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Nutritional therapy for hepatocellular carcinoma

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World Journal of gastrointestinal Oncology 2021年第10期13卷 1440-1452页

作者： Astrid Ruiz-margáin Berenice m Román-Calleja Paulina moreno-guillén joséA gonzález-Regueiro DeyaniraKúsulas-Delint Alejandro Campos-murguía Nayelli C Flores-garcía Ricardo Ulises macías-rodríguez Liver Nutrition Clinic Department of GastroenterologyInstituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Liver Fibrosis and Nutrition Lab MICTLÁN-Network(Mechanisms of Liver InjuryCell Death and Translational Nutrition in Liver Diseases-Research Network)Mexico City 14080Mexico Department of gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico

Hepatocellular carcinoma(HCC)is the most frequent primary liver cancer and presents together with cirrhosis in most *** addition to commonly recognized risk factors for HCC development,such as hepatitis B virus/hepatitis C virus infection,age and alcohol/tobacco consumption,there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat,type of cooking(generation of heterocyclic amines)and contamination of foods with *** the contrary,protective nutritional factors include diets rich in fiber,fruits and vegetables,n-3 polyunsaturated fatty acids and *** the patient is being evaluated for staging and treatment of HCC,special attention should be paid to nutritional support,including proper nutritional assessment and therapy by a multidisciplinary *** must be considered that these patients usually develop HCC on top of long-lasting cirrhosis,and therefore they could present with severe *** complications should be properly addressed and considered for nutritional *** addition to traditional methods,functional testing,phase angle and computed tom.graphy scan derived skeletal muscle index-L3 are among the most useful tools for nutritional *** therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and *** with branched-chain amino acids is also recommended as it improves response to treatment,nutritional status and survival,and finally physical exercise must be encouraged and adapted to individual needs.

关键词： Sarcopenia Liver Cancer Diet Branched-chain amino acids Nutrition

Post-acute pancreatitis diabetes:A complication waiting for more recognition and understanding

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World Journal of gastroenterology 2023年第28期29卷 4405-4415页

作者： Diego garcía-Compeán Alan R Jiménez-rodríguez Juan m muñoz-Ayala josé A gonzález-gonzález Héctor J maldonado-garza Jesús Z Villarreal-Pérez Department of gastroenterology Autonomous University of Nuevo LeónMonterrey 64700Nuevo LeónMexico Department of Endocrinology Autonomous University of Nuevo LeónMonterrey 64700Nuevo LeónMexico

Post-acute pancreatitis diabetes(PAPD)is the second most common type of diabetes below type 2 diabetes *** to the boom in research on this entity carried out during the last decade,its recognition has ***,much of the medical community still does not recognize it as a medium and long-term complication of acute pancreatitis(AP).Recent prospective cohort studies show that its incidence is about 23%globally and 34.5%in patients with severe *** the overall increase in the incidence of AP this complication will be certainly seen more *** to its high morbidity,mortality and difficult control,early detection and treatment are ***,its risk factors and pathophysiological mechanisms are not clearly *** diagnosis should be made excluding pre-existing diabetes and applying the criteria of the American Diabetes Association after 90 d of resolution of one or more AP *** review will show the evidence published so far on the incidence and prevalence,risk factors,possible pathophysiological mechanisms,clinical outcomes,clinical characteristics and preventive and corrective management of *** important gaps needing to be clarified in forthcoming studies will also be discussed.

关键词： Acute pancreatitis Diabetes mellitus Chronic pancreatitis Post-pancreatitis diabetes Pancreatogenic diabetes

CD300a inhibits CD16-mediated NK cell effector functions in HIV-1-infected patients

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Cellular & molecular Immunology 2019年第12期16卷 940-942页

作者： Joana Vitallé Iñigo Terrén Ane Orrantia Raquel Pérez-garay Francesc Vidal joséA.Iribarren Carmen rodríguez Ana m.López Lirola Enrique Bernal Olatz Zenarruzabeitia Francisco Borrego Immunopathology group Biocruces Bizkaia Health Research InstituteBarakaldoSpain Hospital Universitari de Tarragona Joan XXIII IISPVUniversitat Rovira i VirgiliTarragonaSpain Servicio de Enfermedades Infecciosas Hospital Universitario DonostiaInstituto de Investigación Sanitaria BiodonostiaDonostia-San SebastiánSpain Centro Sanitario Sandoval Hospital Clínico San CarlosInstituto de Investigación Sanitaria San CarlosMadridSpain Hospital Universitario de Canarias Santa Cruz de TenerifeSpain Department of Clinical medicine Universidad de Murcia and Hospital General Universitario Reina SofíaMurciaSpain Ikerbasque Basque Foundation for ScienceBilbaoSpain

Natural killer(NK)cell-mediated antibody-dependent cellular cytotoxicity(ADCC)through CD16 plays a critical role in antihuman immunodeficiency virus(HIV)responses.1–3 CD300a is a surface receptor highly expressed on NK cells that has the capacity to inhibit NK cell-mediated cytotoxicity in healthy donors.4 The CD300a molecule has been related to several viral infections and is able to diminish the NK cell killing of pseudorabies-infected cells through interactions with its ligands phosphatidylserine and phosphatidylethanolamine.5 In addition,CD300a expression on B and CD4+T lymphocytes is altered during HIV-1 infection,and combined antiretroviral therapy(cART)does not restore nonpathological expression levels.5,6 However,the expression and function of CD300a on NK cells during HIV-1 infection is still *** have determined the surface expression of CD300a on different NK cell subsets and the capacity of this receptor to inhibit CD16-induced NK cell effector functions in healthy and HIV-1 infected individuals.

关键词： CD16 CD30 ADCC

Validation of Novel model for Identification of Thermal Conditions in the Low Corona

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Advances in Aerospace Science and Technology 2022年第1期7卷 52-84页

作者： Daniel B. Berdichevsky Jenny m. rodríguez gómez Luis E. Vieira Alisson Dal Lago College Park Maryland USA IFIR/UNR-CONICET Rosario Argentina The Catholic University of America Washington D.C. USA NASA goddard Space Flight Center Greenbelt Maryland USA Instituto Nacional de Pesquisas Espaciais INPE S&atilde o josé dos Campos Brazil

The electron density and temperature key properties of the neutral-m.gnetized plasma in the solar corona, which are predicted with a novel model, provide an interesting window along the whole solar cycle. In this work, we test the quantitative validity of the model and prove that the Coronal Density and Temperature (CODET) is reliable. Furthermore, this work contrasts the CODET model results with alternative observational remote and in-situ datasets during the simplest conditions of the quiescent corona near the solar minimum. This successful outcome/validation of the CODET model allowed a good qualitative density and temperature retrieval in the solar corona covering a large portion of time interval from solar cycles 23 and 24.

关键词： Solar Corona Electron Density Temperature

Predictability of the Western North Pacific Subtropical High Associated with Different ENSO Phases in gloSea5

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Journal of meteorological Research 2020年第5期34卷 926-940页

作者： Daquan ZHANg gill m.mARTIN jose mrodrIguez Zongjian KE Lijuan CHEN Laboratory for Climate Studies National Climate CenterChina Meteorological AdministrationBeijing 100081China met Office Hadley Centre Exeter EX 13PBUK

The western North Pacific subtropical high(WNPSH) dominates the summer climate over East Asia. The intensity,position, and shape of WNPSH influence the spatiotemporal distributions of precipitation, temperature, and tropical cyclone activities in this region. This paper intends to investigate the performance of the UK met Office global Seasonal forecast system version 5(gloSea5) in simulation/prediction of the WNPSH based on a hindcast dataset. Analyses of the hindcast data show a systematic bias in the mean circulation over West Pacific, with negative geopotential height anomalies over the western North Pacific(WNP) and cyclonic anomalies in the 850-hPa winds and water vapor transport, indicating a weakening and eastward shift of the WNPSH. Despite the model’s bias in the climatology, it well captured the interannual variability of the monthly and seasonal-mean intensity of the WNPSH and the position of its ridge line in boreal summer from 1993 to 2015. The seasonal hindcasts indicate that there is significant prediction skill at up to three-month lead time for both the intensity and position of the WNPSH ridge line. The relationship between the WNPSH and different phases of the El Nino–Southern Oscillation(ENSO) in both the observational data and gloSea5 hindcasts was then investigated. The model captured the summer WNPSH anomalies well during most of the ENSO phases, except in the La Nina decaying and neutral summers. The intensity of the anticyclone in the WNP is weak in the decaying phase of El Nino in the gloSea5 hindcasts compared with the reanalysis data. gloSea5 is capable of representing the lagged teleconnection between El Nino events in the previous winter and the intensity of the WNPSH in the following summer. Regression analysis reveals weakened negative sea surface temperature anomalies(SSTAs) over the WNP in gloSea5, which reduced the gradient between the tropical western Pacific and the tropical Indian Ocean, resulting in a weaker easterly anomaly a

关键词： western North Pacific subtropical high(WNPSH) global Seasonal forecast system version 5(gloSea5) El Nino–Southern Oscillation(ENSO) precipitation predictability

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考古植物遗存中的碳稳定同位素

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东方考古 2024年第01期 146-179页

作者： Juan Pedro Ferrio mònica Aguilera Jordi Voltas josé Luis Araus 褚黎明阿拉贡研究与发展机构(ARAID) 阿拉贡农业研究与技术中心(CITA)森林资源部 CTFC-AgROTECNIO联合研究单位莱里达大学农作物与森林科学系巴塞罗那大学生物学院植物生理学部综合作物生理生态学组农业技术研究中心(AgROTECNIO) 山东大学文化遗产研究院

考古植物遗存是了解关于过去社会经历的社会和环境条件的宝贵信息来源。植物遗存巨大潜力的充分开发需要分析技术的应用。在这一背景下,考古植物遗存的碳稳定同位素组成或许能够提供关于环境条件、农业管理、食物网和饮食偏好等多方面... 详细信息

考古植物遗存是了解关于过去社会经历的社会和环境条件的宝贵信息来源。植物遗存巨大潜力的充分开发需要分析技术的应用。在这一背景下,考古植物遗存的碳稳定同位素组成或许能够提供关于环境条件、农业管理、食物网和饮食偏好等多方面的线索。本文全面介绍了分析植物遗存的碳稳定同位素在考古学中的潜在应用。在对决定植物碳稳定同位素特性的广泛生理和环境因素进行解释之后,对最相关的方法问题进行了讨论。其中,本文对样品的前处理方式、与大气变化有关的不确定性以及植物遗存在土壤中沉积前后经历的潜在变化进行了评述。以选定的案例研究为例,为碳稳定同位素在考古学中的应用提供了方法和概念上的线索。同时,也强调了依旧存在的挑战。

关键词：碳稳定同位素植物考古环境农业

Expanding the Boundaries of the Chemical Space of DNA methyltransferase 1 modulators

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Computational molecular Bioscience 2024年第1期14卷 1-16页

作者： massyel S. martínez-Cortés Diana L. Prado-Romero josé L. medina-Franco DIFACQUIm Research group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyltransferase 1 (DNmT1), one of the main epigenetic targets, is involved in the duplication of the DNA methylation pattern during replication, and it is essential for proper mammalian development. Small molecule DNmT1 modulators are attractive for biochemical epigenetic studies and have the potential to become drugs. So far, more than five hundred small molecules have been reported as DNmT1 inhibitors. However, only a limited number of DNmT1 activators have been disclosed because, at least in part, DNmT1 activators are typically regarded as negative data in virtual screening campaigns or optimization projects. This manuscript aims to report the chemical structures and biological activity of small molecules that increase the enzymatic activity of DNmT1. Results of the biochemical experimental assays are discussed. It was found that small molecule activators have a large variety of chemical scaffolds but share pharmacophore features. Visual analysis of the chemical space and multiverse based on molecular fingertips supported that activators are structurally diverse. This is the first report of eight small molecules that increase the enzymatic activity of DNmT1 by more than 400% in an enzymatic-based assay. The outcome warrants further investigation of the epigenetic activity of the compounds in a counter-screen assay, e.g., cell-based and in vivo context.

关键词： Chemical multiverse Chemoinformatics Epigenetics Pharmacophore Hypothesis Small molecules

Electrospinning Polylactic Acid Polymer membranes as Biological Sieve for Yeast and Bacteria

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materials Sciences and Applications 2022年第6期13卷 389-400页

作者： Ernesto Suaste-gómez grissel rodríguez-Roldán Ilian Pérez-Solis Ana Laura Torres-Huerta Carlos Cruz-Cruz josé Tapia-Ramírez Department of Electrical Engineering Section of Bioelectronics Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV) Mexico City Mexico National Laboratory of Experimental Services (LaNSE) CINVESTAV Mexico City Mexico Department of genetics and molecular Biology CINVESTAV Mexico City Mexico

Vaginal infections are suffered by millions of women of reproductive age. Recent research has shown that timely diagnosis of these infections avoids complications in the patient’s health. Since the symptoms of infections caused by yeast and bacteria are similar, the patient is not always treated properly. membranes with three different thicknesses (66 μm, 83 μm, 128 μm) were produced by electrospinning of polylactic polymer (PLA) and were used as a biological sieve to detect microorganisms present in vaginal infections, bacteria or yeasts. Electrospinning technique is a technique that allows the generation of membranes from nanofibers of material polymeric and therefore, obtaining porous structures. The size of the fibers was observed as well as the morphology and the size of the pores, using the scanning electron microscopy (SEm). The effectiveness of these membranes was proven by the cultivation of the bacteria that passed through the polymeric membrane and the yeasts retained by it. The membranes allowed the retention of yeasts of Candida albicans type with dimensions of 7 μm, which allowed the separation of Brevibacterium ravens purgense bacteria with dimensions of 1.4 μm, thus demonstrating their effectiveness as biological sieve.

关键词： Biological Sieve Electrospinning Polylactic Acid Vaginal Infections

Effectiveness of sacubitril-varsartan versus angiotensin converting enzyme inhibitors in patients hospitalized for acute heart failure:a retrospective cohort study of the RICA registry

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Journal of geriatric Cardiology 2022年第11期19卷 802-810页

作者： Llanos Soler-Rangel manuel méndez-Bailón joséPérez-Silvestre josémaría Fernández-rodríguez Beatriz Cuesta garcía Adrián Argüelles-Curto Álvaro gonzález-Franco Alicia Conde-martel Sara Carrascosa-garcía marta Sánchez-marteles josémanuel Cerqueiro-gonzález Noel Lorenzo-Villalba manuel montero-Pérez-Barquero Llanos Soler-Rangel Servicio de Medicina InternaHospital Universitario Infanta SofíaFIIB HUIS HHENMadridSpain Servicio de medicina Interna Hospital Clínico San CarlosInstituto de Investigación San Carlos(IdISSC)Spain Servicio de medicina Interna Consorcio Hospital General Universitario de ValenciaSpain Servicio de medicina Interna Hospital Carmen y Severo OchoaCangas del NarceaAsturiasSpain Servicio de medicina Interna Hospital Universitario Central de AsturiasOviedoSpain Servicio de medicina Interna Hospital Universitario de Gran Canaria Dr NegrínSpain Servicio de medicina Interna Hospital Clínico Universitario Lozano Blesa de ZaragozaZaragozaSpain Hospital Universitario Lucus Augusti de Lugo LugoSpain Service de médecine Interne Diabète et Maladies MétaboliquesHôpitaux Universitaires de StrasbourgFrance Servicio de medicina Interna IMIBIC/Hospital Universitario Reina SofíaCórdobaSpain

BACKgROUND Sacubitril-valsartan has been shown to reduce hospitalizations and mortality in patients with heart failure(HF)and reduced ejection *** PIONEER-HF trial demonstrated that initiation of the drug during acute HF hospitalization reduced NT-proBNP levels and a post-hoc analysis of the trial found a reduction in HF hospitalizations and ***-life studies in the elderly population are *** aim of our study was to assess the effectiveness of sacubitril-valsartan versus angiotensin converting enzyme inhibitors(ACEI)in elderly patients who initiate this treatment during hospitalization for acute *** We conducted a retrospective cohort study using the Spanish acute heart failure registry(RICA)comparing rehospitalizations and deaths at 3 months and 1 year among patients aged 70 years or older who had initiated treatment with sacubitrilvalsartan during hospitalization for acute HF versus those treated with *** One hundred and ninety-nine patients hospitalized between October 2016 and November 2020 were included,with a median age of 82 years and high rate of *** these,107 were treated with sacubitril-valsartan and 92 with *** adjusted OR for readmission for HF at 3 months was 0.906(95%CI:0.241-3.404)and for the combined variable readmission for HF or death at 3 months was 0.696(95%CI:0.224-2.167).The adjusted OR for HF readmission at one year was 0.696(95%CI:0.224-2.167).and for the combined variable HF readmission or death at one year 0.724(95%CI:0.325-1.612).CONCLUSION Treatment with sacubitril-valsartan initiated early in hospitalization for HF in elderly patients with high comorbidity was associated with a trend towards a reduction in readmissions and death due to HF compared to treatment with ACEI,which did not reach statistical significance either at 3 months or 1 year of follow-up.

关键词： patients initiated admission