A study was conducted in the forest-steppe region of the Loess Plateau to provide insight into the factors affecting the process of vegetation establishment,and to provide recommendations for the selection of indigeno...
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A study was conducted in the forest-steppe region of the Loess Plateau to provide insight into the factors affecting the process of vegetation establishment,and to provide recommendations for the selection of indigenous species in order to speed up the succession process and to allow the establishment of vegetation more resistant to soil *** distinctive vegetation types were identified,and their distribution was affected not only by the time since abandonment but also by other environmental factors,mainly soil water and total P in the upper soil *** of the vegetation types,dominated by Artemisia scoparia,formed the early successional stage after abandonment while the other three types formed later successional stages with their distribution determined by the soil water content and total *** can be concluded that the selection of appropriate species for introduction to accelerate succession should be determined by the local conditions and especially the total P concentration and soil water content.
The impacts of vegetation restoration on the soil erosion have been widely elucidated in the semi-arid ***,the magnitude of soil erosion on abandoned sloping farmland still remained unclear and their responses to vege...
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The impacts of vegetation restoration on the soil erosion have been widely elucidated in the semi-arid ***,the magnitude of soil erosion on abandoned sloping farmland still remained unclear and their responses to vegetation succession were rarely *** main objective of this study is to determine the magnitude of soil erosion along vegetation succession and explore the impact of vegetation succession on soil erosion from abandoned sloping *** observations were employed to monitor the rainfall,runoff,and soil erosion of seven sloping farmland plots with different abandoned ages and bare land from 2015 to *** results indicated that the annual runoff depth and soil erosion modulus of vegetation types were in the range of 0.46 to 5.49 mm·a^(-1)and 1.3 to 24.5 t·km^(-2)·a^(-1),*** vegetation effectively reduced the annual surface runoff and soil erosion with reduction of 73.8% to 97.8%and 98.0% to 99.9% as opposed to bare ***,there were no significant differences in runoff and soil erosion for different vegetation types along *** largest event of vegetation types contributed to 38.7%-44.1% of the annual runoff and 42.5%-66.3% of the annual soil erosion,*** restoration considerably alleviated the contribution of largest erosive event to annual soil *** relationships between soil erosion,runoff and rainfall factors could be fitted well by linear functions,and the performances of regression models in predicting runoff were more satisfactory compared to predicting soil *** Artemisia gmelinii(Agm)+Stipa bungeana(Sb)optimized the trade-off between sediment reduction and runoff maintenance,which should be selected as the suitable vegetation types to achieve the sustainability of socio-ecological systems.
Severe soil and water loss have led to widespread land degradation on the Loess Plateau in *** the relationship between land use and sediment connectivity can be beneficial to control soil *** this study,three catchme...
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Severe soil and water loss have led to widespread land degradation on the Loess Plateau in *** the relationship between land use and sediment connectivity can be beneficial to control soil *** this study,three catchments in the Yanhe River Basin on the Loess Plateau were selected to analyse the relationship between land use and sediment connectivity using grey correlation *** of connectivity(IC)was employed to quantify sediment connectivity,including two flow direction algorithms(D8 and D-infinity)and two final targets of sediment transport(outlet and main channel of catchment).Then,11 landscape metrics were used to evaluate the land use spatial patterns of *** comparing the IC value ranges,histograms and classes,and their relationship with remote sensing images of the two flow direction algorithms,we find that the D8 algorithm is more suitable for this study *** results showed that the three catchments are characterized by high sediment connectivity in the grassland and forest close to the *** addition,the roads and bare land close to the channel also have high or medium sediment *** correlation analysis showed that landscape division index(DIVISION),fractal dimension index(FRACMN),aggregation index(AI),total class area,patch cohesion index(COHESION),and largest patch index(LPI)indices were the main factors that affect sediment connectivity at the class *** the landscape scale,the landscape shape index(LSI),Shannon’s diversity index(SHDI),and gully density have an essential effect on sediment *** condition provides a way to control the sediment connectivity in the watershed by transforming land use type or changing its spatial pattern,but specific adjustment measures have to be further explored.
Cancer is one of the deadliest diseases affecting the health of human beings. With limited therapeutic options available, complementary and alternative medicine has been widely adopted in cancer management and is incr...
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Cancer is one of the deadliest diseases affecting the health of human beings. With limited therapeutic options available, complementary and alternative medicine has been widely adopted in cancer management and is increasingly becoming accepted by both patients and healthcare workers alike. Chinese medicine characterized by its unique diagnostic and treatment system is the most widely applied complementary and alternative medicine. It emphasizes symptoms and ZHENG(syndrome)-based treatment combined with contemporary disease diagnosis and further stratifies patients into individualized medicine subgroups. As a representative cancer with the highest degree of malignancy, pancreatic cancer is traditionally classified into the "amassment and accumulation". Emerging perspectives define the core pathogenesis of pancreatic cancer as "dampness-heat" and the respective treatment "clearing heat and resolving dampness" has been demonstrated to prolong survival in pancreatic cancer patients, as has been observed in many other cancers. This clinical advantage encourages an exploration of the essence of dampness-heat ZHENG(DHZ) in cancer and investigation into underlying mechanisms of action of herbal formulations against dampness-heat. However, at present, there is a lack of understanding of the molecular characteristics of DHZ in cancer and no standardized and widely accepted animal model to study this core syndrome in vivo. The shortage of animal models limits the ability to uncover the antitumor mechanisms of herbal medicines and to assess the safety profile of the natural products derived from them. This review summarizes the current research on DHZ in cancer in terms of the clinical aspects, molecular landscape, and animal models. This study aims to provide comprehensive insight that can be used for the establishment of a future standardized ZHENG-based cancer animal model.
A residual heterozygous line (RHL) carrying a heterozygous segment between two S SR loci RM 11 and RM134 on the rice chromo- some 7 was selected from a set of recombinant inbred lines from the cross D50 (javanica)...
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A residual heterozygous line (RHL) carrying a heterozygous segment between two S SR loci RM 11 and RM134 on the rice chromo- some 7 was selected from a set of recombinant inbred lines from the cross D50 (javanica)/HB277 (indica). The former parent produces much longer grains than the latter. Selfed progenies of this selection were analyzed genotypically (SSRs) and phenotypically (grain length). Grain length was discontinuously variable in the mapping populations, allowing for the placement of this QTL qGL7-2 within a -4.8 cM interval defined by RM351 and RM234. A set of new markers within this region were developed, which narrowed the QTL to a 278 kb region defined by the markers Indell and RM21945. This region contains 49 predicted genes. The results also suggest that the novel allele for grain length will be used for the application of marker assisted selection for the improvement of grain length.
The clustered regularly interspaced short palindromic repeats(CRISPRJ/associated protein 9(CRISPR/Cas9)gene editing technology,as a revolutionary breakthrough in genetic engineering,offers a promising platform to impr...
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The clustered regularly interspaced short palindromic repeats(CRISPRJ/associated protein 9(CRISPR/Cas9)gene editing technology,as a revolutionary breakthrough in genetic engineering,offers a promising platform to improve the treatment of various genetic and infectious diseases because of its simple design and powerful ability to edit different loci ***,failure to conduct precise gene editing in specific tissues or cells within a certain time may result in undesirable consequences,such as serious off-target effects,representing a critical challenge for the clinical translation of the ***,some emerging strategies using genetic regulation,chemical and physical strategies to regulate the activity of CRISPR/Cas9 have shown promising results in the improvement of spatiotemporal ***,in this review,we first summarize the latest progress of these advanced strategies involving cell-specific promoters,small-molecule activation and inhibition,bioresponsive delivery carriers,and optical/thermal/ultrasonic/magnetic ***,we highlight the advantages and disadvantages of various strategies and discuss their obstacles and limitations in clinical ***,we propose viewpoints on directions that can be explored to further improve the spatiotemporal operability of CRISPR/Cas9.
Background Previous prediction algorithms for cardiovascular diseases(CVD)were established using risk factors retrieved largely based on empirical clinical *** study sought to identify predictors among a comprehensive...
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Background Previous prediction algorithms for cardiovascular diseases(CVD)were established using risk factors retrieved largely based on empirical clinical *** study sought to identify predictors among a comprehensive variable space,and then employ machine learning(ML)algorithms to develop a novel CVD risk prediction *** From a longitudinal population-based cohort of UK Biobank,this study included 473611 CVD-free participants aged between 37 and 73 years *** implemented an ML-based data-driven pipeline to identify predictors from 645 candidate variables covering a comprehensive range of health-related factors and assessed multiple ML classifiers to establish a risk prediction model on 10-year incident *** model was validated through a leave-one center-out *** During a median follow-up of 12.2 years,31466 participants developed CVD within 10 years after baseline visits.A novel UK Biobank CVD risk prediction(UKCRP)model was established that comprised 10 predictors including age,sex,medication of cholesterol and blood pressure,cholesterol ratio(total/high-density lipoprotein),systolic blood pressure,previous angina or heart disease,number of medications taken,cystatin C,chest pain and pack-years of *** model obtained satisfied discriminative performance with an area under the receiver operating characteristic curve(AUC)of 0.762±0.010 that outperformed multiple existing clinical models,and it was well-calibrated with a Brier Score of 0.057±***,the UKCRP can obtain comparable performance for myocardial infarction(AUC 0.774±0.011)and ischaemic stroke(AUC 0.730±0.020),but inferior performance for haemorrhagic stroke(AUC 0.644±0.026).Conclusion ML-based classification models can learn expressive representations from potential high-risked CVD participants who may benefit from earlier clinical decisions.
Bieletan is one of the most important salt lake brine lithium deposits within the Qaidam Basin, northwestern China. In this study, we present the results of chemical composition and isotopic analyses of Li and Sr in...
Bieletan is one of the most important salt lake brine lithium deposits within the Qaidam Basin, northwestern China. In this study, we present the results of chemical composition and isotopic analyses of Li and Sr in brine samples collected from Bieletan hydrological observation wells in different seasons in 2020. We evaluated the evolution processes of Li+, K+, and other ions in the reservoir under the combined influence of sulfate-type river water, CaCl2-type brines, and artificial recharge. In long-term observation wells, the composition of shallow brines varies, and the compositions of deep brines and brines in brine production wells are relatively stable. The concentrations of Li+and B3+in the northern area are higher than those in the southern area, and the ion concentrations of the deep brines in the long-term observation wells are slightly higher than those of the shallow brines. The concentrations of K+and Mg2+vary to some extent in both the deep and shallow brines of the long-term observation wells but are less affected by the season. However, the Ca2+and Sr2+concentrations of the shallow brines show notable seasonal variations, indicating a significant effect of CaCl2-type brines. The decreases in the Li and Sr isotopes of brines in Senie Lake are caused by the inflow of Wutumeiren River water during the high-water period. This finding indicates that during the high-water period, surface brines of salt lakes replenish intercrystalline brines, whereas during the dry season, the intercrystalline brines replenish Senie Lake. This mixed mineralization process resulted in Li+enrichment in the study area, with the highest Li+concentration occurring in the northern area of the Bieletan section. Although the Li+concentration in shallow brines decreases due to exploitation, we predict that deep brines with higher concentrations of Li+would serve as important reserves for sustainable development.
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