelligence Center for Medical Research and Application Osaka University HospitalOsakaJapan Institute for Research in Ophthalmology Foundation for Ophthalmology DevelopmentPoznanPoland A R T I C L

Background:The convergence of smartphone technology and artificial intelligence(AI)has revolutionized the landscape of ophthalmic care,offering unprecedented opportunities for diagnosis,monitoring,and management of ocular ***,there is a lack of systematic studies on discussing the integration of smart-phone and AI in this *** text:This review includes 52 studies,and explores the integration of smartphones and AI in ophthalmology,delineating its collective impact on screening methodologies,disease detection,telemedicine initiatives,and patient *** collective findings from the curated studies indicate promising performance of the smartphone-based AI screening for various ocular diseases which encompass major retinal diseases,glaucoma,cataract,visual impairment in children and ocular surface ***,the utilization of smartphone-based imaging modalities,coupled with AI algorithms,is able to provide timely,efficient and cost-effective screening for ocular *** modality can also facilitate patient self-monitoring,remote patient monitoring and enhancing accessibility to eye care services,particularly in underserved *** involving data pri-vacy,algorithm validation,regulatory frameworks and issues of trust are still need to be ***,evaluation on real-world implementation is imperative as well,and real-world prospective studies are currently ***:Smartphone ocular imaging merged with AI enables earlier,precise diagnoses,personalized treat-ments,and enhanced service accessibility in eye *** is crucial to navigate ethical and data security challenges while responsibly leveraging these innovations,promising a potential revolution in care access and global eye health equity.

关键词： Artificial intelligence Smartphone imaging Ophthalmology Telemedicine Ocular disease management

Network Pharmacology and Experimental Study of MomordicineⅠand MomordicineⅡfrom Bitter Melon Saponins in Inhibiting Fat Accumulation

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Biomedical and Environmental Sciences 2024年第5期37卷 526-530页

作者： HUANG Shi Ting lI Shang Yuan lI Xin Yu ZHU Ying ZHU lin ZHANG Jia Yan ZHAO Yan Sheng DAGlIA maria XIAO Xiang BAI juan School of Food and Biological Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Department of Pharmacy University of Napoli FedericoⅡVia D.Montesano 4980131 NaplesItaly International Research Center for Food Nutrition and Safety Jiangsu UniversityZhenjiang 212013JiangsuChina

Bitter melon(Momordica Charania l.),a member of the Cucurbitaceae family,is widely distributed across tropical and subtropical ***,an important functional component of bitter melon,has been proven to exert hypoglycemic effects similarly to insulin,and also possesses lipid-lowering properties inhibiting preadipocyte differentiation and fat synthesis^([1]).

关键词： melon Momordica subtropical

Bat-derived oligopeptide lE6 inhibits the contact-kinin pathway and harbors anti-thromboinflammation and stroke potential

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Zoological Research 2024年第5期45卷 1001-1012页

作者： li-Na Cha juan Yang Jin-Ai Gao Xin lu Xiao-long Chang Rebecca Caroline Thuku Qi liu Qiu-Min lu Dong-Sheng li Ren lai Ming-Qian Fang Engineering laboratory of Peptides of Chinese Academy of Sciences Key Laboratory of Bioactive Peptides of Yunnan ProvinceKIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesNational Resource Center for Non-Human PrimatesNational Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Key Laboratory of Genetic Evolution&Animal ModelsSino-African Joint Research Centerand New Cornerstone Science LaboratoryKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China School of Molecular Medicine Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhouZhejiang 310024China First Affiliated Hospital of Kunming Medical University KunmingYunnan 650032China

Thrombosis and inflammation are primary contributors to the onset and progression of ischemic *** contact-kinin pathway,initiated by plasma kallikrein(PK)and activated factor XII(FXIIa),functions bidirectionally with the coagulation and inflammation cascades,providing a novel target for therapeutic drug development in ischemic *** this study,we identified a bat-derived oligopeptide from Myotis myotis(Borkhausen,1797),designated lE6(leu-Ser-Glu-Glu-Pro-Glu,702 Da),with considerable potential in stroke therapy due to its effects on the contact kinin ***,lE6 demonstrated significant inhibitory effects on PK and FXIIa,with inhibition constants of 43.97μmol/l and 6.37μmol/l,*** vitro analyses revealed that lE6 prolonged plasma recalcification time and activated partial thromboplastin *** murine models,lE6 effectively inhibited carrageenan-induced mouse tail thrombosis,FeCl3-induced carotid artery thrombosis,and photochemically induced intracerebral ***,lE6 significantly decreased inflammation and stroke injury in transient middle cerebral artery occlusion ***,the low toxicity,hemolytic activity,and bleeding risk of lE6,along with its synthetic simplicity,underscore its clinical *** conclusion,as an inhibitor of FXIIa and PK,lE6 offers potential therapeutic benefits in stroke treatment by mitigating inflammation and preventing thrombus formation.

关键词： PK FXIIa Anti-thromboinflammation Ischemic stroke therapies Oligopeptide