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Magnetic resonance imaging biomarkers for pulsed focused ultrasound treatment of pancreatic ductal adenocarcinoma

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World journal of Gastroenterology 2020年第9期26卷 904-917页

作者： Ezekiel Maloney Yak-Nam wang Ravneet Vohra Helena Son Stella Whang Tatiana Khokhlova joshua Park Kayla Gravelle Stephanie Totten joo Ha Hwang Donghoon Lee Department of Radiology University of WashingtonSeattleWA 98195United States Applied Physics Laboratory University of WashingtonSeattleWA 98195United States Division of Gastroenterology University of WashingtonSeattle 98195WAUnited States Division of Gastroenterology&Hepatology Stanford University School of MedicineRedwood CityCA 94063United States

BACKGROUND The robust fibroinflammatory stroma characteristic of pancreatic ductal adenocarcinoma(PDA)impedes effective drug *** focused ultrasound(pFUS)can disrupt this stroma and has improved survival in an early clinical ***-invasive methods to characterize pFUS treatment effects are desirable for advancement of this promising treatment modality in larger clinical *** To identify promising,non-invasive pre-clinical imaging methods to characterize acute pFUS treatment effects for in vivo models of *** We utilized quantitative magnetic resonance imaging methods at 14 tesla in three mouse models of PDA(subcutaneous,orthotopic and transgenic-KrasLSLG12D/+,Trp53LSL-R172H/+,Cre or“KPC”)to assess immediate tumor response to pFUS treatment(VIFU 2000 Alpinion Medical Systems;475 W peak electric power,1 ms pulse duration,1 Hz,duty cycle 0.1%)vs sham therapy,and correlated our results with histochemical *** pFUS treatment parameters were previously shown to enhance tumor permeability to chemotherapeutics.T1 and T2 relaxation maps,high(126,180,234,340,549)vs low(7,47,81)b-value apparent diffusion coefficient(ADC)maps,magnetization transfer ratio(MTR)maps,and chemical exchange saturation transfer(CEST)maps for the amide proton spectrum(3.5 parts per million or“ppm”)and the glycosaminoglycan spectrum(0.5-1.5 ppm)were generated and analyzed pre-treatment,and immediately post-treatment,using *** were sacrificed immediately following post-treatment *** whole-tumor was selected as the region of interest for data analysis and subsequent statistical analysis.T-tests and Pearson correlation were used for statistical *** Mean high-b value ADC measurements increased significantly with pFUS treatment for all *** glycosaminoglycan CEST and T2 measurements decreased significantly post-treatment for the KPC *** MTR and amide CEST values increased significantly for the KPC *** acid focal int

关键词： Pancreatic adenocarcinoma Multiparametric magnetic resonance imaging Focused ultrasound

Fucoidan and topography modification improved in situ endothelialization on acellular synthetic vascular grafts

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生物活性材料(英文) 2023年第4期22卷 535-550页

作者： Yuan Yao Aung Moe Zaw Deirdre E.j.Anderson Yejin jeong joshua Kunihiro Monica T.Hinds Evelyn K.F.Yim Department of Chemical Engineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada Department of Biomedical Engineering Oregon Health&Science UniversityPortlandOR97239USA Waterloo Institute for Nanotechnology University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada Center for Biotechnology and Bioengineering University of Waterloo200 University Avenue WestWaterlooONN2L 3G1Canada

Thrombogenesis remains the primary failure of synthetic vascular *** coverage is crucial to provide an antithrombogenic ***,most synthetic materials do not support cell adhesion,and transanastomotic endothelial migration is ***,a surface modification strategy using fucoidan and topography was developed to enable fast in situ endothelialization of polyvinyl alcohol,which is not endothelial *** three different immobilization approaches compared,conjugation of aminated-fucoidan promoted endothelial monolayer formation while minimizing thrombogenicity in both in vitro platelet rich plasma testing and ex vivo non-human primate shunt *** of six topographical patterns showed that 2μm gratings increased endothelial cell migration without inducing inflammation responses of endothelial *** studies demonstrated that fucoidan could attract fibronectin,enabling integrin binding and focal adhesion formation and activating focal adhesion kinase(FAK)signaling,and 2μm gratings further enhanced FAK-mediated cell *** a clinically relevant rabbit carotid artery end-to-side anastomosis model,60%in situ endothelialization was observed throughout the entire lumen of 1.7 mm inner diameter modified grafts,compared to 0%of unmodified graft,and the four-week graft patency also *** work presents a promising strategy to stimulate in situ endothelialization on synthetic materials for improving long-term performance.

关键词： Blood-contacting devices Small diameter vascular graft Endothelialization Topography Fucoidan

Informing management of rare species with an approach combining scenario modeling and spatially explicit risk assessment

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Ecosystem Health and Sustainability 2015年第6期1卷 9-26页

作者： jennifer M.Duggan Bradley A.Eichelberger Shan Ma joshua j.Lawler Guy Ziv School of Environmental and Forest Sciences University of WashingtonSeattleWashington 98195 USA Natural Capital Project Stanford UniversityStanfordCalifornia 94305 USA School of Geography University of LeedsLeeds LS29J TUnited Kingdom Division of Science and Environmental Policy California State University Monterey BaySeasideCalifornia 93955 USA

Wildlife managers are tasked with identifying and managing stressors that threaten persistence of *** demonstrate an approach to land-use planning that combines scenario modeling and ecological risk assessment to map and quantify risk to population persistence for three rare prairie species in Washington State,*** corroboration of model output,we found that of the management scenarios considered,only a scenario with year-round restrictions on use of off-road vehicles,digging,and camping enforced in all potential habitat reduces risk to the *** risk is focused primarily in two patches of prairie habitat in our study area,indicating stringent restrictions need not be applied ***,one area is not easily accessed by two of the three species considered,suggesting reintroductions to suitable but inaccessible habitat may play an important role in management of these *** analyses suggest changes in land use and management that might improve habitat for rare species,with options for minimizing monetary and social *** the proposed approach relies on hypothetical management scenarios and uses a model flexible in data requirements to provide spatially explicit output,it can be used to inform adaptive management of rare species in diverse land-planning processes and will be especially useful when management decisions must be made under time or cost constraints.

关键词： adaptive management land-useplanning Mazamapocketgopher(Thomomysmazama) military training PugetSoundprairie rarespeciesmanagement riskassessment scenariomodeling Scotchbroom(Cytisus scoparius) spatiallyexplicitmodel StreakedHornedLark(Eremophilaalpestrisstrigata) Taylor’scheckerspot butterfly(Euphydryasedithataylori)

Yttrium-90 microsphere selective internal radiation therapy for liver metastases following systemic chemotherapy and surgical resection for metastatic adrenocortical carcinoma

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World journal of Clinical Oncology 2018年第1期9卷 20-25页

作者： Mina S Makary Lawrence S Krishner Evan j Wuthrick Mark P Bloomston joshua D Dowell Division of Vascular and Interventional Radiology Department of Radiology the Ohio State University Comprehensive Cancer Center Division of Medical Oncology Department of Internal Medicine the Ohio State University Comprehensive Cancer Center Department of Radiation Oncology the Ohio State University Comprehensive Cancer Center Division of Surgical Oncology Department of Surgery and James Cancer Hospital and Richard Solove Research Institute the Ohio State University Comprehensive Cancer Center

Adrenocortical carcinoma(ACC)is a rare malignancy with generally poor outcomes and limited treatment *** surgical resection can be curative for early local disease,most patients present with advanced ACC owing to nonspecific *** those patients,treatment options include systemic chemotherapy and locoregional therapies including radiofrequency ablation and transarterial *** present the first reported case of utilizing yttrium-90 microsphere selective internal radiation therapy(SIRT)in combination with first line EDP-M(Etoposide,Doxorubicin,Cisplatin,Mitotane)chemotherapy and debulking surgical primary tumor resection for treatment of metastatic *** complete radiologic response has been maintained after twelve months with resolution of clinical *** findings prompt the need for further consideration and studies to elucidate the role of SIRT in combination with systemic and surgical treatment for metastatic ACC.

关键词： Adrenocortical carcinoma Hepatic metastases Radioembolization Yttrium-90

Automated generation and ensemble-learned matching of X-ray absorption spectra

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npj Computational Materials 2018年第1期4卷 566-574页

作者： Chen Zheng Kiran Mathew Chi Chen Yiming Chen Hanmei Tang Alan Dozier joshua j.Kas Fernando D.Vila john j.Rehr Louis F.j.Piper Kristin A.Persson Shyue Ping Ong Department of NanoEngineering University of California San Diego9500 Gilman DriveMail Code 0448La JollaCA 92093-0448USA Department of Materials Science University of California BerkeleyBerkeleyCA 94720USA Division of Applied Research and Technology National Institute for Occupational Safety and HealthCenters for Disease ControlCincinnatiOH 45226USA Department of Physics University of WashingtonSeattleWA 98195USA Department of Physics Applied Physics and AstronomyBinghamton UniversityBinghamtonNY 13902USA Materials Science&Engineering Binghamton UniversityBinghamtonNY 13902USA

X-ray absorption spectroscopy(XAS)is a widely used materials characterization technique to determine oxidation states,coordination environment,and other local atomic structure *** of XAS relies on comparison of measured spectra to reliable reference ***,existing databases of XAS spectra are highly limited both in terms of the number of reference spectra available as well as the breadth of chemistry *** this work,we report the development of XASdb,a large database of computed reference XAS,and an Ensemble-Learned Spectra IdEntification(ELSIE)algorithm for the matching of *** currently hosts more than 800,000 K-edge X-ray absorption near-edge spectra(XANES)for over 40,000 materials from the open-science Materials Project *** discuss a high-throughput automation framework for FEFF calculations,built on robust,rigorously benchmarked *** is a computer program uses a real-space Green’s function approach to calculate X-ray absorption *** will demonstrate that the ELSIE algorithm,which combines 33 weak“learners”comprising a set of preprocessing steps and a similarity metric,can achieve up to 84.2% accuracy in identifying the correct oxidation state and coordination environment of a test set of 19 K-edge XANES spectra encompassing a diverse range of chemistries and crystal *** XASdb with the ELSIE algorithm has been integrated into a web application in the Materials Project,providing an important new public resource for the analysis of XAS to all materials ***,the ELSIE algorithm itself has been made available as part of veidt,an open source machine-learning library for materials science.

关键词： matching XANES ensemble

The essential Marilyn Monroe

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The essential Marilyn Monroe

Tuning the melting point and phase stability of rare-earth oxides to facilitate their crystal growth from the meltv

作者： joshua Greene.

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journal of Advanced Ceramics 2022年第9期11卷 1479-1490页

作者： Matheus PIANASSOLA Kaden L.ANDERSON joshua SAFIN Can AGCA jake W.MCMURRAY Bryan C.CHAKOUMAKOS jöerg C.NEUEFEIND Charles L.MELCHER Mariya ZHURAVLEVA Scintillation Materials Research Center The University of TennesseeKnoxville 37996USA Department of Materials Science and Engineering The University of TennesseeKnoxville 37996USA Materials Science and Technology Division Oak Ridge National LaboratoryOak Ridge 37831USA Neutron Scattering Division Oak Ridge National LaboratoryOak Ridge 37831USA Department of Nuclear Engineering The University of TennesseeKnoxville 37996USA

The challenge of growing rare-earth(RE)sesquioxide crystals can be overcome by tailoring their structural stability and melting point via composition *** work contributes to the advancement of the field of crystal growth of high-entropy oxides.A compound with only small REs(Lu,Y,Ho,Yb,Er)_(2)O_(3)maintains a cubic C-type structure upon cooling from the melt,as observed via in-situ high-temperature neutron diffraction on aerodynamically levitated *** the other hand,a compound with a mixture of small and large REs(Lu,Y,Ho,Nd,La)_(2)O_(3)crystallizes as a mixture of a primary C-type phase with an unstable secondary *** of compositions(Lu,Y,Ho,Nd,La)_(2)O_(3)and(Lu,Y,Gd,Nd,La)_(2)O_(3)were grown by the micro-pulling-down(mPD)method with a single monoclinic B-type phase,while a powder of(Lu,Y,Ho,Yb,Er)_(2)O_(3)did not melt at the maximum operating temperature of an iridium-rhenium *** minimization of the melting point of the two grown crystals is attributed to the mismatch in cation *** electron probe microanalysis reveals that the general element segregation behavior in the crystals depends on the composition.

关键词： high-entropy oxides crystallography neutron diffraction crystal growth

Radical coupling of β-ketoesters and amides promoted by Brønsted/ Lewis acids

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Green Synthesis and Catalysis 2020年第1期1卷 70-74页

作者： joshua L.Zhu Stephen W.Laws Michael j.Rourke Karl A.Scheidt Department of Chemistry Center for Molecular Innovation and Drug DiscoveryNorthwestern UniversityEvanstonIL 60208United States

Recent advances in photocatalysis have enabled radical methods with complementary chemoselectivity to established two electron bond forming *** this radical strategy has previously been limited to substrates with favorable redox potentials,Brønsted/Lewis acid activation has emerged as a means of facilitating otherwise difficult *** report herein our investigations into the Lewis acid-promoted redox activation ofβ-ketocarbonyls in a model photocatalytic radical alkylation *** evaluation of substrates and reactions conditions was achieved by high throughput experimentation using 96-well plate photoreactors.

关键词： Photochemistry Lewis acid Catalysis Alkylation Radicals

Management of non-ST-segment elevation myocardial in-farction in patients aged≥80 years:a meta-analysis of ran-domized controlled trials

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journal of Geriatric Cardiology 2022年第10期19卷 789-790页

作者： Connor j Matthews joshua Kirby jonathan M Blaxill john P Greenwood Abdul M Mozid jennifer A Rossington Murugapathy Veerasamy Nancy Wassef Stephen B Wheatcroft Heerajnarain Bulluck Yorkshire Heart Centre Leeds General InfirmaryLeeds Teaching Hospitals NHS TrustLeedsUnited Kingdom Leeds Institute of Cardiovascular and Metabolic Medicine University of LeedsLeedsUnited Kingdom

Coronary artery disease(CAD)is the major cause of morbidity and mortality in elderly patients.^([1])Despite this,elderly patients are under-represented in most trials of ***-ST-segment elevation myocardial infarction(NSTEMI)is a common cause of hospitalization among patients≥80 years of age,^([2])and with an aging global population,there is a pressing need to establish the optimal management strategy for these ***,we conducted a meta-analysis of all randomized control trials(RCTs)performed to date in patients≥80 years of age,comparing an initial invasive versus conservative strategy to provide insights into their optimal initial management strategy.

关键词： patients mortality analysis