Radical coupling of β-ketoesters and amides promoted by Brønsted/ Lewis acids

作     者：Joshua L.Zhu Stephen W.Laws Michael J.Rourke Karl A.Scheidt 

作者机构：Department of ChemistryCenter for Molecular Innovation and Drug DiscoveryNorthwestern UniversityEvanstonIL 60208United States 

出 版 物：《Green Synthesis and Catalysis》 (绿色合成与催化（英文）)

年 卷 期：2020年第1卷第1期

页      面：70-74页

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：We thank Northwestern University and the National Institute of General Medical Sciences(Nos.R01 GM131431 and R35 GM136440)for support of this work 

主　　题：Photochemistry Lewis acid Catalysis Alkylation Radicals 

摘      要：Recent advances in photocatalysis have enabled radical methods with complementary chemoselectivity to established two electron bond forming *** this radical strategy has previously been limited to substrates with favorable redox potentials,Brønsted/Lewis acid activation has emerged as a means of facilitating otherwise difficult *** report herein our investigations into the Lewis acid-promoted redox activation ofβ-ketocarbonyls in a model photocatalytic radical alkylation *** evaluation of substrates and reactions conditions was achieved by high throughput experimentation using 96-well plate photoreactors.