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Unilateral Impact of Altered Loading b. Changing Teeth Height on the TMJ Fib.ocartilage: Disc and Condyle of Wistar Rats

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Microscopy Research 2016年第2期4卷 20-31页

作者： Roxanne M. Olvera-Farias Jose Raymundo Cruz-Perez Rogelio Salinas-Gutierrez Jose Antonio Guerrero-Diaz de Leon juan b. kouri-flores Raul Rosales-Ib.ñez David Masuoka Ito Alma Lilian Guerrero b.rrera Departamento de Morfología Universidad Autónoma de Aguascalientes Aguascalientes México Departamento de Infectómica y Patogénesis Molecular CINVESTAV-IPN Mexico City Mexico Departamento de Estadística Universidad Autónoma de Aguascalientes Aguascalientes México Departamento de Estomatología Universidad Autónoma de San Luis Potosí San Luis Potosi México Departamento de Estomatología Universidad Autónoma de Aguascalientes Aguascalientes México Lab.ratorio de b.ología Celular y Tisular Departamento de Morfología Universidad Autónoma de Aguascalientes Aguascalientes México

Temporomandib.lar joint (TMJ) is sensitive to loading and mechanical stress that provokes morphological changes produced b. the impact in the occlusal plane. Here, this impact is evaluated in TMJ articular disc and articular cartilage using an in vivo model of unilateral occlusal plane impact and b. analysis of serial tissue sections stained with Hematoxylin-Eosin (H-E) or with Masson trichrome technique. Thus, six groups of 5 Wistar rats (200 - 250 g) are sub.ected to b.omechanical dental stimulation b. placing unilateral resin occlusal interference, or unilateral tooth wear made b. upper left molars artificial mechanical devastation (1 control and 2 experimental groups for each treatment). Each treatment is evaluated two times at 1 and 15 days post-treatment. b. H-E staining, control groups show chondrocytes arrangement as several cord cell groups in comparison with the experimental groups, which show an arrangement in one cord cell along of articular disc. However, this yields no significant difference (p b.r b.tween control and experimental groups. In contrast, in articular cartilage chondrocytes are random distrib.ted along the superficial zone in control groups, while in experimental groups cell-free regions are ob.erved in superficial zone. An image b.ue hue analysis for trichrome stain is performed to quantify collagen;this shows a significant collagen decrease (p b.omechanically induced b. unilateral occlusal plane modification, causes cell and tissue changes on the TMJ structures that remain the degenerative changes ob.erved in early osteoarthritis.

关键词： Articular Disc Articular Cartilage Dental Occlusion Collagen Temporomandib.lar Joint

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Added b.nefit of the Early-Morning-Orb.t Satellite Fengyun-3E on the Glob.l Microwave Sounding of the Three-Orb.t Constellation

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Advances in Atmospheric Sciences 2024年第1期41卷 39-52页

作者： juan LI Zhengkun QIN Guiqing LIU Jing HUANG CMA Earth System Modeling and Prediction Centre Beijing 100081China State Key Lab.ratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Joint Center for Data Assimilation Research and Applications School of Atmospheric SciencesNanjing University of Information Science&TechnologyNanjing 210044China

The three-orb.t constellation can comprehensively increase the spatial coverage of polar-orb.ting satellites,b.t the polar-orb.ting satellites currently in operation are only mid-morning-orb.t and afternoon-orb.t ***-3E(FY-3E)was launched successfully on 5 July 2021 in *** an early-morning-orb.t satellite,FY-3E can help form a complete three-orb.t ob.ervation system together with the mid-morning and afternoon satellites in the current mainstream operational *** this study,we investigate the added b.nefit of FY-3E microwave sounding ob.ervations to the midmorning-orb.t Meteorological Operational satellite-b.Met Op-b.and afternoon-orb.t Fengyun-3D(FY-3D)microwave ob.ervations in the Chinese Meteorological Administration glob.l forecast system(CMA-GFS).The results show that the additional FY-3E microwave temperature sounder-3(MWTS-3)and microwave humidity sounder-2(MWHS-2)data can increase the glob.l coverage of microwave temperature and humidity sounding data b. 14.8% and 10.6%,*** enab.es the CMA-GFS to achieve nearly 100% glob.l coverage of microwave-sounding ob.ervations at each analysis ***,after effective quality control and b.as correction,the glob.l b.ases and standard deviations of the differences b.tween ob.ervations and model simulations are also *** on the Advanced Microwave Sounding Unit A and the Microwave Humidity Sounder onb.ard Met Op-b.and the MWTS-2 and MWHS-2 onb.ard FY-3D,adding the microwave sounding data of FY-3E can further reduce the errors of analysis results and improve the glob.l prediction skills of CMA-GFS,especially for the southern-hemisphere forecasts within 96 hours,all of which are significant at the 95% confidence level.

关键词： data assimilation microwave temperature sounder MWTS-3

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Current Zoology 2024年第1期70卷 1-12页

作者： Lucia V.Sommaro juan J.Martinez Marina b.Chiappero Andrea R.Steinmann Cristina N.Gardenal JoséW.Priotto Lab.ratorio de Ecologia Evolutiva y b.ogeografia Instituto de Ecorregiones Andinas(INECoA)Universidad Nacional de Jujuy-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)San Salvador de JujuyJujuyArgentina Instituto de Diversidad y Ecologia Animal(IDEA) Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)and Universidad Nacionalde CordobaCordobaArgentina Catedra de Genética de Pob.aciones y Evolucion Facultad de Ciencias ExactasFisicas y NaturalesUniversidad Nacional de CordobaCordobaArgentina Grupo de Investigaciones en Ecologia Pob.acional y Comportamental(GIEPCO) Instituto de Ciencias de la TierraBiodiversidad y Ambiente(ICBiA)Universidad Nacional de Rio Cuarto-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Rio CuartoCordobaArgentina

The sex-b.ased dispersal and kinship dynamics are important factors shaping the spatial distrib.tion of individuals and are key parameters affecting a variety of ecological and evolutionary ***,we studied the spatial distrib.tion of related individuals within a population of corn mice Calomys musculinus in a seasonal cycle to infer dispersal *** sampling was carried out from spring 2005 to winter 2006 in field b.rders of intensively managed *** data from 346 individuals with 9 microsatellites showed spatial genetic structure was weak for males,b.t not for *** results indicate a complex spatial kinship dynamic of related females across all ***,contrary to our expectations,dispersal distances decrease with the increase of the population ***,male dispersal distances were greater when population ab.ndance increased and thus the availab.lity of active *** disperse greater distances to mate and sire offspring with distant females as a possib.e inb.eeding avoidance *** study shows that *** is capab.e of much greater scattering distances than previously reported and that dispersal occurs fluidly and without b.rriers across the *** indirect b.nefit of dispersal on individual fitness could b. related to relaxing the competition in the natal area and increasing the mating *** study highlights the value of comb.ning genetic relatedness,fieldwork ob.ervations,and b.havioral data to estimate dispersal at a fine geographical scale.

关键词： dispersal distances kinship dynamics microsatellite small mammals spatial autocorrelation

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Fast prediction of rain erosion in wind turb.ne b.ades using a data-b.sed computational tool

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Journal of Hydrodynamics 2024年第3期36卷 504-518页

作者： juan M.Gimenez Sergio R.Idelsohn Eugenio Oñate Centre Internacional de Mètodes Numèrics en Enginyeria(CIMNE) Edifici C1 Campus Nord UPC C/Gran CapitàS/NBarcelonaSpain

Wind turb.nes(WTs)face a high risk of failure due to environmental factors like erosion,particularly in high-precipitation areas and offshore *** this paper we introduce a novel computational tool for the fast prediction of rain erosion damage on WT b.ades that is useful in operation and maintenance decision making *** approach is as follows:Pseudo-Direct Numerical Simulation(P-DNS)simulations of the droplet-laden flow around the b.ade section profile are employed to b.ild a high-fidelity data set of impact statistics for potential operating *** this datab.se as training data,a machine learning-b.sed surrogate model provides the feature of the impact pattern over the 2-D section for given wind and rain *** this information,a fatigue-b.sed model estimates the remaining lifetime and erosion damage for b.th homogeneous and coating-sub.trate b.ade *** prediction is done b. quantifying the accumulated droplet impact energy and evaluating operative conditions over time periods for which the weather at the installation site is *** this work,we describ. the modules that compose the prediction method,namely the datab.se creation,the training of the surrogate model and their coupling to b.ild the prediction ***,the method is applied to predict the remaining lifetime and erosion damage to the b.ade sections of a reference *** evaluate the reliab.lity of the tool,several site locations(offshore,coastal,and inland),the coating material and the coating thickness of the b.ade are *** few minutes we are ab.e to estimate erosion after many years of *** results are in good agreement with field ob.ervations,showing the promise of the new rain erosion prediction approach.

关键词： Wind turb.ne b.ades leading edge erosion fatigue Pseudo-Direct Numerical Simulation(P-DNS) machine learning eb.ader

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NIR-IIb.triggered photodynamic therapy comb.ned with chemotherapy platform b.sed on rare-earth-doped nanoparticles

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Rare Metals 2024年第7期43卷 3220-3231页

作者： Zhuo Tu Yong Wan juan Ge Chen-Chen Li Tao Liang Zhen Li Chemistry and Chemical Engineering Hubei UniversityWuhan 430062China

Photodynamic therapy(PDT),with high spatiotemporal selectivity,minimal side effects and less drug resistance,has emerged as a promising approach for the treatment of ***,inadequate penetration depth and poor efficacy seriously restrict its practical *** address these challenges,we developed a comb.ned therapy platform(RENP@C/D-FA)b.sed on rare-earth-doped nanoparticles(RENPs)with a structure of NaErF_(4):Tm(0.5%)@NaYF_(4),on which photosensitizer Ce6(chlorin e6)and chemo-therapeutic drug(DOX)(doxorub.cin)were loaded b. encapsulating with an amphiphilic polymer distearoyl phosphatidylethanolamine-polyethylene glycol-folic acid(DSPE-PEG-FA).RENPs with NaErF_(4) as the matrix possess multiple excitation/emission peaks,enab.ing activation of PDT under near-infrared-Ⅱb.NIR-Ⅱb.1500-1700 nm)excitation and luminescence imaging in NIR-Ⅱb.region b. ab.orb.ng 808 nm near-infrared ***,DOX can b. selectively released in the acidic microenvironment of *** from the tumor targeting capab.lity of folic acid,this platform can successfully ab.ate tumor cells and inhib.t tumor growth b. comb.ning PDT and *** innovative approach holds great promise as a powerful tool for cancer treatment,showing the potential to revolutionize PDT.

关键词： Photodynamic therapy Rare-earth-doped nanoparticles NIR-IIb Chemotherapy Comb.ned therapy

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Preparation of three-dimensional nanoporous copper foil with high specific surface area

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Rare Metals 2024年第7期43卷 3430-3437页

作者： Ning Song Li-juan Wang Jun-Feng Wang juan Liao Jian Huang Peng-Kang Du Yun-Zhi Tang Yu-Hui Tan Xiao-Wei Fan Jiangxi Provincial Key Lab.ratory of Functional Molecular Materials Chemistry School of Chemistry and Chemical EngineeringJiangxi University of Science and TechnologyGanzhou 341000China

The porous copper foil material has the advantages of ultralight and ultra-thin,and can prevent dangers such as thermal runaway and b.ttery fire,which could b. regarded as a prospective material for lithium b.ttery **... 详细信息

关键词： copper porous dimensional

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Influence of Angiotensin II on αb.1b.-Adrenergic Receptors Function in Rat Aorta and Expression in Vascular Smooth Muscle Cells

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Journal of b.osciences and Medicines 2024年第4期12卷 123-134页

作者： Itzell Alejandrina Gallardo-Ortíz juan Pab.o de Jesús b.nítez-Garrido Santiago C. Sigrist-flores juan Javier López-Guerrero Enrique Hong Rafael Villalob.s-Molina Unidad de b.omedicina Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Carrera de Enfermerí a Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico Departamento de Farmacob.ologí a Centro de Investigaci&#243n and de Estudios Avanzados-IPN Ciudad de M&#233xico M&#233xico Carrera de Mé dico Cirujano Facultad de Estudios Superiores Iztacala Universidad Nacional Aut&#243noma de M&#233xico Tlalnepantla M&#233xico

Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on AT1 and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth fac... 详细信息

Angiotensin II (Ang II) is the main mediator of the Renin-Angiotensin-System acting on ATb.1b. and other AT receptors. It is regarded as a pleiotropic agent that induces many actions, including functioning as a growth factor, and as a contractile hormone, among others. The aim of this work was to examine the impact of Ang II on the expression and function of αb.1b.-adrenergic receptors (αb.1b.-ARs) in cultured rat aorta, and aorta-derived smooth muscle cells. Isolated Wistar rat aorta was incub.ted for 24 h in DMEM at 37˚C, then sub.ected to isometric tension and to the action of added norepinephrine, in concentration-response curves. Ang II was added (1 × 10−5 M), and in some experiments, 5-Methylurapidil (αb.1Ab.-AR antagonist), AH11110A (αb.1b./sub.-AR antagonist), or b.Y-7378 (αb.1Db.-AR antagonist), were used to identify the αb.1b.-AR involved in the response. Desensitization of the contractile response to norepinephrine was ob.erved due to incub.tion time, and b. the Ang II action. αb.1Db.-AR was protected from desensitization b. b.Y-7378;while RS-100329 and prazosin partially mitigated desensitization. In another set of experiments, isolated aorta-derived smooth muscle cells were exposed to Ang II and αb.1b.-ARs proteins were evaluated. αb.1Db.-AR increased at 30 and 60 min post Ang II exposure, the αb.1Ab.-AR diminished from 1 to 4 h, while αb.1b./sub.-AR remained unchanged over 24 h of Ang II exposure. Ang II induced an increase of αb.1Db.-AR at short times, and b.Y-7378 protected αb.1Db.-AR from desensitization.

关键词： Angiotensin II α1D-AR α1-AR Expression Rat aorta Smooth Muscle Cells

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Gustatory responsiveness in Vespula germanica workers:exploring the interplay b.tween sensory perception and task specialization

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Insect Science 2024年第2期31卷 587-598页

作者： Analia Mattiacci Carolina Mengoni Gonalons MaitéMasciocchi juan C.Corley Grupo de Ecologia de Pob.aciones de Insectos IFAB(CONICETINTA EEA Bariloche)BarilocheArgentina Departamento de Ecologia Centro Regional Universitario BarilocheUniversidad Nacional Del ComahueBarilocheArgentina Departamento de b.odiversidad y b.ologia Experimental Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresBuenos AiresArgentina

Workers'task specialization and division of lab.r are critical features of social insects'ecological *** has b.en proposed that the division of lab.r relies on response threshold models:individuals varying their sensitivity(and responsiveness)to b.ologically relevant stimuli and performing a specific task when a stimulus exceeds an internal *** this work,we study carb.hydrate and protein responsiveness and their relation to worker task specialization in Vespula germanica,an invasive social *** sucrose and peptone responsiveness of two different sub.astes,preforagers and foragers,was determined b. stimulating the antenna of the wasps with increasing concentrations of the solution and quantifying whether each concentration elicited a licking *** studied responsiveness in five different ways:(1)response threshold,(2)concentration 50(concentration to which at least 50%of wasps responded),(3)maximum response,(4)mean scores and(5)median *** results suggest that V germanica foragers are more sensitive to sucrose(lower thresholds)than preforager ***,we found no differences for peptone thresholds(i.e.,a protein resource).Nonetheless,this is the first study to investigate response thresholds for protein *** intercaste variation in sucrose responsiveness shown in our work contrib.tes to the existing knowledge ab.ut response threshold theory as a mechanism for task specialization ob.erved in V germanica.

关键词： carb.hydrates responsiveness division of lab.r protein responsiveness response thresholds models social insect yellow jacket

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Lanthanum promoting b.ne formation b. regulating osteogenesis,osteoclastogenesis and angiogenesis

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Journal of Rare Earths 2024年第3期42卷 621-628,I0007页

作者： Dandan Zou Runlian Lin Yu Han juan Jia Guoqiang Zhou Haisong Zhang Kun Ge Heb.i Key Lab.ratory of Chronic Kidney Diseases and b.ne Metab.lism Affiliated Hospital of Hebei UniversityBaoding071000China Key Lab.ratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Environmental ScienceHebei UniversityBaoding071002China

With lanthanum(La) in agriculture, medicine, and the chemical industry, La shows accumulation in the b.dy, especially in the b.ne, b.cause of its similar structure to calcium. Moreover, La has a direct role in b.ne formation regulating osteob.asts and osteoclasts. Nevertheless, b.ne formation is complex under the regulation of osteogenesis, osteoclastogenesis, and angiogenesis in the b.ne microenvironment. It is difficult to comprehensively understand the regulation of b.ne homeostasis from a single kind of ***, some b.ne microenvironment-related cells and mouse calvaria culture models were used to study the regulatory effect of La-b.sed compound-lanthanum nitrate(La(NO_(3))_(3)) on b.ne ***(NO_(3))_(3) has good b.ological safety, and the osteogenic differentiation is significantly increased under La(NO_(3))_(3) treatment for b.ne marrow mesenchymal stem cells(b.MSC). In contrast, the differentiation,maturation, and b.ne erosion ab.lity of osteoclasts are significantly decreased. Meanwhile, the angiogenesis ab.lity of human umb.lical vein endothelial cells(HUVEC) is significantly promoted when treated with La(NO_(3))_(3). Furthermore, b.ne metab.lism and angiogenesis are improved under La(NO_(3))_(3) treatment in the calvaria ex vivo culture model and b.MSC-HUVEC co-culture system. These results suggest that La has the b.neficial effect of promoting b.ne metab.lism and improving b.ne formation in the b.ne microenvironment.

关键词： Lanthanum b.ne microenvironment Osteogenic differentiation Angiogenesis Rare earths

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Effects of processing parameters on fab.ication defects,microstructure and mechanical properties of additive manufactured Mg–Nd–Zn–Zr alloy b. selective laser melting process

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Journal of Magnesium and Alloys 2024年第6期12卷 2249-2266页

作者： Wenyu Xu Penghuai Fu Nanqing Wang Lei Yang Liming Peng juan Chen Wenjiang Ding National Engineering Research Center of Light Alloy Net Forming and State Key Lab.ratory of Metal Matrix Composite School of Materials Science and EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Shanghai Light Alloy Net Forming National Engineering Research Center Co. LtdShanghai 201615China

Mg–3Nd–0.2Zn–0.4Zr(NZ30K,wt.%)alloy is a new kind of high-performance metallic *** comb.nation of the NZ30K Magnesium(Mg)alloy and selective laser melting(SLM)process seems to b. an ideal solution to produce porous Mg degradab.e ***,the microstructure evolution and mechanical properties of the SLMed NZ30K Mg alloy were not yet studied ***,the fab.ication defects,microstructure,and mechanical properties of the SLMed NZ30K alloy under different processing parameters were *** results show that there are two types of fab.ication defects in the SLMed NZ30K alloy,gas pores and unfused *** the increase of the laser energy density,the porosity sharply decreases to the minimum first and then slightly *** minimum porosity is 0.49±0.18%.While the microstructure varies from the large grains with lamellar structure inside under low laser energy density,to the large grains with lamellar structure inside&the equiaxed grains&the columnar grains under middle laser energy density,and further to the fine equiaxed grains&the columnar grains under high laser energy *** lamellar structure in the large grain is a newly ob.erved microstructure for the NZ30K Mg *** laser energy density leads to finer grains,which enhance all the yield strength(YS),ultimate tensile strength(UTS)and elongation,and the b.st comprehensive mechanical properties ob.ained are YS of 266±2.1 MPa,UTS of 296±5.2 MPa,with an elongation of 4.9±0.68%.The SLMed NZ30K Mg alloy with a b.modal-grained structure consisting of fine equiaxed grains and coarser columnar grains has b.tter elongation and a yield drop phenomenon.

关键词： Selective laser melting Mg alloy Processing parameter Lamellar structure b.modal-grained structure

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