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Investigating the causal associations between five anthropometric indicators and nonalcoholic fatty liver disease:Mendelian randomization study

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World Journal of Clinical Cases 2024年第7期12卷 1215-1226页

作者： Xian-Pei Xiao Yong-Jun Dai Yu Zhang Meng Yang Jian Xie guo Chen zheng-Jun Yang Department of Oncology Luojiang District People's Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina Department of Orthopaedics Luojiang District People's Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina Department of Infectious Diseases Hospital of Chengdu University of Traditional Chinese MedicalChengdu 610500Sichuan ProvinceChina

BACKGROUND Although the etiology of nonalcoholic fatty liver disease(NAFLD)has not been thoroughly understood,the emerging roles of anthropometric indicators in assessing and predicting the risk of NAFLD have been highlighted by accumulating *** To evaluate the causal relationships between five anthropometric indicators and NAFLD employing Mendelian randomization(MR)*** The Anthropometric Consortium provided genetic exposure data for five anthropometric indicators,including hip circumference(HC),waist circumference(WC),waist-to-hip ratio(WHR),body mass index(BMI),and body fat percentage(BF).Genetic outcome data for NAFLD were obtained from the United Kingdom Biobank and FinnGen ***-wide significant single nucleotide polymorphisms were chosen as instrumental *** MR(UVMR)and multivariable MR(MVMR)designs with analytical approaches,including inverse variance weighted(IVW),MR-Egger,weighted median(WM),and weighted mode methods,were used to assess the causal relationships between anthropometric indicators and *** Causal relationships were revealed by UVMR,indicating that a higher risk of NAFLD was associated with a perunit increase in WC[IVW:odds ratio(OR)=2.67,95%CI:1.42-5.02,P=2.25×10^(−3)],and BF was causally associated with an increased risk of NAFLD(WM:OR=2.23,95%CI:1.07-4.66,P=0.033).The presence of causal effects of WC on the decreased risk of NAFLD was supported by MVMR after adjusting for BMI and ***,no causal association between BF and NAFLD was *** addition,other causal relationships of HC,WHR(BMI adjusted),and BMI with the risk of NAFLD were not retained after FDR *** This study establishes a causal relationship,indicating that an increase in WC is associated with a higher risk of *** demonstrates that a suitable decrease in WC is advantageous for preventing NAFLD.

关键词： Anthropometric indicator Waist circumference Nonalcoholic fatty liver disease Mendelian randomization Genetic variant

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Unveiling size-fluorescence correlation of organic nanoparticles and its use in nanoparticle size determination

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Aggregate 2024年第1期5卷 331-336页

作者： Wu-Jie guo Shixiang Ma Hui Wang Lu Qiao Lei Chen Chenyu Hong Bin Liu Xiaoyan zheng Hui-Qing Peng State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijingChina Key Laboratory of Cluster Science of Ministry of Education Beijing Key Laboratory of Photoelectronic/Electro-photonic Conversion MaterialsKey Laboratory of Medicinal Molecule Science and Pharmaceutics Engineering of Ministry of Industry and Information TechnologySchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijingChina

Quantitatively establishing the correlation between nanoparticle size and fluorescence is essential for understanding the behavior and functionality of fluorescent nanoparticles(FNPs).However,such exploration focusing on organic FNPs has not been achieved to ***,we employ the use of supramolecular polymeric FNPs prepared from tetraphenylethylene-based bis-ureidopyrimidinone monomers(bis-UPys)to relate the size to the fluorescence of organic *** an equal concentration of bis-UPys,a logarithmic relationship between them is built with a correlation coefficient higher than *** calculations indicate that variations in fluorescence intensity among FNPs of different sizes are attributed to the distinct molecular packing environments at the surface and within the interior of the *** leads to different nonradiative decay rates of the embedded and exposed bis-UPys and thereby changes the overall fluorescence quantum yield of nanoparticles due to their different specific surface *** established fluorescence intensity-size correlation possesses fine universality and reliability,and it is successfully utilized to estimate the sizes of other nanoparticles,including those in highly diluted dispersions of *** work paves a new way for the simple and real-time determination of nanoparticle sizes and offers an attractive paradigm to optimize nanoparticle functionalities by the size effect.

关键词： aggregation-induced emission fluorescence detection fluorescent nanoparticle nanoparticle size supramolecular polymer

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Factors affecting meibomian gland area loss in symptomatic adults

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1036-1041页

作者： Si-Cheng Ding Jing-Jing Su Qing Zhan Jiao-Man Wang Fang zheng Xu-Xuan Fang Dan Cheng Ping guo The Second Clinical Medical College Jinan UniversityShenzhen 518000Guangdong ProvinceChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040Guangdong ProvinceChina Department of Ophthalmology Jinzhou Medical UniversityJinzhou 121000Liaoning ProvinceChina

AIM:To characterize the distribution of meibomian gland(MG)area loss(MGL)and its relationship with demographic characteristics,mites,and ***:This retrospective observational study included patients who visited the Dry Eye Clinic of Shenzhen Eye Hospital between June 2020 and August *** patient characteristics,ocular symptoms,Demodex test results of the eyelid edges,and the results of a comprehensive ocular surface analysis were *** was analyzed using Image J ***:This study enrolled 1204 outpatients aged 20-80(40.70±13.44)y,including 357 males(29.65%)and 847 females(70.35%).The patients were classified into mild(n=155;12.87%),moderate(n=795;66.03%),severe(n=206;17.11%),and extremely severe(n=48;3.99%)MGL *** was significantly larger in female than in male(P=0.006).The degree of MGL also significantly differed in age(P<0.001)and the more numbers of mites with severity(P<0.001).Multivariate disordered multinomial logistic regression analysis identified that female sex,older age,secretory symptoms,and a large number of mites were risk factors for MGL(P<0.05).CONCLUSION:Patients with MGL are more likely to be older,female,more numbers of mites,and increased secretion.

关键词： meibomianglands aging sex symptomatology Demodex

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Decellularised extracellular matrix-based injectable hydrogels for tissue engineering applications

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Biomaterials Translational 2024年第2期5卷 114-128页

作者： Wan-Ying guo Wei-Huang Wang Pei-Yao Xu Ranjith Kumar Kankala Ai-zheng Chen Institute of Biomaterials and Tissue Engineering Huaqiao UniversityXiamenFujian ProvinceChina Fujian Provincial Key Laboratory of Biochemical Technology(Huaqiao University) XiamenFujian ProvinceChina

Decellularised extracellular matrix(dECM)is a biomaterial derived from natural tissues that has attracted considerable attention from tissue engineering researchers due to its exceptional biocompatibility and malleability *** advantageous properties often facilitate natural cell infiltration and tissue reconstruction for regenerative *** to their excellent fluidity,the injectable hydrogels can be administered in a liquid state and subsequently formed into a gel state in vivo,stabilising the target area and serving in a variety of ways,such as support,repair,and drug release ***,dECM-based injectable hydrogels have broad prospects for application in complex organ structures and various tissue injury *** review focuses on exploring research advances in dECM-based injectable hydrogels,primarily focusing on the applications and prospects of dECM hydrogels in tissue ***,the recent developments of the dECM-based injectable hydrogels are explained,summarising the different preparation methods with the evaluation of injectable hydrogel ***,some specific examples of the applicability of dECM-based injectable hydrogels are ***,we summarise the article with interesting prospects and challenges of dECM-based injectable hydrogels,providing insights into the development of these composites in tissue engineering and regenerative medicine.

关键词： decellularisation methods decellularised extracellular matrix injectable hydrogels tissue engineering

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Rapid and sensitive detection of urinary KIM-1 using fully printed photonic crystal microarrays

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Nano Research 2024年第5期17卷 4329-4337页

作者： Yang Liu Xuwei He Zewei Lian Qian guo Jimei Chi Xiaoxue Lin Liyue Zhang zheng Liu Yingyuan Liu Meng Su Keyu Wang Qiangguo Ao Qingli Cheng Department of Nephrology The Second Medical Center of Chinese PLA General HospitalNational Clinical Research Centre for Geriatric DiseasesBeijing 100853China Chinese PLA Medical School Beijing 100853China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesBeijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Institute of ChemistryChinese Academy of Sciences(ICCAS)Beijing 100190China Department of Rheumatology and Immunology Peking University International HospitalBeijing 102206China Department of Clinical Laboratory The Second Medical Center of Chinese PLA General HospitalNational Clinical Research Centre for Geriatric DiseasesBeijing 100853China

Urinary kidney injury molecule 1(uKIM-1)serves as a reliable marker for the early diagnosis of acute kidney injury(AKI).The rapid and facile detection of changes in uKIM-1 is essential for early AKI diagnosis,ultimately improving the prognosis of *** this study,we developed a fully printed photonic crystal-integrated microarray with photonic crystal-enhanced fluorescence properties,which can detect uKIM-1 levels at the *** confirmed its efficacy in the early diagnosis of AKI using clinical urine *** quantitative detection of uKIM-1 was achieved within 10 *** lowest limit of detection is 8.75 pg·mL^(-1) with an accuracy of 94.2%.The diagnostic efficacy was validated using 86 clinical urine samples,highlighting the high sensitivity and stability of the photonic crystal ***,a facile and reliable immunoassay was designed and prepared for the rapid quantitative detection of uKIM-1,which is crucial for the early identification and convenient detection of AKI in hospital or community ***,convenient,cost-effective,and long-term monitoring of changes in uKIM-1 levels can assist clinicians in making timely adjustments to treatment regimens,preventing the transition from AKI to chronic kidney disease(CKD),improving the quality of life of patients with AKI,and reducing healthcare *** highlights the advantages of utilizing urine samples as a noninvasive and easily accessible medium for early detection and monitoring of kidney-related conditions.

关键词： photonic crystal point-of-care testing urine kidney injury molecule-1(KIM-1) acute kidney injury

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Highly sensitive nanozyme strip:An effective tool for forensic material evidence identification

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Nano Research 2024年第3期17卷 1785-1791页

作者： Juanji Hong Zhanjun guo Dihan Duan Yi Zhang Xin Chen Yongjiu Li zheng Tu Lei Feng Lei Chen Xiyun Yan Lizeng Gao Minmin Liang Demin Duan Experimental Center of Advanced Materials School of Materials Science&EngineeringBeijing Institute of TechnologyBeijing 100081China College of Bioscience and Biotechnology Shenyang Agricultural UniversityShenyang 110866China Chongqing kangjuquanhong biology science and technology Co. ltdChongqing 400026China Key Laboratory of Forensic Genetics Institute of Forensic ScienceMinistry of Public SecurityBeijing 100038China CAS Engineering Laboratory for Nanozyme Key Laboratory of BiomacromoleculesInstitute of BiophysicsChinese Academic of ScienceBeijing 100101China

During criminal case investigations,blood evidence tracing is critical for criminal ***,the blood stains are often cleaned or covered up after the crime,resulting in trace residue and difficult ***,a highly sensitive and specific method for the rapid detection of human blood stains remains *** solve this problem,we established a nanozyme-based strip for rapid detection of blood evidence with high sensitivity and *** construct reliable nanozyme strips,we synthesized CoFe_(2)O_(4) nanozymes with high peroxidase-like activity by scaling up to gram level,which can be supplied for six million tests,and conjugated antibody as a detection probe in nanozyme *** developed CoFe_(2)O_(4) nanozyme strip can detect human hemoglobin(HGB)at a concentration as low as 1 ng/mL,which is 100 times lower than the commercially available colloidal gold strips(100 ng/mL).Moreover,this CoFe_(2)O_(4) nanozyme strip showed high generality on 12 substrates and high specificity to human HGB among 13 animal blood ***,we applied the developed CoFe_(2)O_(4) nanozyme strip to successfully detect blood stains in three real cases,where the current commercial colloidal gold strip failed to *** results suggest that the CoFe_(2)O_(4) nanozyme strip can be used as an effective on-scene detection method for human blood stains,and can further be used as a long-term preserved material evidence for traceability inquiry.

关键词： CoFe_(2)O_(4)nanozyme nanozyme strip peroxidase-like activity human hemoglobin blood evidence

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Thermosphere joint observations by TM-1 constellations and Swarm-B during the April 2023 geomagnetic storm

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Earth and Planetary Physics 2024年第2期8卷 307-316页

作者： YongPing Li YueQiang Sun Xianguo Zhang JiangZhao Ai XiaoLiang zheng Jia Li YuJie Wang BiBo guo Feng Yan ShiLong Wei XinChun Tang YuanYuan Cao National Space Science Center Chinese Academy of SciencesBeijing 100190China Beijing Key Laboratory of Space Environment Exploration Beijing 100190China Key Laboratory of Science and Technology on Space Environment Situational Awareness Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Shenzhen Aerospace Dongfanghong Satellite LtdShenzhen 518057China

The response of thermosphere density to geomagnetic storms is a complicated physical ***-satellite joint observations at the same altitude but different local times(LTs)are important for understanding this process;however,until now such studies have hardly been *** this report,we analyze in detail the thermosphere mass density response at 510 km during the April 23−24,2023 geomagnetic storm using data derived from the TM-1(TianMu-1)satellite constellation and Swarm-B *** observations show that there were significant LT differences in the hemispheric asymmetry of the thermosphere mass density during the geomagnetic *** observed by satellite TM02 at nearly 11.3 and 23.3 LTs were larger in the northern hemisphere than in the *** TM04 dayside density observations appear to be almost symmetrical with respect to the equator,though southern hemisphere densities on the nightside were ***-B data exhibit near-symmetry between the *** addition,the mass density ratio results show that TM04 nightside observations,TM02 data,and Swarm-B data all clearly show stronger effects in the southern hemisphere,except for TM04 on the dayside,which suggest hemispheric *** South-North density enhancement differences in TM02 and TM04 on dayside can reach 130%,and Swarm-B data even achieve 180%*** the observations of all three satellites,large-scale traveling atmospheric disturbances(TADs)first appear at high latitudes and propagate to low latitudes,thereby disturbing the atmosphere above the equator and even into the opposite ***00 model simulations were also performed on this geomagnetic *** are absent in the NRLMSISE00 *** satellite data suggest that NRLMSISE00 significantly underestimates the magnitude of the density response of the thermosphere during geomagnetic storms,especially at high latitudes in both ***,use of the density simulation of NRLM

关键词： TM-1 constellation Swarm-B joint observations geomagnetic storm Local Times

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Intramedullary nailing for irreducible spiral subtrochanteric fractures:A comparison of cerclage and non-cerclage wiring

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Chinese Journal of Traumatology 2024年第5期27卷 305-310页

作者： Yan-Hui guo Zhan-Lin song Hua-Yong zheng Jie Gao Yi-Yun Lin Zhi Liu Lian-Hua Li Department of Orthopedics The Seventh Medical Center of Chinese People's Liberation Army General HospitalBeijing100048China Department of Orthopedics The Fourth Medical Center of Chinese People's Liberation Army General HospitalBeijing100048China

Purpose:Intramedullary nailing is the preferred internal fixation technique for the treatment of subtrochanteric fractures because of its biomechanical ***,no definitive conclusion has been reached regarding whether combined cable cerclage is required during intramedullary nailing *** study is performed to compare the clinical effects of intramedullary nailing with cerclage and non-cerclage wiring in the treatment of irreducible spiral subtrochanteric ***:Patients with subtrochanteric fractures admitted to our center from January 2013 to December 2021 were retrospectively *** patients were enrolled in the case-control study according to the inclusion and exclusion criteria and divided into the non-cerclage group and the cerclage *** patients'clinical data,including the operative time,intraoperative blood loss,hospital stay,reoperation rate,fracture union time,and Harris hip score,were compared between these 2 *** variables were compared using Chi-square or Fisher's exact *** variables with normal distribution were presented as mean±standard deviation and analyzed with Student's *** distributed variables were expressed as median(Q_(1),Q_(3))and assessed using the Mann-Whitney test.A p<0.05 was considered ***:In total,69 patients were included in the study(35 patients in the non-cerclage group and 34 patients in the cerclage group).The baseline data of the 2 groups were *** were no significant difference in the length of hospital stay(z=-0.391,p=0.696),operative time(z=-1.289,p=0.197),or intraoperative blood loss(z=-1.321,p=0.186).However,compared with non-cerclage group,the fracture union time was shorter(z=-5.587,p<0.001),the rate of nonunion was lower(χ^(2)=6.030,p=0.03),the anatomical reduction rate was higher(χ^(2)=5.449,p=0.03),and the Harris hip score was higher(z=-2.99,p=0.003)in the cerclage group,all with statistically significant dif

关键词： Hip fracture Subtrochanteric fracture Intramedullary nail Cerclage wiring

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Efficacy and safety of modified medium-chain triglyceride ketogenic diet in patients with drug-resistant epilepsy

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Acta Epileptologica 2024年第1期7卷 44-52页

作者： Hua Li Yao Wang Jing guo Peiqi Zhang zheng Xu Kai Peng Xiaoli Dong Liming Zhao Department of Neurology Guangdong Sanjiu Brain HospitalGuangzhou510510China

Background Medium-chain triglyceride ketogenic diet(MCTKD)is previously less commonly used in *** study was aimed to assess the efficacy and safety of the modified MCTKD in the treatment of drug-resistant epilepsy in Chinese *** Patients with drug-resistant epilepsy were enrolled to receive treatment with modified MCTKD in Guangdong Sanjiu Brain Hospital during December 2020 and September *** modified MCTKD contained fat that provided 50–70%of the total energy,as well as proteins and carbohydrates that provided 20–30%and 20%of energy,*** fat component was composed of 20–30%medium-chain triglycerides(MCTs)and 30–40%long-chain *** efficacy and safety of the diet were assessed at 1,3 and 6 *** A total of 123 patients aged 2.5 to 65 years,were included in this *** response rates at 1,3 and 6 months were 49.6%,43.1%,and 30.9%,*** seizure freedom rates at 1,3 and 6 months were 12.2%,10.6%,and 6.5%,*** retention rates at 1,3 and 6 months were 98.4%,65.0%and 33.3%*** effects occurred in 21.14%of patients,which were predominantly gastrointestinal symptoms such as abdominal pain,diarrhea,vomiting,and constipation,and most of them resolved after dietary adjustments.A total of 82 patients(66.7%)discontinued the treatment with the reason of refusing to eat(8.1%),poor efficacy(35.0%),poor compliance(4.9%),and inability to follow-up(9.8%).Only 4 patients(3.3%)withdrew the diet due to side *** The modified MCTKD with MCTs providing 20–30%of energy has a good safety in patients with drug-resistant epilepsy,but its effectiveness needs to be *** modifications of MCTKD with an optimal energy ratio are required to achieve a better efficacy and safety.

关键词： Medium-chain triglyceride ketogenic diet Ketogenic diet Drug-resistant epilepsy Efficacy Safety

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Selenium,Type-2 Diabetes,and the Possible Protective Role of Vitamin D

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Biomedical and Environmental Sciences 2024年第6期37卷 661-665页

作者： Runxue Ma Ce Liu Ling Zhang Jingzhe guo Erkai Zhou Ling zheng Li He Xiaobing Shan Yunhui Yu Bin Luo Institute of Occupational Health and Environmental Health School of Public HealthLanzhou UniversityLanzhou 730000GansuChina

Diabetes is a pervasive and serious global health *** to the International Diabetes Federation report,463 million adults worldwide were living with diabetes in 2019,and this number is projected to reach 700 million in... 详细信息

关键词： Diabetes Selenium Vitamin

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