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A discussion about the limitations of the Eurocode’s high-speed load model for railway bridges

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Railway Engineering Science 2024年第2期32卷 211-228页

作者： Gonçalo ferreira Pedro Montenegro joséRui Pinto António Abel Henriques Rui Calçada CONSTRUCT-LESE Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias4200-465 PortoPortugal CONSTRUCT-LABEST Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias4200-465 PortoPortugal

High-speed railway bridges are subjected to normative limitations concerning maximum permissible deck *** the design of these structures,the European norm EN 1991-2 introduces the high-speed load model(HSLM)—a set of point loads intended to include the effects of existing high-speed ***,the evolution of current trains and the recent development of new load models motivate a discussion regarding the limits of validity of the *** this study,a large number of randomly generated load models of articulated,conventional,and regular trains are tested and compared with the envelope of HSLM *** each type of train,two sets of 100,000 load models are considered:one abiding by the limits of the EN 1991-2 and another considering wider *** comparison is achieved using both a bridge-independent metric(train signatures)and dynamic analyses on a case study bridge(the Canelas bridge of the Portuguese Railway Network).For the latter,a methodology to decrease the computational cost of moving loads analysis is *** show that some theoretical load models constructed within the stipulated limits of the norm can lead to effects not covered by the *** is especially noted in conventional trains,where there is a relation with larger distances between centres of adjacent vehicle bogies.

关键词： High-speed load model Dynamic analysis High-speed railways Train signature Railway bridges Deck acceleration

Alpha-1 antitrypsin deficiency and Pi*Z allele as important co-factors in the development of liver fibrosis

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World Journal of Hepatology 2024年第8期16卷 1099-1110页

作者： Ana Isabel ferreira Catarina Guimarães Vitor Macedo Silva Sofia Xavier Joana Magalhães joséCotter Department of Gastroenterology Hospital da Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal Life and Health Sciences Research Institute School of MedicineUniversity of MinhoBraga 4710-057Portugal Life and Health Sciences Research Institute/3B’s PT Government Associate LaboratoryBraga 4710-057Portugal Department of Pulmonology Hospital Senhora da Oliveira-GuimarãesGuimarães 4835-044Portugal

BACKGROUND Alpha-1 antitrypsin deficiency(AATD)is a codominant autosomal hereditary condition that predisposes patients to the development of lung and/or liver disease,and Pi*Z allele is the most clinically relevant *** To evaluate the impact of clinical parameters and AATD phenotypes,particularly the Pi*Z allele,in liver *** Cross-sectional cohort study including consecutive patients with AATD followed in Pulmonology or Hepatology *** Included 69 patients,49.3%had Pi*MZ phenotype and 10.1%Pi**** age≥55 years,age at diagnosis≥41 years and AAT at diagnosis<77 mg/dL predicted a nonalcoholic fatty liver disease fibrosis score(NFS)not excluding advanced fibrosis[area under the curve(AUC)=0.840,P<0.001;AUC=0.836,P<0.001;AUC=0.681,P=0.025].An age≥50 years and age at diagnosis≥41 years predicted a fibrosis-4 index of moderate to advanced fibrosis(AUC=0.831,P<0.001;AUC=0.795,P<0.001).Patients with hypertension,type 2 diabetes mellitus(DM),dyslipidaemia,metabolic syndrome,and regular alcohol consumption were more likely to have a NFS not excluding advanced fibrosis(P<0.001,P=0.002,P=0.008,P<0.001,P=0.033).Patients with at least one Pi*Z allele and type 2 DM were 8 times more likely to have liver stiffness measurement≥7.1 kPa(P=0.040).CONCLUSION Risk factors for liver disease in AATD included an age≥50 years,age at diagnosis≥41 years,metabolic risk factors,regular alcohol consumption,at least one Pi*Z allele,and AAT value at diagnosis<77 mg/*** created an algorithm for liver disease screening in AATD patients to use in primary care,selecting those to be referred to Hepatology consultation.

关键词： Alpha-1 antitrypsin deficiency Liver fibrosis Nonalcoholic fatty liver disease fibrosis score Fibrosis-4 index Liver stiffness measurement

Analysis of Perinatal Outcomes of Twin Pregnancy in a Referral Hospital for High Risk

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Open Journal of Obstetrics and Gynecology 2024年第7期14卷 983-995页

作者： Eduarda Paim Pedro Lucas Carneiro ferreira Luciano Selistre Fernanda Grossi josé Mauro Madi Gabriela Françoes Rostirolla Mdica Residente do Programa de Residncia em Ginecologia e Obstetrcia Hospital Geral de Caxias do Sul Rio Grande do Sul Brasil Faculdade de Medicina Universidade de Caxias do Sul Rio Grande do Sul Brasil Programa de Ps-Graduao Universidade de Caxias do Sul Rio Grande do Sul Brasil Servio de Ginecologia e Obstetrcia Hospital Geral de Caxias do Sul Rio Grande do Sul Brasil

Introduction: The incidence of twin pregnancies has increased significantly in recent decades. These pregnancies require more attention due to their worse outcomes than singleton pregnancies. Objective: To analyze the characteristics and perinatal outcomes of twin pregnancies at the Caxias do Sul General Hospital. Methods: This is a descriptive and retrospective study that included all births related to twin pregnancies between March 1998 and June 2018. Maternal and perinatal variables were analyzed. Descriptive analyses were carried out using measures of central tendency and dispersion for continuous variables (mean and standard deviation or median and interquartile range), according to a prior assessment of distribution using the Shapiro-Wilk test, and absolute (n) and relative (n%) frequencies for categorical variables. Results: 172 pairs of twins/21,972 births (0.8%) were identified. There was a high percentage of interpartum interval of less than 12 months, adherence and prenatal visits, body mass index, and need for neonatal intensive care. Stillbirth and neomortality rates were within acceptable parameters. Conclusion: The sample studied showed a percentage similar to that in the literature, a high rate of maternal and perinatal complications, characterizing it as a high-risk fetal pregnancy.

关键词： Pregnancy Twin Pregnancy High Risk Pregnancy Morbidity Perinatal Mortality Perinatal Results

Evidence-Based Complementary and Alternative Medicine Effects of Capybara Oil on Cardiac Remodeling of C57bl/6 Mice

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Journal of Biosciences and Medicines 2024年第5期12卷 213-232页

作者： Rafael M. Almeida Wagner D. Giannetti Guilherme R. Silveira Carolina R. Castilho Renata V. Lisboa Bianca T. Ciambarella Rodrigo N. ferreira Jorge josé de Carvalho Laboratory of Ultrastructure and Tissue Biology Institute of Biology State University of Rio de Janeiro Rio de Janeiro Brazil Higher Education Center of Valenç a Dom Andr&#233 Arcoverde Educational Foundation Valen&#231a Brazil

Cardiovascular diseases are the main cause of morbidity and mortality in the world, and obesity and the metabolic syndrome are risk factors for its development. One of the therapies to reduce cardiovascular risk is the use of polyunsaturated fatty acids. In Brazil, a source of such acid is the oil extracted from the fat of the capybara. The objective of this work is to study the effects of the capybara oil on lipid and glucose metabolism, as well as its effects on the adipose tissue and cardiac remodeling. We assessed the effects of capybara oil treatment on body mass, lipid and carbohydrate metabolism, systolic blood pressure, adipose tissue and cardiac remodeling, and performed an ultrastructural evaluation of the myocardium in C57Bl/6 mice treated with high-fat diet. Treatment with capybara oil reduced total cholesterol and triglyceride levels, systolic blood pressure, visceral and subcutaneous adipose tissue, and adipocyte diameter. In addition, cardiac remodeling was attenuated, preserving cardiomyocytes, increasing vascularization, reducing cardiomyocyte hypertrophy and the extracellular matrix, and preserving the morphological integrity of mitochondria. Capybara oil has several beneficial effects on the cardiovascular and metabolic system, and further studies are needed to better understand its role in the prevention or treatment of cardiovascular diseases.

关键词： Capybara Oil Cardiac Remodeling Polyunsaturated Fatty Acids Obesity Metabolic Syndrome

Chinese Medicine Pattern Differentiation and Its Implications for Clinical Practice

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Chinese Journal of Integrative Medicine 2011年第11期17卷 818-823页

作者： Arthur Sá ferreira Agnaldo josé Lopes Laboratory of Computational Modeling and Simulation in Rehabilitation Program of Rehabilitation Science Augusto Motta University Laboratory of Cardiopulmonar Analysis Rehabilitation Science Postgraduation Program Augusto Motta University Laboratory of Respiratory Physiology State University of Rio de Janeiro

Chinese medicine practitioners apply the differentiation reasoning for decision-making. The wide scope of Chinese medicine intervention provides coverage of methods and techniques with applications to primary, secondary and tertiary levels of prevention. The rapid evolution of mathematical and computational techniques allowed the implementation of several models for pattern differentiation that were tested for several physiologic systems. Concurrently, it is argued that pattern differentiation might improve the efficacy of either traditional or conventional medical interventions. This article reviewed the influence of pattern differentiation into clinical practice organized by medical field： general pattern differentiation; genitourinary （recurrent cystitis）; cardiovascular （coronary heart disease; arterial hypertension; angina pectoris）; neurology （stroke）; surgery; metabolic （diabetes mellitus）; hepatic （cirrhosis）; gastrointestinal （chronic superficial gastritis）; orthopedic （low back pain; rheumatoid arthritis; cervical spondylosis; elbow arthritis）; oncology （gastric mucosal dysplasia; lung cancer）; gynecologic and obstetric manifestations （nausea and vomiting）. The reviewed studies presented achievements that have contributed to the integration of Chinese medicine and evidence-based medicine in the treatment of many mild and severe diseases. Target diseases considered as major public health problems were also investigated and the results are promising regarding the possibility to treat guided by pattern differentiation.

关键词： Chinese medicine-syndrome differentiation Chinese medicine preventive medicine rehabilitation "health care delivery"

Competition among rare earth elements on sorption onto six seaweeds

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Journal of Rare Earths 2021年第6期39卷 734-741,I0005页

作者： Joāo Pinto Marcelo Costa Bruno Henriques joséSoares Mariana Dias Thainara Viana Nicole ferreira Carlos Vale joséPinheiro-Torres Eduarda Pereira Department of Chemistry University of Aveiro3810-193 AveiroPortugal CESAM Department of ChemistryUniversity of Aveiro3810-193 AveiroPortugal LAQV-REQUIMTE Department of Chemistry&Central Laboratory of AnalysisUniversity of Aveiro3810-193 AveiroPortugal CIIMAR一Interdisciplinary Centre of Marine and Environmental Research MatosinhosPortugal N9VE-Nature Ocean and ValueLdaPortoPortugal Central Laboratory of Analysis University of Aveiro3810-193 AveiroPortugal

Sorption has been proposed as a promising approach towards a sustainable water decontamination and recently to the recycling of rare earth elements(REE).Although living seaweed have been shown to be capable of removing REE from contaminated solutions,no studies have yet compared the effects of REE competition on sorption onto different groups of *** effects were analysed in the present study by exposing six living seaweeds(Ulva lactuca,Ulva intestinalis,Fucus spiralis,Fucus vesiculosus,Gracilaria *** Osmundea pinnatifida)(3 g/L,fresh weight) to mono-element and multi-element solutions of Y,La,Ce,Pr,Nd,Eu,Gd,Tb and Dy(1 μmol/L).Results show a preference towards light REE in mono-element solutions,which is reduced when in competition with other *** competitive effect is less pronounced in heavy REE indicating that these are still able to bind to the macroalgae despite the presence of competing *** to water content(%),seaweed specific surface area(cm^(2)/g) shows to be an important factor in the sorption of REE,since larger surface area is associated with higher removal and larger competitive effect.

关键词： Bioaccumulation Wastewater e-waste Recovery Removal Marine macroalgae

New-onset diabetes after kidney transplantation:Incidence and associated factors

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World Journal of Diabetes 2018年第7期9卷 132-137页

作者： Vania Gomes Florbela ferreira joséGuerra Maria Joao Bugalho Endocrinology Diabetes and Metabolism DepartmentSanta Maria HospitalLisbon 1649-035Portugal Nephrology and Kidney Transplantation Department Santa Maria HospitalLisbon 1649-035Portugal

AIM To determine the incidence and associated factors of new-onset diabetes after transplantation(NODAT) in a Portuguese central hospital. METHODS This single-center retrospective study involved consecutive adult nondiabetic transplant recipients, who had undergone kidney transplantation between January 2012 and March 2016. NODAT was diagnosed according to the criteria of the American Diabetes Association. Data were collected from an institutional database of the Nephrology and Kidney Transplantation Department(Santa Maria Hospital, Lisbon, Portugal) and augmented with data of laboratorial parameters collected from the corresponding patient electronic medical records. Exclusion criteria were preexisting diabetes mellitus, missing information and follow-up period of less than 12 mo. Data on demographic and clinical characteristics as well as anthropometric and laboratorial parameters were also collected. Patients were divided into two groups: With and without NODAT-for statistical *** A total of 156 patients received kidney transplantduring the study period, 125 of who were included in our analysis. NODAT was identified in 27.2% of the patients(n = 34; 53% female; mean age: 49.5 ± 10.8 years; median follow-up: 36.4 ± 2.5 mo). The incidence in the first year was 24.8%. The median time to diagnosis was 3.68 ± 5.7 mo after transplantation, and 76.5% of the patients developed NODAT in the first 3 mo. In the group that did not develop NODAT(n = 91), 47% were female, with mean age of 46.4 ± 13.5 years and median follow-up of 35.5 ± 1.6 mo. In the NODAT group, the pretransplant fasting plasma glucose(FPG) levels were significantly higher [101(96.1-105.7) mg/d L vs 92(91.4-95.8) mg/d L, P = 0.007] and pretransplant impaired fasting glucose(IFG) was significantly more frequent(51.5% vs 27.7%, P = 0.01). Higher pretransplant FPG levels and pretransplant IFG were found to be predictive risk factors for NODAT development [odds ratio(OR): 1.059, P = 0.003; OR: 2.77

关键词： New-onset diabetes after transplant Incidence Kidney transplantation Impaired fasting glucose Immunosuppression

Effect of Homogenizing Procedures on the Properties of Reaction Sialon Suspension

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厦门大学学报（自然科学版） 2002年第S1期41卷 132-133页

作者： Xavier Venceslau Kexin Chen josé M F ferreira Department of Ceramics and Glass Engineering CICECO University of AveiroDepartment of Ceramics and Glass EngineeringCICECO University of AveiroDepartment of Ceramics and Glass EngineeringCICECO University of Aveiro PortugalPortugalPortugal

Homogeneous, high concentrated ceramic suspensions wi th low viscosity are the key controlling factors for the production of ceramic c omponents through colloidal processing. A well-dispersed suspension can be obta ined by choosing suitable dispersant, solvent, particle size distribution etc. B esides these factors, the homogenizing procedure is also a key step. In this paper, reaction sialon suspensions were prepared using 3-wt% KD1 as dis persant in organic media composed of 60-vol% methyletheylketone and 40-vol% et hanol. Different homogenizing procedures have been used and compared, including planetary milling, low energy ball milling and ultrasonic disaggregation. The ef fects of different homogenizing routes and mixing times on the rheology and stab ility of suspensions, and on the microstructure of slip casting green bodies, ha ve been studied. The varying dispersion efficiencies observed could be attribute d to differences in deagglomeration degrees achieved and in adsorption amount of dispersant onto the surface of reaction sialon powders.

关键词： Effect of Homogenizing Procedures on the Properties of Reaction Sialon Suspension

Application of data science in the prediction of solar energy for the Amazon basin:a study case

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Clean Energy 2023年第6期7卷 1344-1355页

作者： AndréLuis ferreira Marques Márcio joséTeixeira Felipe Valencia de Almeida Pedro Luiz Pizzigatti Corrêa Polytechnic School of the University of Sao Paulo Av.Prof.Luciano Gualberto380-ButantaSao Paulo-SP05508-010Brazil Institute of Physics of the University of Sao Paulo Brazil

The need for renewable energy sources has challenged most countries to comply with environmental protection actions and to handle climate *** energy figures as a natural option,despite its *** has a green energy matrix with significant expansion of solar form in recent *** preserve the Amazon basin,the use of solar energy can help communities and cities improve their living standards without new hydroelectric units or even to burn biomass,avoiding harsh environmental *** novelty of this work is using data science with machine-learning tools to predict the solar incidence(W.h/m^(2))in four cities in Amazonas state(north-west Brazil),using data from NASA satellites within the period of ***-tree-based models and vector autoregressive(time-series)models were used with three time aggregations:day,week and *** predictor model can aid in the economic assessment of solar energy in the Amazon basin and the use of satellite data was encouraged by the lack of data from ground *** mean absolute error was selected as the output indicator,with the lowest values obtained close to 0.20,from the adaptive boosting and light gradient boosting algorithms,in the same order of magnitude of similar references.

关键词： solar energy renewable energy Amazon basin machine learning time series data science decision-trees ensemble vector autoregression