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Superior growth performance in broiler chicks fed chelated compared to inorganic zinc in presence of elevated dietary copper

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Journal of Animal Science and biotechnology 2016年第4期7卷 561-569页

作者： Junmei Zhao Robert b. Shirley Julia J. Dibner Karen J. Wedekind Frances Yan Paula Fisher Thomas R. Hampton joseph L. Evans Mercedes Vazquez-Anon research and development novus international20 Research Park DriveSaint CharlesMO 63304USA current affiliation:poultry technical services adisseo usaAlpharettaGA 30022USA

background： The goal of this study was to compare the antagonism of elevated dietary Cu （250 mg/kg） from CuS04 on three different Zn sources （ZnS04. H20; [Zn bis（-2-hydroxy-4-（methylthio）butanoic acid）], Zn（HMTba）2 a chelated Zn methionine hydroxy analogue; and Zn-Methionine）, as measured using multiple indices of animal performance in ROSS 308 broilers. Methods： Three experiments were conducted in broiler chicks fed a semi-purified diet. All birds were fed a Zn-deficient diet （8.5 mg/kg diet） for 1 wk, and then provided with the experimental diets for 2 wks. Results： Experiment 1 was a 2 x 2 factorial design with two levels of Cu （8 vs. 250 mg/kg diet from CuSO4） and two Zn sources at 30 mg/kg [ZnSO4. H20 vs. Zn（HMTba）2]. Elevated Cu impaired growth performance only in birds fed ZnSO4. Compared to ZnSO4. H20, Zn（HMTba）2 improved feed intake （12 %; P 〈 0.001） and weight gain （12 %, P 〈 0.001） and the benefits were more pronounced in the presence of 250 mg/kg diet Cu. Experiment 2 was a dose titration of ZnSO4- H20 and Zn（HMTba）2 at 30, 4,5, 60, and 75 mg/kg diet in the presence of 250 mg/kg CuSO4. Feed：gain was decreased and tibia Zn was increased with increasing Zn levels from 30 to 75 mg/kg. birds fed Zn（HMTba）2 consumed more food and gained more weight compared to birds fed ZnSO4, especially at lower supplementation levels （30 and 45 mg/kg; interaction P 〈 0,05）. Experiment 3 compared two organic Zn sources （Zn（HMTba）2 vs. Zn-Methionine） at 30 mg/kg with or without 250 mg/kg CuSO4. No interactions were observed between Zn sources and Cu levels on performance or tissue mineral concentrations. High dietary Cu decreased weight gain （P 〈 0.01）. Tibia Cu and liver Cu were significantly increased with 250 mg/kg dietary Cu supplementation （P 〈 0.01）. No difference was observed between the two Zn sources. Conclusions： Dietary 250 mg/kg Cu significantly impaired feed intake and weight gain in birds fed ZnSO4. H20, but had less impact in birds fed Zn（HMTba）2. No difference

关键词： Antagonism broilers Chelates Growth MineraLs Organic Performance

Macrophage polarization in response to wear particles in vitro

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Cellular & Molecular Immunology 2013年第6期10卷 471-482页

作者： joseph K Antonios Zhenyu Yao Chenguang Li Allison J Rao Stuart b Goodman Orthopaedic Research Laboratories Department of Orthopaedic Surgery Stanford University School of Medicine Stanford CA USA

Total joint replacement is a highly successful surgical procedure for treatment of patients with disabling arthritis and joint dysfunction. However, over time, with high levels of activity and usage of the joint, implant wear particles are generated from the articulating surfaces. These wear particles can lead to activation of an inflammatory reaction, and subsequent bone resorption around the implant （periprosthetic osteolysis）. Cells of the monocyte/macrophage lineage orchestrate this chronic inflammatory response, which is dominated by a pro-inflammatory （M 1） macrophage phenotype rather than an anti-inflammatory pro-tissue healing （M2） macrophage phenotype. While it has been shown that interleukin-4 （IL-4） selectively polarizes macrophages towards an M2 anti-inflammatory phenotype which promotes bone healing, rather than inflammation, little is known about the time course in which this occurs or conditions in which repolarization through I L-4 is most effective. The goal of this work was to study the time course of murine macrophage polarization and cytokine release in response to challenge with combinations of polymethyl methacrylate （PMMA） particles, lipopolysaccharide （LPS） and IL-4 in vitro. Treatment of particle-challenged monocyte/macrophages with IL-4 led to an initial suppression of pro-inflammatory cytokines and inducible nitric oxide synthase （iNOS） production and subsequent polarization into an M2 anti-inflammatory phenotype. This result was optimized when IL-4 was delivered before PMMA particle challenge, to an M 1 phenotype rather than to uncommitted （MO） macrophages. The effects of this polarization were sustained over a 5-day time course. Polarization of M1 macrophages into an M2 phenotype may be a strategy to mitigate wear particle associated periprosthetic osteolysis.

关键词： IL-4 macrophage polarization osteolysis PMMA particles total joint replacement

MLD-MPC Approach for Three-Tank Hybrid benchmark Problem

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Computers, Materials & Continua 2023年第5期75卷 3657-3675页

作者： Hanen Yaakoubi Hegazy Rezk Mujahed Al-Dhaifallah joseph Haggège Research Laboratory in Automatic Control(LARA) National Engineering School of Tunis(ENIT)University of Tunis El ManarTunis1002Tunisia Department of Electrical Engineering College of Engineering in Wadi AlddawasirPrince Sattam bin Abdulaziz UniversityWadi Alddawasir11911Saudi Arabia Control and Instrumentation Engineering Department King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center(IRC)for Renewable Energy and Power Systems King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia

The present paper aims at validating a Model Predictive Control(MPC),based on the Mixed Logical Dynamical(MLD)model,for Hybrid Dynamic Systems(HDSs)that explicitly involve continuous dynamics and discrete *** proposed benchmark system is a three-tank process,which is a typical case study of *** MLD-MPC controller is applied to the level control of the considered tank *** study is initially focused on the MLD approach that allows consideration of the interacting continuous dynamics with discrete events and includes the operating *** feature of MLD modeling is very advantageous when an MPC controller synthesis for the HDSs is *** the MLD model of the system is well-posed,then the MPC law synthesis can be developed based on the Mixed Integer Programming(MIP)optimization *** solving this MIP problem,a branch and bound(b&b)algorithm is proposed to determine the optimal control ***,a comparative study is carried out to illustrate the effectiveness of the proposed hybrid controller for the HDSs compared to the standard MPC *** results show that the MLD-MPC approach outperforms the standardMPCone that doesn’t consider the hybrid aspect of the *** paper also shows a behavioral test of the MLDMPC controller against disturbances deemed as liquid leaks from the *** results are very satisfactory and show that the tracking error is minimal less than 0.1%in nominal conditions and less than 0.6%in the presence of *** results confirm the success of the MLD-MPC approach for the control of the HDSs.

关键词： Hybrid dynamic system model predictive control mixed logical dynamical model mixed integer programming three-tank hybrid system

Effect of hydrostatic pressure and polaronic mass of the binding energy in a spherical quantum dot

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Chinese Physics b 2015年第11期24卷 92-97页

作者： A.Rejo Jeice Sr.Gerardin Jayam K.S.joseph Wilson Department of Physics Annai Velankanni College Department of Physics Holy Cross College Departmant of Physics Arul Anandar College (Autonomous)

Simultaneous effect of hydrostatic pressure and polaronic mass on the binding energies of the ground and excited states of an on-center hydrogenic impurity confined in a GaAs/GaA1As spherical quantum dot are theoretically investigated by the variational method within the effective mass approximation. The binding energy is calculated as a function of dot radius and pressure. Our findings proved that the hydrostatic pressure led to the decrease of confined energy and the increase of donor binding energy. Conduction band non-parabolicity and the polaron masses are effective in the donor binding energy which is significant for narrow dots not in the confined energy. The maximum donor binding energy achieved by the polaronic mass in the ground and excited states are 2%-19% for the narrow dots. The confined and donor binding energies approach zero as the dot size approaches infinity.

关键词： spherical quantum dot square well confinement confined energies effective mass approximation

Fenton氧化处理爆炸物污染土壤的实验研究

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环境科学学报 2007年第10期27卷 1657-1662页

作者：何义亮 joseph b.Hughes Sung SooHan School of Civil and Environmental Engineering Georgia Institute of TechnologyAtlanta.GA30332USA 上海交通大学环境科学与工程学院上海200240

采用摇瓶和玻璃柱试验考察了Fenton氧化处理爆炸物污染土壤中2,4-DNT、2,6-DNT以及COD等的去除效果及其最佳参数.当3%H2O2投加量达到26.46mmol、FeSO4和H2O2的物质的量之比约为1:73.56时,2,4-DNT和2,6-DNT均可被完全氧化,COD去除率可达... 详细信息

采用摇瓶和玻璃柱试验考察了Fenton氧化处理爆炸物污染土壤中2,4-DNT、2,6-DNT以及COD等的去除效果及其最佳参数.当3%H2O2投加量达到26.46mmol、FeSO4和H2O2的物质的量之比约为1:73.56时,2,4-DNT和2,6-DNT均可被完全氧化,COD去除率可达到87%.对于2,4-DNT和2,6-DNT,反应时间只需要2h,但要同时去除其它芳香族硝基化合物,则反应时间需要超过8h.土壤直接Fenton氧化的效果并不理想,而对洗出液进行Fenton氧化可以取得很好的效果.通过反应动力学分析和丙酮抑制试验得出,2,4-DNT比2,6-DNT容易氧化.GC-MS分析结果表明,不仅土壤中的2,4-DNT、2,6-DNT可被氧化,其它的硝基芳香族有机化合物也可被氧化去除.

关键词： Fenton氧化爆炸物污染土壤 2,4-DNT 2,6-DNT

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大块光学晶体的生长技术

压电与声光 1989年第2期11卷 48-51页

作者： joseph b.Milstein 朱翠英美.罗威尔大学电气工程系

大块光学晶体已经生长成功,它们分别用作窗或滤光器等无源元件,以及用于激光、闪烁器或二次谐波发生器等有源元件的材料。光学晶体的生长方法主要有三种:布里支曼法、提拉法和溶液生长法。

关键词：光学晶体晶体生长

Enhancing the dissolution of phenylbutazone using Syloid based mesoporous silicas for oral equine applications

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Journal of Pharmaceutical Analysis 2018年第3期8卷 181-186页

作者： Laura J. Waters John P. Hanrahan joseph M. Tobin Catherine V. Finch Gareth M.b. Parkes Shamsuddeen A. Ahmad Faraj Mohammad Maria Saleem School of Applied Sciences University of Huddersfield Queensgate Huddersfield HD1 3DH UK Glantreo Ltd ERI Building Lee Road Cork City T23 XE1O Ireland

Three mesoporous silica excipients （Syloid~ silicas AL-1 FR XDP 3050 and XDP 3150） were formulated with a model drug known for its poor aqueous solubility, namely phenylbutazone, in an attempt to enhance the extent and rate of drug dissolution. Although other forms of mesoporous silica have been investigated in previous studies, the effect of inclusion with these specific Syloid silica based excipients and more interestingly, with phenylbutazone, is unknown. This work reports a significant enhancement for both the extent and rate of drug release for all three forms of Syloid silica at a 1：1 drug：silica ratio over a period of 30 min. An explanation for this increase was determined to be conversion to the amorphous form and an enhanced drug loading ability within the pores. Differences between the release profiles of the three silicas were concluded to be a consequence of the physicochemical differences between the three forms. Overall, this study confirms that Syloid silica based excipients can be used to enhance dissolution, and potentially therefore bioavailability, for compounds with poor aqueous solubility such as phenylbutazone. In addition, it has been confirmed that drug release can be carefully tailored based on the choice of Syloid~ silica and desired release profile.

关键词： Dissolution Syloid silicas Drug-loading Phenylbutazone Solubility

Red osier dogwood and its use in animal nutrition:A review

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Animal Nutrition 2023年第2期13卷 64-77页

作者： Taiwo joseph Erinle Martine boulianne Younes Miar Robert Scales Deborah Adewole Department of Animal Science and Aquaculture Faculty of AgricultureDalhousie UniversityTruro NSB2N 5E3Canada Department of Clinical Sciences Faculty of Veterinary MedicineUniversity of Montreal3200 Sicotte StreetSaint-Hyacinthe QCJ2S 2M2Canada Red Dog Enterprises Ltd. Swan River MBR0L 1Z0Canada

As the human population increases globally,the food animal industry has not been spared from the monumental demand for edible animal products,particularly *** has necessitated the simulta-neous expansion of the productivity of the animal sector to meet the ever-growing human *** antibiotics have been used in food animal production with commendable positive impacts on their growth performance,their sole contributive factor to the increasing incidence of antimicrobial resistance has ushered the strict restrictions placed on their use in the animal *** has handed a setback to both animals and farmers;thus,the intense push for a more sustainable antibiotic alternative for use in animal *** use of plants with concentrated phytogenic compounds has gained much interest due to their beneficial bioactivities,including antioxidant and selective *** the reported beneficial activities of phytogenic additives on animals vary due to their varying total polyphenol concentrations(TPC),red osier dogwood(ROD)plant materials boast of high TPC with excellent antioxidant prowess and growth improvement capacities compared to some plant extracts commonly used in ***,its adoption in research and commercial scale is still ***,the present review aims to provide concise information on the dietary potential of ROD plant materials in animal feeding.

关键词： Red osier dogwood Antibiotic-alternative Polyphenolic compounds Antioxidant Antimicrobial

Indicators and Influence Factors for Sustainability Assessment of Inclusive Smart Innovation Clusters

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Journal of Geological Resource and Engineering 2016年第7期4卷 305-327页

作者： b. Suresh Erinjery joseph James Jegathambal, P. Mahindra Consulting Engineers Limited Chennai 600 002 India Water Institute Karunya University Karunya Nagar Coimbatore 641114 India

A new manufacturing and business infrastructure industrial ecosystem model with the state-of-the art core infrastructure and smart applications in the form of inclusive smart innovation cluster is seen as a powerful tool to drive industrial symbiosis, economic, social and inclusive development. Essentially an integrated eco-industrial park, these clusters demonstrate applications of industrial ecology principles among the occupant units, besides promoting sustainable societies from economic, environmental and social perspectives. The holistic planning and development of these clusters from economic, environmental and social sustainability considerations or alternatively, the sustainability assessment of these clusters is highly complex. The research reported upon forms part of a larger study that aims to develop an integrated decision support system for sustainability assessment of inclusive smart innovation cluster. The paper discusses the conceptual model of the cluster and the need to establish context specific key indicators and influence factors from economic, environmental and social sustainability considerations. The paper proposes a structured methodology for development of key indicators and influence factors. The paper concludes by identifying a set of 184 key indicators and influence factors for comprehensive sustainability assessment of inclusive smart innovation cluster.

关键词： Eco-industrial cluster and park sustainability indicator and assessment influence factors smart development sustainable infrastructure.