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Digestive and breast cancer patients managed during the first wave of COVID-19 pandemic:Short and middle term outcomes

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World Journal of Methodology 2024年第2期14卷 107-126页

作者： Jacobo Trébol Ana Carabias-Orgaz María Carmen Esteban-Velasco Asunción García-Plaza juan Ignacio González-Munoz Ana Belén Sánchez-Casado Felipe carlos Parreno-Manchado Marta Eguía-Larrea José Antonio Alcázar-Montero Cirugía General y del Aparato Digestivo Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain Cirugía Universidad de SalamancaSalamanca 37007SalamancaSpain Oftalmología Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain

BACKGROUND The first wave of coronavirus disease 2019(COVID-19)pandemic in Spain lasted from middle March to the end of June *** population was subjected to lockdown periods and scheduled surgeries were discontinued or reduced during variable *** our centre,we managed patients previously and newly diagnosed with *** established a strategy based on limiting perioperative social contacts,preoperative screening(symptoms and reverse transcriptionpolymerase chain reaction)and creating separated in-hospital COVID-19-free pathways for non-infected *** also adopted some practice modifications(surgery in different facilities,changes in staff and guidelines,using continuously changing personal protective equipment…),that supposed new *** To analyse cancer patients with a decision for surgery managed during the first wave,focalizing on outcomes and pandemic-related *** We prospectively included adults with a confirmed diagnosis of colorectal,oesophago-gastric,liver-pancreatic or breast cancer with a decision for surgery,regardless of whether they ultimately underwent *** analysed short-term outcomes[30-d postoperative morbimortality and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection]and outcomes after 3 years(adjuvant therapies,oncological events,death,SARS-CoV-2 infection and vaccination).We also investigated modifications to usual *** From 96 included patients,seven didn’t receive treatment that period and four never(3 due to COVID-19).Operated patients:28 colon and 21 rectal cancers;laparoscopy 53.6%/90.0%,mortality 3.57%/0%,major complications 7.04%/25.00%,anastomotic leaks 0%/5.00%,3-years disease-free survival(DFS)82.14%/52.4%and overall survival(OS)78.57%/76.2%.Six liver metastases and six pancreatic cancers:no mortality,one major complication,three grade A/B liver failures,one bile leak;3-year DFS 0%/33.3%and OS 50.0%/33.3%(liver metastases/pancreatic carcinoma).5 g

关键词： COVID-19 SARS-CoV-2 Colon cancer Rectal cancer Breast cancer Liver cancer Pancreatic cancer Gastric cancer Oesophageal cancer Surgery

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Assessment of effectiveness of oral supplementation of isolated fiber of carrot on metabolic parameters in mature rats

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Food Science and Human Wellness 2023年第6期12卷 2022-2028页

作者： Maria Rosana Ramirez Debora Manuale juan carlos Yori Instituto Universitario de Ciencias de la Salud Fundación BarcelóCONICETCenteno 710CP 3340Santo TomeCorrientesArgentina Consejo Nacional de Investigaciones Científi cas Técnicas(CONICET) Buenos Aires C1033AAJArgentina Instituto de Investigaciones en Catálisis y Petroquímica(INCAPE)FIQ-UNL-CONICET Parque Tecnológico Litoral Centro 3000Santa FeArgentina Facultad de Ingeniería Química Universidad nacional del Litoral 3000Santa FeArgentina

This present study was conducted to evaluate the metabolic effects of isolated fi ber of carrot supplementation in *** properties of fi ber were *** groups were as follows:animals fed a standard diet,control group;high fi ber supplementation(70 mg);low fi ber supplementation(35 mg);for 12 *** samples were collected at the time of sacrifi *** weights of heart,liver,kidneys and spleen of the experimental rats with respect to body weight were *** kits were used to determine serum glucose concentration,lipid profi le(cholesterol,HDL-cholesterol,triglycerides),and the two main aminotransferases glutamic-oxalacetic transaminase(GOT)/glutamate-pyruvate transaminase(GPT).A histopathological assay was performed on the heart,liver,and spleen tissues of *** with fi ber favors weight loss in female((242.03±23.73)-(197.81±10.45)g);and male rats((262.50±32.21)-(213.96±12.56)g and induces a decrease in glucose levels in the supplemented *** the exception of total high-density lipoprotein cholesterol,the other lipid fractions decrease signifi cantly in rats *** supplementation did not induce changes in the dissected organs of the supplemented *** conclusion supplementation of fiber,improves glucose control,lower plasma lipid concentrations and reduced body weight in normal rats.

关键词： Carrot fiber Oral supplementation Animal studies

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A systematic review of cytoreductive prostatectomy outcomes and complications in oligometastatic disease

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Asian Journal of Urology 2024年第2期11卷 208-220页

作者： Andrey Morozov Leonid Chuvalov Mark Taratkin Mikhail Enikeev Leonid Rapoport Nirmish Singla Eric Barret Elena Poddubskaya Maria Borodina Georg Salomon juan Gomez Rivas Dmitry Enikeev Institute for Urology and Reproductive Health Sechenov UniversityMoscowRussia Young Academic Urologists EAUthe Netherlands Department of Urology James Buchanan Brady Urological InstituteThe Johns Hopkins University School of MedicineBaltimoreUSA Department of Urology Institut Mutualiste MontsourisParisFrance Sechenov University MoscowRussia Hertsen Moscow Oncology Research InstituteMoscowRussia Hertsen Moscow Oncology Research Institute MoscowRussia Martini Clinic University Medical Center Hamburg-EppendorfHamburgGermany Department of Urology Clinico San Carlos University HospitalMadridSpain Department of Urology Medical University of ViennaViennaAustria

Objective: To analyze outcomes and complications of cytoreductive prostatectomy (CRP) for oligometastatic prostate cancer (PCa) in order to elucidate its role in this ***: We performed a systematic literature search using three databases (Medline, Scopus, and Web of Science). The primary endpoints were oncologic outcomes. The secondary endpoints were complication rates and functional ***: In all studies, overall survival was better or at least comparable variable in the groups with CRP compared to no local treatment. The greatest benefit from CRP in 5-year overall survival in one study was 67.4% for CRP versus 22.5% for no local treatment. Cancer-specific survival (CSS) showed the same trend. Several authors found significant benefits from CSS in the CRP group: from 79% vs. 46% to 100% vs. 61%. CRP was a predictor of better CSS (hazard ratio 0.264, p=0.004). Positive surgical margin rates differed widely from 28.6% to 100.0%. Urinary continence in CRP versus RP for localized PCa was significantly lower (57.4% vs. 90.8%, p<0.0001). Severe incontinence occurred seldom (2.5%-18.6%). Total complication rates after CRP differed widely, from 7.0% to 43.6%. Rates of grades 1 and 2 events prevailed. Patients on ADT alone also showed a considerable number of complications varying from 5.9% to 57.7%.Conclusion: CRP improves medium-term cancer control in patients with oligometastatic PCa. The morbidity and complication rates of this surgery are comparable with other approaches, but postoperative incontinence rate is higher compared with RP for localized disease.

关键词： Systematicreview Prostatecancer Oligometastatic Bone metastases Cytoreductive prostatectomy

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Woody plant taxonomic,functional,and phylogenetic diversity decrease along elevational gradients in Andean tropical montane forests:Environmental filtering and arrival of temperate taxa

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Plant Diversity 2024年第4期46卷 491-501页

作者： Guillermo Bañares-de-Dios Manuel J.Macía Gabriel Arellano Íñigo Granzow-de la Cerda Julia Vega-álvarez Itziar Arnelas carlos I.Espinosa Norma Salinas Luis Cayuela Departamento de Biología y Geología Física y Química InorgánicaUniversidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain Departamento de Biología Área de BotánicaUniversidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Centro de Investigación en Biodiversidad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Oikobit LLC ***AlbuquerqueNM87120USA Real Jardín Botánico–CSIC Plaza Murillo 2MadridES-28014Spain Departamento de Biología Animal EcologíaParasitologíaEdafología y Química AgrícolaUniversidad de SalamancaCalle Donantes de Sangre s/nSalamancaES-37007Spain Departamento de Biodiversidad Ecología y EvoluciónUniversidad Complutense de MadridCalle JoséAntonio Nováis 12Ciudad UniversitariaES-28040Spain Departamento de Ciencias Biológicas y Agropecuarias Universidad Técnica Particular de LojaA.P.11-01-608 LojaEcuador Sección Química Pontificia Universidad Católica del PerúA.P.Lima 32LimaPeru ECI School of Geography and EnvironmentUniversity of OxfordOX13QYOxfordshireUnited Kingdom Instituto de Investigación en Cambio Global(IICG-URJC) Universidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain

Mountains are paramount for exploring biodiversity patterns due to the mosaic of topographies and climates encompassed over short *** research has traditionally focused on taxonomic diversity when investigating changes along elevational gradients,but other facets should be *** first time,we simultaneously assessed elevational trends in taxonomic,functional,and phylogenetic diversity of woody plants in Andean tropical montane forests and explored their underlying ecological and evolutionary *** investigation covered four transects(traversing ca.2200 m a.s.l.) encompassing 114 plots of 0.1 ha across a broad latitudinal range(ca.10°).Using Hill numbers to quantify abundance-based diversity among 37,869 individuals we observed a consistent decrease in taxonomic,functional,and phylogenetic diversity as elevation increased,although the decrease was less pronounced for higher Hill *** exception was a slight increase in phylogenetic diversity when dominant species were *** decrease in taxonomic and functional diversity might be attributed to an environmental filtering process towards highlands,where the increasingly harsher conditions exclude species and functional ***,the differences in steepness decrease between Hill orders suggest that rare species disproportionately contribute to functional *** phylogenetic diversity the shifting elevational trend between Hill orders indicates a greater than previously considered influence in central Andean highlands of tropical lowlands originated species with strong niche conservatism relative to distantly related temperate *** could be explained by a decreasing presence and abundance of temperate,extratropical taxa towards the central Andes relative to northern or southern Andes,where they are more prevalent.

关键词： Altitudinal gradients Andes Environmentalﬁltering Out of the Tropical Lowlands Functional rarity Tropical Niche Conservatism

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A LoRa-based protocol for connecting IoT edge computing nodes to provide small-data-based services

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Digital Communications and Networks 2022年第3期8卷 257-266页

作者： Kiyoshy Nakamura Pietro Manzoni Alessandro Redondi Edoardo Longo Marco Zennaro juan-carlos Cano carlos T.Calafate Universitat Politécnica de Valéncia ValenciaSpain Abdus Salam International Centre for Theoretical Physics(ICTP) TriesteItaly Politecnico di Milano MilanItaly

Data is becoming increasingly *** regularly interact with a variety of structured data,ranging from SQLite databases on the phone to personal sensors and open government ***“digital traces left by individuals through these interactions”are sometimes referred to as“small data”.Examples of“small data”include driving records,biometric measurements,search histories,weather forecasts and usage *** this paper,we present a flexible protocol called LoRaCTP,which is based on LoRa technology that allows data“chunks”to be transferred over large distances with very low energy *** provides all the mechanisms necessary to make LoRa transfer reliable by introducing a lightweight connection setup and allowing the ideal sending of an as-long-as necessary data *** designed this protocol as communication support for small-data edge-based IoT solutions,given its stability,low power usage,and the possibility to cover long *** evaluated our protocol using various data content sizes and communication distances to demonstrate its performance and reliability.

关键词： Small data Edge computing LoRa IoT

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Biomedical overview of *** molecular modeling,synthesis mechanism,and supramolecular properties regarding melanoma therapy

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BIOCELL 2022年第6期46卷 1391-1415页

作者： juan carlos STOCKERT ALFONSO BLÁZQUEZ-CASTRO Facultad de Medicina Instituto de Oncología“Angel H.Roffo”Universidad de Buenos AiresBuenos AiresC1417DTBArgentina Centro Integrativo de Biología y Química Aplicada(CIBQA) Universidad Bernardo O’HigginsSantiago8370854Chile Departamento de Biología Facultad de CienciasUniversidad Autónoma de MadridMadrid28049Spain

Melanins represent one of the most ancient and important group of natural macromolecular *** have multiple biological roles in almost all organisms across the Phyla,examples being photoprotection,anti-oxidative action,radical scavenger activity,and heavy metal *** the biomedical point of view,melanocytes are involved in the origin of melanoma tumors,and the main therapeutic advances for their treatment have been revised in Part 1 of this *** chemical structure of eumelanin is a biological concern of great importance,and therefore,exploring theoretical molecular models and synthesis mechanisms will be here described,as well as molecular orbital features and supramolecular organization,which are responsible for the key properties that make these biological pigments so important,and so ***,this updated overview is devoted to describe present structural models and physico-chemical characteristics of eumelanin,in order to explain and utilize melanin properties on which new photothermal and ultrasonic protocols for melanoma treatment can be devised and applied.

关键词： Eumelanin Melanin models Melanin synthesis Molecular orbitals Supramolecular structure

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An unsupervised pattern recognition methodology based on factor analysis and a genetic-DBSCAN algorithm to infer operational conditions from strain measurements in structural applications

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Chinese Journal of Aeronautics 2021年第2期34卷 165-181页

作者： juan carlos PERAFAN-LOPEZ Julian SIERRA-perez Grupo de Investigacion en Ingenieria Aeroespacial Universidad Pontificia BolivarianaCircular 170-01Medellin 050031Colombia

Structural Health Monitoring(SHM) suggests the use of machine learning algorithms with the aim of understanding specific behaviors in a structural system. This work introduces a pattern recognition methodology for operational condition clustering in a structure sample using the well known Density Based Spatial Clustering of Applications with Noise(DBSCAN) *** methodology was validated using a data set from an experiment with 32 Fiber Bragg Gratings bonded to an aluminum beam placed in cantilever and submitted to cyclic bending loads under 13 different operational conditions(pitch angles). Further, the computational cost and precision of the machine learning pipeline called FA + GA-DBSCAN(which employs a combination of machine learning techniques including factor analysis for dimensionality reduction and a genetic algorithm for the automatic selection of initial parameters of DBSCAN) was measured. The obtained results have shown a good performance, detecting 12 of 13 operational conditions, with an overall precision over 90%.

关键词： Clustering DBSCAN Factor analysis FBGs Pattern recognition Strain field

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The cold-induced factor CBF3 mediates root stem cell activity,regeneration,and developmental responses to cold

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Plant Communications 2023年第6期4卷 197-211页

作者： Pablo perez-Garcia Ornella Pucciariello Alvaro Sanchez-Corrionero Javier Cabrera Cristina del Barrio juan carlos del Pozo Mariano Perales Krzysztof Wabnik Miguel A.Moreno-Risueno Centro de Biotecnologíay Genómica de Plantas(Universidad Politécnica de Madrid(UPM)–Instituto Nacional de Investigacióny Tecnología Agraria y Alimentaria–CSIC(INIA-CSIC)) MadridSpain

Plant growth and development involve the specification and regeneration of stem cell niches(SCNs).Although plants are exposed to disparate environmental conditions,how environmental cues affect developmental programs and stem cells is not well *** stem cells are accommodated in meristems in SCNs around the quiescent center(QC),which maintains their *** a combination of genetics and confocal microscopy to trace morphological defects and correlate them with changes in gene expression and protein levels,we show that the cold-induced transcription factor(TF)C-REPEAT BINDING FACTOR 3(CBF3),which has previously been associated with cold acclimation,regulates root development,stem cell activity,and ***3 is integrated into the SHORT-ROOT(SHR)regulatory network,forming a feedback loop that maintains SHR ***3 is primarily expressed in the root endodermis,whereas the CBF3 protein is localized to other meristematic tissues,including root *** of cbf3-1 using a wild-type CBF3 gene and a CBF3 fusion with reduced mobility show that CBF3 movement capacity is required for SCN patterning and regulates root ***,cold induces CBF3,affecting QC ***,exposure to moderate cold around 10℃–12℃promotes root regeneration and QC respecification in a CBF3-dependent manner during the recuperation *** contrast,CBF3 does not appear to regulate stem cell survival,which has been associated with recuperation from more acute cold(-4℃).We propose a role for CBF3 in mediating the molecular interrelationships among the cold response,stem cell activity,and development.

关键词： stem cells regeneration organ patterning protein movement cell fate low temperature

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A Non-Destructive Time Series Model for the Estimation of Cherry Coffee Production

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Computers, Materials & Continua 2022年第3期70卷 4725-4743页

作者： Jhonn Pablo Rodríguez David Griol Zoraida Callejas juan carlos Corrales Telematics Engineering Group University of CaucaPopayán190002Colombia INRAE University of ToulouseUMR 1248 AGIRF-31326Castanet TolosanFrance Department of Software Engineering University of GranadaGranada18071Spain

Coffee plays a key role in the generation of rural employment in *** than 785,000 workers are directly employed in this activity,which represents the 26%of all jobs in the agricultural *** coffee growers estimate the production of cherry coffee with the main aim of planning the required activities,and resources(number of workers,required infrastructures),anticipating negotiations,estimating,price,and foreseeing losses of coffee production in a specific *** important processes can be affected by several factors that are not easy to predict(e.g.,weather variability,diseases,or plagues.).In this paper,we propose a non-destructive time series model,based on weather and crop management information,that estimate coffee production allowing coffee growers to improve their management of agricultural activities such as flowering calendars,harvesting seasons,definition of irrigation methods,nutrition calendars,and programming the times of concentration of production to define the amount of personnel needed for *** combination of time series and machine learning algorithms based on regression trees(XGBOOST,TR and RF)provides very positive results for the test dataset collected in real conditions for more than a *** best results were obtained by the XGBOOST model(MAE=0.03;RMSE=0.01),and a difference of approximately 0.57%absolute to the main harvest of 2018.

关键词： Cherry coffee production estimation learner approaches time series weather data crop management data

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Virtual Conductance Based Cascade Voltage Controller for VSCs in Islanded Operation Mode

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Journal of Modern Power Systems and Clean Energy 2022年第6期10卷 1704-1713页

作者： Francisco Jesús Matas-Díaz Manuel Barragán-Villarejo juan carlos Olives-Camps juan Manuel Mauricio JoséMaría Maza-Ortega Department of Elec‐trical Engineering Universidad de SevillaSeville 41092Spain

Voltage source converters have become the main enabler for the integration of distributed energy resources in *** the case of islanded operation,these devices normally set the amplitude and frequency of the network voltage by means of a cascade controller composed of an outer voltage control loop and an inner current control *** strategies to compute the gains of both control loops have been proposed in the literature in order to obtain a fast and decoupled response of the voltages at the point of common *** paper proposes an alternative and simple methodology based on the introduction of a virtual conductance in the classic cascade *** strategy allows to design each control loop independently,obtaining a closed-loop response of a first-order *** this way,the gains of each control loop are easily derived from the parameters of the LC coupling filter and the desired closed-loop time ***,a state observer is included in the controller to estimate the inductor current of the LC filter in order to reduce the number of required measurements.A laboratory testbed is used to validate and compare the proposed *** experimental results demonstrate the effectiveness of the proposal both in steady-state and transient regimes.

关键词： Voltage source converter microgrid cascade controller virtual conductance

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