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Perfluorocarbon in vitreoretinal surgery and preoperative bevacizumab in diabetic tractional retinal detachment

World Journal of diabetes 2014年第5期5卷 724-729页

作者： J Fernando Arevalo Martin A Serrano juan d arias From the Retina division Wilmer Eye Institute Johns Hopkins University School of Medicine Baltimore MD 21287 United States the Vitreoretinal division King Khaled Eye Specialist Hospital Riyadh 11462 Saudi Arabia division of Ophthalmology Faculty of Medicine and Health Sciences University of Stellenbosch Stellenbosch 7600 South Africa the Retina and Vitreous Service Clinica Oftalmologica Centro Caracas Caracas 1010 Venezuela

AIM: To describe the en bloc perfluorodissection(EBPd) technique and to demonstrate the applicabilityof using preoperative intravitreal bevacizumab duringsmall-gauge vitreoretinal surgery(23-gauge transconjunctival sutureless vitrectomy) in eyes with advancedproliferative diabetic retinopathy(PdR) with tractionalretinal detachment(TRd).METHOdS: This is a prospective, interventional caseseries. Participants included 114(eyes) with advancedproliferative diabetic retinopathy and TRd. EBPd wasperformed in 114 eyes(consecutive patients) during23-gauge vitrectomy with the utilization of preoperativebevacizumab(1.25 mg/-0.05 mL). Patients mean age was 45 years(range, 21-85 years). Surgical time had a mean of 55 min(Range, 25-85 min). Mean follow up of this group of patients was 24 mo(range, 12-32 mo). Main outcome measures included best-corrected visual acuity(BCVA), retinal reattachment, and ***: Anatomic success occurred in 100%(114/-114) of eyes. Significant visual improvement [≥ 2 Early Treatment diabetic Retinopathy Study(ETdRS) lines] was obtained in 69.2%(79/-114), in 26 eyes(22.8%) BCVA remained stable, and in 8 eyes(7%) BCVA decreased(≥ 2 ETdRS lines). Final BCVA was 20/-50 or better in 24% of eyes, between 20/-60 and 20/-400 in 46% of eyes, and worse than 20/-400 in 30% of eyes. Complications included cataract in 32(28%) eyes, iatrogenic retinal breaks in 9(7.8%) eyes, vitreous hemorrhage requiring another procedure in 7(6.1%) eyes, and phthisis bulbi in 1(0.9%) ***: This study demonstrates the usefulne-ss of using preoperative intravitreal bevacizumab and EBPd during smallgauge vitreoretinal surgery in eyes with TRd in PdR.

关键词： Avastin Intravitreal bevacizumab Intravitreal injections Proliferative diabetic retinopathy Tractional retinal detachment Perfluorodissection Minimally invasive vitreoretinal surgery Vitrectomy

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei Yaru Qiao Jiming Xie Xianchao Pan juan Xing department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. during the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness

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Reassessing the AMPK-MTORC1 balance in autophagy in the central nervous system

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Neural Regeneration Research 2025年第11期20卷 3209-3210页

作者： Marta García-juan Mario Villa Irene Benito-Cuesta Lara Ordónez-Gutiérrez Francisco Wandosell Centro de Biología Molecular“Severo Ochoa”(CSIC-UAM) Nicolas Cabrera 1Universidad Autónoma de MadridMadridSpain Fisiología Animal Departamento de BiologíaFacultad de CienciasUniversidad Autónoma de MadridMadridSpain department of Clinical Neuroscience CMM Karolinska Universitetssjukhuset SolnaStockholmSweden departamento de Bioquímica y Biología Molecular Universidad Complutense de MadridMadridSpain Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas(CIBERNEd) MadridSpain

Autophagy is a cellular degradation and recycling system,indispensable for cellular and organ development,homeostasis,and *** cellular process is evolutionarily highly conserved to quality control of many proteins and dysfunctional organelles,which finally recycle components as amino *** process is effective during normal physiology as part of anabolism and plays an additional important role during starvation(dikic and Elazar,2018).different types of autophagy have been chara cterized based on their dynamic,mechanism of action,target substrates,and protein *** of them are macroautophagy(hereafter called"autophagy"),microa utophagy,and chape rone-media ted autophagy(Fleming et al.,2022).

关键词： homeostasis system hereafter

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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHdF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHdF2

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Image classification on smart agriculture platforms:Systematic literature review

Artificial Intelligence in Agriculture

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Artificial Intelligence in Agriculture 2024年第3期13卷 1-17页

作者： juan Felipe Restrepo-arias John W.Branch-Bedoya Gabriel Awad Escuela de Ciencias Aplicadas e Ingeniería Universidad EAFIT050022 MedellínColombia Facultad de Minas Universidad Nacional de Colombia050041 Sede MedellínColombia

In recent years,smart agriculture has gained strength due to the application of industry 4.0 technologies in *** a result,efforts are increasing in proposing artificial vision applications to solvemany ***,many of these applications are developed *** academic works have proposed solutions integrating image classification techniques through IoT *** this reason,this paper aims to answer the following research questions:(1)What are themain problems to be solvedwith smart farming IoT platforms that incorporate images?(2)What are the main strategies for incorporating image classification methods in smart agriculture IoT platforms?and(3)What are the main image acquisition,preprocessing,transmission,and classification technologies used in smart agriculture IoT platforms?This study adopts a Systematic Literature Review(SLR)*** searched Scopus,Web of Science,IEEE Xplore,and Springer Link databases from January 2018 to July *** we could identify five domains corresponding to(1)disease and pest detection,(2)crop growth and health monitoring,(3)irrigation and crop protectionmanagement,(4)intrusion detection,and(5)fruits and plant *** are three types of strategies to integrate image data into smart agriculture IoT platforms:(1)classification process in the edge,(2)classification process in the cloud,and(3)classification process *** main advantage of the first is obtaining data in real-time,and its main disadvantage is the cost of *** the other hand,the main advantage of the second is the ability to process high-resolution images,and its main disadvantage is the need for high-bandwidth ***,themixed strategy can significantly benefit infrastructure investment,butmostworks are experimental.

关键词： Smart agriculture Artificial vision Internet of things Artificial intelligence

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Mixed reality head mounted displays for enhanced indoor point cloud segmentation with virtual seeds

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Resilient Cities and Structures 2024年第3期3卷 43-52页

作者： juan C.Navares-Vázquez Pedro arias Lucía díaz-Vilarino Jesús Balado CINTECX Universidade de VigoGeoTECH group36310 VigoSpain

Mixed Reality(MR)Head Mounted displays(HMds)offer a hitherto underutilized set of advantages compared to conventional 3d *** benefits,inherent to MR-HMds albeit not originally intended for such appli-cations,encompass the freedom of hand movement,hand tracking capabilities,and real-time mesh *** study leverages these attributes to enhance indoor scanning *** primary innovation lies in the con-ceptualization of manual-positioned MR virtual seeds for the purpose of indoor point cloud segmentation via a region-growing *** proposed methodology is effectively implemented using the HoloLens 2 *** application is designed to enable the remote placement of virtual tags based on the user’s visual focus on the MR-HMd *** non-intrusive interface is further enriched with expedited tag saving and deletion functionalities,as well as augmented tag visualization through overlaying them on real-world *** assess the practicality of the proposed method,a comprehensive real-world case study spanning an area of 330 s^(2) is ***,the survey demonstrates remarkable efficiency,with 20 virtual tags swiftly deployed,each requiring a mere 2 s for precise ***,these virtual tags are employed as seeds in a region-growing algorithm for point cloud *** accuracy of virtual tag positioning is found to be exceptional,with an average error of 2.4±1.8 ***,the user experience is significantly enhanced,leading to improved seed positioning and,consequently,more accurate final segmentation results.

关键词： Augmented reality eXtended Reality Handheld mobile laser scanning Region growing Semantic segmentation

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Coherent modulation of chiral nonlinear optics with crystal symmetry

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Light(Science & Applications) 2022年第8期11卷 1909-1915页

作者： Yi Zhang Xueyin Bai juan arias Muñoz Yunyun dai Susobhan das Yadong Wang Zhipei Sun department of Electronics and Nanoengineering Aalto University02150EspooFinland QTF Centre of Excellence Department of Applied PhysicsAalto University02150EspooFinland Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of Technology100081BeijingChina

Light modulation is of paramount importance for photonics and optoelectronics. Here we report all-optical coherent modulation of third-harmonic generation (THG) with chiral light via the symmetry enabled polarization selectivity. The concept is experimentally validated in monolayer materials (MoS2) with modulation depth approaching ~100%, ultra-fast modulation speed (d wavelength-independence features. Moreover, the power and polarization of the incident optical beams can be used to tune the output chirality and modulation performance. Major performance of our demonstration reaches the fundamental limits of optical modulation: near-unity modulation depth, instantaneous speed (ultra-fast coherent interaction), compact footprint (atomic thickness), and unlimited operation bandwidth, which hold an ideal optical modulation solution for emerging and future nonlinear optical applications (e.g., interconnection, imaging, computing, and quantum technologies).

关键词： polarization interconnection symmetry

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Perspectives on the role of Pannexin 1 in neural precursor cell biology

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Neural Regeneration Research 2016年第10期11卷 1540-1544页

作者： juan C.Sanchez-arias Leigh E.Wicki-Stordeur Leigh Anne Swayne division of Medical Sciences University of Victoria Island Medical Program and department of Cellular and Physiological Sciences University of British Columbia

We recently reported that targeted deletion of Pannexin 1 in neural precursor cells of the ventricular zone impairs the maintenance of these cells in healthy and stroke-injured brain. Here we frame this exciting new finding in the context of our previous studies on Pannexin 1 in neural precursors as well as the close rela- tionship between Pannexin 1 and purinergic receptors established by other groups. Moreover, we identify important gaps in our understanding of Pannexin 1 in neural precursor cell biology in terms of the under- lying molecular mechanisms and functional/behavioural outcomes.

关键词： neural precursor ventricular zone pannexin ATP cytoskeleton proliferation phagoptosis

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Estimating Risk-aware Flexibility Areas for Electric Vehicle Charging Pools via AC Stochastic Optimal Power Flow

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Journal of Modern Power Systems and Clean Energy 2023年第4期11卷 1247-1256页

作者： juan S.Giraldo Nataly Bañol arias Pedro P.Vergara Maria Vlasiou Gerwin Hoogsteen Johann L.Hurink Energy Transition Studies Group Netherlands Organisation for Applied Scientific Research(TNO)Amsterdam1043 NTThe Netherlands department of Electrical Engineering Mathematics and Computer ScienceUniversity of TwenteEnschede7522 NBThe Netherlands Intelligent Electrical Power Grids Group Electrical EngineeringMathematics and Computer ScienceDelft University of TechnologyDelft2628 CDThe Netherlands

This paper introduces an AC stochastic optimal power flow(SOPF)for the flexibility management of electric vehicle(EV)charging pools in distribution networks under *** AC SOPF considers discrete utility functions from charging pools as a compensation mechanism for eventual energy not served to their charging *** application of the AC SOPF is described where a distribution system operator(dSO)requires flexibility to each charging pool in a day-ahead time frame,minimizing the cost for flexibility while guaranteeing technical *** areas are defined for each charging pool and calculated as a function of a risk parameter involving the uncertainty of the *** show that all players can benefit from this approach,i.e.,the dSO obtains a riskaware solution,while charging pools/tasks perceive a reduction in the total energy payment due to flexibility services.

关键词： Electric vehicle flexibility management stochastic optimal power flow(SOPF) risk awareness compensation mechanism

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