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New therapeutic strategy with extracorporeal membrane oxygenation for refractory hepatopulmonary syndrome after liver transplant: A case report

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World Journal of Transplantation 2024年第1期14卷 210-214页

作者： Belinda Sánchez Pérez María Pérez Reyes jose Aranda Narvaez Julio Santoyo Villalba jose antonio Perez daga Claudia Sanchez-gonzalez Julio Santoyo-Santoyo Hepatobiliary and Trasplantation Unit General and Digestive Surgery DepartmentUniversity Regional HospitalMalaga 29010Spain Department of General and Digestive Surgery Regional University Hospital of MalagaMalaga 29010Spain

BACKGROUND Due to the lack of published literature about treatment of refractory hepatopulmonary syndrome(HPS)after liver transplant(LT),this case adds information and experience on this issue along with a treatment with positive *** is a complication of end-stage liver disease,with a 10%-30%incidence in cirrhotic *** can reverse the physiopathology of this process and restore normal ***,in some cases,refractory hypoxemia persists,and extracorporeal membrane oxygenation(ECMO)can be used as a rescue therapy with good *** SUMMARY A 59-year-old patient with alcohol-related liver cirrhosis and portal hypertension was included in the LT waiting list for *** had good liver function(Model for End-Stage Liver Disease score 12,Child-Pugh class B7).He had pulmonary fibrosis and a mild restrictive respiratory pattern with a basal oxygen saturation of 82%.The macroaggregated albumin test result was>*** demonstrated a forced expiratory volume in one second(FEV1)of 78%,forced vital capacity(FVC)of 74%,FEV1/FVC ratio of 81%,diffusion capacity for carbon monoxide of 42%,and carbon monoxide transfer coefficient of 57%.He required domiciliary oxygen at 2 L/min(16 h/d).The patient was admitted to the intensive care unit(ICU)and extubated in the first 24 h,needing high-flow therapy and non-invasive ventilation and inhaled nitric oxide *** was needed after 72 *** to the non-response to supportive therapies,installation of ECMO was decided with progressive recovery after 9 *** was possible on the tenth day,maintaining a high-flow nasal cannula and de-escalating to conventional oxygen therapy after 48 *** was discharged from ICU on postoperative day(POD)20 with a 90%-92%oxygen *** recycling was needed twice for acute *** patient was discharged from hospital on POD 27 with no symptoms,with an 89%-90%oxygen *** Due to the favorable results observed,ECMO could bec

关键词： Liver transplantation Hepatopulmonary syndrome Refractory hypoxemia Treatment Extracorporeal membrane oxygenation Case report

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Multi-omic study to unmask genes involved in prostate cancer development in amulti-case family

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Cancer Communications 2024年第3期44卷 443-447页

作者： Lucia Chica-Redecillas Sergio Cuenca-Lopez Eduardo Andres-Leon Laura Carmen Terron-Camero Blanca Cano-Gutierrez jose Manuel Cozar jose antonio Lorente Fernando Vazquez-Alonso Luis Javier Martinez-gonzalez Maria Jesus Alvarez-Cubero GENYO Centre for Genomics and Oncological ResearchPfizerUniversity of GranadaAndalusian Regional GovernmentPTS GranadaGranadaGranadaSpain Department of Biochemistry Molecular Biology III and ImmunologyFaculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Bioinformatics Unit Institute of Parasitology and Biomedicine“López-Neyra”Spanish National Research CouncilGranadaGranadaSpain Nursery Service.University Hospital Clínico San Cecilio GranadaGranadaSpain Urology Department University Hospital Virgen de las NievesGranadaGranadaSpain Legal Medicine and Toxicology Department Faculty of MedicineUniversity of GranadaPTS GranadaGranadaGranadaSpain Ibs Biosanitary Research InstituteGranadaGranadaSpain

Dear Editor,Hereditary prostate cancer(PC)comprises 5%-10%of all PC *** increased risk of PC in menwith a family his-tory of the disease is well known and is commonly caused by germline mutations,leading to clinical guidelines men-tioning various genes for identifying high-risk ***,the complex inheritance patterns involvingmul-tiple single nucleotide polymorphisms(SNPs)make it a genetically heterogeneous disease,with genetic testing still in its early stages.

关键词： cancer clinical cases

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Practical Approach Design Piezoresistive Pressure Sensor in Circular Diaphragm

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材料科学与工程（中英文B版） 2019年第3期9卷 85-91页

作者： Renan Gabbi Luiz antonio Rasia daniel Curvello de Mendonca Müller Jorge Ramírez Beltrán jose antonio gonzalez da silva Manuel Martin Perez Reimbold Federal Institute of Education Science and Technology FarroupilhaCampus PanambiPanambi 98280-000Brazil Department of Exact Sciences and Engineering Regional University of the Northwest of the State of Rio Grande do SulPanambi 98280-000Brazil University Veterinary Hospital Federal University of Santa MariaSanta Maria 97105-900Brazil Technological University of Habana Joséantonio Echeverría Havana 62644Cuba

This paper presents a methodology for analytical calculation and computational simulation using the finite element method for piezoresistive graphite sensor element on flexible polymer substrate,A4 *** computer simulation aims to find the region of greatest mechanical tension and deflection of the circular diaphragm set in the circumference *** steps for simulation are geometry definition,mesh generation,inclusion of material physical properties and simulation *** mathematical modeling of maximum mechanical stress and deflection is described analytically and *** analytical calculations were compared with the computer simulation and presented a relative percentage error of 3.38%for the maximum *** results show that the piezoresistor should be positioned at the edges of the circular diaphragm to take advantage of maximum mechanical stress by defining the best location for graphite film deposition for sensor device designs and fabrications.

关键词： Piezoresistivity sensor element finite elements and mathematical modeling

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Multi-camera systems for rehabilitation therapies:a study of the precision of Microsoft Kinect sensors

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Frontiers of Information Technology & Electronic Engineering 2016年第4期17卷 348-364页

作者： Miguel OLIVER Francisco MONTERO jose Pascual MOLINA Pascual gonzalez antonio FERNANDEZ-CABALLERO Instituto de Investigacidn en Informdtica de Albacete Universidad de Castilla-La ManchaAlbacete 02071Spain Departamento de Sistemas Informaticos Universidad de Castilla-La ManchaAlbacete 02071Spain

This paper seeks to determine how the overlap of several infrared beams affects the tracked position of the user, depending on the angle of incidence of light, distance to the target, distance between sensors, and the number of capture devices used. We also try to show that under ideal conditions using several Kinect sensors increases the precision of the data collected. The results obtained can be used in the design of telerehabilitation environments in which several RGB-D cameras are needed to improve precision or increase the tracking range. A numerical analysis of the results is included and comparisons are made with the results of other studies. Finally, we describe a system that implements intelligent methods for the rehabilitation of patients based on the results of the tests carried out.

关键词： Kinect sensor Rehabilitation system Capture precision Multi-camera system

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Non-Intrusive Elastic Query Processing in the Cloud

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Journal of Computer Science & Technology 2013年第6期28卷 932-947页

作者： Ticiana L. Coelho da silva Mario A. Nascimento jose antonio F. de Macedo Flavio R. C. Sousa Javam C. Machado Department of Computing Federal University of Ceara Fortaleza Ceara Brazil Department of Computing Science University of Alberta Edmonton Alberta T6G 2E8 Canada

Cloud computing is a very promising paradigm of service-oriented computing. One major benefit of cloud computing is its elasticity, i.e., the system＇s capacity to provide and remove resources automatically at runtime. For that, it is essential to design and implement an efficient and effective technique that takes full advantage of the system＇s potential flexibility. This paper presents a non-intrusive approach that monitors the performance of relational database management systems in a cloud infrastructure, and automatically makes decisions to maximize the efficiency of the provider＇s environment while still satisfying agreed upon ＂service level agreements＂（SLAs）. Our experiments conducted on Amazon＇s cloud infrastructure, confirm that our technique is capable of automatically and dynamically adjusting the system＇s allocated resources observing the SLA.

关键词： elasticity query processing non-intrusive service level agreement

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Assessment of hybrid geoids in Chile and Spain,combining GGM and GNSS/Leveling observations

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Geodesy and Geodynamics 2021年第2期12卷 65-92页

作者： jose antonio Tarrio Mosquera Marcelo Caverlotti silva Fernando Isla Carlos Prado University of Santiago of Chile(USACH) Faculty of EngineeringGeographical Engineering DepartmentChile Geographic Military Institute Chile

This research presents the results for analyses done to five geopotential global models(GGM),comparing them with ground data from GNSS and leveling in heterogenic zones from the geodetic perspective,in Chile and *** the official and complete implementation of the International Height Reference Frame(IHRF)has not yet been established,the vertical geodetic system of many countries is not calculated on a global scale;instead,it is calculated by the variation of relative heights between one or more local tide gauges,such as in the case of Spain and *** aspect creates regional and specific altimetry data,which disables the use of GGM to directly obtain the orthometric height of the vertical reference system(VRS)from the GNSS *** models currently reach centimetric precision due to their high resolution but are directly incompatible for a local *** solve this,we expose in this article the contrast between geometric geoidal undulation(ellipsoidal heights and orthometric data from the leveling networks in Spain and Chile)with the geoidal undulation in more recent models and higher resolution:Earth Gravitational Model 2008(EGM08),European Improved Gravity model of the Earth by New techniques(EIGEN6 C4),Gravity Observation Combination(GOCO05 C),Experimental Gravity Field Model(XGM2016),and Ultra-High Resolution Global Geopotential Model(SGG-UGM),adjusting the residual between both referential heights by different parametric models and polynomials of determined *** evaluated,their geoidal undulations are combined with GNSS/leveling data from the corresponding VRS to generate a correcting surface,which is also known as a hybrid geoid,resulting in a model of optimal adjustment for the combination of five parameters of the EIGEN-6 C4 with orthometric heights and ellipsoids of both Chile and *** results show 2-3 cm precisions,which were statistically analyzed to determine the suitability for *** final products are three grids of indep

关键词： GNSS levelling Correcting surface IHRS SIRGAS EIGEN-6C4

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Building＇s Rehabilitation towards Sustainable Behavior

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Journal of Civil Engineering and Architecture 2012年第1期6卷 107-113页

作者： jose antonio Raimundo Mendes da silva Ana Teresa Vaz Ferreira Ramos Faculty of Science and Technology University of Coimbra School of Technology Polytechnic Institute of Castelo Branco

To achieve a sustainable building＇s behaviour and preserve the environmental balance, three laws must be taken into account （l） the resources＇ consume must not be faster than the rate at which nature can restock them, （2） the creation of systems that consume maximum energy-quality and （3） the maximization of the use of renewable and recycled materials. Therefore, the buildings＇ rehabilitation process must increase, instead of the proliferation of new buildings, in order to provide the sustainability of the built environment and minimize its ecological impact. The sustainable rehabilitation process is even more difficult in historical areas, in general sited in central zones of the urban mesh, with fragile comfort conditions and a rigid structure. In this paper, different evaluation tools for sustainable buildings were analysed in order to provide a set of evaluation criteria to be applied in the rehabilitation process in historical zones.

关键词： Sustainable development rehabilitation constructive traditions sustainable construction.

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Managing liver transplantation during the COVID-19 pandemic:A survey among transplant centers in the Southeast United States

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World Journal of Hepatology 2021年第12期13卷 2161-2167页

作者： Adalberto jose gonzalez Nikhil Kapila Emmanuel Thomas antonio Pinna Andreas Tzakis Xaralambos Bobby Zervos Department of Gastroenterology Cleveland Clinic FloridaWestonFL 33324United States Department of Transplant Cleveland Clinic FloridaWestonFL 33331United States Schiff Center for Liver Diseases University of Miami Miller School of MedicineMiamiFL 33136United States

BACKGROUND The coronavirus disease-2019(COVID-19)pandemic has had a profound worldwide ***,it has led to a vast decrease in organ transplantation,including liver transplants(LT).There is little data regarding adjustments made by LT centers as a response to the COVID-19 *** To assess the experience of LT centers in the United States during the *** We performed an observational survey study from May 11,2020 to June 5,*** sent out a 13 question survey to 15 LT centers across the southeastern United *** Eleven LT centers responded to the *** found that(11/11)100%of transplant centers made adjustments because of the COVID-19 *** least 50%of transplant centers had at least one transplant recipient infected with *** adjust,greater than 50%of centers performed fewer LT,100%of patients were tested for COVID-19,and most centers implemented a virtual *** The COVID-19 pandemic greatly affected liver transplantation in the southeastern United *** was evident that a concerted effort was made by LT centers to protect their patients and employees from COVID-19 but also to continue the lifesaving procedure of LT in this sick patient *** studies are needed to assess how LT centers around the world managed the pandemic in order to learn strategies to continue life-saving procedures in this patient population.

关键词： COVID-19 Liver transplantation Survey Telemedicine Immunosuppression Solid organ transplantation

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Association between COVID-19 and anxiety during social isolation:A systematic review

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World Journal of Clinical Cases 2021年第25期9卷 7433-7444页

作者： Erlene Roberta Ribeiro dos Santos jose Lucas silva de Paula Felipe Maia Tardieux Vânia NazaréCosta-e-silva Amos Lal antonio Flaudiano Bem Leite Department of Neuropsychiatry and Behavioral Science-Neurosciences Research Circle on TechnologiesStrategies and Instruments Applied to Collective HealthVitória de Santo Antão 55608680Brazil Department of Collective Health Research Circle on TechnologiesStrategies and Instruments Applied to Collective HealthVitória de Santo Antão 55608680Brazil State Audit Component of the Unified Health System State Health SecretariatRecife 50751530Brazil Department of Medicine Division of Pulmonary and Critical Care MedicineMayo ClinicRochesterMN 55905United States Department of Epidemiological Surveillance Henrique de HolandaMunicipal Health SecretariatVitória de Santo Antão 55608680Brazil

BACKGROUND The uncertainties about coronavirus disease 2019(COVID-19),the change in routine,lifestyles and the reduction of physical contact can cause stress,anxiety,emotional overload,poor sleep and even physical health *** To evaluate the scientific publications available on the relationship between COVID-19 and anxiety experienced in the general population,during the period of social isolation,adopted by governmental organizations and public health policymakers as a measure to contain the spread of *** A literature search was performed systematically exploring the PubMed and Medline databases using the following terms classified as MeSH descriptors:(“anxiety”AND“pandemic”AND“COVID-19”).For the search,in the Biblioteca Virtual em Saúde–BVS,***,Web of Science and National Library plat forms, the following keywords were used: ("anxiety" AND "coronavirus" AND"social isolation"). Thirty-seven peer-reviewed articles were found. PRISMA andthe Downs & Black checklist were used for qualitative *** applying the inclusion criteria, seven (n = 7) original scientific articles wereselected. The collated evidence demonstrated increased levels of symptoms ofanxiety and depression during the period of social isolation. The populationbetween 21 to 40 years was most affected. The risk of severe depression was twiceas high at the epicenter of the pandemic. Sleep quality was significantly *** about politics, religion, and consumption of products from China werefound to generate fear and anticipate probable changes in the pattern of postpandemicconsumption. Social isolation exacerbated feelings of extreme hopelessness,sadness, loneliness and suicidal *** conclude that there is a potential relationship between social isolation duringthe COVID-19 pandemic and symptoms of anxiety. It is important to note that thedirect and indirect costs of not identifying the detrimental effects of thisphenomenon and ne

关键词： Pandemic COVID-19 Anxiety Social isolation Mental health Public health

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Polyphenolic composition, antibacterial, modulator and neuroprotective activity of Tarenaya spinosa(Jacq.) Raf.(Cleomaceae)

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Asian Pacific Journal of Tropical Biomedicine 2019年第1期9卷 12-17页

作者： Francisca Samara Muniz dos Santos jose Weverton Almeida Bezerra Jean Paul Kamdem Aline Augusti Boligon Marli Matiko Anraku Ana Raquel Pereira da silva Kleber Ribeiro Fidelis Nadghia Figueiredo Leite antonio Ivanildo Pinho Henrique Douglas Melo Coutinho jose Edilson Goncalves dos Santos Microscopy Laboratory Regional University of Cariri (URCA) Program Post graduate in Plant Biology (UFPE) Phytochemical Laboratory Department of Industrial Pharmacy Federal University of Santa Maria (UFSM) Microbiology and Molecular Biology Laboratory Regional University of Cariri (URCA)

Objective: To evaluate the antibacterial activity and neuroprotective capacity of the ethanolic and aqueous extracts of Tarenaya spinosa(T. spinosa) as well as to determine and quantify some of its polyphenols by high performance liquid chromatography with diode-array detection(HPLC-daD). Methods: The bacterial Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa strains, grown in Heart Agar Infusion, were tested. The drugs gentamicin, norfloxacin and imipenem were used to evaluate the modulating or antagonistic capacity of the T. spinosa extracts. The extract was analysed by HPLC-daD to determine the main phenolic compounds. For the cell viability tests, individual heads of the Nauphoeta cinerea arthropod model were removed, homogenized in Trifluoromethyl ketone and centrifuged afterwards. Subsequently, 20 μL of NaN O2 were added to the biological material, except in the control group, to evaluate the protection capacity of the extracts. The homogenate of the insect heads was incubated for 2 h in tubes containing tetrazolium bromide. Results: HPLC-daD demonstrated that the ethanolic extract of T. spinosa presented caffeic acid as the major compound. The ethanolic extract also showed neuroprotective effects at concentrations ≥ 10 μg/mL, while aqueous extract was shown to have a protective effect only at the concentration of 100 μg/mL. The aqueous extract demonstrated a clinically relevant antibacterial activity against the Staphylococcus aureus multidrug resistant strain-MDR, with MIC 512 μg/m L. However, when the extracts were associated with gentamicin and imipenem, a synergism was detected against Staphylococcus aureus and Escherichia coli MDR strains. Conclusions: Although it does not present an antibacterial action, the extracts of T. spinosa can be used in the pharmaceutical industries since its extracts show modulating action of drugs. Besides, these natural products have neuroprotective capacity.

关键词： Tarenaya spinosa Cleome spinose Nauphoeta cinerea Synergism Antibiotic resistance

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