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Extrahepatic cholestasis associated with paracoccidioidomycosis:Challenges in the differential diagnosis of biliopancreatic neoplasia

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2531-2540页

作者： jose Sebastiao dos santos Vitor de Moura Arrais William jose Rosseto Ferreira Ricardo Ribeiro Correa filho Mariangela Ottoboni Brunaldi Rafael Kemp Ajith Kumar Sankanrakutty Jorge Elias Junior Fernando Bellissimo-Rodrigues Roberto Martinez Edson Zangiacomi Martinez jose Celso Ardengh Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP) Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de PatologiaRibeirao Preto 14048900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Imagens MédicasHematologia e Oncologia ClínicaRibeirao Preto 14048900Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Medicina SocialRibeirao Preto 14015-010Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Clínica MédicaRibeirao Preto 14015-010Sao PauloBrazil Universidade de Sao Paulo Faculdade de Medicina de Ribeirao Preto da Universidade de Sao Paulo(FMRP-USP)Departamento de Cirurgia e AnatomiaRibeirao Preto 14049-900Sao PauloBrazil and Hospital MoriahServico de Endoscopia DigestivaSao Paulo 04084-002Sao PauloBrazil

BACKGROUND Paracoccidioidomycosis(PCM)may involve the hepatic pedicle and peripan creatic lymph nodes,cause damage to the bile duct and manifest,exceptionally,in combination with extrahepatic cholestasis(EHC),making investigation and treatment *** To investigate the management of patients with visceral PCM admitted with *** All patients diagnosed with PCM treated in a public,tertiary teaching hospital between 1982 and 2020 were retrospectively *** also identified with EHC were allocated to two groups according to the treatment approach for the purpose of comparing clinical,laboratory,and imaging findings,resources used for etiological diagnosis,treatment results,and *** analyses were performed using the linear mixed-effects model(random and fixed effects),which was adjusted using the PROC MIXED procedure of the SAS®9.0 software,and Fisher’s exact *** Of 1645 patients diagnosed with PCM,40(2.4%)had *** these,20(50.0%)lived in the rural area and 29(72.5%)were men,with a mean age of 27.1 years(3-65 years).Jaundice as first symptom and weight loss of at least 10 kg were observed in 16 patients(40.0%),and a mass in the head of the pancreas was observed in 8(20.0%).The etiological diagnosis was made by tissue collection during surgery in 4 cases(10.0%)and by endoscopic methods in 3 cases(7.5%).Twenty-seven patients(67.5%)received drug treatment alone(Group 1),whereas 13(32.5%)underwent endoscopic and/or surgical procedures in combination with drug treatment(Group 2).EHC was significantly reduced in both groups(40.7% in Group 1,with a mean time of 3 months;and 38.4% in Group 2,with a mean time of 7.5 months),with no statistically significant difference between *** recurrence rates,associated mainly with treatment nonadherence,were similar in both groups:37% in Group 1 and 15.4% in Group *** mortality rate was 18.5% in Group 1 and 23% in Group 2,with survival estimates of 71.3% and 72.5%,respectively,with

关键词： Cholestasis Jaundice Obstructive Blastomycosis Paracoccidioides Diagnosis Treatment

Mayaro fever:A brief review on the immune profile

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Asian Pacific Journal of Tropical Biomedicine 2020年第3期10卷 95-100页

作者： Jean Moisés Ferreira Danielly santos Campos-Ferreira Elaine Virgínia Martins de Sousa Figueiredo jose Luizde Lima filho Laboratório de Imunopatologia Keizo Asami-LIKA Centro de BiociênciasUniversidade Federal de Pernambuco(UFPE)50670-901RecifePernambucoBrazil Laboratório de Biologia Molecular e Expressao Genica-LABMEG Departamento de Ciências BiológicasUniversidade Federal de Alagoas(UFAL)Campus Arapiraca57300-970ArapiracaAlagoasBrazil

Mayaro virus is an emergent alphavirus that infects humans,leading to Mayaro *** fifty percent of infected patients develop arthritis symptoms in the recovery phase,a phase that can last up to a *** literature about Mayaro virus infection and its immune response is scarce,which may hamper the development of treatment *** summarize changes in cytokines and chemokines in the acute and recovery phase in Mayaro virus infected patients,and relate this molecular characterization with the immune *** and IL-12/p70 show pronounced changes in patients in the acute phase,suggesting the development of cellular immunity and Th1 ***-6,IL-7,CXCL8/IL-8,IL-13,IL-17,and IFN-γare elevated in patients with arthritis symptoms in the long-term recovery phase,which may be related to the continuous inflammatory process,a possible Th2 inhibiting and promoting Th17 *** few studies discuss the issue,with a small number of patients and different backgrounds,inflammatory and immune response and manifestations seem to be closely *** information may help to develop the appropriate treatment strategies in Mayaro virus ***,we analyzed and summarized data available in literature.

关键词： Emergent virus Mayaro virus Cytokines Chemokine Molecular characterization

Whole body vibration and auriculotherapy improve handgrip strength in individuals with knee osteoarthritis

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Journal of Traditional Chinese Medicine 2019年第5期39卷 707-715页

作者： Eloa Moreira-Marconi Carla F Dionello Danielle S Morel Danubia C Sa-Caputo Cintia R Sousa-Goncalves Laisa L Paineiras-Domingos Ygor Teixeira-Silva Mario jose dos santos Pereira Mario Bernardo-filho Postgraduate Program in Clinical and Experimental Physiopathology University of the State of Rio de JaneiroRio de JaneiroRJBrazil Department of Biophysics and Biometrics Laboratory of Mechanical Vibrations and Integrative Practices-LAVIMPIInstitute of Biology Roberto Alcantara GomesRio de Janeiro State UniversityRio de JaneiroRJBrazil Postgraduate Program in Medical Sciences Rio de Janeiro State UniversityRio de JaneiroRJBrazil Danubia C Sa-Caputo Faculdade Bezerra de AraujoRio de JaneiroBrazilCentro Universitario Serra dos OrgaosTeresopolisRio de JaneiroBrasil Universidade do Estado do Rio de Janeiro Rio de JaneiroRJBrazil-Department of Biophysics and BiometricsInstitute of Biology Roberto Alcantara Gomes-Department of Physiological Sciences

OBJECTIVE: To verify the action of non-pharmacological interventions, whole body vibration exercise (WBVE) and auriculotherapy (AT) on the management of knee osteoarthritis (KOA) analyzing the handgrip strength (HS). METHODS: One hundred twelve participants with KOA were allocated in (a) WBVE group with peak-to-peak displacement of 2.5 to 7.5 mm, frequency from 5 up to 14 Hz, acceleration peak from 0.12 up to 2.95 g (2 d/weekly for 5 weeks),(b) AT group, points of both ears (Kidney, Knee-correspondent point and Shenmen) were stimulated with seeds,(c) WBVE + AT group and (d) respective control groups. HS was assessed in all the participants, in acute and cumulative responses. RESULTS: The intervention with WBVE alone and combined with AT improved (P < 0.05), in a cumulative response, the HS. CONCLUSION: WBVE alone or combined with AT might promote biological effects that interfere with the HS in individuals with KOA.

关键词： Osteoarthritis,knee Exercise therapy Physical and rehabilitation medicine Auriculotherapy Muscle strength dynamometer

Application of Heterogenous Catalysis with TiO2 Photo Irradiated by Sunlight and Latter Activated Sludge System for the Reduction of Vinasse Organic Load

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Engineering（科研） 2012年第11期4卷 746-760页

作者： Juliana Sanches Carrocci Rodrigo Yuji Mori Oswaldo Luiz Cobra Guimaraes Rodrigo Fernando dos santos Salazar Marcos Fernandes de Oliveira Andre Luis de Castro Peixoto Helcio jose Izario filho Construfer Engenharia GuaratinguetaBrasil OXITENO TremembeBrasil Departamento Basico Escola de Engenharia de Lorena EEL/USPLorenaBrasil Departamento de Quimica Universidade Federal de Sao Carlos(UFSCar)Sao CarlosBrasil Unidade Cruz Alta Universidade Estadual do Rio Grande do Sul(UERGS)Cruz AltaBrasil DuPont do Brasil S/A GuarulhosBrasil Instituto Federal de Educacao Ciencia e Tecnologia(IFSP)CapivariBrasil Departamento de Engenharia Quimica Escola de Engenharia de Lorena EEL/USPLorenaBrasil

Vinasse is the main residue generated during alcohol, sugar and blue rum production by fermentation process. This residue is effluent that could cause serious environmental pollution due to high organic load when is not treated adequately. The aim of this work consists of evaluating the efficiency and application of heterogeneous photocatalysis with TiO2, followed by a biological treatment (activated sludge system) to reduce organic load in the referred effluent. Complete factorial designs indicated the best experimental conditions subsequent to photacatalytic and biological treatments providing a reduction of non-purgeable organic carbon (NPOC) as a variable response. After the photocatalytic process, the sample from the best experiment condition was treated by a biological process in order to verify the degradation efficiency of the effluent organic matter studied according to the hybrid system (Advanced Oxidation Process—Acti- vated Sludge System). This system, which presented more efficiency, had a photochemical treatment of 180 minutes carried out in aerated solutions, pH 9 and effluent in natura, while the biological treatment was performed at pH 8 and sludge concentration of 5 gL–1. The reduction of biochemical oxygen demand (BOD) was >80%.

关键词： Heterogenous Catalysis Activated Sludge Organic Load

Dengue Climate Variability in Rio de Janeiro City with Cross-Wavelet Transform

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Journal of Environmental Protection 2022年第3期13卷 261-276页

作者： Suellen Araujo Franco dos santos Hugo Abi Karam Augusto José Pereira filho Jú lio Cesar Barreto da Silva jose Luis Flores Rojas Julio Migue Angeles Suazo Isela Leonor Vá squez Panduro Cesar Arturo Sanchez Peñ a Departamento de Meteorologia Instituto de Geoci&ecirc ncias Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brasil Departamento de Ciê ncias Atmosfé ricas Instituto de Astronomia Geofísica e Ci&ecirc ncias Atmosfé ricas Universidade de S&atilde o Paulo (IAG-USP) S&atilde o Paulo Brasil Programa de Pós-Graduaç ã o em Ciê ncias Ambientais Universidade Estadual do Rio de Janeiro (UERJ) Rio de Janeiro Brasil Instituto Geofísico do Peru (IGP) Lima Per&uacute Facultad de Ingeniería Forestal y Ambiental. Universidad Nacional Autó noma de Tayacaja Daniel Herná ndez Morillo (UNAT) Pampas Per&uacute Universidad Tecnoló gicadel Perú Faculdad de Engenier&iacute a Industrial Lima Per&uacute Centro de Previsã o do Tempo e Estudos Climá ticos Cachoeira Paulista Brasil Programa de Pó s-Graduaç ã o em Computaç ã o Aplicada Instituto Nacional de Pesquisas Espaciais (INPE) S&atilde o José dos Campos S&atilde o Paulo SP Brasil

Dengue is one of the most prominent tropical epidemic diseases present in the Rio de Janeiro city and Southeast part of Brazil, due to the widespread conditions of occurrence of the dengue vector, the mosquito Aedesaegypti, such as high-temperature days interlaced with afternoon or nocturnal rainstorms in summer. This work has the objective of investigating the relationships between variabilities of the El Ni?o-South Oscillation (ENSO) and greater epidemics of dengue in Rio de Janeiro city. To accomplish this goal, the analysis and signal decomposition by cross-wavelet transform (WT) was applied to obtain the cross variability associated with variations of power and phase of both signals by characteristic periods and along with the time series. Data considered in the analysis are (the decimal logarithm of normalized value) of the monthly available notifications of dengue worsening, provided by the public health system of Brazil, and the Southern Oscillation Index (SOI) Ni?o 3.4 data, provided by the National Oceanic and Atmospheric Administration (NOAA), in the period 2000-2017. A maximum cross-wavelet power close to 0.45 was obtained for the representative period of 1 year and also to periods between 3 and 4 years, associated with the positive phase of the SOI index (i.e. , La Ni?a) or with a transition to the positive phase. The evolution of the combined variability of SOI and dengue can be expressed by progressive differences in phase along the time, eventually resulting in yielding phases (i.e., La Niña-Dengue epidemic).

关键词： Dengue Fever Cross-Wavelet Transform Analysis El Niño-Southern Oscillation Index

Endoscopic papillectomy: The limits of the indication, technique and results

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World Journal of Gastrointestinal Endoscopy 2015年第10期7卷 987-994页

作者： jose Celso Ardengh Rafael Kemp Eder Rios Lima-filho jose Sebastiao dos santos Division of Digestive and Endoscopic Surgery Department of Surgery and Anatomy Ribeirao Preto School of Medicine University of Sao Paulo Department of Surgery Hospital Federal dos Servidores do Estado Rua Sacadura Cabral Rio de Janeiro 20221-903 Brazil

In the majority of cases, duodenal papillary tumors are adenomas or adenocarcinomas, but the endoscopy biopsy shows low accuracy to make the correct differentiation. Endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography are important tools for the diagnosis, staging and management of ampullary lesions. Although the endoscopic papillectomy(EP) represent higher risk endoscopic interventions, it has successfully replaced surgical treatment for benign or malignant papillary tumors. The authors review the epidemiology and discuss the current evidence for the use of endoscopic procedures for resection, the selection of the patient and the preventive maneuvers that can minimize the probability of persistent or recurrent lesions and to avoid complications after the procedure. The accurate staging of ampullary tumors is important for selecting patients to EP or surgical treatment. Compared to surgery, EP is associated with lower morbidity and mortality, and seems to be a preferable modality of treatment for small benign ampullary tumors with no intraductal extension. The EP procedure, when performed by an experienced endoscopist, leads to successful eradication in up to 85% of patients with ampullary adenomas. EP is a safe and effective therapy and should be established as the first-line therapy for ampullary adenomas.

关键词： Epidemiology Ampullary tumors Endo-scopic resection Endoscopic ultrasound Staging Endoscopic papillectomy Surgical ampullectomy

Protective Effect of Taurine in the Induction of Genotoxicity by Mutagenic Drugs

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Journal of Pharmacy and Pharmacology 2018年第1期6卷 1-9页

作者： Priscila Longhin Bosquesi Caue Benito Scarim jose Ricardo Soares de Oliveira Ednir de Oliveira Vizioli Jean Leandro dos santos Chung Man Chin Departamento de Farmacos e Medicamentos Faculdade de Ciencias Farmaceuticas Universidade Estadual Paulista "Julio deMesquita Filho " UNESP Araraquara 14800-903 Brasil

Genotoxicity is a toxic action of several drugs, such as anti-neoplastic and nitro-related compounds. TAU （Taurine, 2-aminoetano sulfonic acid） is an important and potent antioxidant amino acid involved in the maintenance of homeostasis in many systems like leukocytes, skeletal muscle, the heart, the kidney, the liver, the bowel, the brain and the retina. The aim of this work was evaluated by the protective effect of TAU co-administered with mutagenic drugs such as benznidazole, cyclophosphamide, hydroxyurea, metronidazole, and nitrofurazone in an in vivo model using a micronucleus assay, evaluatation for the ability of different substances to promote DNA injury. The results showed that TAU decreased genotoxic activity of all drugs suggesting that the protective action of TAU supplementation can be beneficial to reduce genotoxicity of drugs. In this context, we propose one possible mechanism for how TAU blocks the chromosomal aberrations caused by the action of genotoxic substances.

关键词： Battery TAU genotoxicity micronucleus protective effect.

An Application of Paraconsistent Annotated Logic for Design Software Testing Strategies

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Journal of Software Engineering and Applications 2014年第5期7卷 371-386页

作者： Marcos Ribeiro do Nascimento Luiz Alberto Vieira Dias Joao Inacio Da Silva filho Brazillian Aeronautics Institute of Technology—ITA Sao Jose dos Campos Brazil Santa Cecília University—UNISANTA Santos Brazil

Nowadays, application model systems for decision-making based on non-classical logic such as Paraconsistent Logic are used successfully in the treatment of uncertainties. The method presented in this paper is based on the fundamental concepts of Paraconsistent Annotated Logic with annotation of 2 values (PAL2v). In this study, two algorithms based on PAL2v are presented gradually, to extract the effects of the contradiction in signals of information from a database of uncertain knowledge. The Paraconsistent Extractors Algorithms of Contradiction Effect-Para Extrctr is applied to filters of networks of analyses (PANets) of signal information, where uncertain and contradictory signals may be found. Software test case scenarios are subordinated to an application model of Paraconsistent decision-making, which provides an analysis using Paraconsistent Logic in the treatment of uncertainties for design software testing strategies. This quality-quantity criterion to evaluate the software product quality is based on the characteristics of software testability analysis. The Para consistent reasoning application model system presented in this case study, reveals itself to be more efficient than the traditional methods because it has the potential to offer an appropriate treatment to different originally contradicting source information.

关键词： Paraconsistent Logic Design Testing Strategies Software Testability Paraconsistent Decision Making Model