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The combined application of stem cells and three-dimensional bioprinting scaffolds for the repair of spinal cord injury

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Neural Regeneration Research 2024年第8期19卷 1751-1758页

作者： Dingyue ju Chuanming dong Department of Anatomy Medical College of Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina

Spinal cord injury is considered one of the most difficult injuries to repair and has one of the worst prognoses for injuries to the nervous *** surgery,the poor regenerative capacity of nerve cells and the generation of new scars can make it very difficult for the impaired nervous system to restore its neural *** treatments can only alleviate secondary injuries but cannot fundamentally repair the spinal ***,there is a critical need to develop new treatments to promote functional repair after spinal cord *** recent years,there have been seve ral developments in the use of stem cell therapy for the treatment of spinal cord *** significant developments in the field of tissue engineering,three-dimensional bioprinting technology has become a hot research topic due to its ability to accurately print complex *** led to the loading of three-dimensional bioprinting scaffolds which provided precise cell *** three-dimensional bioprinting scaffolds co uld repair damaged neural circuits and had the potential to repair the damaged spinal *** this review,we discuss the mechanisms underlying simple stem cell therapy,the application of different types of stem cells for the treatment of spinal cord injury,and the different manufa cturing methods for three-dimensional bioprinting *** particular,we focus on the development of three-dimensional bioprinting scaffolds for the treatment of spinal cord injury.

关键词： biomaterials embryonic stem cells induced pluripotent stem cells mesenchymal stem cells nerve regeneration spinal cord injury stem cell therapy stem cells three-dimensional bioprinting

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Deep learning in hepatocellular carcinoma:Current status and future perspectives

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World Journal of Hepatology 2021年第12期13卷 2039-2051页

作者： Joseph C Ahn Touseef Ahmad Qureshi Amit G Singal Debiao Li ju-dong yang Gastroenterology and Hepatology Mayo ClinicRochesterMN 55904United States Biomedical Imaging Research Institute Cedars-Sinai Medical CenterLos AngelesCA 90048United States Internal Medicine University of Texas Southwestern Medical CenterDallasTX 75390United States Karsh Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCA 90048United States

Hepatocellular carcinoma(HCC)is among the leading causes of cancer incidence and *** decades of research and development of new treatment options,the overall outcomes of patients with HCC continue to remain *** are areas of unmet need in risk prediction,early diagnosis,accurate prognostication,and individualized treatments for patients with *** years have seen an explosive growth in the application of artificial intelligence(AI)technology in medical research,with the field of HCC being no *** the various AI-based machine learning algorithms,deep learning algorithms are considered state-of-the-art techniques for handling and processing complex multimodal data ranging from routine clinical variables to high-resolution medical *** article will provide a comprehensive review of the recently published studies that have applied deep learning for risk prediction,diagnosis,prognostication,and treatment planning for patients with HCC.

关键词： Hepatocellular carcinoma Artificial intelligence Deep learning

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Trends of Cirrhosis-related Mortality in the USA during the COVID-19 Pandemic

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 751-756页

作者： Yee Hui Yeo Xinyuan He Fan Lv Yunyu Zhao Yi Liu ju dong yang Jian Zu Fanpu Ji Mindie H.Nguyen Division of General Internal Medicine Cedars-Sinai Medical CenterLos AngelesCaliforniaUSA Department of Infectious Diseases the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina School of Mathematics and Sta-tistics Xi’an Jiaotong UniversityXi’anShaanxiChina Karsh Division of Gastroenterology and Hepatology Cedars-Sinai Medical CenterLos AngelesCAUSA National&Local Joint Engineering Research Center of Biodiagnosis and Biotherapy the Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxiChina Division of Gastroenterology and Hepa-tology Stanford University Medical CenterPalo AltoCaliforniaUSA Department of Epidemiology and Population Health Stanford University Medical CenterPalo AltoCaliforniaUSA

Immunocompromised status and interrupted routine care may render patients with cirrhosis vulnerable to the coronavi-rus disease 2019(COVID-19)pandemic.A nationwide data-set that includes more than 99%of the decedents in the *** April 2012 and September 2021 was *** age-standardized mortality during the pandemic were esti-mated according to prepandemic mortality rates,stratified by *** deaths were determined by estimating the difference between observed and projected mortality rates.A temporal trend analysis of observed mortality rates was also performed in 0.83 million decedents with cirrhosis between April 2012 and September 2021 was *** an increasing trend of cirrhosis-related mortality before the pandemic,with a semiannual percentage change(SAPC)of 0.54%[95%confidence interval(CI):(0.0-1.0%),p=0.036],a precipitous increase with seasonal variation occurred dur-ing the pandemic(SAPC 5.35,95%CI:1.9-8.9,p=0.005).Significantly increased mortality rates were observed in those with alcohol-associated liver disease(ALD),with a SAPC of 8.44(95%CI:4.3-12.8,p=0.001)during the ***-cause mortality of nonalcoholic fatty liver disease rose stead-ily across the entire study period with a SAPC of 6.79(95%CI:6.3-7.3,p<0.001).The decreasing trend of HCV-related mortality was reversed during the pandemic,while there was no significant change in HBV-related *** there was significant increase in COVID-19-related deaths,more than 55%of the excess deaths were the indirect impact of the *** observed an alarming increase in cirrhosis-related deaths during the pandemic especially for ALD,with evidence in both direct and indirect *** findings have implications on formulating policies for patients with cirrhosis.

关键词： Cirrhosis mortality Alcohol-associated liver disease Epidemiology Nonalcoholic fatty liver disease COVID-19

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Current impact of viral hepatitis on liver cancer development: The challenge remains

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World Journal of Gastroenterology 2021年第24期27卷 3556-3567页

作者： Ângelo Zambam de Mattos Jose D Debes Andre Boonstra ju-dong yang Domingo C Balderramo Giovana D P Sartori Angelo Alves de Mattos Department of Gastroenterology and Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90020-090Brazil Gastroenterology and Hepatology Unit Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90050-170Brazil Department of Medicine Division of Gastroenterology and Infectious DiseasesUniversity of MinnesotaMinneapolisMN 55455United States Department of Gastroenterology and Hepatology Erasmus Medical CenterRotterdam NL-3015Netherlands Division of Digestive and Liver Diseases Department of MedicineCedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Gastroenterology Hospital Privado Universitario de CórdobaCórdoba 5016Argentina Department of Medicine Instituto Universitario de Ciencias Biomédicas de CórdobaCórdoba 5016Argentina Department of Internal Medicine Hospital Nossa Senhora da ConceiçãoPorto Alegre 91350-200Brazil

Chronic infections due to hepatitis B and hepatitis C viruses are responsible for most cases of hepatocellular carcinoma(HCC)worldwide,and this association is likely to remain during the next ***,viral hepatitis-related HCC imposes an important burden on public health in terms of disability-adjusted life *** order to reduce such a burden,some major challenges must be *** vaccination against hepatitis B virus,especially in the neonatal period,is probably the most relevant primary preventive measure against the development of ***,considering the large adult population already infected with hepatitis B and C viruses,it is also imperative to identify these individuals to ensure their access to *** hepatitis B and C currently have highly effective therapies,which are able to diminish the risk of development of liver ***,it is essential for individuals at high-risk of HCC to be included in surveillance programs,so that tumors are detected at an early *** with hepatitis B or C and advanced liver fibrosis or cirrhosis benefit from being followed in a surveillance *** hepatitis B virus is oncogenic and capable of leading to liver cancer even in individuals with early stages of liver fibrosis,other high-risk groups of patients with hepatitis B are also candidates for *** effort is required concerning these strategies in order to decrease the incidence and the mortality of viral hepatitis-related HCC.

关键词： Hepatitis B virus Hepatitis C virus Hepatocellular carcinoma Epidemiology Vaccination Surveillance

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Metformin does not improve survival in patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第42期20卷 15750-15755页

作者： Mamatha Bhat Roongruedee Chaiteerakij William S Harmsen Cathy D Schleck ju dong yang Nasra H Giama Terry M Therneau Gregory J Gores Lewis R Roberts Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine Division of Gastroenterology McGill University Health Centre Department of Medicine Chulalongkorn University and King Chulalongkorn Memorial Hospital Thai Red Cross Society Division of Biomedical Statistics and Informatics Mayo Clinic College of Medicine

AIM: To assess whether metformin, which has a chemopreventive effect in chronic liver disease, has any chemotherapeutic effect in hepatocellular carcinoma.

关键词： Hepatocellular carcinoma Metformin Diabetes Survival Liver disease Lactic acidosis

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Boosted Lithium-Ion Transport Kinetics in n-Type Siloxene Anodes Enabled by Selective Nucleophilic Substitution of Phosphorus

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Nano-Micro Letters 2024年第10期16卷 618-637页

作者： Se In Kim Woong-ju Kim Jin Gu Kang dong-Wan Kim School of Civil Environmental and Architectural EngineeringKorea University02841 SeoulSouth Korea Nanophotonics Research Center Korea Institute of Science and Technology02792 SeoulSouth Korea

Doped two-dimensional(2D)materials hold significant promise for advancing many technologies,such as microelectronics,optoelectronics,and energy ***,n-type 2D oxidized Si nanosheets,namely n-type siloxene(n-SX),are employed as Li-ion battery *** thermal evaporation of sodium hypophosphite at 275℃,P atoms are effectively incorporated into siloxene(SX)without compromising its 2D layered morphology and unique Kautsky-type crystal ***,selective nucleophilic substitution occurs,with only Si atoms being replaced by P atoms in the O_(3)≡Si-H *** resulting n-SX possesses two delocalized electrons arising from the presence of two electron donor types:(i)P atoms residing in Si sites and(ii)H *** doping concentrations are varied by controlling the amount of precursors or their mean free *** at 2000 mA g^(-1),the n-SX electrode with the optimized doping concentration(6.7×10^(19) atoms cm^(-3))delivers a capacity of 594 mAh g^(-1) with a 73%capacity retention after 500 *** improvements originate from the enhanced kinetics of charge transport processes,including electronic conduction,charge transfer,and solid-state *** approach proposed herein offers an unprecedented route for engineering SX anodes to boost Li-ion storage.

关键词： Li-ion battery Two-dimensional N-type siloxene Doping mechanism Kinetics

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Hepatic sinusoidal obstruction syndrome due to tacrolimus in a liver-transplantation recipient

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Gastroenterology Report 2021年第5期9卷 485-487,I0003页

作者： Shuang-Nan Zhou Dan-Ni Feng Ning Zhang Yan-Ling Sun Yong-Wu Li Xia Zhou ju dong yang Zhen-Wen Liu Hong-Ling Liu Liver Transplantation Center Fifth Medical Center of Chinese PLA General HospitalBeijingP.R.China Department of Integrated TCM&Western Medicine Fifth Medical Center of Chinese PLA General HospitalBeijingP.R.China Department of Radiology Fifth Medical Center of Chinese PLA General HospitalBeijingP.R.China Division of Digestive and Liver Diseases Department of MedicineCedars Sinai Medical CenterLos AngelesCAUSA Samuel Oschin Comprehensive Cancer Institute Cedars Sinai Medical CenterLos AngelesCAUSA Comprehensive Transplant Center Cedars Sinai Medical CenterLos AngelesCAUSA

Introduction Hepatic sinusoidal obstruction syndrome(HSOS)is a hepatic vascular disease characterized by injury of the endothelial cells in the sinusoidal hepatic and interlobular veins,intra-hepatic congestion,liver dysfunction,and portal hypertension[1].In Western countries,HSOS is often associated with myeloablative regimens used for hematopoietic stem-cell transplantation,while,in China,it is often associated with oral intake of Gynura segetum plants that contain pyrrolidine alkaloids[2].In addition,new-onset HSOS after solid-organ transplantation has received increasing attention[3-8].

关键词：肝移植术后他克莫司肝窦

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Microstructural evolution in lithium plating process and its effect on the calendar storage life

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Nano Research 2024年第10期17卷 8834-8841页

作者： Ki Hwan Koh dong ju Lee Anthony Mu Kangwoon Kim Taehee Kim Zheng Chen Department of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Program of Materials Science and Engineering University of California San DiegoLa JollaCA 92093USA Sustainable Power and Energy Center University of California San DiegoLa JollaCA 92093USA

The growing demand for electric vehicles highlights the need for energy storage solutions with higher densities,spotlighting Li metal anodes as potential successors to traditional Li-ion batteries(LIBs).Achieving longer calendar aging life for Li metal anodes is crucial for their practical use,given their propensity for corrosion due to a low redox potential,which leads to compromised cycling stability and significant capacity loss during *** research investigated that this susceptibility is mainly dependent on the surface area of Li metal anode and the properties of the solid electrolyte interphase(SEI),particularly its stability and growth *** research adds to this understanding by demonstrating that the amount of Li plating is a key factor in its corrosion during open-circuit storage,as assessed across various *** discovered that increasing the Li plating amount effectively reduces Coulombic efficiency(C.E.)loss during aging,due to a lower surface area-to-Li *** implies that the choice of electrolyte for optimal storage life should consider the amount of Li plating,with higher capacities promoting better storage characteristics.

关键词： lithium metal batteries anode-free batteries calendar life of batteries lithium anode corrosion

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Atomic-Scale Insights into Damage Mechanisms of GGr15 Bearing Steel Under Cyclic Shear Fatigue

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1265-1278页

作者： Qiao-Sheng Xia dong-Peng Hua Qing Zhou Ye-Ran Shi Xiang-Tao Deng Kai-ju Lu Hai-Feng Wang Xiu-Bing Liang Zhao-dong Wang State Key Laboratory of Solidification Processing Center of Advanced Lubrication and Seal MaterialsNorthwestern Polytechnical UniversityXi’an710072China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China Defense Innovation Institute Academy of Military ScienceBeijing100071China

Alternating shear stress is a critical factor in the accumulation of damage during rolling contact fatigue,severely limiting the service life of ***,the specific mechanisms responsible for the cyclic shear fatigue damage in bearing steel have not been fully *** the mechanical response and microstructural evolution of a model GGr15 bearing steel under cyclic shear loading are investigated through the implementation of molecular dynamics *** samples undergo 30 cycles under three different loading conditions with strains of 6.2%,9.2%,and 12.2%,*** findings indicate that severe cyclic shear deformation results in early cyclic softening and significant accumulation of plastic damage in the bearing ***,samples subjected to higher strain-controlled loading exhibit higher plastic strain energy and shorter fatigue ***,strain localization is identified as the predominant damage mechanism in cyclic shear fatigue of the bearing steel,which accumulates and ultimately results in fatigue ***,simulation results also revealed the microstructural reasons for the strain localization(e.g.,BCC phase transformation into FCC and HCP phase),which well explained the formation of white etching *** study provides fresh atomic-scale insights into the mechanisms of cyclic shear fatigue damage in bearing steels.

关键词： Cyclic shear fatigue Molecular dynamic simulation Bearing steels Plastic damage accumulation

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Photocatalytic vinyl radical-mediated multicomponent 1,4-/1,8-carboimination across alkynes and olefins/(hetero)arenes

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Science China Chemistry 2024年第2期67卷 558-567页

作者： Shan-Shan Li Yu-Shi Jiang Xue-Ling Luo Xuming Ran Yuqiang Li dong Wu Cheng-Xue Pan Peng-ju Xia School of Chemistry and Pharmaceutical Sciences Guangxi Normal UniversityGuilin541004China Shanghai Artificial Intelligence Laboratory Shanghai200433China The Institute for Advanced Studies Wuhan UniversityWuhan430064China

We developed a highly selective and efficient multicomponent transformation by utilizing alkynes and olefins/(hetero)arenes through photoinduced energy-transfer *** reaction involves the formation of three distinct chemical bonds,namely C(sp~3)–C(sp~2),C(sp~2)–C(sp~3),and C(sp~3)–N,in a single coordinated *** strategy used a vinyl radical-mediated radical relay approach under mild conditions,exhibiting a broad substrate scope(>70 examples),excellent functional-group tolerance,and remarkable regio-and *** the utilization of a combination of experimental techniques and density functional theory(DFT),we delved deeper into the mechanistic intricacies of this distinctive *** revealed that the selective radical addition to electron-deficient alkynes,rather than olefins,was governed by the inherent reactivity of alkyl *** discovery presented a highly effective approach for the synthesis of stereodefined multisubstituted alkenes.

关键词： alkyne-olefin coupling DFT studies regio-and anti-stereoselectivity multisubstituted alkenes

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