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Towards seamless environmental prediction-development of Pan-Eurasian EXperiment(PEEX)modelling platform

Big Earth Data 2024年第2期8卷 189-230页

作者： Alexander Mahura Alexander Baklanov Risto Makkonen Michael Boy Tuukka Petäjä Hanna KLappalainen Roman Nuterman Veli-Matti Kerminen Stephen R.Arnold Markus Jochum Anatoly Shvidenko Igor Esau Mikhail Sofiev Andreas Stohl Tuula Aalto Jianhui Bai Chuchu Chen Yafang Cheng Oxana Drofa Mei Huang Leena Järvi Harri Kokkola Rostislav Kouznetsov Tingting Li Piero Malguzzi Sarah Monks Mads Bruun Poulsen Steffen M.Noe Yuliia Palamarchuk benjamin Foreback Petri Clusiu Till Andreas Soya Rasmussen Jun She Jens Havskov Sørensen Dominick Spracklen Hang Su Juha Tonttila Siwen Wang Jiandong Wang Tobias Wolf-Grosse Yongqiang Yu Qing Zhang Wei Zhang Wen Zhang Xunhua Zheng Siqi Li Yong Li Putian Zhou Markku Kulmala Faculty of Science Institute for Atmospheric and Earth System Research(INAR)/PhysicsUniversity of Helsinki(UHEL)HelsinkiFinland Science and Innovation Department World Meteorological Organization(WMO)GenevaSwitzerland Niels Bohr Institute University of CopenhagenCopenhagenDenmark Climate System Research Finnish Meteorological Institute(CSR-FMI)HelsinkiFinland School of Engineering Sciences Lappeenranta University of TechnologyLappeenrantaFinland Institute for Climate and Atmospheric Science School of Earth and EnvironmentUniversity of LeedsLeedsUK Biodiversity and Natural Resources Program International Institute for Applied Systems Analysis(IIASA)LaxenburgAustria Department of Physics and Technology UiT-The Arctic University of NorwayTromsoNorway Nansen Environmental and Remote Sensing Center(NERSC) BergenNorway Atmospheric Composition Finnish Meteorological Institute(AC-FMI)HelsinkiFinland Norwegian Institute for Air Research(NILU) KjellerNorway LAGEO Institute of Atmospheric PhysicsChinese Academy of Sciences(IAP-CAS)BeijingChina Max Planck Institute for Chemistry(MPI-Chem) MainzGermany Institute of Atmospheric Sciences and Climate National Research Council of Italy(CNR-15SAC)BolognaItaly Institute of Geographic Sciences and Natural Resources Research(IGSNRR) Chinese Academy of Sciences(CAS)BeijingChina Faculty of Science Helsinki Institute of Sustainability Science(HELSUS)University of Helsinki(UHEL)HelsinkiFinland Atmospheric Research Centre of Eastern Finland Finnish Meteorological Institute(ARCEF-FMI)KuopioFinland Institute of Atmospheric Physics Chinese Academy of Sciences(IAP-CAS)BeijingChina Department of Plant Physiology Estonian University of Life Sciences(EULS)Institute of Agricultural and Environmental Sciences(IAES)TartuEstonia Danish Meteorological Institute(DMI) CopenhagenDenmark State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry(LAPC) Institute of Atmospheric Physics(IAP)Chinese Academy of Sciences(CAS)BeijingChina Uni

The Pan-Eurasian Experiment Modelling Platform(PEEX-MP)is one of the key blocks of the PEEX Research *** PEEX MP has more than 30 models and is directed towards seamless envir-onmental *** main focus area is the Arctic-boreal regions and *** models used in PEEX-MP cover several main components of the Earth’s system,such as the atmosphere,hydrosphere,pedosphere and biosphere,and resolve the physicalchemicalbiological processes at different spatial and temporal scales and *** paper introduces and discusses PEEX MP multi-scale modelling concept for the Earth system,online integrated,forward/inverse,and socioeconomical modelling,and other approaches with a particular focus on applications in the PEEX geographical *** employed high-performance com-puting facilities,capabilities,and PEEX dataflow for modelling results are *** virtual research platforms(PEEXView,Virtual Research Environment,Web-based Atlas)for handling PEEX modelling and observational results are *** over-all approach allows us to understand better physical-chemicalbiological processes,Earth’s system interactions and feedbacks and to provide valuable information for assessment studies on evaluating risks,impact,consequences,*** population,envir-onment and climate in the PEEX *** work was also one of the last projects of *** Zilitinkevich,who passed away on 15 February *** the finalization took time,the paper was actually submitted in 2023 and we could not argue that the final paper text was agreed with him.

关键词： Multi-scale and-processes modelling concept seamless coupling high-performance computing data infrastructure virtual research platforms

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WONCA Online电子病例介绍——慢性结节性耳轮软骨皮炎

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中国全科医学 2008年第20期11卷 1891-1891页

作者： Alim Devani benjamin Barankin 李井泉中国全科医学杂志社

·病例简介:患者,女,64岁,因右耳廓出现4mm大小的结节而就诊(见图1)。结节有触痛,影响睡眠。患者否认有局部外伤史。图1慢性结节性耳轮软骨皮炎·可能的诊断:基底细胞瘤;鳞癌;痛风石;慢性结节性耳轮软骨皮炎(CNCH);角化棘皮瘤。·诊断:C... 详细信息

·病例简介:患者,女,64岁,因右耳廓出现4mm大小的结节而就诊(见图1)。结节有触痛,影响睡眠。患者否认有局部外伤史。图1慢性结节性耳轮软骨皮炎·可能的诊断:基底细胞瘤;鳞癌;痛风石;慢性结节性耳轮软骨皮炎(CNCH);角化棘皮瘤。·诊断:CNCH。·讨论:CNCH是一种常见的外耳疾患,常发生于40岁以上的人群,以右侧多见,可能与睡眠习惯有关。CNCH的病因还不清楚,可能与长期的压迫或环境因素造成外耳的损伤有关。有研究认为压迫导致耳廓软骨的坏死是导致CNCH的病因,因耳廓软骨下无脂肪组织,在长时间的压迫下软骨容易发生缺血。大部分患者无明显的诱因,如损伤、压迫或者受凉等。现在已经有使用手机后引起CNCH的报道,其原因据认为与长时间持手机时对耳廓下部的压迫有关。这种外耳的炎性结节可缓慢发生,也可突然出现。通常结节的直径不超过1cm,呈圆形,边界清楚,灰红色,中间可以有瘢痕或鳞屑样改变。结节触之坚硬,有轻微的触痛,移动性差,稍隆起。结节也可以呈溃疡状,表皮脱落或红斑。大多数患者没必要行进一步检查,仅根据患者的临床表现就可以确诊。部分患者行进一步检查主要是为了排除肿瘤性疾患。[第一段]

关键词：慢性结节性耳轮软骨皮炎诊断治疗

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AIWW:a new nutrition-screening tool for the oncologic population

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Science China(Life Sciences) 2023年第8期66卷 1831-1840页

作者： Yi-Zhong Ge Zhen-Ming Fu Qi Zhang Meng-Meng Song Guo-Tian Ruan Xi Zhang Xiao-Wei Zhang Xiang-Rui Li Kang-Ping Zhang Meng Tang Xiao-Yue Liu Ming Yang Tong Liu Hai-Lun Xie He-Yang Zhang Zi-Wen Wang Chun-Lei Hu Shi-Qi Lin Rui Zhang Hong-Xia Xu Wei Li Chun-Hua Song Ming Liu Jun-Qiang Chen Kun-Hua Wang Li Bo Ming-Hua Cong Zeng-Ning Li Zeng-Qin Guo Xiao-Bin Wang Bin-Yan Wang benjamin Xu Xian-Hui Qin Xi-Ping Xu Rocco Barazzoni Qing-Hua Yao Min Weng Xian Shen Han-Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group Department of Gastrointestinal Surgery/Department of Clinical Nutrition Beijing Shijitan HospitalCapital Medical UniversityBeijing 100038China The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University Wenzhou 325000China National Clinical Research Center for Geriatric Diseases Xuanwu HospitalCapital Medical UniversityBeijing 100053China Beijing International Science and Technology Cooperation Base for Cancer Metabolism and Nutrition Beijing 100038China Key Laboratory of Cancer FSMP for State Market Regulation Beijing 100038China Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Colorectal Surgery Cancer Hospital of University of Chinese Academy of SciencesZhejiang Cancer HospitalHangzhou 310022China Department of Clinical Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Cancer Center of the First Hospital of Jilin University Changchun 130021China Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou450001China Department of Colorectal Surgery the Second Affiliated Hospital of Harbin Medical UniversityHarbin 150081China Department of Gastrointestinal Surgery First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China Yunnan University Kunming 650091China General Surgery Clinical Medical Center of Yunnan Province Kunming 650032China Affiliated Hospital of Yunnan University Kunming 650091China Comprehensive Oncology Department Cancer HospitalChinese Academy of Medical SciencesBeijing 100021China Department of Clinical Nutrition The First Hospital of Hebei Medical UniversityShijiazhuang 050031China Department of Medical Oncology Fujian Cancer HospitalFujian Medical University Cancer HospitalFuzhou 350014China Department of Population Family and Reproductive HealthJohns Hopkins University Bloomberg School of Public HealthBaltimore MD 21228USA Shenzhen Evergreen Medical Institute Shenzhen 518052China Department of Epid

Malnutrition is a common comorbidity among patients with ***,no nutrition-screening tool has been recognized in this population.A quick and easy screening tool for nutrition with high sensitivity and easy-to-use is *** on the previous 25 nutrition-screening tools,the Delphi method was made by the members of the Chinese Society of Nutritional Oncology to choose the most useful item from each *** to these results,we built a nutrition-screening tool named age,intake,weight,and walking(AIWW).Malnutrition was defined based on the scored patient-generated subjective global assessment(PG-SGA).Concurrent validity was evaluated using the Kendall tau coefficient and kappa consistency between the malnutrition risks of AIWW,nutritional risk screening 2002(NRS-2002),and malnutrition screening tool(MST).Clinical benefit was calculated by the decision curve analysis(DCA),integrated discrimination improvement(IDI),and continuous net reclassification improvement(c NRI).A total of 11,360 patients(male,n=6,024(53.0%)were included in the final study cohort,and 6,363 patients had malnutrition based on *** on AIWW,NRS-2002,and MST,7,545,3,469,and1,840 patients were at risk of malnutrition,*** sensitivities of AIWW,NRS-2002,and MST risks were 0.910,0.531,and 0.285,and the specificities were 0.768,0.946,and *** Kendall tau coefficients of AIWW,NRS-2002,and MST risks were 0.588,0.501,and 0.326,*** area under the curve of AIWW,NRS-2002,and MST risks were0.785,0.739,and 0.630,*** IDI,c NRI,and DCA showed that AIWW is non-inferior to NRS-2002(IDI:0.002(-0.009,0.013),c NRI:-0.015(-0.049,0.020)).AIWW scores can also predict the survival of patients with *** missed diagnosis rates of AIWW,NRS-2002,and MST were 0.09%,49.0%,and 73.2%,*** showed a better nutritionscreening effect than NRS-2002 and MST for patients with cancer and could be recommended as an alternative nutritionscreening tool

关键词： nutrition-screening AIWW NRS-2002 MST cancer

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WONCA Online电子病例介绍——亚急性皮肤红斑狼疮

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中国全科医学 2008年第19期11卷 1807-1807页

作者： Irina Turchin benjamin Barankin 李井泉中国全科医学杂志社

·病例简介:病人,男,68岁,因胸部、面颊部红斑就诊.红斑于6个月前发生,经治疗后消失,现再次出现且蔓延至右侧肢体.病人因2年前患心脏病曾服用过氢氯噻嗪、苯丁酸赖脯酸以及阿司匹林.·体格检查:除局部病变外,无其他阳性发现,实验室检查... 详细信息

·病例简介:病人,男,68岁,因胸部、面颊部红斑就诊.红斑于6个月前发生,经治疗后消失,现再次出现且蔓延至右侧肢体.病人因2年前患心脏病曾服用过氢氯噻嗪、苯丁酸赖脯酸以及阿司匹林.·体格检查:除局部病变外,无其他阳性发现,实验室检查无异常.

关键词：红斑狼疮皮肤诊断治疗

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本的忠言

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语言教育 1998年第12期 69-页

作者： benjamin Franklin 黄震赵永生

关键词： things

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循环脂肪因子和血管功能:以社区为基础的横断面研究

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中华高血压杂志 2015年第11期23卷 1086-1086页

作者：刘莉叶鹏 Zachariah JP Hwang S Hamburg NM benjamin EJ Larson MG Levy D Vita JA Sullivan LM Mitchell GF Vasan RS

脂肪细胞因子可能是过度肥胖和血管功能障碍之间关系的潜在调节因子。该研究在一以社区为基础的较年轻人群中对循环脂肪因子和血管弹性的横断面关系进行评估。方法：研究人员在Framingham第3代队列研究无心血管病的3505例受试者中（平... 详细信息

脂肪细胞因子可能是过度肥胖和血管功能障碍之间关系的潜在调节因子。该研究在一以社区为基础的较年轻人群中对循环脂肪因子和血管弹性的横断面关系进行评估。方法：研究人员在Framingham第3代队列研究无心血管病的3505例受试者中（平均40岁,53%为女性）,研究循环瘦素和瘦素受体浓度、脂联素、视黄醇结合蛋白4、

关键词：脂肪因子脂肪酸结合蛋白脂肪细胞因子血管功能血管弹性视黄醇结合蛋白过度肥胖队列研究瘦素受体动脉僵硬度

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父母高血压与其非高血压后代的动脉僵硬度的关系

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中华高血压杂志 2016年第8期24卷 757-757页

作者：刘莉叶鹏 Andersson C Quiroz R Enserro D Larson MG Hamburg NM Vita JA Levy D benjamin EJ Mitchell GF Vasan RS

高动脉僵硬度似乎参与高血压的发病。该研究旨在验证患高血压父母其后代在临床表现为高血压之前,就体现出较高的动脉僵硬度,毕竟高血压具有遗传性。方法：纳入Framingham心脏研究第三代队列中的1564名非高血压者（平均年龄38岁,55%为女... 详细信息

高动脉僵硬度似乎参与高血压的发病。该研究旨在验证患高血压父母其后代在临床表现为高血压之前,就体现出较高的动脉僵硬度,毕竟高血压具有遗传性。方法：纳入Framingham心脏研究第三代队列中的1564名非高血压者（平均年龄38岁,55%为女性,其父母是Framingham后代研究受试者）,比较动脉张力测量值。结果：最终分别纳入父母均无高血压（对照组）（468人）、父母其中一人患高血压（715人）、父母均患高血压的受试者（381人）进行研究。

关键词：动脉僵硬度动脉张力平均动脉压脉搏波传导速度第三代波振幅影响因素

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家电用交流开关技术:智能电力管理的前景

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电子设计技术 2002年第8期 70-70页

作者： Thierry Castagnet Arnaud Bonnet benjamin Cheron 意法半导体公司意法半导体公司意法半导体公司

家用电器,例如洗衣机、电冰箱和空调机,是用电子控制的方法来降低能量的消耗,提高使用人员的舒适感。它们是直接由120V或者230V电网供电,最多会用到8只高电压AC开关来控制定时器的电源、带动电动机、阀和电阻丝加热器。

关键词：开关技术 AC

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钢结构的局部屈曲性能

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钢结构(中英文) 2011年第2期 81-81页

作者： Mina Seif benjamin W. Schafer

考虑了单元间相互作用,提出热轧钢结构局部弹性屈曲应力的解析式,将局部屈曲分析结果与美国AISC钢结构规范中确定局部允许长细比时的内在假定进行对比。采用有线条法确定横截面局部屈曲应力。分析了AISC构件数据库中(不含管)每个截面在... 详细信息

考虑了单元间相互作用,提出热轧钢结构局部弹性屈曲应力的解析式,将局部屈曲分析结果与美国AISC钢结构规范中确定局部允许长细比时的内在假定进行对比。采用有线条法确定横截面局部屈曲应力。分析了AISC构件数据库中(不含管)每个截面在轴压下及绕主、次轴正、负弯曲时的局部稳定性。将求局部屈曲应力转化为计算平面屈曲系数k,给出了k的简化公式。新公式明确考虑了构件腹板-翼缘的弹性相互作用。结果表明:有线条法计算的k值与AISC规范中的假定明显不同。

关键词：局部屈曲平面屈曲系数允许长细比有线条法横截面稳定临界屈曲应力

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Hyperhomocysteinemia: Risk Factors and Faster Onset of Degenerative Complications of Type 2 Diabetes in Brazzaville

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Journal of Diabetes Mellitus 2023年第3期13卷 257-267页

作者： Ikia Monde Valsy Russelh Evariste Bouenizabila Farel Elilie Mawa Ongoth Raissa Laure Mayanda Ohouna Aymande Okoumou-Moko Paulin Kibeke Ghislain Loubano-Voumbi Luc Magloire Boumba Anicet Wilson Fabrice Ondongo Mayindou Kimbangu Archimède Gotran Tienelle Freiss Mabiala Wann Koumou Onanga Thierry Raoul Ngombea benjamin Longo Mbenza Edouard Ngou Milama Christian Andres Etienne Mokondjimobe Henri Germain Monabeka Biochemistry Laboratory Department University Hospital Center Brazzaville Republic of the Congo Faculty of Health Sciences Marien Ngouabi University Brazzaville Republic of the Congo Department of Metabolic and Endocrine Diseases University Hospital Brazzaville Republic of the Congo Pointe-Noire Research Area National Institute for Research in Health Sciences Pointe-Noire Republic of the Congo Department of Statistics Health Information and Epidemiological Surveillance Departmental Directorate of Health Care and Services Brazzaville Republic of the Congo Department of Public Health LOMO Research University Kinshasa Democratic Republic of the Congo Faculty of Medicine University of Health Sciences Libreville Gabon Department of Biochemistry and Molecular Biology Tours Regional University Hospital Tours France

Background: Type 2 diabetes (T2D) remains a major global public health problem. This complex metabolic disorder can lead to various complications, including cardiovascular diseases (leading cause of death) in T2D. Among the biochemical markers associated with increased risk for cardiovascular disease, homocysteine is currently one of the predictive markers under evaluation. We investigate the link between hyperhomocysteinemia and diabetes complications in DT2 population in Brazzaville. Methodology: We conducted a cross-sectional analytical study, from October to December 2022. One hundred and fifty participants were included, 100 patients T2D (34 with complications, 33 with comorbidities, 33 without), and 50 patients controls. Sociodemographic and clinical characteristics were collected. Homocysteine (Hcy) serum levels were measured using Sandwich ELISA method. Results: Study population was composed of 50% males and 50% females with sex ratio of 1;mean age was 52.2 ± 10.8 years (30 - 83). The prevalence of hyperhomocysteinemia (HHcy) was 36% (20% moderate Hcy, 15% intermediate and 1% severe). Mean Hcy concentration was 31.9 μmol/l (18 - 103). Age, gender and physical inactivity were strongly correlated to Hcy (OR of 3.5;9.4 and 3 respectively). Multivariate analysis showed that HHcy was a risk accelerator for degenerative complications (stroke: OR = 6.2;ischemic heart disease: 4.9;neuropathy: 9.2;retinopathy: 4.5 and peripheral arterial disease: 4.9). Conclusion: These findings suggest that hyperhomocysteinemia can be considered as a predictive marker to be taken into account in targeting cardiovascular risk in Congolese subjects with T2D.

关键词： Hyperhomocysteinemia Patients with T2D Risk Factor Acceleration Factor Degenerative Complications Congo

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