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molecular mechanisms underlying SARS-CoV-2 hepatotropism and liver damage

World Journal of Hepatology 2024年第1期16卷 1-11页

作者： jorge Quarleri m Victoria Delpino Instituto de Investigaciones Biomédicas en Retrovirus y Sida(INBIRS) Universidad de Buenos Aires(UBA)Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET)Buenos Aires 1121Argentina

In coronavirus disease 2019(COVID-19),severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)primarily targets the respiratory system,but evidence suggests extrapulmonary organ involvement,notably in the *** RNA has been detected in hepatic tissues,and in situ hybridization revealed virions in blood vessels and endothelial *** microscopy confirmed viral particles in hepatocytes,emphasizing the need for understanding hepatotropism and direct cytopathic effects in COVID-19-related liver *** factors contribute to liver injury,including direct cytotoxicity,vascular changes,inflammatory responses,immune reactions from COVID-19 and vaccinations,and druginduced liver *** a typical hepatitis presentation is not widely documented,elevated liver biochemical markers are common in hospitalized COVID-19 patients,primarily showing a hepatocellular pattern of ***-term studies suggest progressive cholestasis may affect 20%of patients with chronic liver disease post-SARS-CoV-2 *** molecular mechanisms underlying SARS-CoV-2 infection in the liver and the resulting liver damage are ***“Editorial”highlights the expression of the Angiotensin-converting enzyme-2 receptor in liver cells,the role of inflammatory responses,the impact of hypoxia,the involvement of the liver's vascular system,the infection of bile duct epithelial cells,the activation of hepatic stellate cells,and the contribution of monocyte-derived *** also mentions that pre-existing liver conditions can worsen the outcomes of *** the interaction of SARS-CoV-2 with the liver is still evolving,and further research is required.

关键词： SARS-CoV-2 COVID-19 Hepatotropism Angiotensin-converting enzyme-2

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Deep optics preconditioner for modulation-free pyramid wavefront sensing

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Photonics Research 2024年第2期12卷 301-312页

作者： FELIPE GUZmÁN jorge TAPIA CAmILO WEINBERGER NICOLÁS HERNÁNDEZ jorge BACCA BENOIT NEICHEL ESTEBAN VERA School of Electrical Engineering Pontificia Universidad Católica de Valparaı´soValparaı´soChile Department of Systems Engineering Universidad Industrial de SantanderBucaramangaColombia Laboratoire d’Astrophysique de marseille MarseilleFrance

The pyramid wavefront sensor(PWFS)can provide the sensitivity needed for demanding adaptive optics applications,such as imaging exoplanets using the future extremely large telescopes of over 30 m of diameter(D).However,its exquisite sensitivity has a limited linear range of operation,or dynamic range,although it can be extended through the use of beam modulation—despite sacrificing sensitivity and requiring additional optical *** by artificial intelligence techniques,this work proposes to train an optical layer—comprising a passive diffractive element placed at a conjugated Fourier plane of the pyramid prism—to boost the linear response of the pyramid sensor without the need for cumbersome *** develop an end-2-end simulation to train the diffractive element,which acts as an optical preconditioner to the traditional least-square modal phase estimation *** results with a large range of turbulence conditions show a noticeable improvement in the aberration estimation performance equivalent to over 3λ∕D of modulation when using the optically preconditioned deep PWFS(DPWFS).Experimental results validate the advantages of using the designed optical layer,where the DPWFS can pair the performance of a traditional PWFS with 2λ∕D of *** and adding an optical preconditioner to the PWFS is just the tip of the iceberg,since the proposed deep optics methodology can be used for the design of a completely new generation of wavefront sensors that can better fit the demands of sophisticated adaptive optics applications such as ground-to-space and underwater optical communications and imaging through scattering media.

关键词： process optics pyramid

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Experimental and numerical analysis of multi-chamber oscillating water column devices

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Journal of Hydrodynamics 2024年第3期36卷 492-503页

作者： jorge Gadelho Kourosh Rezanejad C.Guedes Soares Centre for marine Technology and Ocean Engineering(CENTEC) Instituto Superior TécnicoUniversidade de LisboaAvenida Rovisco PaisLisboaPortugal

A review of multi-chamber oscillating water column(OWC)device designs is *** significant variations of these devices are discussed,onshore OWC(OOWC)and a floating OWC(FOWC).The efficiency results of several theoretical studies based on low-and high-fidelity numerical models are presented and compared with the model scale ***,low-fidelity numerical models are very fast to run,but their accuracy is limited compared with high-fidelity numerical *** model experiments usually give results much more accurate than numerical models,but they need adequate facilities and are very *** the case of the OOWC,all models show a similar trend of total efficiency,but while the analytical model shows a maximum value of around 90%efficiency,the CFD model shows 60%,and the experiments only go up to 40%.The main reason is connected with the mathematical simplifications and assumptions that do not represent all the hydrodynamic and aerodynamic processes between the water,air,and *** the case of the FOWC,interestingly,the experimental results show a maximum efficiency of almost 100%,while the analytical model only predicts a maximum of 80%.The efficiency seems highly dependent on the heave motion resonance of the entire device,where the analytical model fails to predict this natural frequency.

关键词： Wave energy converters oscillating water column(OWC) multi-chambers experimental modelling numerical modelling

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Review of Networked microgrid Protection:Architectures,Challenges,Solutions,and Future Trends

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 448-467页

作者： jorge de la Cruz Ying Wu John E.Candelo-Becerra Juan C.Vasquez Josep m.Guerrero Center for Research on microgrids(CROm) Department of Energy TechnologyAalborg University9220 AalborgDenmark Facultad de minas Departamento de Energia Eléctrica y AutomaticaUniversidad Nacional de ColombiaSede MedellinCarrera 80 No.65-223RobledoMedellin 050041Colombia. Center for Research on microgrids at UPC(UPC CROm) Department of Electronic EngineeringTechnical University of Catalonia(UPC)08019 Barcelona Spain ICREA Pg.Lluis Companys 2308010 BarcelonaSpain Center for Research on microgrids at AAU(AAU CROm) AAU EnergyAalborg University(AAU)9220 Aalborg EastDenmark

Design and selection of advanced protection schemes have become essential for reliable and secure operation of networked *** protection schemes that allow correct operation of microgrids have been proposed for individual systems in different topologies and ***,protection schemes for networked microgrids are still in devel-opment,and further research is required to design and operate advanced protection in interconnected *** of these microgrids in different nodes with various intercon-nection technologies increases fault occurrence and complicates protection *** paper aims to point out challenges in developing protection for networked microgrids,potential solutions,and research areas that need to be addressed for their ***,this article presents a systematic analysis of different microgrid clusters proposed since 2016,including several architectures of networked microgrids,operation modes,components,and utilization of renewable sources,which have not been widely explored in previous review ***,the paper presents a discussion on protection systems currently available for microgrid clusters,current challenges,and solutions that have been proposed for these ***,it discusses the trend of protection schemes in networked microgrids and presents some conclusions related to ***—Adaptive eprotection,microgrid cluster,microgrid,multiple microgrid,networked microgrid,real-time simulation,smart grid.

关键词： Adaptive eprotection microgrid cluster microgrid multiple microgrid networked microgrid real-time simulation smart grid

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Patients’dissatisfaction with multifocal intraocular lenses managed by exchange with other multifocal lenses of diferent optical profles

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Eye and Vision 2024年第1期10卷 31-40页

作者： Olena Al‑Shymali Colm mcAlinden jorge L.Alio del Barrio mario Canto‑Cerdan jorge L.Alio Research&Development Department VISSUm Innovation and Department of Cornea Cataract and Refractive SurgeryVISSUM CorporationAlicanteSpain Department of Ophthalmology Singleton HospitalSwansea Bay University Health BoardSwanseaUK Division of Ophthalmology School of MedicineVISSUM AlicanteUniversidad Miguel HernándezCalle Cabañal 103016 AlicanteSpain Cornea Cataract and Refractive Surgery DepartmentVISSUM CorporationAlicanteSpain

Background:The aim of the study was to evaluate the outcomes of dissatisfed patients reporting poor visual quality following implantation of multifocal intraocular lenses(mF-IOLs),managed by IOL exchange with another multifocal optical ***:This is a retrospective series of ***-IOL exchange was done in 15 dissatisfed patients(30 eyes)with the perception of poor visual quality for far distance afected by neuroadaptation *** underwent a bilateral exchange of a mF-IOL with another mF-IOL of a diferent optical *** outcomes and complications were *** including Quality of Vision(QoV),Visual Function Index-14(VF-14)and its Rasch-revised version(VF-8R)and a satisfaction questionnaire were also used for outcome ***:The mean elapsed time from implantation to explantation-reimplantation was 11.8 *** QoV scores improved signifcantly across all the three *** function improved with a change in VF-14 score from 60.41±24.81 to 90.16±10.91(Pmproved as *** uncorrected distance visual acuity improved from 0.24 to 0.12 logmAR after exchange(Pmproved from 0.15 to 0.04 logmAR(PmF-IOL exchange,80%of the patients reported they would have the mF-IOL reimplantation procedure ***:Patient dissatisfaction with neuroadaptation failure following mF-IOL implantation can be managed in 80%of our cases by mF-IOL exchange with a diferent mF-IOL optical profle.

关键词： multifocal intraocular lenses IOL exchange Visual acuity Neuroadaptation failure

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The■Q(q=u,d;Q=c,b)tetraquark system in a chiral quark model

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Chinese Physics C 2024年第7期48卷 84-105页

作者：杨刚平加伦 jorge Segovia Department of Physics Zhejiang Normal UniversityJinhua 321004China Department of Physics and Jiangsu Key Laboratory for Numerical Simulation of Large Scale Complex Systems Nanjing Normal UniversityNanjing 210023China Departamento de Sistemas Físicos Químicos y NaturalesUniversidad Pablo de OlavideE-41013 SevillaSpain

The S-wave■tetraquarks,with spin-parities■,and 2+,in both isoscalar and isovector sectors,are systematically studied using a chiral quark *** meson-meson,diquark-antidiquark,and K-type arrangements of quarks and all possible color wave functions are comprehensively *** four-body system is solved using the Gaussian expansion method,a highly efficient computational ***,a complex-scaling formulation of the problem is established to disentangle bound,resonance,and scattering *** theoretical framework has already been successfully applied in various tetra-and penta-quark *** the complete coupled channel and within the complex-range formulation,several narrow resonances of■systems are obtained,in each allowed■-channel,within the energy regions of■GeV and 5.7-6.7GeV,*** predicted exotic states,which indicate a richer color structure when going towards multiquark systems beyond mesons and baryons,are expected to be confirmed in future high-energy particle and nuclear experiments.

关键词： quantum chromodynamics quark models

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Incorporating physiological knowledge into correlative species distribution models minimizes bias introduced by the choice of calibration area

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marine Life Science & Technology 2024年第2期6卷 349-362页

作者： Zhixin Zhang Jinxin Zhou jorge García molinos Stefano mammola Ákos Bede‑Fazekas Xiao Feng Daisuke Kitazawa jorge Assis Tianlong Qiu Qiang Lin CAS Key Laboratory of Tropical marine Bio-resources and Ecology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China Guangdong Provincial Key Laboratory of Applied marine Biology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China marine Biodiversity and Ecological Evolution Research Center South China Sea Institute of OceanologyGuangzhou 510301China Global Ocean and Climate Research Center South China Sea Institute of OceanologyGuangzhou 510301China Institute of Industrial Science The University of Tokyo5-1-5 KashiwanohaKashiwaChiba 277-8574Japan Arctic Research Center Hokkaido UniversitySapporoHokkaido 001-0021Japan Finnish museum of Natural History University of HelsinkiHelsinkiFinland molecular Ecology Group(mEG) Water Research Institute(IRSA)National Research Council of Italy(CNR)28922 Verbania PallanzaItaly National Biodiversity Future Center(NBFC) PalermoItaly Institute of Ecology and Botany HUN-REN Centre for Ecological ResearchVácrátótHungary Department of Environmental and Landscape Geography ELTE Eötvös Loránd UniversityBudapestHungary Department of Biology University of North CarolinaChapel HillNC 27599USA Centre of marine Sciences University of AlgarveCampus de GambelasFaroPortugal CAS Key Laboratory of Experimental marine Biology Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Correlative species distribution models(SDms)are important tools to estimate species’geographic distribution across space and time,but their reliability heavily relies on the availability and quality of occurrence *** can be biased when occurrences do not fully represent the environmental requirement of a *** tested to what extent species’physiological knowledge might influence SDm *** on the Japanese sea cucumber Apostichopus japonicus within the coastal ocean of East Asia,we compiled a comprehensive dataset of occurrence *** then explored the importance of incorporating physiological knowledge into SDms by calibrating two types of correlative SDms:a naïve model that solely depends on environmental correlates,and a physiologically informed model that further incorporates physiological information as *** further tested the models’sensitivity to calibration area choices by fitting them with different buffered areas around known *** with naïve models,the physiologically informed models successfully captured the negative influence of high temperature on *** and were less sensitive to the choice of calibration *** naïve models resulted in more optimistic prediction of the changes of potential distributions under climate change(i.e.,larger range expansion and less contraction)than the physiologically informed *** findings highlight benefits from incorporating physiological information into correlative SDms,namely mitigating the uncertainties associated with the choice of calibration *** these promising features,we encourage future SDm studies to consider species physi-ological information where available.

关键词： Bayesian approach Climate change Habitat suitability Physiological knowledge Species distribution model

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Perianal disease in inflammatory bowel disease:Broadening treatment and surveillance strategies for anal cancer

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World Journal of Gastroenterology 2024年第28期30卷 3373-3385页

作者： Tatiana Pacheco Sara monteiro Luísa Barros jorge Silva Department of Gastroenterology Centro Hospitalar do Tamega e SousaPenafiel 4560-136Portugal

The perianal disease affects up to one-third of individuals with Crohn's disease(CD),causing disabling symptoms and significant impairment in quality of life,particularly for those with perianal fistulising CD(PFCD).The collaborative effort between gastroenterologists and surgeons is essential for addressing PFCD to achieve fistula closure and promote luminal *** fistula healing rates with conventional therapies have prompted the emergence of new biological agents,endoscopic procedures and surgical techniques that show promising *** these,mesenchymal stem cells injection is a particularly hopeful *** addition to the burden of fistulas,individuals with perianal CD may face an increased risk of developing anal *** underscores the importance of surveillance programmes and timely interventions to prevent late diagnoses and poor ***,there is no established formal anal screening *** this review,we provide an overview of the current state of the art in managing PFCD,including novel medical,endoscopic and surgical *** discussion also focuses on the relevance of establishing an anal cancer screening programme in CD,intending to propose a risk-based surveillance *** validation of this surveillance programme would be a significant step forward in improving patient care and outcomes.

关键词： Inflammatory bowel disease Crohn's disease Perianal Fistula Anus diseases management Anal cancer Screening

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Avian responses to an extreme weather event:The case of the‘Filomena’snowstorm in madrid(central Spain)

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Avian Research 2024年第2期15卷 180-186页

作者： Carlos Lazaro Carlos Sanchez-García Fabian Casas E.jorge Tizado Department of Research Fundacion Artemisan13001 Ciudad RealSpain Department of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain Department of Biodiversity and Environmental management Universidad de Leon24401 PonferradaSpain

Cold spells and severe weather may have detrimental effects in wild birds,but owing to the stochastic nature of these events,it is not always possible to measure their *** January 2021,a strong snowstorm known as‘Filomena’affected Spain,mainly the region of madrid(Central Spain),which was fully covered with snow and suffered freezing temperatures for a *** bird surveys conducted in the winter-spring of 2020 and 2021(before and after Filomena)at same locations,we addressed the possible impact of the cold spell in three widespread gamebirds:Wood Pigeon(Columba palumbus),Eurasian magpie(Pica pica)and Red-legged Partridge(Alectoris rufa).No significant abundance differences were found between years for none of the species and hunting pressure was only significantly reduced for Partridges,hence this species may have been negatively affected by *** suggest that in response to Filomena,Pigeons conducted partial migration in search of better conditions,while magpies aggregated in certain areas of madrid and Partridges endured the harsh conditions within their home *** results highlight the importance to alleviate negative impacts of extreme weather events in wild birds through management actions,especially for sedentary species.

关键词： Alectoris rufa Climate change Cold spell Columba palumbus migration Pica pica Winter

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measuring Impact of Lean manufacturing Tools for Continuous Improvement on Economic Sustainability

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 452-474页

作者： Luis Javier márquez Figueroa jorge Luis García-Alcaraz Ahmed IOsman Alfonso Jesús Gil López Yashar Aryanfar mika Sillanpää mamdouh El Haj Assad Department of Electrical Engineering and Computer Science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Department of Industrial Engineering and manufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico School of Chemistry and Chemical Engineering Queens UniversityBelfastNorthern IrelandUK Department of Economic and managerial Sciences University of La RiojaLa RiojaSpain Department of Chemical Engineering University of JohannesburgJohannesburgSouth Africa Department of Sustainable and Renewable Energy Engineering University of SharjahSharjahUAE

Using Lean manufacturing(Lm)tools in production processes is crucial for companies’economic,environmental,and social sustainability *** study shows a structural equation model(SEm)that shows the relationship between Lm Tools like Kaizen(KAI),Gemba(GEm),Value Stream mapping(VSm)and Key Performance Indicator(KPI)with Economic Sustainability(ECS).Seven hypotheses were evaluated with data from 179 responses to a questionnaire about the mexican maquiladora industry,showing that these variables are *** a 95%confidence level,the model was evaluated using the partial least squares *** findings indicate that the relationships between KAI and GEm and KAI and VSm have the strongest relationship,followed by VSm and ECS;however,VSm has the strongest effect on *** on these findings,it is recommended that managers adopt a continuous improvement(KAI)approach based on working directly on the shop floor(GEm and VSm)to support their decisions regarding economic growth(ECS).

关键词： Lean manufacturing economic sustainability structural equation model quality improvement

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