Hippo pathway in intestinal homeostasis and tumorigenesis

作     者：Lanfen Chen Funiu Qin Xianming Deng Joseph Avruch Dawang Zhou 

作者机构：State Key Laboratory of Stress Cell BiologySchool of Life SciencesXiamen UniversityXiamen 361005China Department of Molecular BiologyMassachusetts General HospitalBostonMA 02114USA Department of MedicineHarvard Medical SchoolBostonMA 02115USA􀀍 

出 版 物：《Protein & Cell》 (蛋白质与细胞（英文版）)

年 卷 期：2012年第3卷第4期

页      面：305-310页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the China’s 1000 Young Talents Program,the 111 Project of The Ministration of Education of China(No.B06016) the Fundamental Research Funds for the Central Universities of China(No.2010111079) National Natural Science Foundation of China(Grant No.81101503)and Natural Science Foundation of Fujian(No.2011J05096) supported by the RO1 awards CA136567(JA),DK17776(JA)and institutional funds.The authors have no financial conflicts to disclose 

主　　题：Hippo/Mst1/2 YAP/Yorkie intestinal stem cells 

摘      要：The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell *** findings implicate that this pathway is involved in the process of intestinal regeneration and *** we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis,regeneration and tumorigenesis,and the crosstalk between the Hippo signaling pathway and other major signaling pathways,***,Notch and Jak/Stat signaling pathways in intestinal compartment.