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Long-term follow-up study of gastroduodenal lesions after radioembolization of hepatic tumors

World Journal of Gastroenterology 2013年第19期19卷 2935-2940页

作者： Iago Rodríguez-Lago cristina carretero Maite Herráiz josé c subtil Maite Betés Macarena Rodríguez-Fraile Jesús J Sola josé I Bilbao Miguel Muoz-Navas Bruno Sangro Endoscopy Unit Department of GastroenterologyUniversity of Navarra Clinic31008 PamplonaNavarraSpain Department of Nuclear Medicine University of Navarra Clinic31008 PamplonaNavarraSpain Department of Pathology University of Navarra Clinic31008 PamplonaNavarraSpain Department of Radiology University of Navarra Clinic31008 PamplonaNavarraSpain Liver Unit University of Navarra Clinic31008 PamplonaNavarraSpain National Biomedical Research centre Network for Hepatic and Digestive Diseases 08036 BarcelonaCataluaSpain

AIM:To evaluate the long-term natural history of the gastroduodenal lesions secondary to extrahepatic embolization with Ytrium 90(90 Y) ***:From September 2003 to January 2012,379 procedures of liver radioembolization(RE) using resin microspheres loaded with 90 Y were performed in our *** have retrospectively compiled the data from 379 RE procedures performed in our *** report a comprehensive clinical,analytical,endoscopic and histologic long-term follow-up of a series of patients who developed gastroduodenal lesions after the ***:Six patients(1.5%) developed gastrointestinal symptoms and had gastrointestinal lesions as shown by upper endoscopy in the next 12 wk after *** mean time between RE and the appearance of symptoms was 5 *** one patient required endoscopic and surgical *** incidence of gastrointestinal ulcerations was 3.75%(3/80) when only planar images were used for the pre-treatment *** was reduced to 1%(3/299) when singlephoton emission computed tomography(SPEcT) images were also *** symptoms that lasted for a longer time were nausea and vomiting,until 25 mo after the ***:All patients were free from severe symptoms at the end of *** routine use of SPEcT has decreased the incidence of gastrointestinal lesions due to unintended deployment of 90 Y particles.

关键词： Radioembolization Liver neoplasms Gastroduodenal ulcer Single-photon emission computed tomography Liver

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The emerging role of mesenchymal stem cell-derived extracellular vesicles to ameliorate hippocampal NLRP3 inflammation induced by binge-like ethanol treatment in adolescence

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Neural Regeneration Research 2025年第4期20卷 1153-1163页

作者： Susana Mellado María joséMorillo-Bargues carla Perpiñá-clérigues Francisco García-García Victoria Moreno-Manzano consuelo Guerri María Pascual Department of Physiology School of Medicine and DentistryUniversity of ValenciaValenciaSpain Bioinformatics and Biostatistics Unit Príncipe Felipe Research CenterValenciaSpain Neuronal and Tissue Regeneration Laboratory Príncipe Felipe Research CenterValenciaSpain

Our previous studies have reported that activation of the NLRP3(NOD-,LRR-and pyrin domain-containing protein 3)-inflammasome complex in ethanol-treated astrocytes and chronic alcohol-fed mice could be associated with neuroinflammation and brain *** stem cell-derived extracellular vesicles(MSc-EVs)have been shown to restore the neuroinflammatory response,along with myelin and synaptic structural alterations in the prefrontal cortex,and alleviate cognitive and memory dysfunctions induced by binge-like ethanol treatment in adolescent *** the therapeutic role of the molecules contained in mesenchymal stem cell-derived extracellular vesicles,the present study analyzed whether the administration of mesenchymal stem cell-derived extracellular vesicles isolated from adipose tissue,which inhibited the activation of the NLRP3 inflammasome,was capable of reducing hippocampal neuroinflammation in adolescent mice treated with binge *** demonstrated that the administration of mesenchymal stem cell-derived extracellular vesicles ameliorated the activation of the hippocampal NLRP3 inflammasome complex and other NLRs inflammasomes(e.g.,pyrin domain-containing 1,caspase recruitment domain-containing 4,and absent in melanoma 2,as well as the alterations in inflammatory genes(interleukin-1β,interleukin-18,inducible nitric oxide synthase,nuclear factor-kappa B,monocyte chemoattractant protein-1,and c–X3–c motif chemokine ligand 1)and miRNAs(miR-21a-5p,miR-146a-5p,and miR-141-5p)induced by binge-like ethanol treatment in adolescent *** analysis further revealed the involvement of miR-21a-5p and miR-146a-5p with inflammatory target genes and NOD-like receptor signaling *** together,these findings provide novel evidence of the therapeutic potential of MSc-derived EVs to ameliorate the hippocampal neuroinflammatory response associated with NLRP3 inflammasome activation induced by binge drinking in adolescence.

关键词： adolescence binge-like ethanol treatment extracellular vesicles hippocampus mesenchymal stem cells neuroinflammation NOD-,LRR-and pyrin domain-containing protein 3(NLRP3)

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Prevalence of iron deficiency in patients aged 75 years or older with heart failure

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Journal of Geriatric cardiology 2018年第11期15卷 682-686页

作者： Paul Mini Bonnefoy Marc subtil Fabien Michel chuzeville Geriatric cardiology Department Edouard Herriot Hospital Hospices Civils de Lyon Lyon France Geriatric Department Lyon South Hospital Hospices Civils de Lyon Lyon France Biostatistics Health Department University Claude Bernard Lyon 1 Hospices Civils de Lyon Lyon France

Background The latest studies presented at the American Heart Association (AHA) meeting on heart failure and the update of the European cardiology Society’s (EcS) recommendations on heart failure in 2016 recommend intravenous iron supplementation in patients with heart failure, reduced ejection fraction and iron deficiency for improves walking performance and quality of life, and reduces morbidity. In the present study, we investigated the prevalence of iron deficiency in heart failure patients aged 75 years or older, as there is currently no data on these patients. Methods We performed an observational study on hospitalized patients in Geriatric cardiology Department. Among the 462 patients hospitalized during eight months, 176 were eligible for inclusion;22 patients was significant interference with an inflammatory syndrome (high ferritin with high c-reactive protein), and for 13 patients iron-related data were not available. For each patient included, a complete iron assessment and type of heart failure was available. Results A total of 141 patients were included, the mean age was 88 years (range: 75–101), and there were 52 (36.9%) of patients with reduced ejection fraction (EF), 37 (26.2%) with mid-range EF, and 52 (36.9%) with preserved EF. Irrespective of heart failure type, 73.8% had iron deficiency (95% cI: 65.7%–80.8%);this was found in 57.7%(95% cI: 43.2%–71.3%) of those with reduced EF, 78.4%(95% cI: 61.8%–90.2%) of those with mid-range EF, and 86.5%(95% cI: 74.2%–94.4%) of those with preserved EF (P = 0.003). conclusion The prevalence of iron deficiency was very high in very elderly patients with heart failure, especially those with HF with mid-range EF or HF with preserved EF.

关键词： Heart failure Iron deficiency Very elderly patient

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NASH EQUILIBRIA WITHOUT cONTINUITY OF THE cHOIcE RULES

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Acta Mathematica Scientia 2011年第4期31卷 1535-1540页

作者： josé c. R. Alcantud Facultad de Economía y Empresa Universidad de Salamanca Campus Miguel de Unamuno E 37007 Salamanca

The proposal in Alcantud and Alo′s-Ferrer [1], where players that express their tastes according to choice rules facing a competitive situation, is further exploited here. We prove that, under lack of continuity of the choice rules it is also possible to ensure the existence of equilibrium. We shall appeal to general situations that are fulfilled by well-established models, where players have non-transitive preferences of various types.

关键词： Nash equilibrium choice rules continuity Kakutani’s theorem

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Processing of Aerosol Particles in convective cumulus clouds:cases Study in the Mexican East Pacific

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Advances in Atmospheric Sciences 2010年第6期27卷 1331-1343页

作者： josé c.JIMNEZ-EScALONA Oscar PERALTA ESIME UP Ticomán National Polytechnic Institute chemistry Faculty National Autonomous University of MexicoCiudad Universitaria

In the Mexican Intertropical convergence Zone, particle size distributions within 500 m of cloud boundaries at altitudes of 1000, 2500, and 4200 m, were compared against size distributions at the same levels but 1500 m away from the clouds. The differences in the distributions near and far from the cloud are related to processes that may change particle properties inside the cloud. chemical changes in the aerosols are deduced from the particles＇ refractive index, as derived from comparisons with the scattering coeflcient measured by a nephelometer. An analysis of ten cloud systems indicates that vertical transport of cloud base aerosol followed by entrainment/detrainment is the cloud processing signature most frequently observed in the comparisons （65%）. changes in the chemical composition are observed in approximately 20% of the cases and another 20% of the cases showed removal by precipitation. About 5% of the comparisons showed clear evidence of changes by coalescence. The principal effect of these cloud-processed aerosols is observed in the increase of optical depth in the layer from 30 m to 4200 m in the near-cloud regions, in comparison with the atmosphere further from clouds.

关键词： cloud processing cloud interaction scattering redistribution entrainment

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Differential response of injured and healthy retinas to syngeneic and allogeneic transplantation of a clonal cell line of immortalized olfactory ensheathing glia:a double-edged sword

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Neural Regeneration Research 2025年第8期20卷 2395-2407页

作者： María Norte-Muñoz María Portela-Lomba Paloma Sobrado-calvo Diana Simón Johnny Di Pierdomenico Alejandro Gallego-Ortega Mar Pérez joséMcabrera-Maqueda Javier Sierra Manuel Vidal-Sanz María Teresa Moreno-Flores Marta Agudo-Barriuso Grupo de Investigación Oftalmología Experimental Departamento de OftalmologíaOptometríaOtorrinolaringología y Anatomía PatológicaFacultad de MedicinaUniversidad de MurciaInstituto Murciano de Investigación Biosanitaria(IMIB)Campus de Ciencias de la SaludMurciaSpain Experimental Sciences Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain Anatomy Histology and Neuroscience DepartmentMedicine FacultyUniversidad Autónoma de MadridMadridSpain center of Neuroimmunology Service of NeurologyLaboratory of Advanced Imaging in Neuroimmunological DiseasesHospital Clínic of BarcelonaInstitut d’Investigacions Biomèdiques August Pi i Sunyer(IDIBAPS)and Universitat de BarcelonaBarcelonaSpain Medicine Faculty Universidad Francisco de VitoriaPozuelo de AlarcónMadridSpain

Olfactory ensheathing glia promote axonal regeneration in the mammalian central nervous system,including retinal ganglion cell axonal growth through the injured optic ***,it is unknown whether olfactory ensheathing glia also have neuroprotective *** ensheathing glia express brain-derived neurotrophic factor,one of the best neuroprotectants for axotomized retinal ganglion ***,we aimed to investigate the neuroprotective capacity of olfactory ensheating glia after optic nerve *** ensheathing glia cells from an established rat immortalized clonal cell line,TEG3,were intravitreally injected in intact and axotomized retinas in syngeneic and allogeneic mode with or without microglial inhibition or immunosuppressive *** and gene expression analyses were *** bulb-derived primary olfactory ensheathing glia and TEG3 express major histocompatibility complex classⅡ*** and syngenically transplanted TEG3 cells survived in the vitreous for up to 21 days,forming an *** axotomized retinas,only the allogeneic TEG3 transplant rescued retinal ganglion cells at 7 days but not at 21 *** these retinas,microglial anatomical activation was higher than after optic nerve crush *** intact retinas,both transplants activated microglial cells and caused retinal ganglion cell death at 21 days,a loss that was higher after allotransplantation,triggered by pyroptosis and partially rescued by microglial inhibition or ***,neuroprotection of axotomized retinal ganglion cells did not improve with these *** different neuroprotective properties,different toxic effects,and different responses to microglial inhibitory treatments of olfactory ensheathing glia in the retina depending on the type of transplant highlight the importance of thorough preclinical studies to explore these variables.

关键词： cell therapy immune recognition major histocompatibility complex class II(MHcII) neuroprotection olfactory ensheathing glia retinal ganglion cells

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An Optimized Divide-and-conquer Algorithm for the closest-Pair Problem in the Planar case

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Journal of computer Science & Technology 2012年第4期27卷 891-896页

作者： josé c.Pereira Fernando G.Lobo Department of Electronics and computer Science University of AlgarveCampus de Gambelas8005-139 FaroPortugal Center for Environmental and Sustainability ResearchCampus de Caparica2829-516 CaparicaPortugal

We present an engineered version of the divide-and-conquer algorithm for finding the closest pair of points, within a given set of points in the XY-plane. For this version of the algorithm we show that only two pairwise comparisons are required in the combine step, for each point that lies in the 25-wide vertical slab. The correctness of the algorithm is shown for all Minkowski distances with p ≥ 1. We also show empirically that, although the time complexity of the algorithm is still O（n lgn）, the reduction in the total number of comparisons leads to a significant reduction in the total execution time, for inputs with size sufficiently large.

关键词： geometrical problem and computation closest-pair problem Basic-2 algorithm

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Ultrastructural analysis of the loss of desiccation tolerance in germinating Eremanthus erythropappus seeds

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Journal of Forestry Research 2019年第4期30卷 1331-1336页

作者： Rayana S.Martins Anderson c.josé josé Marcio R.Faria Wilson V.S.Pereira Department of Forest Sciences Federal University of Lavras(UFLA)

Eremanthus erythropappus(Dc.)MacLeish is an important forest species native to the Brazilian savanna biome,an environment with well-defined rainy and dry *** seeds are desiccation tolerant,non-dormant and dispersed at the end of dry *** exposes them to the first sporadic rains that can trigger germination but the subsequent dry days can compromise survival of the newly germinated *** study evaluates if the damages caused by drying of germinating *** seeds,at the stage when they have lost desiccation tolerance,are *** percentage of normal seedlings was evaluated when seeds with different imbibition times were dried to their initial water content and then pre-humidified and *** tolerance was fully lost after 0.5 mm of hypocotyl-radicle protrusion(approximately 72 h)when the radicle had root hairs,a possible indicator of sensitivity to *** of cell contents and ultrastructural damage to the seeds subjected to drying were observed by electron scanning *** hairs disappeared after drying,reappearing after pre-humidification,possibly an attempt to increase the surface area of the radicle for water ***,the hypocotylradicle axis became darkened,probably by antioxidant system failure,causing seed death.

关键词： candeia Drying Desiccation tolerant seeds Rehydration Scanning electron microscopy

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Impact of coronary angioplasty in elderly patients with non-ST-segment elevation myocardial infarction

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Journal of Geriatric cardiology 2020年第8期17卷 449-454页

作者： Fernando F.Goncalves josé P.Guimaraes Sara c.Borges Pedro S.Mateus josé I.Moreira cardiology Department Centro Hospitalar de Trás-os-Montes e Alto DouroVila RealPortugal

Background As treatment of coronary artery disease improved over the last years,management of elder patients remained a matter of debate since this age group has been underrepresented in most *** study aimed to evaluate a population of patients with≥85 years old with non-ST-segment elevation myocardial infarction(NSTEMI)and compare the prognosis according to coronary revascularization *** We retrospectively studied 324 patients included in a national multicenter registry between October 2010 and October 2018,who underwent coronary angiography and had at least one stenosis≥50%.Results In this population,73.1%of the patients underwent percutaneous coronary intervention(PcI)and 26.9%of the patients underwent optimized medical treatment(OMT).The OMT group had more past history of diabetes,stroke and *** coronary angiography,the PcI group used more often the femoral artery access and single-vessel lesions were also more ***-vessel disease was more common in the OMT *** hospitalization,there were more major bleeding events and death in the PcI *** the one-year follow-up,there were no significant differences in all-cause mortality *** Very old patients with NSTEMI submitted to OMT had more comorbidities and more three-vessel disease,factors that could have influenced the therapeutic *** undergoing PcI had more in-hospital major bleeding events and mortality,with no significant differences after one year.

关键词： coronary artery disease Revascularization The elderly

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Effect of rare-earth oxides on properties of silicon nitride obtained by normal sintering and sinter-HIP

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Journal of Rare Earths 2012年第11期30卷 1177-1183页

作者： cecilia c.Guedes-Silva Flávio Machado de Souza carvalho josé carlos Bressiani Nuclear and Energy Research Institute-IPEN/cNEN Geoscience Institute-IGc/USP

This paper presented the microstructure, mechanical properties and oxidation behavior of silicon nitride obtained by both conventional sintering and sintering followed by hot isostatic pressing （HIP）. Silicon nitride with additives such as 5 wt.% Al2O3 and 5 wt.% Ln203 （Ln= La, La concentrate, Gd or La＋Gd） were studied. The results revealed that Gd203 additions increased the formation of elongated grains of β-Si3N4, the fracture toughness and oxidation resistance. La2O3 additions led to higher densification and hardness values, while addition of La2O3 concentrate promoted the formation of materials with intermediate properties, compared to the other studied compositions. Hot isostatic pressing increased the hardness but decreased the fracture toughness of the material, mainly because it allowed residual pores to close and also reduced the average aspect ratio of β-Si3N4 grains.

关键词： rare earths silicon nitride properties normal sintering sinter-HIP

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