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Circulating extracellular vesicles:friends and foes in neurodegeneration

Neural Regeneration Research 2022年第3期17卷 534-542页

作者： Anna Picca flora Guerra Riccardo Calvani Hélio josécoelho-Junior Cecilia Bucci Emanuele Marzetti fondazione Policlinico Universitario“Agostino Gemelli”IRCCS RomeItaly Aging Research Center Department of NeurobiologyCare Sciences and SocietyKarolinska Institutet and Stockholm UniversityStockholmSweden Department of Biological and Environmental Sciences and Technologies Universitàdel SalentoLecceItaly UniversitàCattolica del Sacro Cuore Institute of Internal Medicine and GeriatricsRomeItaly

Extracellular vesicles have been identified as pivotal mediators of intercellular communication with critical roles in physiological and pathological *** this route,several molecules(e.g.,nucleic acids,proteins,metabolites) can be transferred to proximal and distant targets to convey specific *** vesicle-associated cargo molecules have been proposed as markers of several disease conditions for their potential of tracking down the generating ***,circulating extracellular vesicles may represent biomarkers of dysfunctional cellular quality control systems especially in conditions characterized by the accrual of intracellular misfolded ***,the identification of extracellular vesicles as tools for the delivery of nucleic acids or other cargo molecules to diseased tissues makes these circulating shuttles possible targets for therapeutic *** increasing interest in the study of extracellular vesicles as biomarkers resides mainly in the fact that the identification of peripheral levels of extracellular vesicle-associated proteins might reflect molecular events occurring in hardly accessible tissues,such as the brain,thereby serving as a "brain liquid biopsy".The exploitation of extracellular vesicles for diagnostic and therapeutic purposed might offer unprecedented opportunities to develop personalized ***,we discuss the bright and dark sides of extracellular vesicles in the setting of two main neurodegenerative diseases(i.e.,Parkinson's and Alzheimer's diseases).A special focus will be placed on the possibility of using extracellular vesicles as biomarkers for the two conditions to enable disease tracking and treatment monitoring.

关键词： Alzheimer's disease amyloid protein exosomes misfolded proteins mitochondrial-derived vesicles neuroinflammation Parkinson's disease quality control Tau protein α-synuclein

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Are the number and size of scales in Liolaemus lizards driven by climate?

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Integrative Zoology 2018年第5期13卷 579-594页

作者： María joséTULLI félix BCRUZ Unidad Ejecutora Lillo(UEL-CONICET) Instituto de HerpetologíaFundación Miguel LilloSan Miguel de TucumánTucumánArgentina Instituto de Investigaciones en Biodiversidad y Medioambiente(INIBIOMA)CONICET-UNCOMA BarilocheRío NegroArgentina

Ectothermic vertebrates are sensitive to thermal fluctuations in the environments where they *** buffer these fluctuations,ectotherms use different strategies,including the integument,which is a barrier that minimizes temperature exchange between the inner body and the surrounding *** lizards,this barrier is constituted by keratinized scales of variable size,shape and texture,and its main function is protection,water loss avoidance and *** size of scales in lizards has been proposed to vary in relation to climatic gradients;however,it has also been observed that in some groups of Iguanian lizards it could be related to ***,here,we studied the area and number of scales(dorsal and ventral)of 60 species of Liolaemus lizards distributed in a broad latitudinal and altitudinal gradient to determine the nature of the variation of the scales with climate,and found that the number and size of scales are related to climatic variables,such as temperature and geographical variables as *** evolutionary process that best explained how these morphological variables evolved was the Ornstein–Uhlenbeck *** number of scales seemed to be related to common ancestry,whereas dorsal and ventral scale areas seemed to vary as a consequence of ecological *** fact,the ventral area is less exposed to climate conditions such as ultraviolet radiation or wind and is,thus,under less pressure to change in response to alterations in external *** is possible that scale ornamentation,such as keels and granulosity,may bring some more information in this regard.

关键词： climate variables habitat use Lioalemidae scale traits

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Multiparameter resonant imaging for studying cell interactions

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Light(Science & Applications) 2018年第1期7卷 652-653页

作者： joséJuan-Colás Thomas f Krauss Department of Physics The University of YorkHeslignton YO105DDUK Department of Electronic Engineering The University of YorkHeslignton YO105DDUK

The development of optical microscopy techniques has provided major insights into the machinery of life,from molecules to cells to tissues and *** techniques have been particularly successful in this respect by elucidating biological pathways and helping us understand the complex relationships that underpin all living *** example,the first use of fluorescence as an analytical tool in 18641 paved the way for the study of biological entities and interactions,but it was not until nearly 60 years later,in the 1930s,that fluorophores were first employed to perform biological investigations into specific tissue components and bacteria that do not *** advances led to the first labeling of an antibody with a visible label in 19413,which gave birth to the field of immunofluorescence and allowed us obtain unprecedented insight into antibody structure.

关键词： organs insight visible

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KnoE:A Web Mining Tool to Validate Previously Discovered Semantic Correspondences

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Journal of Computer Science & Technology 2012年第6期27卷 1222-1232页

作者： Jorge Martinez-Gil josé f.Aldana-Montes Department of Computer Languages and Computing Sciences University of MlagaBoulevard Louis Pasteur 35 Mlaga 29071Spain

The problem of matching schemas or ontologies consists of providing corresponding entities in two or more knowledge models that belong to a same domain but have been developed separately. Nowadays there are a lot of techniques and tools for addressing this problem, however, the complex nature of the matching problem make existing solutions for real situations not fully satisfactory. The Google Similarity Distance has appeared recently. Its purpose is to mine knowledge from the Web using the Google search engine in order to semantically compare text expressions. Our work consists of developing a software application for validating results discovered by schema and ontolog2/ matching tools using the philosophy behind this distance. Moreover, we are interested in using not only Google, but other popular search engines with this similarity distance. The results reveal three main facts. firstly, some web search engines can help us to validate semantic correspondences satisfactorily. Secondly there are significant differences among the web search engines. And thirdly the best results are obtained when using combinations of the web search engines that we have studied.

关键词： database integration data and knowledge engineering similarity distance

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Extrahepatic right hepatic duct diverticulum: a rare entity

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Hepatobiliary & Pancreatic Diseases International 2010年第2期9卷 213-215页

作者： Eduardo SM fernandes Raquel L Bernardo Moacir M fernandes Rogério MC Araújo Renato Sebbe Asterio Monte jos.f coelho Antonio AP Souza Joaquim Ribeiro filho Department of General Surgery Section of Hepatobiliary Surgery and TransplantationRio de Janeiro Federal University Department of Digestive Surgery and Gastroenterology Pio XII General Hospital

BACKGROUND:Douglas described choledochal cysts in 1852 and Todani proposed an anatomy-based classification in 1977. The classification is the most extensively used,but does not include some rare *** present a case of hepatic duct diverticulum,one of the variations,and discuss its diagnosis and treatment. METHODS:A 57-year-old woman presented with upper abdominal pain and discomfort associated with nausea and *** was finally diagnosed with cholelithiasis and right hepatic duct diverticulum. RESULT:The patient underwent resection of the hepatic duct diverticulum and cholecystectomy,and was asymptomatic 26 months after surgery. CONCLUSIONS:Hepatic duct diverticulum is a rare form of choledochal cyst,not included in Todani’s classification. Todani’s classification including this and other uncommon variations of choledochal cysts must be *** best diagnostic imaging methods and treatment for choledochal cysts must be defined.

关键词： choledochal cysts hepatic duct diverticulum Todani's classification intrahepatic diverticulum

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Phasor-domain Dynamic Model of Asymmetric Current Injection Controller for Converter-interfaced Generator

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Journal of Modern Power Systems and Clean Energy 2021年第6期9卷 1269-1278页

作者： Victor A.f.Almeida Glauco N.Taranto josé M.T.Marinho Electrical Engineering Department of the federal University of Rio de Janeiro(COPPE/UfRJ) Petrobras S.A.

This paper presents a controller model of asymmetric current injection for converter-interfaced generators suitable for root-mean-square(RMS)phasor-domain,fundamentalfrequency,three-phase,and dynamic simulation *** effectiveness of the proposed controller is assessed with simulations in test systems with high percentage of converter-interfaced *** simulations focus on the operation of protection relays that use negative-sequence quantities in their directional *** paper also presents and compares two strategies to limit reactive negative-sequence currents,and active and reactive positive-sequence currents.A tutorial test system and a regional system part of the actual Brazilian Interconnected Power System are used to assess the correctness of the proposed controller in three-phase fundamental-frequency RMS dynamic simulations.

关键词： Converter-interfaced generator three-phase model power system protection negative-sequence current injection negative-sequence current protection unbalanced fault three-phase root-mean-square(RMS)dynamic simulation

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Impact of coronary angioplasty in elderly patients with non-ST-segment elevation myocardial infarction

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Journal of Geriatric Cardiology 2020年第8期17卷 449-454页

作者： fernando f.Goncalves josé P.Guimaraes Sara C.Borges Pedro S.Mateus josé I.Moreira Cardiology Department Centro Hospitalar de Trás-os-Montes e Alto DouroVila RealPortugal

Background As treatment of coronary artery disease improved over the last years,management of elder patients remained a matter of debate since this age group has been underrepresented in most *** study aimed to evaluate a population of patients with≥85 years old with non-ST-segment elevation myocardial infarction(NSTEMI)and compare the prognosis according to coronary revascularization *** We retrospectively studied 324 patients included in a national multicenter registry between October 2010 and October 2018,who underwent coronary angiography and had at least one stenosis≥50%.Results In this population,73.1%of the patients underwent percutaneous coronary intervention(PCI)and 26.9%of the patients underwent optimized medical treatment(OMT).The OMT group had more past history of diabetes,stroke and *** coronary angiography,the PCI group used more often the femoral artery access and single-vessel lesions were also more ***-vessel disease was more common in the OMT *** hospitalization,there were more major bleeding events and death in the PCI *** the one-year follow-up,there were no significant differences in all-cause mortality *** Very old patients with NSTEMI submitted to OMT had more comorbidities and more three-vessel disease,factors that could have influenced the therapeutic *** undergoing PCI had more in-hospital major bleeding events and mortality,with no significant differences after one year.

关键词： Coronary artery disease Revascularization The elderly

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Is more evidence needed for thrombectomy in basilar artery occlusion? The BASICS and BEST meta- analytical approaches

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Stroke & Vascular Neurology 2021年第4期6卷 671-672,I0094-I0096页

作者： Davi J fontoura Solla felipe coelho Argolo Karol P Budohoski Angelos G Kolias joséGuilherme M P Caldas Jamary Oliveira-filho Division of Neurosurgery Department of NeurologyUniversity of Sao PauloSao PauloBrazil NIHR Global Health Research Group on Neurotrauma Cambridge UniversityCambridgeUK Machine Learning for Mental Health Lab King's College LondonLondonUK Division of Neurosurgery Department of Clinical NeurosciencesAddenbrooke's HospitalCambridge UniversityCambridgeUK Radiology University of Sao PauloSao PauloBrazil Postgraduate Program in Health Sciences Federal University of BahiaSalvadorBahiaBrazil

INTRODUCTION The benefit of mechanical thrombectomy for stroke associated with anterior circulation large vessel occlusion(LVO)is well established and among the most effective treatments in medicine.1 Stroke associated with basilar artery occlusion(BAO)was not included in the seminal thrombectomy randomised clin-ical trials(RCTs).BAO accounts for 1%of the ischaemic strokes and 5%-10%of the LVO,but 70%-80%of BAO victims evolve to death or full dependence.23 The terminal nature of the brainstem and thalamic circulations may predispose to such dismal *** two RCT designed to assess the efficacy of early(for BAO treatment,the BEST and BASICS trials.24 Given the prior evidence for thrombectomy benefit for anterior circu-lation stroke is well settled;BAO stroke shares a similar physiopathology with very poor prog-nosis.

关键词： throm occlusion basilar

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Numerical analysis of synthetic granulate deposition in a physical model study

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International Journal of Sediment Research 2014年第1期29卷 110-117页

作者： Gabriele HARB Stefan HAUN jos.f SCHNEIDER Nils Reidar B.OLSEN Institute of Hydraulic Engineering and Water Resources Management Graz University of Technology Department of Hydraulic and Environmental Engineering The Norwegian University of Science and Technology

The current study focuses on the application of a three-dimensional numerical model for the prediction of morphological bed *** sediment deposition in a reservoir during a 10-year-fiood was investigated and the results of the simulation were validated with data derived from a physical model *** of the small grain sizes in the prototype,synthetic granulate was used in the physical *** numerical computation domain was a reproduction of the physical model,including the grain sizes and the density of the particles,in order to ensure *** CfD code SSIIM,which solves the RANS-equations in three-dimensions,was used for the *** sediment transport in SSIIM is divided into suspended sediment transport,computed by solving the convection-diffusion equation,and bed-load transport,calculated by an empirical *** results of the numerical simulation correspond well to the results of the physical model *** simulated location and the pattern of the sediment deposition in the reservoir are an accurate representation of the observed distribution in the physical model.

关键词： Physical modeling Numerical modeling RANS-equations Reservoir management Sediment

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The CASTOR-K Code,Recent Developments and Applications

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Plasma Science and Technology 2015年第2期17卷 89-96页

作者： f.NABAIS D.BORBA R.coelho A.fIGUEIREDO J.fERREIRA N.LOUREIRO P.RODRIGUES Associao EURATOM/IST Instituto de Plasmas e Fuso Nuclear-Instituto Superior TcnicoUniversidade de Lisboa

The CASTOR-K code is a hybrid magnetohydrodynamic （MHD）-drift kinetic code developed for the study of MHD modes in the presence of energetic ion populations. It allows a fast assessment of the linear stability of the modes, as well as an accurate calculation of damping due to thermal species （Landau damping）. These capabilities make the code an invaluable tool for parametric studies and data analysis. In recent years, CASTOR-K has been mostly used to analyze JET data, including the identification of mechanisms involved in the expulsion of energetic ions from the plasma. However, in order to prepare the code to be used for a wider range of tokamaks including ITER, the code is being subject to a series of important improvements. These improvements aim not only to introduce new physics in the code but also to make it capable of exchanging data with other codes through its integration in modelling infrastructures. In this paper a description of the CASTOR-K code is presented, as well as a summary of the most important results obtained with this code and a description of the new improvements being implemented.

关键词： controlled fusion tokamaks plasma instabilities magnetohydrodynamics(MHD) Alfven waves energetic particles

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