检索结果-南通市图书馆

Evaluation of the Mrp2-mediated flavonoid-drug interaction potential of quercetin in rats and in vitro models

Asian Journal of Pharmaceutical Sciences 2019年第6期14卷 621-630页

作者： ju-hee oh Joo Hyun Lee Young-Joo Lee Division of Biopharmaceutics College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea Department of Life and Nanopharmaceutical Sciences College of PharmacyKyung Hee UniversitySeoul 02447Republic of Korea

Quercetin is a biologically active flavonoid that has been used as a popular health *** is reported that quercetin may cause flavonoid-drug interaction mediated by P-glycoprotein,the most predominant efflux *** this study,we comprehensively evaluated the potential of the pharmacokinetic interaction of quercetin mediated by multidrug resistance-associated protein 2(MRP2),another major efflux ***2-transfected MDCKII cells and LS174T cells were used to evaluate the potential inhibition and induction of MRP2 by quercetin in *** evaluate the induction effect of quercetin on Mrp2 in vivo,Mrp2 mRNA expression in rat liver,kidney,and small intestinal tissues was determined after the oral administration of quercetin(50,100,or 250 mg/kg)for seven ***2-mediated interaction potential was also evaluated by the pharmacokinetic study of phenolsulfonphthalein in rats after single or multiple doses of ***,the effect of quercetin on absorption of docetaxel,a P-glycoprotein and CYP3A4 substrate,was also *** inhibited the function of MRP2 at 10μM and induced the mRNA expression of MRP2 at 50μM in ***,at 100 mg/kg,quercetin markedly increased Mrp2 expression in the small intestine of ***,there was no significant change in phenolsulfonphthalein pharmacokinetics due to single-(50,100,or 250 mg/kg)or multiple-dose(50,100,or 250 mg/kg for seven days)quercetin *** contrast,a significant interaction caused by quercetin(100 mg/kg)was observed in the absorption of *** results suggested that although quercetin modulates the function and expression of MRP2 in vitro,it may have a low potential of Mrp2-mediated interaction and present negligible safety concerns related to the interaction.

关键词： Quercetin P-glycoprotein Multidrug resistance-associated protein 2 Pharmacokinetics Flavonoid-drug interaction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in nonalcoholic fatty liver disease

引用

World Journal of Gastroenterology 2018年第48期24卷 5477-5490页

作者： Waqar Khalid Saeed Dae Won jun Kiseok Jang Sang Bong Ahn ju hee oh Yeon Ji Chae Jai Sun Lee Hyeon Tae Kang Department of Gastroenterology Hanyang University College of Medicine Seoul 04763 South Korea Department of Pathology Hanyang University College of Medicine Seoul 04763 South Korea Department of Internal Medicine Eulji University Daejeon 34824 South Korea Department of Translational Medicine Hanyang University College of Medicine Seoul 04763 South Korea

AIM To validate the effects of receptor interacting protein kinase-3(RIP3) deletion in non-alcoholic fatty liver disease(NAFLD) and to clarify the mechanism of *** Wild-type(WT) and RIP3 knockout(KO) mice werefed normal chow and high fat(HF) diets for 12 wk. The body weight was assessed once weekly. After 12 wk, the liver and serum samples were extracted. The liver tissue expression levels of RIP3, microsomal triglyceride transfer protein, protein disulfide isomerase, apolipoprotein-B, X-box binding protein-1, sterol regulatory element-binding protein-1c, fatty acid synthase, cluster of differentiation-36, diglyceride acyltransferase, peroxisome proliferator-activated receptor alpha, tumor necrosis factor-alpha(TNF-α), and interleukin-6 were assessed. Oleic acid treated primary hepatocytes from WT and RIP3 KO mice were stained with Nile red. The expression of inflammatory cytokines, including chemokine(C-X-C motif) ligand(CXCL) 1, CXCL2, and TNF-α, in monocytes was *** RIP3 KO HF diet fed mice showed a significant gain in body weight, and liver weight, liver to body weight ratio, and liver triglycerides were increased in HF diet fed RIP3 KO mice compared to HF diet fed WT mice. RIP3 KO primary hepatocytes also had increased intracellular fat droplets compared to WT primary hepatocytes after oleic acid treatment. RIP3 overexpression decreased hepatic fat content. Quantitative real-time polymerase chain reaction analysis showed that the expression of very-low-density lipoproteins secretion markers(microsomal triglyceride transfer protein, protein disulfide isomerase, and apolipoprotein-B) was significantly suppressed in RIP3 KO mice. The overall NAFLD Activity Score was the same between WT and RIP3 KO mice; however, RIP3 KO mice had increased fatty change and decreased lobular inflammation compared to WT mice. Inflammatory signals(CXCL1/2, TNF-α, and interleukin-6) increased after lipopolysaccharide and pancaspase inhibitor(necroptotic conditi

关键词： Necroptosis Receptor interacting protein kinase-3 Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Steatosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

地黄的炮制对梓醇和5-羟甲基糠醛含量的影响

引用

中国中药杂志 2007年第12期32卷 1155-1157页

作者：朱梅芬刘向前吴柱熹陆昌洙崔胡荣李济铉韩国庆熙大学汉药学系韩国首尔130701 中南大学制药工程系湖南长沙410083 韩国庆熙大学汉医学系韩国首尔130701 韩国东国大学汉医学系韩国庆州780714

目的:研究地黄炮制过程对梓醇(catalpol)和5-羟甲基糠醛(5-HMF)含量变化的影响。方法:鲜地黄制成干地黄后分别以10%和50%的乙醇为液体辅料并分别在90℃和100℃的条件下反复蒸制得熟地黄,各条件下制得的样品经30%甲醇超声波提取2 h,利用... 详细信息

目的:研究地黄炮制过程对梓醇(catalpol)和5-羟甲基糠醛(5-HMF)含量变化的影响。方法:鲜地黄制成干地黄后分别以10%和50%的乙醇为液体辅料并分别在90℃和100℃的条件下反复蒸制得熟地黄,各条件下制得的样品经30%甲醇超声波提取2 h,利用反相HPLC分别在204,284 nm,流速1.0 ***-1,流动相3%乙腈条件下测定梓醇和5-HMF的含量。结果:随着蒸制次数的增加,梓醇的含量减少,5-HMF的含量增加。液体辅料乙醇的体积分数和蒸制温度都对梓醇和5-HMF的含量有影响,10%乙醇,100℃的条件下炮制的熟地黄最优,在此条件下蒸7次以上的熟地黄中5-HMF的含量符合大韩药典标准。结论:分析了地黄炮制对梓醇和5-HMF含量的影响,为进一步研究地黄提供了依据。

关键词：地黄梓醇 5-羟甲基糠醛(5-HMF) HPLC

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

引用

Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol Na J.Jay Liu Young-ju Kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and Materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Reconstructing the post-LGM deglacial history of Hollingsworth Glacier on Ricker Hills,Transantarctic Mountains,Antarctica

引用

Journal of Mountain Science 2022年第5期19卷 1217-1230页

作者： Rhee Hyun-hee SEONG Yeong-Bae WOO ju-Sun oh Changhwan YU Byung-Yong Division of Glacial Environment Research Korea Polar Research InstituteIncheon 21990Republic of Korea Department of Geography Education Korea UniversitySeoul 02841Republic of Korea School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Republic of Korea Department of Earth and Environmental Science Chungbuk National UniversityCheongju 28644Republic of Korea AMS laboratory Korea Institute of Science and TechnologySeoul 02792Republic of Korea

The Transantarctic Mountains are an important corridor between the East Antarctic Ice Sheet and the Western Ross Sea,where most current ice streams and outlet glaciers *** investigated Ricker Hills,the largest exposed mountainous region between Southern Victoria Land and Terra Nova Bay,and dated the glacial landforms using in-situ cosmogenic-nuclide 10 Be surface exposure dating to reconstruct the paleo-glacial *** surface of the Hollingsworth glacier lowered since the middle of Marine Isotope Stage(MIS)2(22.1 ka);therefore,the Last Glacial Maximum(LGM)occurred before that ***,geomorphic,and climatic records constrained the glacial surface slope to be between 5.4°and 6.8°.The ice was 270-320 m thicker at the LGM(MIS 2)than presently but did not override the top surface of the Benson ***,previous glacial periods such as the local LGM(MIS 4)or Penultimate Glacial Maximum(MIS 6)maintained thicker ice than the LGM(MIS 2).The Ross Ice Shelf opening during the mid-Holocene(~6 ka)caused the rapid collapse of the terminal outlet glaciers and supplied notable snow accumulation upstream,which stagnated *** greatest lowering and retreat occurred during the late Holocene(2.3~0.8 ka),when elephant seal colonies thrived in the Ross Embayment.

关键词： East Antarctic Ice Sheet Last Glacial Maximum Deglaciation Holocene Cosmogenic nuclide exposure dating Glacier reconstruction

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cobalt phosphide nanoarrays with crystalline-amorphous hybrid phase for hydrogen production in universal-pH

引用

Nano Research 2020年第9期13卷 2469-2477页

作者： Hyunseok Yoon hee Jo Song Bobae ju Dong-Wan Kim School of Civil Environmental and Architectural EngineeringKorea UniversitySeoul 02841Republic of Korea

To accomplish mass hydrogen production by electrochemical water-splitting,it is a necessary to develop robust,highly active,stable,and cost-effective hydrogen evolution reaction(HER)electrocatalysts that perform comparably to Pt in the universal pH *** this work,cobalt phosphide hybrid nanosheets supported on carbon felt(CoP HNS/CF)are presented,which exhibit the superior electrocatalytic hydrogen production under a *** these nanosheets,a single CoP HNS is composed of polycrystalline CoP and oxygen-enriched amorphous Co-O-P *** from its unique nanoarchitecture,as-fabricated CoP HNS/CF exhibits a tremendous electrocatalytic HER activity and outperforms Pt/C as well as state-of-the-art CoP electrocatalysts in *** acidic and neutral media,the CoP HNS/CF shows superior electrocatalytic activity while maintaining its original hybrid crystalline-amorphous phase and *** alkaline medium,the unexpected phase and morphological reorganization of CoP HNS/CF results in outstanding electrocatalytic *** HNS/CF not only achieves high electrocatalytic activity and kinetics,but also a stable and long operating lifetime even under a high current density of 500 mA cm'***,the fabrication of CoP HNS/CF can be scaled up easily,and the large CoP HNS/CF electrode also exhibits similar electrocatalytic activity and stability.

关键词： cobalt phosphide self-supporting electrocatalyst hydrogen evolution reaction universal-ph large-scale

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Xanthogranulomatous cholecystitis managed by laparotomy may go through troublesome clinical course: Reflection of severe inflammation

引用

Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 210-212页

作者： hee ju Kim Kwang Yeol Paik Department of Surgery Yeoiudo St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea College of MedicineSeoul 07345Korea

To the Editor: Xanthogranulomatous cholecystitis(XGC) is an uncommon inflammatory disease of the gallbladder, and its incidence is reported to be 1.3%-5.2% [1]. XGC is diagnosed by histopathological examination, characterized by severe inflammatory destruction followed by a granulomatous reaction, marked proliferative fibrosis, and infiltration of inflammatory cells [2].

关键词： granuloma cholecystitis inflammation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Direct modification of spermatogonial stem cells using lentivirus vectors in vivo leads to efficient generation of transgenic rats

引用

Asian Journal of Andrology 2019年第2期21卷 190-195页

作者： Bang-Jin Kim Yong-hee Kim Myeong-Geun oh Ki-jung Kim Sang-Eun jung ju-hee Jin Sun-Uk Kim Kwan-Sik Min Buom-Yong Ryu Department of Animal Scienee and Technology College of Biotechnology and Natural ResourcesChung-Ang UniversityAnseongGyeonggi-do 17546Korea National Primate Research Center Korea Research Institute of Bioscienee and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and BiotechnologyCheongjuChungcheongbuk-do 28116Korea Animal Biotechnology Graduate School of Future Con verge nee Tech no logyDepartment of Animal Life ScienceInstitute of Genetic Engi neeringHankyong National UniversityAnseongGyeon ggi-do 17579Korea Department of Cancer Biology University of PennsylvaniaPhiladelphiaPA 19104USA.

Spermatogonial stem cells(SSCs)transmit genetic information to the next progeny in ***,SSCs are a potential target for germ I i ne modifications to gen erate tran sgenic an *** this study,we report a technique for the gen erati on of tran sgenic rats by in vivo manipulation of SSCs with a high success *** in juvenile rats were transduced in vivo with high titers of lentivirus harbori ng enhan ced green fluoresce nt protei n and mated with wild-type females to create foun der *** founder rats expressed the transgene and passed on the transgene with an overall success rate of 50.0%.Subsequent generations of progeny from the founder rats both expressed and passed on the ***,direct modification of SSCs in juvenile rats is an effective means of generating transgenic rats through the male *** technology could be adapted to larger animals,in which existing methods for gene modificatio n are in adequate or in applicable,resulti ng in the gen eration of tran sge nic an imals in a variety of species.

关键词： germline modification lentivirus spermatogonial stem cell testis transgenic animal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Polyherbal formula SC-E3 inhibits rheumatoid arthritis activity in a mouse model of type-Ⅱcollagen-induced arthritis

引用

Journal of Integrative Medicine 2021年第3期19卷 265-273页

作者： ju-Yeon Park Young-Won Kwon Sun-Ah Kim Sun-Dong Park Chang-Hyun Kim Jin-hee Kim ju-hee Lee College of Korean Medicine Dongguk UniversityGoyang 10326Republic of Korea Department of Medicine College of MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Biomedical Laboratory Science College of Health ScienceCheongju UniversityCheongju 28503Republic of Korea

Objective:SC-E3 is a polyherbal formula that contains five medicinal herbs used frequently in traditional herbal *** our previous study,we demonstrated the antioxidant and anti-inflammatory effects of *** present study examined the effects of SC-E3 in a mouse model of type-II collagen-induced arthritis(CIA).Methods:In vivo,male DBA/1 J mice were immunized by intradermal injection of bovine type-II collagen and complete or incomplete Freund’s adjuvant,to induce ***-E3 was orally administered daily for 23 *** vitro,bone marrow-derived macrophages(BMMs)were treated with macrophage colony-stimulating factor(M-CSF)and receptor activator of nuclear factor-j B ligand(RANKL)in the absence or presence of ***:Administrations of SC-E3 were found to have anti-arthritic effects in the joints of CIA mice,as evidenced by reduced paw swelling,bone erosion and deformation,inflammatory cell infiltration,and inflammation in synovial ***-E3 also reduced serum levels of tumor necrosis factor-a,interleukin-1 b,aspartate aminotransferase and alanine ***,tartrateresistant acid phosphatase-positive osteoclast numbers in the joints were significantly lower in SC-E3-treated CIA mice than in CIA *** addition,the differentiations of BMMs to multinucleated osteoclasts induced by M-CSF and RANKL stimulation were dose-dependently reduced by ***:These results suggest that SC-E3 possesses substantial anti-arthritic activity because it inhibits pro-inflammatory cytokines and osteoclastogenesis,and that SC-E3 has potential therapeutic use for the treatment of rheumatoid arthritis.

关键词： Herbal formula Anti-inflammatory Rheumatoid arthritis Collagen-induced arthritis Osteoclastogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spatial Control of Lithium Deposition by Controlling the Lithiophilicity with Copper(Ⅰ)Oxide Boundaries

引用

Energy & Environmental Materials 2023年第5期6卷 183-191页

作者： ju Ye Kim oh B.Chae Gukbo Kim Woo-Bin jung Sungho Choi Do Youb Kim San Moon jungdon Suk Yongku Kang Mihye Wu hee-Tae jung Department of Chemical and Biomolecular Engineering(BK-21 four)and Institute for Nanocentury Korea Advanced Institute of Science and Technology(KAIST)DaejeonKorea Chemical&Process Technology Division Korea Research Institute of Chemical TechnologyDaejeon 34114Korea School of Engineering Brown UniversityProvidence 02912USA Department of Chemistry University of Rhode IslandKingston 02881USA School of Engineering and Applied Sciences Harvard UniversityCambridge 02138USA Advanced Materials Division Korea Research Institute of Chemical TechnologyDaejeon 34114Korea

Spatial control of lithium deposition is the most important issue in lithium-metal batteries because of the considerable control of lithium dendrite suppression via the uniform distribution of Li^(+)*** seed materials are crucial for the behavior of lithium deposition,in-depth studies on their physical and chemical control have not been ***,we describe a new design of seed structure comprising a wrinkled Cu/graphene substrate surrounded by copper(Ⅰ)oxide(Cu_(2)O)on a graphene grain boundary over a large area,which is fabricated by the oxidation of the Cu surface via graphene boundary defects by using chemical vapor deposition(CVD).Scanning and transmission electron microscopy results reveal that Cu_(2)O on the graphene boundary can render a preferential reaction with lithium during the first deposition and assist in the uniform deposition of lithium by preventing the agglomeration of lithium clusters during the second *** two-step process is attributed to the degree of selectivity due to the difference in lithium affinity,which allows long-term electrochemical stability and a high rate capability via boundary *** study highlights the significance of the boundary effect,which can open new avenues for the formation of a large family of seed structures in lithium-metal batteries.

关键词： Cu_(2)O boundary dendrite-free lithium deposition lithium-metal battery lithium spatial control seed boundary effect

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：