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Hankel operators on exponential Bergman spaces

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Science China Mathematics 2022年第2期65卷 421-442页

作者： Zhangjian Hu jordi pau Department of Mathematics Huzhou UniversityHuzhou 313000China Departament de Matematiques i Informatica Universitat de BarcelonaBarcelona 08007Spain

We completely describe the boundedness and compactness of Hankel operators with general symbols acting on Bergman spaces with exponential type weights.

关键词： weighted Bergman space Hankel operator ?-equation

Metabolomic fingerprinting of pig seminal plasma identifies in vivo fertility biomarkers

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Journal of Animal Science and Biotechnology 2022年第2期13卷 473-487页

作者： Yentel Mateo-Otero Pol Fernández-López Ariadna Delgado-Bermúdez pau Nolis jordi Roca jordi Miró Isabel Barranco Marc Yeste Biotechnology of Animal and Human Reproduction(TechnoSperm) Institute of Food and Agricultural TechnologyUniversity of GironaES-17003 GironaSpain Department of Biology Unit of Cell BiologyFaculty of SciencesUniversity of GironaES-17003 GironaSpain Centre d’Estudis Avançats de Blanes(CEAB) Spanish Research Council(CSIC)ES-17300 GironaSpain Magnetic Nuclear Resonance Facility Autonomous University of BarcelonaBellaterraES-08193 Cerdanyola del VallèsSpain Department of Animal Medicine and Surgery Faculty of Veterinary MedicineUniversity of MurciaES-30100 MurciaSpain Equine Reproduction Service Department of Animal Medicine and SurgeryFaculty of Veterinary MedicineAutonomous University of BarcelonaBellaterraES-08193 Cerdanyola del VallèsSpain Department of Veterinary Medical Sciences University of BolognaIT-40064 Ozzano dell’EmiliaBolognaItaly

Background:Metabolomic approaches,which include the study of low molecular weight molecules,are an emerging-omics technology useful for identification of *** this field,nuclear magnetic resonance(NMR)spectroscopy has already been used to uncover(in)fertility biomarkers in the seminal plasma(SP)of several mammalian ***,NMR studies profiling the porcine SP metabolome to uncover in vivo fertility biomarkers are yet to be carried ***,this study aimed to evaluate the putative relationship between SPmetabolites and in vivo fertility *** this end,24 entire ejaculates(three ejaculates per boar)were collected from artificial insemination(AI)-boars throughout a year(one ejaculate every 4 months).Immediately after collection,ejaculates were centrifuged to obtain SP-samples,which were stored for subsequent metabolomic analysis by NMR *** outcomes from 1525 inseminations were recorded over a year,including farrowing rate,litter size,stillbirths per litter and the duration of ***:A total of 24 metabolites were identified and quantified in all *** operating characteristic(ROC)curve analysis showed that lactate levels in SP had discriminative capacity for farrowing rate(area under the curve[AUC]=0.764)while carnitine(AUC=0.847),hypotaurine(AUC=0.819),sn-glycero-3-phosphocholine(AUC=0.833),glutamate(AUC=0.799)and glucose(AUC=0.750)showed it for litter ***,citrate(AUC=0.743),creatine(AUC=0.812),phenylalanine(AUC=0.750),tyrosine(AUC=0.753)and malonate(AUC=0.868)levels had discriminative capacity for stillbirths per litter;and malonate(AUC=0.767)and fumarate(AUC=0.868)levels for gestation ***:The assessment of selected SP-metabolites in ejaculates through NMR spectroscopy could be considered as a promising non-invasive tool to predict in vivo fertility outcomes in ***,supplementing AI-doses with specific metabolites should also be envisaged as a way to improve their f

关键词： Artificial insemination in vivo fertility Metabolomics NMR Pregnancy outcomes Seminal plasma

Analgesic effect of inhaled lavender essential oil for frenotomy in healthy neonates:a randomized clinical trial

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World Journal of Pediatrics 2022年第6期18卷 398-403页

作者： Silvia Maya-Enero Montserrat Fàbregas-Mitjans Rosa Maria Llufriu-Marquès Júlia Candel-pau jordi Garcia-Garcia MaríaÁngeles López-Vílchez Department of Neonatology Service of PediatricsHospital del MarParc de Salut MarUniversitat Pompeu FabraPasseig Marítim 25-2908003BarcelonaSpain

Background Neonatal pain may affect long-term neurodevelopment and must be *** is a painful procedure wherein a common strategy to relieve pain(sucking)cannot be used because the technique is performed on the *** essential oil(LEO)has sedative and antispasmodic properties and has been successfully used to treat pain during heel puncture and *** aim was to demonstrate if the use of inhaled LEO is effective in reducing pain during frenotomy in healthy,full-term *** We conducted a randomized clinical trial in neonates who underwent a frenotomy between August 2020 and April *** assessed pain using pre and post-procedure heart rate and oxygen saturation,crying time and Neonatal Infant Pain Scale(NIPS)*** with type 3 tongue tie were randomized into the“experimental group”and“control group”.In both groups,we performed swaddling,administered oral sucrose,and let the newborn suck for two *** the experimental group,we also placed a gauze pad with one drop of LEO under the neonate’s nose for two minutes prior to and during the *** We enrolled 142 patients(71 per group).The experimental group showed significantly lower NIPS scores(1.88 vs 2.92)and cried almost half the amount of time(14.8 vs.24.6 seconds,P=0.006).Comparing with the control group,we observed no side effects in either of the *** We observed a significant decrease in crying time and lower NIPS scores in the neonates who received inhaled LEO and underwent a frenotomy for type 3 ***,we recommend using inhaled LEO during neonatal frenotomies.

关键词： Ankyloglossia Aromatherapy Frenotomy Lavender Neonate Neonatal pain Tongue-tie

Efficacy and safety of deep sclerectomy with uveoscleral implant plus collagen matrix implant overcoming the superficial scleral flap in glaucoma surgery

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International Journal of Ophthalmology(English edition) 2023年第11期16卷 1806-1813页

作者： Jéssica Botella-García Marta Balboa pau Romera-Romero Theo Stijnen Adrián Sánchez-Fortún Karl Mercieca jordi Loscos-Arenas Department of Ophthalmology Hospital Germans Trias i PujolBadalona 08916Spain International University of Catalonia(UIC) Barcelona 08017Spain Department of Surgery Barcelona Autonomous University(UAB)Barcelona 08035Spain Department of Biomedical Data Sciences Leiden University Medical CenterLeiden 2333The Netherlands University Hospitals Bonn Eye Clinic Bonn53127Germany Germans Trias i Pujol Research Institute(IGTP) Badalona 08916Spain

AIM:To assess the efficacy and safety of non-penetrating deep sclerectomy(NPDS)with uveoscleral implant plus subconjunctival and intrascleral collagen matrix overcoming the superficial scleral flap lips(modified deep sclerectomy technique,DS)and minimal use of mitomycin C in glaucoma ***:A retrospective review of 47 consecutive glaucoma patients who underwent NPDS with DS between January 2017 and May ***-corrected visual acuity,intraocular pressure(IOP),post-operative need for glaucoma medications,visual field mean deviation(MD),re-interventions,needling revisions and laser goniopuncture were *** success was defined as IOP≤18 mm Hg without topical *** success was defined as the same criteria but with the addition of any antihypertensive *** over 18 mm Hg on two consecutive followup visits was considered as a ***:Fifty-two eyes of 47 patients were *** preoperative IOP was 25.37±6.47 mm Hg,and decreased to 15.04±4.73 at 12mo and 12.21±4.1 at 24mo(all P<0.0001).Requirement for topical medications dropped from a mean of 3.06±0.25 per patient to 0.51±0.99 and 1.11±1.23 respectively after 12 and 24mo(all P<0.0001).No medications were required in 45.5%of patients after *** and absolute success rate at 24mo were 85.5%±5%and 48.5%±7.4%,***:DS is a safe and effective nonpenetrating glaucoma surgery *** aims to retain the patency of all pathways created for aqueous humor drainage:the intrascleral bleb,the supraciliary space and the open communication between intrascleral and subconjunctival compartments.

关键词： deep sclerectomy glaucoma surgery uveoscleral implant

Preventive care for burnout: General practitioner pilot program in Barcelona

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Health 2013年第6期5卷 24-31页

作者： Jorge L. Tizón pau Gràcia Anna Larripa jordi Artigue Josep Casajuana Mental Health Prevention and Early Attention Team for Patients at Risk for Psychosis (EAPPP) Catalan Health Institute (Institut Catalá de la Salut) Barcelona Spain Mental Health Prevention and Early Attention Team for Patients at Risk for Psychosis (EAPPP) Catalan Health Institute (Institut Catalá de la Salut) Barcelona Spain Primary Care Catalan Health Institute (Institut Catalá de la Salut) Barcelona Spain

Background: Despite the prevalence of “professsional exhaustion syndrome” or “burnout”, very few intervention programs for healthcare professionals have been proposed, and even fewer have been evaluated. The Catalan Health Institute requested an intervention that would be preventive, integrated, and would differentiate between those affected by burnout and those with established psychopathologic disorders requiring specific treatment. Aims: To describe the experience and initial reflections from the first cohort of primary care physicians in the Barcelona public health system to participate in a program designed to prevent burnout. Methods: Descriptive analysis of the characteristics of this secondary prevention program: design, cost estimates, recruitment and screening, and activities (training, organization, and group techniques). Particular emphasis on the process of identifying potentially affected professionals, how they were offered the opportunity to participate, and the coordinated and confidential nature of the program. Results: Of a target population of 969 family doctors and pediatricians in public primary care services in Barcelona, 6 (0.61%) applied for full program participation. All of them, along with 2 non-medical professionals in primary care services who joined the program, met the clinical and psychometric criteria (Shirom-Melamed Burnout Measure, General Health Questionnaire, and the 16 Personality Factors Questionnaire) of the desired participant profile. Conclusions: The level of participation could suggest defects in program design or, alternatively, problems in the concept of burnout. This construct may be more useful for detecting stress attributed to occupational contexts than for facilitating participation in activities related to its prevention or treatment.

关键词： Burnout Psychopathology Preventive Programs Professional health Mental Health

Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

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Translational Neurodegeneration 2021年第4期10卷 666-677页

作者： Nuole Zhu Miguel Santos-Santos Ignacio lllán-Gala Victor Montal Teresa Estellés Isabel Barroeta Miren Altuna Javier Arranz Laia Muñoz Olivia Belbin Isabel Sala Maria Belén Sánchez-Saudinós Andrea Subirana Laura Videla jordi Pegueroles Rafael Blesa jordi Clarimón Maria Carmona-Iragui Juan Fortea Alberto Lleó Daniel Alcolea Sant pau Memory Unit Department of NeurologyInstitut d'Investigacions Biomèdiques Sant Pau-Hospital de Sant PauUniversitat Autònoma de Barcelona08041 BarcelonaSpain Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas(CIBERNED) 28031 MadridSpain Autonomous University of Barcelona 08913 BarcelonaSpain Fundación Catalana Sindrome de Down Centre Mèdic Down08029 BarcelonaSpain

Background:Astrocytes play an essential role in neuroinflammation and are involved in the pathogenesis of neurodenegerative *** of glial fibrillary acidic protein(GFAP),an astrocytic damage marker,may help advance our understanding of different neurodegenerative *** this study,we investigated the diagnostic performance of plasma GFAP(pGFAP),plasma neurofilament light chain(pNfL)and their combination for frontotemporal dementia(FTD)and Alzheimer's disease(AD)and their clinical utility in predicting disease ***:pGFAP and pNfL concentrations were measured in 72 FTD,56 AD and 83 cognitively normal(CN)participants using the Single Molecule Array *** the 211 participants,199 underwent cerebrospinal(CSF)analysis and 122 had magnetic resonance *** compared cross-sectional biomarker levels between groups,studied their diagnostic performance and assessed correlation between CSF biomarkers,cognitive performance and cortical *** prognostic performance was investigated,analyzing cognitive decline through group comparisons by ***:Unlike pNfL,which was increased similarly in both clinical groups,pGFAP was increased in FTD but lower than in AD(all P<0.01).Combination of both plasma markers improved the diagnostic performance to discriminate FTD from AD(area under the curve[AUC]:combination 0.78;pGFAP 0.7;pNfL 0.61,all P<0.05).In FTD,pGFAP correlated with cognition,CSF and plasma NfL,and cortical thickness(all P<0.05).The higher tertile of pGFAP was associated with greater change in MMSE score and poor cognitive outcome during follow-up both in FTD(1.40 points annually,hazard ratio[HR]3.82,P<0.005)and in AD(1.20 points annually,HR 2.26,P<0.005).Conclusions:pGFAP and pNfL levels differ in FTD and AD;and their combination is useful for distinguishing between the two *** could also be used to track disease severity and predict greater cognitive decline during follow-up in patients with FTD.

关键词： Glial fibrillary acidic protein Neurofilament Frontotemporal dementia Plasma biomarkers

Anemia in patients with high-risk acute coronary syndromes admitted to Intensive Cardiac Care Units

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Journal of Geriatric Cardiology 2020年第1期17卷 35-42页

作者： Victoria Lorente Jaime Aboal Cosme Garcia jordi Sans-Rosello Antonia Sambola Rut Andrea Carlos Tomas Gil Bonet David Vinas Nabil el Ouaddi Santiago Montero Javier Cantalapiedra Margarida Pujol Isabel Hernandez Maria Perez-Rodriguez Isaac Llao Jose C Sanchez-Salado Miquel Gual Albert Ariza-Sole 无 Hospital Universitari de Bellvitge L’Hospitalet de LlobregatBarcelonaSpain Hospital Unversitari Josep Trueta GironaSpain Hospital Universitari Germans Trias i Pujol Badalona BarcelonaSpain Hospital de la Santa Creu i Sant pau Instituto de Investigación Biomedica IIB Sant PauUniversitat Autonoma de Barcelona(UAB)BarcelonaSpain Hospital Universitari de la Vall d’Hebron BarcelonaSpain Hospital Clinic i Provicial BarcelonaSpain Hospital Arnau de Vilanova LleidaSpain Hospital Joan XXIII TarragonaSpain the Grup de Treball de Cures Agudes Cardiologiques de la Societat Catalana de Cardiologia

Background Little information exists about the role of anemia in patients with acute coronary syndromes(ACS)admitted to Intensive Cardiac Care Units(ICCU).The aim of this study was to assess the prevalence of anemia and its impact on management and outcomes in this clinical *** All consecutive patients admitted to eight different ICCUs with diagnosis of non-ST segment elevation ACS(NSTEACS)were prospectively *** was defined as hemoglobin<130 g/L in men and<120 g/L in *** association between anemia and mortality or readmission at six months was assessed by the Cox regression *** A total of 629 patients were *** age was 66.6 years.A total of 197 patients(31.3%)had *** angiography was performed in most patients(96.2%).Patients with anemia were significantly older,with a higher prevalence of comorbidities,poorer left ventricle ejection fraction and higher GRACE score *** with anemia underwent less often coronary angiography,but underwent more often intraaortic counterpulsation,non-invasive mechanical ventilation and renal replacement *** ICCU and hospital stay were significantly longer in patients with *** the incidence of mortality(HR=3.36,95%CI:1.43–7.85,P=0.001)and the incidence of mortality/readmission were significantly higher in patients with anemia(HR=2.80,95%CI:2.03–3.86,P=0.001).After adjusting for confounders,the association between anemia and mortality/readmission remained significant(P=0.031).Conclusions Almost one of three NSTEACS patients admitted to ICCU had *** patients underwent coronary *** was independently associated to poorer outcomes at 6 months.

关键词： Acute coronary syndromes Anemia Intensive cardiac care units Prognosis

PKR and PP1C Polymorphisms in Alzheimer’s Disease Risk

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Neuroscience & Medicine 2011年第3期2卷 226-231页

作者： Ernest Palomer Gerard ILL-Raga Marta Tajes Eva Ramos-Fernández Mònica Bosch-Morató Biuse Guivernau Jose J.Galan jordi Clarimon Carmen Antunez Merce Boada Luis M.Real César Fandos Francisco J.Munoz Laboratory of Molecular Physiology and Channelopathies Department of Experimental and Health SciencesPompeu Fabra University(UPF)BarcelonaSpain NeoCodex SevillaSpain Alzheimer Laboratory Neurology DepartmentSanta Creu and Sant Pau HospitalBiomedical Research Center on Neurodegenerative Diseases(CIBERNED)BarcelonaSpain Fundacion Alzheimur Dementia UnitVirgen de la Arrixaca HospitalMurciaSpain Memory Clinic of ACE Foundation Catalan Institute of Applied NeurosciencesBarcelonaSpain Neurology Department Vall d’Hebron Universitary HospitalBarcelonaSpain

Alzheimer’s disease (AD) is a neurodegenerative disease characterized by senile plaques and neurofibrillary tangles. Senile plaques are deposits of amyloid ?-peptide (A?) produced by the cleavage of a transmembrane protein termed Amyloid Precursor Protein (APP). The amyloidogenic cleavage of APP is performed by γ-secretase complex and ?-site APP cleaving enzyme 1 (BACE1), a key enzyme in AD that can be activated by different noxious stimuli. Interestingly, some viruses could activate double-stranded RNA-activated protein kinase (PKR), which phosphorylates Eukaryotic Initiation Factor 2 alpha (eIF2α). This phosphorylation stops global translation to avoid any synthesis of viral infective proteins, but paradoxically up-regulates BACE1 translation. One of the viral mechanisms to circumvent eIF2α phosphorylation is the recruitment of protein phosphatase 1 (PP1), to fully dephosphorylate eIF2α and allow viral protein synthesis. Due to the functional relationship between BACE1, PKR, PP1 and AD we have performed a large (1122 cases and 1191 control individuals) case-control genetic analysis using two biallelic polymorphisms rs2254958 and rs7480390, located within the genes coding for PKR and the catalytic unit A of PP1, respectively. Although a trend to association of the rs2254958 TT genotype with AD risk was found, our results show that neither rs7480390 nor rs2254958 are associated with AD susceptibility.

关键词： Alzheimer’s Disease BACE1 PKR PP1 eIF2α

Prognostic value of increased carbohydrate antigen in patients with heart failure

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World Journal of Cardiology 2014年第4期6卷 205-212页

作者： Ana B Méndez jordi Ordonez-Llanos Andreu Ferrero Mariana Noguero Teresa Mir Josefina Mora Antoni Bayes-Genis Sònia Mirabet Juan Cinca Eulàlia Roig Cardiology Department Hospital de la Santa Creu i Sant PauInstitut de Recerca Biomèdica Sant Pau and Universitat Autònoma Biochemistry Department Hospital de la Santa Creu i Sant PauInstitut de Recerca Biomèdica Sant Pau and Universitat Autònoma Cardiology Department Hospital Germans Trias I Pujol

AIM:To study the prognostic value of carbohydrateantigen 125(CA125) and whether it adds prognostic information to N-terminal pro-brain natriuretic peptide(NT-proBNP) in stable heart failure(HF) ***:The predictive value of CA125 was retrospectively assessed in 156 patients with stable HF remitted to the outpatient HF unit for monitoring from 2009 to *** were included in the study if they had a previous documented episode of HF and received HF ***125 and NT-proBNP concentrations were *** independent association between NT-proBNP or CA125 and mortality was assessed with Cox regression analysis,and their combined predictive ability was tested by the integrated discrimination improvement(IDI) ***:The mean age of the 156 patients was 72 ± 12 *** follow-up(17 ± 8 mo),27 patients died,1 received an urgent heart transplantation and 106 required hospitalization for *** CA125 values were correlated with outcomes:58 ± 85 KU/L if hospitalized vs 34 ± 61 KU/L if not(P 60 KU/L identified patients in stable HF with poor *** CA125 level adds prognostic value to NT-proBNP level in predicting HF outcomes.

关键词： Heart failure Prognosis Carbohydrate antigen 125 Brain natriuretic peptides Survival