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Energy Engineering 2023年第2期120卷 263-275页

作者： Yashar Aryanfar jorge luis garcía alcaraz Department of Electric Engineering and Computation Autonomous University of Ciudad JuárezCiudad JuárezChihuahuaMéxico Department of Industrial Engineering and Manufacturing Autonomous University of Ciudad JuárezCiudad JuárezChihuahuaMéxico

The usage of renewable energies,including geothermal energy,is expanding rapidly *** low efficiency of geothermal cycles has consistently highlighted the importance of recovering heat loss for these *** paper proposes a combined power generation cycle(single flash geothermal cycle with trans-critical CO_(2) cycle)and simulates in the EES(Engineering Equation Solver)*** results show that the design parameters of the proposed system are significantly improved compared to the BASIC single flash ***,the proposed approach is optimized using the genetic algorithm and the Nelder-Mead Simplex *** pressure,steam turbine output pressure,and CO_(2) turbine inlet pressure are three assumed variable parameters,and exergy efficiency is the target *** the default operating mode,the system exergy efficiency was 32%,increasing to 39%using the genetic algorithm and 37%using the Nelder-Mead method.

关键词： Optimization geothermal genetic algorithm Nelder-Mead simplex exergy efficiency

Measuring Impact of Lean Manufacturing Tools for Continuous Improvement on Economic Sustainability

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 452-474页

作者： luis Javier Márquez Figueroa jorge luis garcía-alcaraz Ahmed I.Osman Alfonso Jesús Gil López Yashar Aryanfar Mika Sillanpää Mamdouh El Haj Assad Department of Electrical Engineering and Computer Science Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico Department of Industrial Engineering and Manufacturing Universidad Autónoma de Ciudad JuárezCiudad JuárezChihuahuaMéxico School of Chemistry and Chemical Engineering Queens UniversityBelfastNorthern IrelandUK Department of Economic and Managerial Sciences University of La RiojaLa RiojaSpain Department of Chemical Engineering University of JohannesburgJohannesburgSouth Africa Department of Sustainable and Renewable Energy Engineering University of SharjahSharjahUAE

Using Lean Manufacturing(LM)tools in production processes is crucial for companies’economic,environmental,and social sustainability *** study shows a structural equation model(SEM)that shows the relationship between LM Tools like Kaizen(KAI),Gemba(GEM),Value Stream Mapping(VSM)and Key Performance Indicator(KPI)with Economic Sustainability(ECS).Seven hypotheses were evaluated with data from 179 responses to a questionnaire about the Mexican maquiladora industry,showing that these variables are *** a 95%confidence level,the model was evaluated using the partial least squares *** findings indicate that the relationships between KAI and GEM and KAI and VSM have the strongest relationship,followed by VSM and ECS;however,VSM has the strongest effect on *** on these findings,it is recommended that managers adopt a continuous improvement(KAI)approach based on working directly on the shop floor(GEM and VSM)to support their decisions regarding economic growth(ECS).

关键词： Lean manufacturing economic sustainability structural equation model quality improvement

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris K.Salgado Jose M.Santiago Samuel E.Ocasio Rivera Dina P.Bracho-Rincon luis H.Pagan Rivera jorge D.Miranda Department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma

Multi-objective evolutionary optimization and thermodynamics performance assessment of a novel time-dependent solar Li-Br absorption refrigeration cycle

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Science China(Technological Sciences) 2022年第11期65卷 2703-2722页

作者： MOHTARAM Soheil WU WeiDong ARYANFAR Yashar ABRISHAMI Arya OMIDI Mohammad YANG QiGuo garcIA alcaraz jorge luis CHEN YongBao School of Energy and Power Engineering University of Shanghai for Science and Technology Shanghai 20093China Department of Electric Engineering and Computation Autonomous University of Ciudad JudrezJuarezChihuahuaMexico School of Aerospace Engineering Tsinghua University Bejing 100084China School of Energy and Power Engineering Dalian University of TechnologyDalian116024China Depariment of Industrial Engineering and Manufacturing Autonomous University of Ciudad JudrezJudrezChihuahuaMexico

This research paper aims to perform dynamics analysis,3E assessment including energy,exergy,exergoeconomic,and the multiobjective evolutionary optimization on a novel solar Li-Br absorption refrigeration *** research is time-dependent,owing to solar radiation variability during different ***,all the necessary thermodynamic,energy,and exergy equations are applied *** is followed by the thermoeconomic analysis,which takes place after defining the designing variables during the thermoeconomic optimization process and is presented together with the economic relations of the system and its thermoeconomic ***,the sensitivity analysis is undertaken,the source of system inefficiency is determined,the multi-objective evolutionary optimization of the whole system is carried out,and the optimal values are compared with the primary *** Equation Solver(EES)software has been used to accomplish comprehensive *** part of the validation process,the results of the research are compared with those published previously and are found to be relatively consistent.

关键词： solar absorption refrigeration water-lithium bromide thermodynamics performance exergy analysis multi-objective optimization

Local excision by transanal endoscopic surgery

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World Journal of Gastroenterology 2015年第31期21卷 9286-9296页

作者： luis J garcía-Flórez jorge L Otero-Díez General and Digestive Surgery Service Colorectal UnitHospital San Agustín

Transanal endoscopic surgery(TES) consists of a series of anorectal surgical procedures using different devices that are introduced into the anal canal. TES has been developed significantly since it was first used in the 1980 s. The key point for the success of these techniques is how accurately patients are selected. The main indication was the resection of endoscopically unresectable adenomas. In recent years,these techniques have become more widespread which has allowed them to be applied in conservative rectal procedures for both benign diseases and selected cases of rectal cancer. For more advanced rectal cancers it should be considered palliative or,in some controlled trials,experimental. The role of newer endoscopic techniques available has not yet been defined. TES may allow for new strategies in the treatment of rectal pathology,like transanal natural orifice transluminal endoscopic surgery or total mesorectal excision.

关键词： Transanal endoscopic surgery Rectal adenoma Early

Role of platelets and breast cancer stem cells in metastasis

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World Journal of Stem Cells 2020年第11期12卷 1237-1254页

作者： Gretel Mendoza-Almanza luis Burciaga-Hernandez Vilma Maldonado jorge Melendez-Zajgla jorge Olmos CONACYT Universidad Autónoma de Zacatecas.Zacatecas 98060Mexico Maestría en Ciencias Biomédicas Universidad Autónoma de ZacatecasZacatecas 98160Mexico Laboratorio de Epigenética Instituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Génómica funcional del cáncer Instituto Nacional de Medicina GenómicaCiudad de México 14610Mexico Biotecnología Marina Centro de Investigación Científica y de Estudios Superiores de EnsenadaEnsenada 22860Mexico

The high mortality rate of breast cancer is mainly caused by the metastatic ability of cancer cells,resistance to chemotherapy and radiotherapy,and tumor regression *** recent years,it has been shown that the presence of breast cancer stem cells is closely associated with the migration and metastatic ability of cancer cells,as well as with their resistance to chemotherapy and *** tumor microenvironment is one of the main molecular factors involved in cancer and metastatic processes development,in this sense it is interesting to study the role of platelets,one of the main communicator cells in the human body which are activated by the signals they receive from the microenvironment and can generate more than one *** can ingest and release RNA,proteins,cytokines and growth *** the platelets interact with the tumor microenvironment,they are called"tumor-educated platelets."Tumor-educated platelets transport material from the tumor microenvironment to sites adjacent to the tumor,thus helping to create microenvironments conducive for the development of primary and metastatic *** has been observed that the clone capable of carrying out the metastatic process is a cancer cell with stem cell *** stem cells go through a series of processes,including epithelial-mesenchymal transition,intravasation into blood vessels,movement through blood vessels,extravasation at the site of the establishment of a metastatic focus,and site ***-educated platelets support all these processes.

关键词： Breast cancer stem cells Platelets Metastasis Tumor microenvironment Epithelial-mesenchymal transition

Optimal Design of Hybrid Microgrid in Isolated Communities of Ecuador

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 488-499页

作者： luis A.Pesantes Ruben Hidalgo-León Johnny Rengifo Miguel Torres jorge Aragundi JoséCordova-garcia luis F.Ugarte Facultad de Ingeniería en Electricidad y Computación of Escuela Superior Politécnica del Litoral(ESPOL)University GuayaquilEcuador Department of Electrical Engineering at Universidad Técnica Federico Santa María SantiagoChile IEEE

In rural territories, the communities use energy sources based on fossil fuels to supply themselves with electricity, which may address two main problems: greenhouse gas emissions and high fuel prices. Hence, there is an opportunity to include renewable resources in the energy mix. This paper develops an optimization model to determine the optimal sizing, the total annual investment cost in renewable generation, and other operating costs of the components of a hybrid microgrid. By running a k-means clustering algorithm on a meteorological dataset of the community under study, the hourly representative values become input parameters in the proposed optimization model. The method for the optimal design of hybrid microgrid is analyzed in six operating scenarios considering:(1) 24-hour continuous power supply;(2) load shedding percentage;(3) diesel power generator(genset) curtailment;(4) the worst meteorological conditions;(5) the use of renewable energy sources including battery energy storage systems(BESSs);and(6) the use of genset. A mathematical programming language(AMPL) tool is used to find solutions of the proposed optimization model. Results show that the total costs of microgrid in the scenarios that cover 100% of the load demand(without considering the scenario with 100% renewables) increase by over 16% compared with the scenario with genset operation limitation. For the designs with power supply restrictions, the total cost of microgrid in the scenario with load shedding is reduced by over 27% compared with that without load shedding.

关键词： Battery energy storage system(BESS) isolated community microgrid renewable energy optimization

Pharmacological treatments of presbyopia:a review of modern perspectives

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Eye and Vision 2017年第1期4卷 14-17页

作者： Antonio Renna jorge L.Alió luis Felipe Vejarano Vissum Alicante AlicanteSpain Studi Medici Renna MelendugnoLecceItaly Universidad Miguel Hernandez Calle Cabañal 103016 AlicanteSpain Vissum Instituto Oftalmologico de Alicante AlicanteSpain Fundación Oftalmológica Vejarano PopayanColombia Universidad del Cauca PopayanColombia

Introduction:Presbyopia affects people from the 4^(th) decade of life and is characterized by accommodative loss that leads to negative effects on vision-targeted health-related quality of life.A non-invasive pharmacological treatment providing near-lenses independence would be a truly groundbreaking approach in the treatment of *** purpose of this review is to analyze the emerging pharmacological solutions proposed to address ***:Several ophthalmic eye drops compounds solutions have been described in peer-reviewed papers or presented in ophthalmological tabloids and *** topical treatment deals with drug combinations aimed to modify one or more factors involved in the accommodative process and have been proposed to be instilled either monocularly or *** remains unclear how much each drug in the final combined form is involved in the achievement of the outcome and contributes to ***:Despite the lack of a completely well understood mechanism,pharmacological control of presbyopia seems to be a possible and very attractive alternative for presbyopic *** studies mentioned in this review are to be considered pilot investigations as they involve either a small number of subjects or are single case *** studies are needed to confirm which will be the more effective pharmacological compound for the treatment of presbyopia.

关键词： Presbyopia Ageing Near vision Glasses Multifocality Accommodation Pharmacological therapy Eyedrops

Comparing surgical efficiencies between phacoemulsification systems: a single surgeon retrospective study of 2000 eyes

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International Journal of Ophthalmology(English edition) 2022年第4期15卷 581-585页

作者： luis Escaf-Jaraba jorge Escobar-DiazGranados Bartolomé Valdemarín Clínica Oftalmológica del Caribe Barranquilla 080003Colombia Universidad Simón Bolívar Barranquilla 080004Colombia

AIM: To compare under similar conditions intraoperative surgical efficiencies metrics between an active fluidics and a gravity based phacoemulsification ***: Adult patients who were diagnosed with a cataract that compromised visual acuity inferior to 20/40 were included in the study. Patients were excluded from the study if they had a history of severe retinal disorders, clinically significant corneal endothelial dystrophy or history of corneal disease. All phacoemulsification surgeries were performed by a single surgeon. Both phacoemulsification systems used the 0.9 mm 45-degree aspiration bypass system Intrepid Balanced tip and the 0.9 mm Intrepid Ultra infusion sleeve. All cataracts were classified using the Lens Opacities Classification System III, cumulative dissipated energy(CDE) and aspiration fluids were measured in each ***: Totally 2000 eyes were included in the study. Phacoemulsification was performed in 1000(50%) eyes with an active fluid dynamics system and in 1000(50%) eyes with a gravity-based fluidic system. Mean CDE until fracture of the lens was 1.1 and 1.9 percent-seconds and total mean CDE used was 5.6 and 7.2 percent-seconds using an active fluidics dynamics system and gravity-based fluidic system, respectively(P<0.001). Mean aspiration fluids used were 70 m L using an active fluidics dynamics system and 85 m L using a gravity-based fluidic system(P<0.001).CONCLUSION: This study evidences that surgeries performed under similar conditions(same surgeon, phaco tip and sleeve) with the active fluidics dynamics system required significantly lower CDE and aspiration fluids.

关键词： ophthalmology phacoemulsification surgical ef ficiencies cumulative dissipated energy aspiration fluids

Capillary hydrodynamic fractionation of hydrophobic colloids:Errors in the estimated particle size distribution

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Particuology 2014年第6期12卷 97-105页

作者： luis A.Clementi Zohartze Artetxe Ziortza Aguirreurreta Amaia Agirre Jose R.Leiza luis M.Gugliotta jorge R.Vega INTEC(CONICET and Universidad Nacional del Litoral) FRSF-UTN(Facultad Regional Santa Fe-Universidad Tecnologica Nacional) POLYMAT Kimika Aplikatua SailaKimika Zientzien FakultateaUniversity of the Basque Country UPV/EHUJoxe Mari Korta Zentroa

Capillary hydrodynamic fractionation（CHDF） with turbidity detection at a single wavelength is an analytical technique that is often used for sizing the sub-micrometric particles of hydrophobic *** article investigates three sources of errors that affect the particle size distribution（PSD） estimated by CHDF：diameter calibration errors,uncertainties in the particle refractive index（PRI）,and instrumental broadening（IB）.The study is based on simulated and experimental examples that involve unimodal and bimodal *** errors in the diameter calibration curve can produce important deviations in the number average diameter due to systematic shifts suffered by the PSD *** uncertainties in the PRI are unimportant in the analysis of unimodal PSDs,but in the specific case of bimodal PSDs,errors in the PRI can strongly affect the estimated number concentration of each *** typical IB correction（based on the IB function estimated from narrow standards） produces slightly erroneous average diameters but can lead to PSDs with underestimated widths and distorted *** practice,the three investigated sources of errors can be present simultaneously,and uncertainties in the average diameters,the shape and width of the PSD,and the number concentration of the PSD modes are unavoidable.

关键词： Particle size distribution Capillary hydrodynamic fractionation Nanoparticle Particle refractive index Instrumental broadening