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XAANTAL2 （AGL14） Is an Important Component of the Complex Gene Regulatory Network that Underlies Arabidopsis Shoot Apical Meristem Transitions

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Molecular Plant 2015年第5期8卷 796-813页

作者： Rigoberto V. Perez-R.u.iz Berenice Garcia-Ponce Nayelli Marsch-Martinez Yamel Ugartechea-Chirino Mitzi Villajuana-Bonequi Stefan de Folter Eugenio Azpeitia jose davila-velderrain David Cruz-Sanchez Adriana Garay-Arroyo Maria de la Paz Sanchez Juan M. Estevez-Palmas Elena R. Alvarez-Buylla Instituto de Ecologia Universidad Nacionat Autonoma de Moxico 3er Circuito Exterior s/no Junto al Jardin Bot~nico and Centro de Ciencias de la ComplejidadCiudad Universitaria Coyoacan 04510 Mexico D.F. Mexico Laboratorio Nacional de Genemica para la Biodiversidad (Langebio) Centro de Investigaci6n y de Estudios Avanzados del Instituto Polit~cnico Nacional(CINVESTAV-IPN) Km. 9.6 Carretera Irapuato - Leen AP 629 36821 Irapuato Guanajuato Mexico University of California 431 Koshland Hall Berkeley CA 94720 USA These authors contributed equally to this article. present address: Departamento de Biotecnologia y Biquimica Centro de )nvestigaci6n y de Estudios Avanzados del Instituto Polit6cnico Nacional(CINVESTAV-IPN) Km. 9.6 Libramiento Norte Carr. Irapuato-Leen 36821 Irapuato Guanajuato Mexico present address: Max Planck Institute for Plant Breeding Research D-50829 Cologne Germany Present address: INRIA Project-Team Virtual Plants/CIRAD/INRA UMR AGAP Campus St Priest - BAT 5 CC 05018 860 rue de St Priest 34095 Montpellier Cedex5 France

In Arabidopsis thaliana, multiple genes involved in shoot apical meristem （SAM） transitions have been char- acterized, but the mechanisms required for the dynamic attainment of vegetative, inflorescence, and floral meristem （VM, IM, FM） cell fates during SAM transitions are not well understood. Here we show that a MADS-box gene, XAANTAL2 （XAL2/AGL14）, is necessary and sufficient to induce flowering, and its regula- tion is important in FM maintenance and determinacy, xal2 mutants are late flowering, particularly under short-day （SD） condition, while XAL2 overexpressing plants are early flowering, but their flowers have vege- tative traits. Interestingly, inflorescences of the latter plants have higher expression levels of LFY, AP1, and TFL1 than wild-type plants. In addition we found that XAL2 is able to bind the TFL1 regulatory regions. On the other hand, the basipetal carpels of the 35S：：XAL2 lines lose determinacy and maintain high levels of WUS expression under SD condition. To provide a mechanistic explanation for the complex roles of XAL2 in SAM transitions and the apparently paradoxical phenotypes of XAL2 and other MADS-box （SOCl, AGL24） over- expressors, we conducted dynamic gene regulatory network （GRN） and epigenetic landscape modeling. We uncovered a GRN module that underlies VM, IM, and FM gene configurations and transition patterns in wild- type plants as well as loss and gain of function lines characterized here and previously. Our approach thus provides a novel mechanistic framework for understanding the complex basis of SAM development.

关键词： XAL2/AGL14 MADS-box TFL1 SAM transitions floral reversion gene regulatory networks,epigenetic landscape modeling

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Ethyl Methanesulfonate as Inductor of Somaclonal Variants in Different Crops

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Phyton-International Journal of Experimental Botany 2020年第4期89卷 835-850页

作者： jose Gregorio Joya-davila F.A.Gutierrez-Miceli Plant Biotechnology Laboratory Tecnologico Nacional de MexicoInstituto Tecnologico de Tuxtla GutierrezTuxtla Gutierrez29050Mexico

Ethyl methanesulfonate is a chemical mutagen,which is currently being used in plant breeding,to increase genetic variability in genes of agronomic interest,of species useful in agriculture.It primarily causes single base point mutations by inducing guanine alkylation,resulting in GC to AT transitions.Its effect is different between clones of a genotype and between genotypes of the same species.This review presents the results obtained in recent research,where its effect on plant tissues,callus,and cells in suspension has been evaluated.Changes in the phenotypic expression of somaclonal variants were reported,involving morphology,production of secondary metabolites,changes in metabolic routes of resistance,tolerance to stress,increased seed yield,among others.In addition,this review compiles the doses and guidelines to consider before using this mutagen,which can serve as a guide for future trials in deciding the response variables,the type of plant explants and the selection of the study model.Mutant lines have allowed plant breeders to have a collection of plants with different characteristics,in places where the cultivar does not have its center of origin.It is important to note that it is still necessary to continue evaluating the heritability of mutations and their behaviour in the environment where they will be established,in order to obtain new varieties of plants that can be cultivated with uniformity in their genetic response.

关键词： Geneticvariability plantbreeding pointmutation guaninealkylation chemical mutagen

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Diet switch and omega-3 hydroxy-fatty acids display differential hepatoprotective effects in an obesity/nonalcoholic fatty liver disease model in mice

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World Journal of Gastroenterology 2018年第4期24卷 461-474页

作者： Roberto Rodriguez-Echevarria jose Macias-Barragan Marcela Parra-Vargas Judith Rebeca davila-Rodriguez Eduardo Amezcua-Galvez Juan Armendariz-Borunda Institute for Molecular Biology and Gene Therapy-CUCS Department of Molecular Biology and GenomicsUniversity of GuadalajaraGuadalajara 44340Mexico Department of Health Sciences-CUValles University of GuadalajaraGuadalajara 46600Mexico Hospital Civil de Guadalajara Guadalajara 46600Mexico

AIM To study the effect of 18-hydroxy-eicosapentaenoic acid(18-HEPE) and 17-hydroxy-docosahexaenoic acid(17-HDHA) in a murine model of obesity/nonalcoholic fatty liver disease.METHODS C57 BL/6 mice were fed with standard chow diet(CD) or high-fat, fructose-enriched diet(HFD) for 16 wk. Then, three groups were treated for 14 d with either, diet switch(HFD for CD), 18-HEPE, or 17-HDHA. Weightand fasting glucose were recorded on a weekly basis. Insulin tolerance test was performed at the end of treatment. Histological analysis(HE and Masson's trichrome stain) and determination of serum insulin, glucagon, glucagon-like peptide 1(GLP-1), glucose-dependent insulinotropic polypeptide, adiponectin and resistin were carried out as well as liver proteins by western blot.RESULTS Mice treated with hydroxy-fatty acids 18-HEPE and 17-HDHA displayed no weight loss or improved insulin sensitivity. However, these mice groups showed a significant amelioration on serum GLP-1, adiponectin and resistin levels. Also, a significant reduction on inflammatory infiltrate was observed at both portal and lobular zones. Furthermore, up-regulation of PPARα/γ protein levels was observed in liver tissue and it was associated with decreased levels of NF-κB also determined by western blot analysis. On the other hand, diet switch regimen resulted in a marked improvement in most parameters including: weight loss, increased insulin sensitivity, decreased steatosis, restored levels of insulin, glucagon, leptin, adiponectin and resistin. However, no significant changes were observed regarding inflammatory infiltrate in this last group.CONCLUSION 18-HEPE and 17-HDHA differentially exert hepatoprotective effects through up-regulation of nuclear receptors PPARα/γ and amelioration of serum adipokines profile.

关键词： Nonalcoholic fatty liver disease Polyunsaturated fatty acids 18-hydroxy-eicosapentaenoic acid 17-hydroxy-docosahexaenoic acid Obesity

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Cerebral dopamine neurotrophic factor transfection in dopamine neurons using neurotensin-polyplex nanoparticles reverses 6-hydroxydopamine-induced nigrostriatal neurodegeneration

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Neural Regeneration Research 2022年第4期17卷 854-866页

作者： Manuel A.Fernandez-Parrilla David Reyes-Corona Yazmin M.Flores-Martinez Rasajna Nadella Michael J.Bannon Lourdes Escobedo Minerva Maldonado-Berny Jaime Santoyo-Salazar Luis O.Soto-Rojas Claudia Luna-Herrera jose Ayala-davila Juan A.Gonzalez-Barrios Gonzalo Flores Maria E.Gutierrez-Castillo Armando JEspadas-Alvarez Irma A.Martínez-Dávila Porfirio Nava Daniel Martinez-Fong Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Programa Institucional de Biomedicina Molecular Escuela Nacional de Medicina y HomeopatíaInstituto Politécnico NacionalCiudad de MéxicoMéxico Department of Biosciences IIIT-SrikakulamRajiv Gandhi University of Knowledge Technologies(RGUKT)Andhra PradeshIndia Department of Pharmacology Wayne State University School of MedicineDetroitMIUSA Departamento de Física Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico Facultad de Estudios Superiores Iztacala Universidad Nacional Autónoma de MéxicoTlalnepantla de BazEdo.de MéxicoMéxico Departamento de Fisiología Escuela Nacional de Ciencias BiológicasCiudad de MéxicoMéxico Laboratorio de Medicina Genómica Hospital Regional“1°de Octubre”ISSSTECiudad de MéxicoMéxico Laboratorio de Neuropsiquiatría Instituto de FisiologíaBenemérita Universidad Autónoma de PueblaPueblaPueblaMéxico Departamento de Biociencias e Ingeniería Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y DesarrolloInstituto Politécnico NacionalCiudad de MéxicoMéxico Programa de Nanociencias y nanotecnología Centro de Investigación y de Estudios AvanzadosCiudad de MéxicoMéxico

Overexpression of neurotrophic factors in nigral dopamine neurons is a promising approach to reverse neurodegeneration of the nigrostriatal dopamine system,a hallmark in Parkinson's disease.The human cerebral dopamine neurotrophic factor(h CDNF)has recently emerged as a strong candidate for Parkinson's disease therapy.This study shows that h CDNF expression in dopamine neurons using the neurotensinpolyplex nanoparticle system reverses 6-hydroxydopamine-induced morphological,biochemical,and behavioral alterations.Three independent electron microscopy techniques showed that the neurotensin-polyplex nanoparticles containing the h CDNF gene,ranging in size from 20 to 150 nm,enabled the expression of a secretable h CDNF in vitro.Their injection in the substantia nigra compacta on day 21 after the 6-hydroxydopamine lesion resulted in detectable h CDNF in dopamine neurons,whose levels remained constant throughout the study in the substantia nigra compacta and striatum.Compared with the lesioned group,tyrosine hydroxylase-positive(TH^(+))nigral cell population and TH+fiber density rose in the substantia nigra compacta and striatum after h CDNF transfection.An increase inβIII-tubulin and growth-associated protein 43 phospho-S41(GAP43 p)followed TH^(+)cell recovery,as well as dopamine and its catabolite levels.Partial reversal(80%)of drugactivated circling behavior and full recovery of spontaneous motor and non-motor behavior were achieved.Brain-derived neurotrophic factor recovery in dopamine neurons that also occurred suggests its participation in the neurotrophic effects.These findings support the potential of nanoparticle-mediated h CDNF gene delivery to develop a disease-modifying treatment against Parkinson's disease.The Institutional Animal Care and Use Committee of Centro de Investigación y de Estudios Avanzados approved our experimental procedures for animal use(authorization No.162-15)on June 9,2019.

关键词： axonal growth brain-derived neurotrophic factor gene delivery nanoparticles neuritogenesis neuronal cytoskeleton neuroregeneration neurorestoration neurotrophic therapy Parkinson's disease reinnervation substantia nigra

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Effect of homogenization process on the hardness of Zn-Al-Cu alloys

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International Journal of Minerals,Metallurgy and Materials 2015年第10期22卷 1076-1081页

作者： jose D.Villegas-Cardenas Maribel L.Saucedo-Munoz Victor M.Lopez-Hirata Antonio De Ita-De la Torre Erika O.Avila-davila Jorge Luis Gonzalez-Velazquez Department of Metallurgy and Materials Instituto Politecnico Nacional(IPN-ESIQIE)Mexico City 07300Mexico Department of Industrial Engineering Universidad Politecnica del Valle de MexicoMexico CityMexico Department of Materials Universidad Autonoma Metropolitana(UAM)Unidad AzcapotzalcoMexico

The effect of a homogenizing treatment on the hardness of as-cast Zn–Al–Cu alloys was investigated. Eight alloy compositions were prepared and homogenized at 350 °C for 180 h, and their Rockwell 'B' hardness was subsequently measured. All the specimens were analyzed by X-ray diffraction and metallographically prepared for observation by optical microscopy and scanning electron microscopy. The results of the present work indicated that the hardness of both alloys(as-cast and homogenized) increased with increasing Al and Cu contents; this increased hardness is likely related to the presence of the θ and τ′ phases. A regression equation was obtained to determine the hardness of the homogenized alloys as a function of their chemical composition and processing parameters, such as homogenization time and temperature, used in their preparation.

关键词： zinc–aluminum–copper alloys casting hardness homogenization phases microstructure

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Multi-Temporal Analysis of Land Subsidence in Toluca Valley (Mexico) through a Combination of Persistent Scatterer Interferometry (PSI) and Historical Piezometric Data

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Advances in Remote Sensing 2014年第2期3卷 49-60页

作者： Norma davila-Hernandez Delfino Madrigal jose Luis Exposito Xanat Antonio Department of Hydrology American Center of Water Resources Atlacomulco Mexico Laboratory of Remote Sensing and Geographic Information Systems Faculty of Geography Autonomous University of Mexico State Toluca Mexico

The Toluca Valley Aquifer (TVA) is considered one of the most overexploited aquifers in Mexico because of the high rate of groundwater extraction for supplying urban and industrial water to Mexico City and Toluca City, which causes land subsidence in urban and suburban areas. In this paper, we propose a multi-temporal analysis that uses persistent scatterer interferometry (PSI) method to evaluate the subsidence processes in Toluca Valley. The PSI results revealed differential movements of the ground of as much as 83 mm/year. A spatial variation of PSI results was identified with respect to previous studies using the conventional Din SAR methodology. The spatial distribution and density suggested the possibility of an expanding trend of subsidence process at north, northeast and east of the TVA, which corresponds to the region with the highest density of pumping wells for industrial and agricultural use.

关键词： Subsidence of Lands Toluca Valley Aquifer Persistent Scatterer Interferometry

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Early Feeding vs 5-Day Fasting after Distal Elective Bowel Anastomoses in Children.A Randomized Controlled Trial

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Surgical Science 2013年第1期4卷 45-48页

作者： Roberto davila-Perez Eduardo Bracho-Blanchet Francisco Galindo-Rocha jose Tovilla-Mercado Gustavo Varela-Fascinetto Emilio Fernandez-Portilla Pablo Lezama-del-Valle Jaime Nieto-Zermeno Pediatric Surgery Department Hospital Infantil de Mexico Federico GomezMexico CityMexico

Purpose: Determine the safety and efficacy of early enteral feeding after distal elective bowel anastomoses (DEBA) in children. Methods: Controlled randomized trial including pediatric patients with DEBA, excluding non-elective and high risk patients. Variables: Demographics, operative time, anastomosis placement, beginning peristalsis and bowel movement, time to full diet intake, post-operative stay, persisting vomiting and abdominal distention, wound infection or dehiscence, anastomotic leak, reoperation, death. Randomization into: 1) Experimental group (EG): early feeding group, after a minimum 24 hours fasting period, oral fluids and diet was started;2) Control group (CG): obligatory 5-day fasting. Descriptive Statistics: Student’s t test for quantitative and Chi square for qualitative variables, a p-value 0.05 was considered significant. Results: 60 patients were included since June 2003 to May 2004, 30 ineach group. Mean age 2 years, weight16 kg, malnutrition 33%. Stomal Ethiology: Anorectal-malformation 46%, Hirschsprung 13%, inflammatory 35%, tumoral 5%. Mostly in colon 71%. Mean surgical time 142 min. None developed vomiting or required nasogastric-tube. Mild abdominal distension 13%, mild fever 16.5% and wound complications 18%. Anastomosis leakage 6.5%, none required reoperations. Demographic variables showed no statistical differences. Full oral intake was in the 2nd postoperative day in the EG vs CG (p = 0.001). Postoperative hospital stay was 6.0 ± 3 in the EG vs 9.8 ± 4 days in the CG with clinical but not statistical significance. Peristalsis beginning, first flatus passage and bowel movements showed no statistical differences. The complication incidence was low and equally distributed. Conclusions: Early feeding after DEBA is safe and well tolerated in children.

关键词： Early Feeding Bowel Anastomosis Children

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Attenuation of UV-C Solar Radiation as a Function of Altitude(0≤z≤100 km):Rayleigh Diffusion and Photo Dissociation of O_(2) Influence

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Atmospheric and Climate Sciences 2017年第4期7卷 540-553页

作者： jose Luis Pinedo-Vega Carlos Rios-Martínez David Jacobo Navarro-Solis J.Ignacio davila-Rangel Fernando Mireles-Garcia Sonia Azucena Saucedo-Anaya Eduardo Manzanares-Acuna Valentin Badillo-Almaraz Department:UAEN Universidad Autonoma de ZacatecasZacatecasMexico

In this paper, we present an analysis of attenuation for UV-C radiation () as a function of the altitude z () by calculating the interaction ratio between the UV-C radiation and the molecular species susceptible of interact with UV-C radiation. The Rayleigh scattering spectral cross sections were calculated, the UV-C spectral cross sections of the species susceptible of interact with UV-C radiation and the UV extraterrestrial (ETR) solar spectrum were standardized with wavelength steps of 1 nm, and The International Standard Atmosphere model (ISO 1972) was adapted to calculate the molecular density. These data were utilized to calculate the photodissociation and Rayleigh scattering ratios as a function of the altitude and to determine to what measure the photodissociation and the Rayleigh diffusion were determinants of the attenuation of UV-C radiation. It became clear that the photo dissociation of O2 is the primordial mechanism of attenuation for the UV-C radiation, but the Rayleigh diffusion appears like a mechanism that encreases the photon flux, raising the performance of the O2 photodissociation. The attenuation capacities of N2O, CO2 and water vapor (H2O) over the UV-C radiation are all similar, although smaller (less than 0.6%), and this is due to their low concentration. The O3, has the theoretical greater attenuation capacity, but it is found in mid-range altitudes? (), where the residual UV-C photons has almost vanished by O2 photo dissociation or Rayleigh diffusion, so the real effect over the UV-C attenuation is minimum.

关键词： UV-C Radiation Rayleigh Scattering O_(2) Photodissociation

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