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Experimental study on the wear evolution of different PVD coated tools under milling operations of LDX2101 duplex stainless steel

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Advances in Manufacturing 2023年第1期11卷 158-179页

作者： Vitor F.C.sousa Francisco J.G.silva Ricardo Alexandre jose s.fecheira Gustavo Pinto Andresa Baptista IsEP-school of Engineering Polytechnic of PortoRua Dr.António Bernardino de Almeida4314200–072PortoPortugal INEGI-Driving science and Innovation Rua Dr.Roberto Frias4004200–465PortoPortugal TEandM-Technology Engineering and MaterialsS.A.Parque Industrial do TaveiroLotes 41-423045–504TaveiroPortugal

Duplex stainless steels are being used on applications that require,especially,high corrosion resistance and overall good mechanical properties,such as the naval and oil-gas exploration *** components employed in these industries are usually obtained by machining,however,these alloys have low machinability when compared to conventional stainless *** this work,a study of the wear developed when milling duplex stainless-steel,LDX 2101,is going to be presented and evaluated,employing four types of milling tools with different geometries and coatings,while studying the influence of feed rate and cutting length in the wear of these *** used have been provided with two and four flutes,as well as three different coatings,namely:TiAlN,TiAlsiN and *** cutting behavior of these tools was analyzed;data relative to the cutting forces developed during the process were obtained;and roughness measurements of the machined surfaces were *** tools were then submitted to scanning electron microscope(sEM)analysis,enabling the identification of the wear mechanisms that tools were subjected to when machining this material,furthermore,the early stages of these mechanisms were also *** this work was done with the goal of relating the machining parameters and cutting force values obtained,identifying,and discussing the wear patterns that were observed in the coating and tools after the milling tests,providing further information on the machining of these alloys.

关键词： Duplex stainless-steel Milling Tool coatings surface roughness Wear mechanisms

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Genes & Diseases 2024年第3期11卷 66-68页

作者： Aswathi N Jincy M.jose sreelata B.Nair Prabha s.N Pappachan s Department of Medical Genetics Lifeline Super Specialty HospitalPathanamthittaKerala 691523India Lifeline super specialty Hospital PathanamthittaKerala 691523India

Alagille syndrome(ALGs;OMIM#118450)is a highlyvariable,multi-systemic,autosomal dominant disorder,caused by mutations in the Jagged Canonical Notch Ligand 1(JAG1)gene(20p12.2)or in the Neurogenic locus notch homolog protein 2(NOTCH2)gene(1p13).^(1)It primarily affects the liver,heart,eyes,face,kidney,skin,vertebrae,and skeleton.^(1,2)The JAG1 gene has 26 exons and about 90%of the ALGs cases result from pathogenic variants in the JAG1 and around 7%of cases have deletions in chromosome 20 that include this gene.

关键词： JAG1 cases Notch

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Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2512-2522页

作者： Juan jose Urquijo-Ponce Carlos Alventosa-Mateu Mercedes Latorre-sánchez Inmaculada Castelló-Miralles Moisés Diago Hepatology Unit Department of Digestive Diseases Consorcio Hospital General Universitario of ValenciaValencia 46014Spain

Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic *** therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at *** the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical *** systemic therapies(sT),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of *** review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel sT in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative *** also investigate the potential role of sT in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative ***,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of sT in the treatment schedules of early and intermediate HCC stages.

关键词： Hepatocellular carcinoma Early stage Intermediate stage Neoadjuvant Adjuvant systemic therapy

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Predicting the clothing insulation through machine learning algorithms:A comparative analysis and a practical approach

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Building simulation 2024年第5期17卷 839-855页

作者： Pablo Aparicio-Ruiz Elena Barbadilla-Martin jose Guadix Jesus Munuzuri Grupo de Ingenieria de Organizacion Escuela Tecnica Superior de IngenieriaUniversidad de SevillaCamino de los Descubrimientos S/N41092SevilleSpain

since indoor clothing insulation is a key element in thermal comfort models,the aim of the present study is proposing an approach for predicting it,which could assist the occupants of a building in terms of recommendations regarding their *** that,a systematic analysis of input variables is exposed,and 13 regression and 12 classification machine learning algorithms were developed and *** results are based on data from 3352 questionnaires and 21 input variables from a field study in mixed-mode office buildings in *** temperature at 6 a.m.,indoor air temperature,indoor relative humidity,comfort temperature and gender were the most relevant features for predicting clothing *** comparing machine learning algorithms,decision tree-based algorithms with Boosting techniques achieved the best *** proposed model provides an efficient method for forecasting the clothing insulation level and its application would entail optimising thermal comfort and energy efficiency.

关键词： clothing insulation simulation adaptive thermal comfort behavioural adaptive actions machine learning

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sexual dimorphism in the antitumor immune responses elicited by the combination of fasting and chemotherapy

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Cancer Communications 2024年第4期44卷 508-513页

作者： Andrés Pastor-Fernández Manuel Montero Gómez de las Heras jose Ignacio Escrig-Larena Marta Barradas Cristina Pantoja Adrian Plaza jose Luis Lopez-Aceituno Esther Durán Alejo Efeyan Maria Mittelbrunn Lola Martinez Pablo jose Fernandez-Marcos Metabolic syndrome Group(BIOPROMET) Madrid Institute for Advanced Studies(IMDEA)FoodE28049MadridSpain Molecular Biology Center severo Ochoa(CBMsO) Spanish National Research Council(CSIC)Madrid Autonoma University(UAM)MadridSpain Department of Basic Medical sciences Institute of Applied Molecular MedicineSchool of MedicineUniversity Studies Center(CEU)-San Pablo UniversityMadridSpain Metabolism and Cell signaling Laboratory Spanish National Cancer Research Centre(CNIO) MadridSpain 5Flow Cytometry UnitBiotechnology ProgrammeSpanish National Cancer Research Centre(CNIO)MadridSpain

Fasting reduces chemotherapy toxicity[1],enhances immunogenic tumor cell death[2,3]and increases CD8^(+)T cell infiltration in tumors,particularly when combined with chemotherapy[2,3]or immunotherapy[4].More-over,fast... 详细信息

关键词： chemotherapy fasting immune

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Critical evaluation of transit policies in Lima,Peru;resilience of rail rapid transit(Metro)in a developing country

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Green Energy and Intelligent Transportation 2024年第5期3卷 23-33页

作者： Manuel jose Martinez Representante Legal Instituto de Avance del Transporte Peruano EIRLCalle Schrader 179dpto.202Lima 41San BorjaLimaPeru

This paper evaluates rail transit within the context of the transit policies implemented in Lima,*** it reviews the implementation of rapid transit,and bus ***,it evaluates the outcomes of such policies by using Total Factor Productivity for policy effectiveness,Data Envelopment Analysis for rapid transit performance,and Generalized Cost of Travel for *** paper finds that implementation failed in enforcing key requirements for rail transit regarding penetration of CBD and short transfers to bus transit;and that the basic assumptions of bus reform did not hold regarding bus oversupply,bus congestion or bus *** paper also finds that outcomes of policies failed dramatically in achieving the planning goals;however,rail transit(Metro)shows high level of resilience in serving large ridership at high *** the other hand,bus reform was associated with a disproportionate increase of motorization,well over the effect of income growth or car attractiveness,and more related to the excessive reduction of bus transit capacity ill-advised from unproved bus reform *** paper recommends expanding rail rapid transit due to its intensive use of green renewable energy and its potential of demand growth if combined with modern Intelligent Transportation services,but this opportunity can be wasted without the proposed policy constraint to achieve lower Generalized Cost of Travel at any governmental intervention for bus reform,instead of just reducing bus transit capacity as ***,this paper recommends government to government contracts to build rail transit and to enforce proper planning.

关键词： Public transportation Bus rapid transit Rail transportation Bus transit Developing countries Resilient

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Unraveling the interaction between soil microbiomes and their potential for restoring polluted soils

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Frontiers of Environmental science & Engineering 2024年第8期18卷 149-151页

作者： Carlos O.Lomeli-Ortega Mingming sun jose Luis Balcazar Catalan Institute for Water Research(ICRA-CERCA) Girona 17003Spain University of Girona Girona 17004Spain soil Ecology Laboratory College of Resources and Environmental SciencesNanjing Agricultural UniversityNanjing 210095China

soils are not exempt from anthropogenic pollution,which can eventually cause disturbance of the microbial communities and areas without any kind of *** soil microbiota,bacteria play an important role in pollutant degradation,enabling them to thrive in contaminated *** this,several techniques have been used to increase the number of pollutantdegrading bacteria in situ or for subsequent ***,bacteriophages exhibit a high tolerance to pollutants and enhance bacterial metabolic activity through phage-encoded auxiliary metabolic genes(AMGs),thereby augmenting their skills for nutrient assimilation,resistance to phage infection,antibiotic resistance,heavy metal resistance,and degradation of pesticides and xenobiotics,among *** phage-encoded AMGs have been described during the last few years,but their diversity,distribution,and function have not been extensively explored,warranting further ***,we highlight soil microbiome interactions,especially bacterium and phage interactions to understand this unexplored world with a high potential for restoring polluted soils.

关键词： Auxiliary metabolic genes Microbiome Pollutants soils Viruses

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New therapeutic strategy with extracorporeal membrane oxygenation for refractory hepatopulmonary syndrome after liver transplant: A case report

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World Journal of Transplantation 2024年第1期14卷 210-214页

作者： Belinda sánchez Pérez María Pérez Reyes jose Aranda Narvaez Julio santoyo Villalba jose Antonio Perez Daga Claudia sanchez-Gonzalez Julio santoyo-santoyo Hepatobiliary and Trasplantation Unit General and Digestive Surgery DepartmentUniversity Regional HospitalMalaga 29010Spain Department of General and Digestive surgery Regional University Hospital of MalagaMalaga 29010Spain

BACKGROUND Due to the lack of published literature about treatment of refractory hepatopulmonary syndrome(HPs)after liver transplant(LT),this case adds information and experience on this issue along with a treatment with positive *** is a complication of end-stage liver disease,with a 10%-30%incidence in cirrhotic *** can reverse the physiopathology of this process and restore normal ***,in some cases,refractory hypoxemia persists,and extracorporeal membrane oxygenation(ECMO)can be used as a rescue therapy with good *** sUMMARY A 59-year-old patient with alcohol-related liver cirrhosis and portal hypertension was included in the LT waiting list for *** had good liver function(Model for End-stage Liver Disease score 12,Child-Pugh class B7).He had pulmonary fibrosis and a mild restrictive respiratory pattern with a basal oxygen saturation of 82%.The macroaggregated albumin test result was>*** demonstrated a forced expiratory volume in one second(FEV1)of 78%,forced vital capacity(FVC)of 74%,FEV1/FVC ratio of 81%,diffusion capacity for carbon monoxide of 42%,and carbon monoxide transfer coefficient of 57%.He required domiciliary oxygen at 2 L/min(16 h/d).The patient was admitted to the intensive care unit(ICU)and extubated in the first 24 h,needing high-flow therapy and non-invasive ventilation and inhaled nitric oxide *** was needed after 72 *** to the non-response to supportive therapies,installation of ECMO was decided with progressive recovery after 9 *** was possible on the tenth day,maintaining a high-flow nasal cannula and de-escalating to conventional oxygen therapy after 48 *** was discharged from ICU on postoperative day(POD)20 with a 90%-92%oxygen *** recycling was needed twice for acute *** patient was discharged from hospital on POD 27 with no symptoms,with an 89%-90%oxygen *** Due to the favorable results observed,ECMO could bec

关键词： Liver transplantation Hepatopulmonary syndrome Refractory hypoxemia Treatment Extracorporeal membrane oxygenation Case report

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Low-Cost and Biodegradable Thermoelectric Devices Based on van der Waals semiconductors on Paper substrates

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Energy & Environmental Materials 2024年第1期7卷 201-206页

作者： Gulsum Ersu Carmen Munuera Federico J.Mompean Daniel Vaquero Jorge Quereda João Elias F.s.Rodrigues jose A.Alonso Eduardo Flores jose R.Ares Isabel J.Ferrer Abdullah M.Al-Enizi Ayman Nafady sruthi Kuriakose Joshua O.Island Andres Castellanos-Gomez Materials science Factory Instituto de Ciencia de Materiales de Madrid(ICMM-CSIC)Madrid E-28049Spain Nanotechnology Group USAL-NanolabUnivesidad de SalamancaSalamanca Junta de Castilla y León 37007Spain GIsC Departamento de Física de MaterialesUniversidad Complutense de MadridMadrid E-28040Spain Departamento de Física Aplicada Centro de Investigación y Estudios AvanzadosMérida 97310Mexico MIRE Group Departamento de Física de MaterialesUniversidad Autónoma de MadridMadrid E-28049Spain Instituto Nicolás Cabrera Universidad Autónoma de MadridMadrid E-28049Spain Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Physics and Astronomy University of Nevada Las VegasLas Vegas NV 89154USA

We present a method to fabricate handcrafted thermoelectric devices on standard office paper *** devices are based on thin films of Ws_(2),Te,and BP(P-type semiconductors)and Tis_(3)and Tis_(2)(N-type semiconductors),deposited by simply rubbing powder of these materials against *** thermoelectric properties of these semiconducting films revealed maximum seebeck coefficients of(+1.32±0.27)mV K^(-1)and(-0.82±0.15)mV K^(-1)for Ws_(2)and Tis_(3),***,Peltier elements were fabricated by interconnecting the P-and N-type films with graphite electrodes.A thermopower value up to 6.11 mV K^(-1)was obtained when the Peltier element were constructed with three *** findings of this work show proof-of-concept devices to illustrate the potential application of semiconducting van der Waals materials in future thermoelectric power generation as well as temperature sensing for low-cost disposable electronic devices.

关键词： paper-based electronics seebeck effect semiconductors thermoelectrics van der Waals materials

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Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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Neural Regeneration Research 2025年第1期20卷 186-187页

作者： Fernando jose Bustos Instituto de Ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium Nucleus of Neuroepigenetics and Plasticity(EpiNeuro) SantiagoChile

since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

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