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Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms

Stroke & Vascular Neurology 2019年第1期4卷 36-42页

作者： Edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez Mario Zanaty jorge A roa Pascal Jabbour David M Hasan Department of Neurology Neurosurgery and RadiologyUniversity of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurosurgery Thomas Jefferson UniversityPhiladelphiaPennsylvaniaUSA

Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow *** IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications *** sought to determine the safety of tirofiban and DAPT in these *** We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow *** tirofiban-DAPT protocol used is *** regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and *** One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 *** and major haemorrhagic events were recognised in 20%(30/148)*** 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 *** average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were *** haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was *** administration of heparin did not increase haemorrhagic *** The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was *** and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications.

关键词： aneurysm intracranial infusion

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Stroke mechanisms and outcomes of isolated symptomatic basilar artery stenosis

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Stroke & Vascular Neurology 2019年第4期4卷 189-197页

作者： Edgar A Samaniego Amir Shaban Santiago Ortega-Gutierrez jorge A roa David M Hasan Colin Derdeyn Biyue Dai Harold Adams Enrique Leira Neurology Neurosurgery and RadiologyUniversity of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurology and Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Radiology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Biostatistics and Public Health University of Iowa Hospitals and ClinicsIowa CityIowaUSA

background While diffuse atherosclerotic disease affecting the posterior circulation has been described extensively,the prevalence,natural history and angiographic characteristics of isolated symptomatic basilar artery stenosis(ISBAS)remain *** We reviewed our prospective institutional database to identify patients with≥50% symptomatic basilar artery(BA)stenosis without significant atherosclerotic burden in the vertebral or posterior cerebral *** mechanism,collateral circulation,and degree and length of stenosis were *** primary outcome was time from index event to new transient ischaemic attack(TIA),acute ischaemic stroke(AIS)or *** outcome variables included modified Rankin Scale(mRS)score on discharge and last *** Of 6369 patients with AIS/TIA,91(1.43%)had ***-three(80.2%)patients presented with AIS and 18(19.8%)with ***-nine(31.9%)were women and the median age was 66.8±13.6 *** mean follow-up time was 2.7 *** most common stroke mechanism was artery-to artery thromboembolism(45.2%),followed by perforator occlusion(28.7%)and flow-dependent/hypoperfusion(15.1%).The percentage of stenosis was lower in patients who had favourable outcome compared with those with mRS 3-6 on discharge(78.3±14.3 vs 86.9±14.5,p=0.007).Kaplan-Meier curves showed higher recurrence/death rates in patients with≥80% stenosis,mid-basilar location and poor collateral *** 13% of patients with ISBAS presented with complete BA *** ISBAS is an uncommon(1.43%)cause of TIA and *** in their 60s are mostly affected,and artery-to artery embolism is the most common stroke ***-basilar location,≥80% stenosis and poor collateral circulation are important factors associated with worse prognosis.

关键词： stenosis basilar artery

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Further studies on the effects of acamprosate on tolerance to the analgesic effects of morphine and NO synthesis in the brain

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Health 2013年第11期5卷 1-6页

作者： Jacqueline Sepúlveda Andrea Ortega jorge roa Enrique Contreras Department of Pharmacology School of Biological Sciences University of Concepción Concepción Chile Department of Pharmacology School of Biological Sciences University of Concepción Concepción Chile Department of Physiology School of Biological Sciences University of Concepción Concepción Chile Department of Pre-Clinical and Clinical Sciences School of Medicine Catholic University of the Holy Conception Concepción Chile

The aim of this work was to investigate whether acamprosate modifies the expression of the enzyme responsible for neuronal NO synthesis (nNOS) in the nucleus accumbens (NAc) of mice chronically treated with morphine and during the abstinence syndrome induced by naloxone. The enzyme was monitored by the NADPH diaphorase method. The number of cells stained for NADPH diaphorase in the NAc of mice was counted in 40 μm thick coronal brain slices at 40X. The intensity of the histochemical reaction of stained cells from naive morphine plus saline and morphine plus acamprosate treated mice was analyzed by Image Pro Plus 4.5.1. Morphine administered in a slow release preparation increased the stain intensity of the positive neurons. The increase in the NADPH staining persisted after naloxone was given to mice chronically treated with morphine. Acamprosate antagonized the effects induced by chronic morphine treatment in the NAc of mice. These results indicate that up-regulation of nNOS in the NAc is a consequence of the sustained effects of morphine stimulation, which, in turn, may result from an increased in glutamate release during the abstinence syndrome.

关键词： Morphine Nitric Oxide Nucleus Accumbens Acamprosate

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Foaming supramolecular surfactants for gas mobility control in naturally fractured carbonate reservoirs at high temperature,salinity,and hardness

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Petroleum Science 2022年第6期19卷 3134-3148页

作者： Enrique Soto-Castruita Raúl Hern andez-Altamirano Eduardo Buenrostro-González Erick-Emanuel Luna-Rojero Sung Jae Ko-Kim Violeta-Yasmín Mena-Cervantes Mirna Pons-Jiménez jorge-Francisco Ramírez-Pérez David-Aaσn Nieto-Alvarez Ricardo Cerón-Camacho Jos e-Ernesto Parra Raúl Oviedo-roa Jos e-Manuel Martínez-Magadán Rodolfo Cisneros-Dévora Luis-S.Zamudio-Rivera Instituto Mexicano del Petr oleo Eje Central Lazaro Cardenas Norte 152Col.San Bartolo AtepehuacanCiudad de Mexico07730Mexico CONACy T-Instituto Mexicano del Petroleo Eje Central Lazaro Cardenas Norte 152Col.San Bartolo AtepehuacanCiudad de Mexico07730Mexico Centro Mexicano para la Produccion mas Limpia Instituto Politecnico NacionalAvenida Acueducto s/nCol.La Laguna TicomanCiudad de Mexico07340Mexico Centro de Tecnologías para Exploracion y Produccion Camino de Terracería 800Col.San Jose NovilleroBoca delRíoVeracruz94286Mexico

Oil production and mainte nance are essential issues in naturally fractured reservoirs because they are the largest and most productive on ***,they present early water and gas channeling but could be remediated by using foaming agents to control these phenomena through blocking channeling *** Mexico these reservoirs have pressure up to 5,500 psi,high temperature up to 200℃,salinity up to400,000 ppm,and hardness up to 250,000 ppm;due to these thermodynamic conditions,there has been no available technology to form stable enough *** this work,a foaming supramolecular surfactant with the capability to chelate Ca^(2+)ions is *** a result,surfactant monomers are bridged by captured Ca^(2+)cations leading to the formation of high-molecular-weight oligomers,which significantly increment the viscosity of the solution improving the foam stability,and since at this manner the Ca2+cations are no longer available to precipitate as components of solid salts,the foaming supramolecular surfactant also performs as *** observations are explained through quantum theoretical *** foam is stable,effectively blocking the gas channels,whereas in presence of oil the foam is broken leading the oil to pass into the *** characteristic rheological properties of the foam allow its injection into the formation at a range of flow rates,foam qualities,and shear stress to achieve the flooding and the blocking of a variety of fractured carbonate formations,and the change of the wettability of the matrix,which is a desirable behavior in a huff and puff process,as reported in a previous publication about a successful pilot test of this foam.

关键词： Calcium chelation Foaming composition Supramolecular surfactant Molecular design Gas mobility control Flow assurance Improved oil recovery Conformance control

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Characterization of oral yeasts isolated from healthy individuals attended in different Colombian dental clinics

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The Journal of Biomedical Research 2019年第5期33卷 333-342页

作者： Raul Eduardo Rivera Alejandra Zuluaga Karen Arango Itzjak Kadar Paola Andrea Pinillos Luis Fernando Montes Eugenia Catalina Cepeda Ernesto Gonzalez Pedro Antonio Alfonso Andrea Alejandra Villalba Luis Fernando Casanova Adolfo Perez Armando roa Martha Jhoana Arias jorge Orlando Francisco Cuellar Lorena Pedraza Adiel Alberto Vasquez Blanca Lynne Suarez Beatriz LGomez Catalina De Bedout Luz Elena Cano Group of Investigation in Oral Health Faculty of DentistryAntonio Narino UniversityArmeniaQuindio 630001Colombia Medical and Experimental MycologyUnit Corporation for Biological Research(CIB)MedellinAntioquia 050034Colombia School of Medicine and Health Sciences Universidad del RosarioCarreraBogota 111221Colombia School of Microbiology University of AntioquiaMedellinAntioquia 050036Colombia.

The aim of this study was to identify the most frequent yeasts in the oral cavity of adult individuals without immune disorders and to associate the presence of these oral yeasts with different characteristics of each individual. Oral rinse samples were obtained from 96 healthy adults and cultured in Sabouraud dextrose agar media and CHROMagar. Yeasts were identified by sequencing the D1/D2 region of the 28 S rRNA gene. Probable association among the socio-demographic characteristics, body mass index, family and personal medical history,oral hygiene, tobacco and/or alcohol consumption habits and presence of oral fungi was analyzed. Contingency tables and logistic regression were employed to evaluate possible relationships between the presence of oral fungi and mixed colonization with these variables. 57.3% of the healthy individuals had oral yeasts and 21.8% had mixed colonization. The most prevalent yeasts were Candida albicans(52%), C. parapsilosis(17.9%), and ***(7.57%). Yeasts with most frequently mixed colonization were C. albicans and C. parapsilosis. No relationships were found among the variables analyzed. However, the presence of mixed colonization was related to the presence of dental prostheses(P<0.006), dental apparatuses(P=0.016) and O’Leary index(P=0.012). This is the first study that characterized oral yeasts in Colombian healthy individuals, determined the most prevalent oral yeasts C. albicans, C. parapsilosis and C. dublinensis and an association of mixed colonization with the use of dental prostheses and aparatology and poor hygiene.

关键词： oral yeast Candida species microbial epidemiology

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Surface Elastic Waves of Semi-infinite Superlattice： On the Acoustic-Electromagnetic-Quantum Analogies

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材料科学与工程（中英文A版） 2014年第11期4卷 373-379页

作者： Gerardo jorge Vazquez Sebastian Tejada Fabiola Sanchez-roa Solid State Department Physics Institute National Autonomous University of Mexico Mexico

In this work, the propagation of transverse elastic waves and the existence and behavior of surface acoustic modes associated with the interface between an isotropic medium and a semi-infinite of periodically layered media, consisting of alternating isotropic layers composed by the elements, W/Al are investigated. The dispersion relations for such waves are obtained analytically and solved numerically. It has shown that the existence of surface modes is dependent upon the relative parameters of the isotropic medium and the semi-infinite superlattice. Furthermore, we study the mathematical analogy between acoustic, electromagnetic waves and quantum confined states. A general mathematical expression that described physical phenomena of different nature is obtained.

关键词：半无限表面模弹性波超晶格电磁波量子各向同性介质数学表达式

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菲律宾、马尼拉、菲律宾总医院结核病人的耐药特征和多种药物耐药结核病的预测指标

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国际结核病与肺部疾病杂志 1997年第1期 33-37页

作者： M.T.Mendoza A.J.Gonzaga C.roa M.A.Velmonte M.jorge J.C.Montoya T.TanTorres M.Ong.M.Y.C.Barez C.F.Ang 屠德华 philippine General Hospital Manilaphilippines

背景:本研究在菲律宾、马尼拉、菲律宾大学—菲律宾总医院(UP-PGH)进行。目的:确定肺结核病人耐药特征和多种药物耐药结核病的临床预测指标。设计:前瞻性分析描述。方法:对结核分支杆菌培养阳性的病人进行会面,了解有关抗结核治疗既往史... 详细信息

背景:本研究在菲律宾、马尼拉、菲律宾大学—菲律宾总医院(UP-PGH)进行。目的:确定肺结核病人耐药特征和多种药物耐药结核病的临床预测指标。设计:前瞻性分析描述。方法:对结核分支杆菌培养阳性的病人进行会面,了解有关抗结核治疗既往史,卡介苗接种史,胸部X线检查及家庭接触情况,从299名病人中分离的结核杆菌应用浸没纸片比例法,进行了利福平、异烟肼(INH),乙胺丁醇和链霉素的敏感性测定。用标准实验室粉剂在7H10培养基中测定吡嗪酰胺(PZA)的敏感性。结果:在299名分离的结核杆菌中17％对五种主要药物全敏感,54％对二种或二种以上药物耐药(多种药物耐药结核病,MDR-TB)。初始耐药率乙胺丁醇(39％)和INH(17％)是高的,MDR-TB明显地与既往抗结核治疗史相关(优势比[OR]2.44,95％可信限)。不正规抗结核治疗超过三个月增加MDR-TB的可能性(OR4.6,P<0.0001)。结论:高的MDR-TB率与既往抗结核治疗情况有关,当不正规的先期抗结核治疗超过三个月时发生MDR-TB的机会明显增加。

关键词：结核病肺耐药 MDR-TB(多种药物耐药结核病) 耐药性

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