Investigating the causal associations between five anthropometric indicators and nonalcoholic fatty liver disease:Mendelian randomization study

作     者：Xian-Pei Xiao Yong-Jun Dai Yu Zhang Meng Yang Jian Xie Guo Chen Zheng-Jun Yang 

作者机构：Department of OncologyLuojiang District People's Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina Department of OrthopaedicsLuojiang District People's Hospital of Deyang CityDeyang 618000Sichuan ProvinceChina Department of Infectious DiseasesHospital of Chengdu University of Traditional Chinese MedicalChengdu 610500Sichuan ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2024年第12卷第7期

页      面：1215-1226页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by Science and Technology Research Project of Sichuan Administration of Traditional Chinese Medicine No.2023MS419 

主　　题：Anthropometric indicator Waist circumference Nonalcoholic fatty liver disease Mendelian randomization Genetic variant 

摘      要：BACKGROUND Although the etiology of nonalcoholic fatty liver disease(NAFLD)has not been thoroughly understood,the emerging roles of anthropometric indicators in assessing and predicting the risk of NAFLD have been highlighted by accumulating *** To evaluate the causal relationships between five anthropometric indicators and NAFLD employing Mendelian randomization(MR)*** The Anthropometric Consortium provided genetic exposure data for five anthropometric indicators,including hip circumference(HC),waist circumference(WC),waist-to-hip ratio(WHR),body mass index(BMI),and body fat percentage(BF).Genetic outcome data for NAFLD were obtained from the United Kingdom Biobank and FinnGen ***-wide significant single nucleotide polymorphisms were chosen as instrumental *** MR(UVMR)and multivariable MR(MVMR)designs with analytical approaches,including inverse variance weighted(IVW),MR-Egger,weighted median(WM),and weighted mode methods,were used to assess the causal relationships between anthropometric indicators and *** Causal relationships were revealed by UVMR,indicating that a higher risk of NAFLD was associated with a perunit increase in WC[IVW:odds ratio(OR)=2.67,95%CI:1.42-5.02,P=2.25×10^(−3)],and BF was causally associated with an increased risk of NAFLD(WM:OR=2.23,95%CI:1.07-4.66,P=0.033).The presence of causal effects of WC on the decreased risk of NAFLD was supported by MVMR after adjusting for BMI and ***,no causal association between BF and NAFLD was *** addition,other causal relationships of HC,WHR(BMI adjusted),and BMI with the risk of NAFLD were not retained after FDR *** This study establishes a causal relationship,indicating that an increase in WC is associated with a higher risk of *** demonstrates that a suitable decrease in WC is advantageous for preventing NAFLD.